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Article

Cyclooxygenase I and II inhibitors distinctly enhance hippocampal- and cortex-dependent cognitive functions in mice

  • Authors:
    • Huma Syed
    • Muhammad Faisal Ikram
    • Ahmed Yaqinuddin
    • Touqeer Ahmed
  • View Affiliations / Copyright

    Affiliations: Neurobiology Laboratory, Atta‑ur‑Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad 44000, Pakistan, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia
  • Pages: 7649-7656
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    Published online on: September 23, 2015
       https://doi.org/10.3892/mmr.2015.4351
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Abstract

Cyclooxygenase (COX) enzymes are expressed in the brain; however, their role in hippocampus-dependent and cortex-dependent cognitive functions remains to be fully elucidated. The aim of the present study was to comparatively investigate the effects of piroxicam, a selective COX-I inhibitor, and celecoxib, a selective COX‑II inhibitor, on cognitive functions in an AlCl3‑induced neurotoxicity mouse model to understand the specific role of each COX enzyme in the hippocampus and cortex. The AlCl3 (250 mg/kg) was administered to the mice in drinking water and the drugs were administered in feed for 30 days. Assessments of memory, including a Morris water maze, social behavior and nesting behavior were performed in control and treated mice. The RNA expression of the COX enzymes were analyzed using reverse transcription‑quantitative polymerase chain reaction analysis. An ex‑vivo 2,2‑Diphenyl‑1‑picrylhydrazyl assay was performed in the hippocampus and cortex. Following 30 days of treatment with thedrugs, the mice in the celecoxib‑ and piroxicam‑treated groups exhibited enhanced learning (6.84±0.76 and 9.20±1.08, respectively), compared with the AlCl3‑induced neurotoxicity group (21.14±0.76) on the fifth day of the Morris water maze test. Celecoxib treatment improved social affiliation in the AlCl3‑induced neurotoxicity group, the results of which were superior to piroxicam. Piroxicam led to better improvement in nesting score in the AlCl3‑induced neurotoxicity group. Both drugs decreased the expression levels of COX‑I and COX‑II in the hippocampus and cortex, and rescued oxidative stress levels. These findings suggested that each drug distinctly affected cognitive functions, highlighting the distinctive roles of COX-I and COX-II in learning and memory.
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View References

1 

Choi SH, Aid S, Choi U and Bosetti F: Cyclooxygenases-1 and -2 differentially modulate leukocyte recruitment into the inflamed brain. Pharmacogenomics J. 10:448–457. 2010. View Article : Google Scholar

2 

McGeer PL, Itagaki S, Tago H and McGeer EG: Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR. Neurosci Lett. 79:195–200. 1987. View Article : Google Scholar : PubMed/NCBI

3 

Haga S, Akai K and Ishii T: Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody. Acta Neuropathol. 77:569–575. 1989. View Article : Google Scholar : PubMed/NCBI

4 

Wisniewski HM, Wegiel J, Wang KC and Lach B: Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease. Acta Neuropathol. 84:117–127. 1992. View Article : Google Scholar : PubMed/NCBI

5 

McGeer PL, Schulzer M and McGeer EG: Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies. Neurology. 47:425–432. 1996. View Article : Google Scholar : PubMed/NCBI

6 

in t'Veld BA, Ruitenberg A, Hofman A, Launer LJ, van Duijn CM, Stijnen T, Breteler MM and Stricker BH: Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med. 345:1515–1521. 2001. View Article : Google Scholar

7 

McGeer PL and McGeer EG: NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies. Neurobiol Aging. 28:639–647. 2007. View Article : Google Scholar

8 

Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, Tran T, Ubeda O, Ashe KH, Frautschy SA and Cole GM: Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci. 20:5709–5714. 2000.PubMed/NCBI

9 

Lim GP, Yang F, Chu T, Gahtan E, Ubeda O, Beech W, Overmier JB, Hsiao-Ashec K, Frautschy SA and Cole GM: Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol Aging. 22:983–991. 2001. View Article : Google Scholar

10 

McKee AC, Carreras I, Hossain L, Ryu H, Klein WL, Oddo S, LaFerla FM, Jenkins BG, Kowall NW and Dedeoglu A: Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Res. 1207:225–236. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Choi SH, Aid S, Caracciolo L, Minami SS, Niikura T, Matsuoka Y, Turner RS, Mattson MP and Bosetti F: Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease. J Neurochem. 124:59–68. 2013. View Article : Google Scholar :

12 

Williams CS and DuBois RN: Prostaglandin endoperoxide synthase: Why two isoforms? Am J Physiol. 270:G393–G400. 1996.PubMed/NCBI

13 

Candelario-Jalil E: A role for cyclooxygenase-1 in beta-amyloid-induced neuroinflammation. Aging (Albany NY). 1:350–353. 2009.

14 

Kelley KA, Ho L, Winger D, Freire-Moar J, Borelli CB, Aisen PS and Pasinetti GM: Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2. Am J Pathol. 155:995–1004. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Hoozemans JJ, Rozemuller AJ, Janssen I, De Groot CJ, Veerhuis R and Eikelenboom P: Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain. Acta Neuropathol. 101:2–8. 2001.PubMed/NCBI

16 

Li XB, Zheng H, Zhang ZR, Li M, Huang ZY, Schluesener HJ, Li YY and Xu SQ: Glia activation induced by peripheral administration of aluminum oxide nanoparticles in rat brains. Nanomedicine. 5:473–479. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Garcia-Bueno B, Serrats J and Sawchenko PE: Cerebrovascular cyclooxygenase-1 expression, regulation and role in hypothalamic-pituitary-adrenal axis activation by inflammatory stimuli. J Neurosci. 29:12970–12981. 2009. View Article : Google Scholar

18 

Matousek SB, Hein AM, Shaftel SS, Olschowka JA, Kyrkanides S and O'Banion MK: Cyclooxygenase-1 mediates prostaglandin E(2) elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1beta expression. J Neurochem. 114:247–258. 2010.PubMed/NCBI

19 

Choi SH and Bosetti F: Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. Aging (Albany NY). 1:234–244. 2009.

20 

Choi SH, Langenbach R and Bosetti F: Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury. FASEB J. 22:1491–1501. 2008. View Article : Google Scholar :

21 

Candelario-Jalil E, de Oliveira AC, Gräf S, Bhatia HS, Hüll M, Muñoz E and Fiebich BL: Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia. J Neuroinflammation. 4:252007. View Article : Google Scholar : PubMed/NCBI

22 

Candelario-Jalil E, Taheri S, Yang Y, Sood R, Grossetete M, Estrada EY, Fiebich BL and Rosenberg GA: Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat. J Pharmacol Exp Ther. 323:488–498. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Ahmed T and Gilani AH: A comparative study of curcuminoids to measure their effect on inflammatory and apoptotic gene expression in an Aβ plus ibotenic acid-infused rat model of Alzheimer's disease. Brain Res. 1400:1–18. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Masferrer JL, Zweifel BS, Seibert K and Needleman P: Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice. J Clin Invest. 86:1375–1379. 1990. View Article : Google Scholar : PubMed/NCBI

25 

Choi SH, Aid S and Bosetti F: The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: Implications for translational research. Trends Pharmacol Sci. 30:174–181. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Hoozemans JJ, Rozemuller JM, van Haastert ES, Veerhuis R and Eikelenboom P: Cyclooxygenase-1 and -2 in the different stages of Alzheimer's disease pathology. Curr Pharm Des. 14:1419–1427. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Niwa K, Araki E, Morham SG, Ross ME and Iadecola C: Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex. J Neurosci. 20:763–770. 2000.PubMed/NCBI

28 

Yang H and Chen C: Cyclooxygenase-2 in synaptic signaling. Curr Pharm Des. 14:1443–1451. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Pasinetti GM and Aisen PS: Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. Neuroscience. 87:319–324. 1998. View Article : Google Scholar : PubMed/NCBI

30 

Fujimi K, Noda K, Sasaki K, Wakisaka Y, Tanizaki Y, Iida M, Kiyohara Y, Kanba S and Iwaki T: Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: The Hisayama study. Dement Geriatr Cogn Disord. 23:423–431. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Yermakova AV and O'Banion MK: Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease. Neurobiol Aging. 22:823–836. 2001. View Article : Google Scholar

32 

Tocco G, Freire-Moar J, Schreiber SS, Sakhi SH, Aisen PS and Pasinetti GM: Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: Implications for Alzheimer's disease. Exp Neurol. 144:339–349. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Miettinen S, Fusco FR, Yrjünheikki J, Keinänen R, Hirvonen T, Roivainen R, Närhi M, Hökfelt T and Koistinaho J: Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A2. Proc Natl Acad Sci USA. 94:6500–6505. 1997. View Article : Google Scholar : PubMed/NCBI

34 

Greenberg ER and Baron JA: Aspirin and other nonsteroid anti-inflammatory drugs as cancer-preventive agents. IARC Sci Publ. 91–98. 1996.PubMed/NCBI

35 

Abd-Elhady RM, Elsheikh AM and Khalifa AE: Anti-amnestic properties of Ginkgo biloba extract on impaired memory function induced by aluminum in rats. Int J Dev Neurosci. 31:598–607. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Belaid-Nouira Y, Bakhta H, Bouaziz M, Flehi-Slim I, Haouas Z and Ben Cheikh H: Study of lipid profile and parieto-temporal lipid peroxidation in AlCl3 mediated neurotoxicity. Modulatory effect of fenugreek seeds. Lipids Health Dis. 11:162012. View Article : Google Scholar

37 

Meyer-Baron M, Schäper M, Knapp G and van Thriel C: Occupational aluminum exposure: Evidence in support of its neurobehavioral impact. Neurotoxicology. 28:1068–1078. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Hashmi AN, Yaqinuddin A and Ahmed T: Pharmacological effects of Ibuprofen on learning and memory, muscarinic receptors genes expression and APP isoforms levels in Pre-frontal cortex of AlCl3-induced toxicity mouse model. Int J Neurosci. 125:277–287. 2015. View Article : Google Scholar

39 

Bondy SC: The neurotoxicity of environmental aluminum is still an issue. Neurotoxicology. 31:575–581. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Andrasi E, Páli N, Molnár Z and Kösel S: Brain aluminum, magnesium and phosphorus contents of control and Alzheimer-diseased patients. J Alzheimers Dis. 7:273–284. 2005.PubMed/NCBI

41 

National Research Council: Guide for the care and use of laboratory animals. Washington, D.C: National Academy Press; 1996

42 

Thirunavukkarasu SV, Venkataraman S, Raja S and Upadhyay L: Neuroprotective effect of Manasamitra vatakam against aluminium induced cognitive impairment and oxidative damage in the cortex and hippocampus of rat brain. Drug Chem Toxicol. 35:104–115. 2012. View Article : Google Scholar

43 

Ahmed T and Gilani AH: Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease. Pharmacol Biochem Behav. 91:554–559. 2009. View Article : Google Scholar

44 

Meeker HC, Chadman KK, Heaney AT and Carp RI: Assessment of social interaction and anxiety-like behavior in senescence-accelerated-prone and -resistant mice. Physiol Behav. 118:97–102. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Deacon R: Assessing burrowing, nest construction and hoarding in mice. J Vis Exp. e26072012.

46 

Ahmed T, Enam SA and Gilani AH: Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Neuroscience. 169:1296–1306. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Habila N, Agbaji AS, Ladan Z, Bello IA, Haruna E, Dakare MA and Atolagbe TO: Evaluation of in vitro activity of essential oils against trypanosoma brucei brucei and trypanosoma evansi. J Parasitol Res. 2010:2010. View Article : Google Scholar : PubMed/NCBI

48 

Kotilinek LA, Westerman MA, Wang Q, Panizzon K, Lim GP, Simonyi A, Lesne S, Falinska A, Younkin LH, Younkin SG, et al: Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain. 131:651–664. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Bickart KC, Hollenbeck MC, Barrett LF and Dickerson BC: Intrinsic amygdala-cortical functional connectivity predicts social network size in humans. J Neurosci. 32:14729–14741. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Guo JY, Li CY, Ruan YP, Sun M, Qi XL, Zhao BS and Luo F: Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclo-oxygenase-2 expression in rat brain. Eur J Pharmacol. 612:54–60. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Min Z, Wang S, Wu J and Zhang S: Impairment of nesting behavior in APPswe/PS1dE9 mice. Life Sci J. 10:1942–1945. 2013.

52 

Deacon RM, Croucher A and Rawlins JN: Hippocampal cytotoxic lesion effects on species-typical behaviours in mice. Behav Brain Res. 132:203–213. 2002. View Article : Google Scholar : PubMed/NCBI

53 

Holson RR and Walker C: Mesial prefrontal cortical lesions and timidity in rats II Reactivity to novel stimuli. Physiol Behav. 37:231–238. 1986. View Article : Google Scholar

54 

Rogers J, Kirby LC, Hempelman SR, Berry DL, McGeer PL, Kaszniak AW, Zalinski J, Cofield M, Mansukhani L and Willson P: Clinical trial of indomethacin in Alzheimer's disease. Neurology. 43:1609–1611. 1993. View Article : Google Scholar : PubMed/NCBI

55 

Reines SA, Block GA, Morris JC, Liu G, Nessly ML, Lines CR, Norman BA and Baranak CC; Rofecoxib Protocol 091 Study Group: Rofecoxib: No effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study. Neurology. 62:66–71. 2004. View Article : Google Scholar : PubMed/NCBI

56 

Smith MA, Rottkamp CA, Nunomura A, Raina AK and Perry G: Oxidative stress in Alzheimer's disease. Biochim Biophys Acta. 1502:139–144. 2000. View Article : Google Scholar : PubMed/NCBI

57 

Chazot G and Broussolle E: Alterations in trace elements during brain aging and in Alzheimer's dementia. Prog Clin Biol Res. 380:269–281. 1993.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Syed H, Ikram MF, Yaqinuddin A and Ahmed T: Cyclooxygenase I and II inhibitors distinctly enhance hippocampal- and cortex-dependent cognitive functions in mice. Mol Med Rep 12: 7649-7656, 2015.
APA
Syed, H., Ikram, M.F., Yaqinuddin, A., & Ahmed, T. (2015). Cyclooxygenase I and II inhibitors distinctly enhance hippocampal- and cortex-dependent cognitive functions in mice. Molecular Medicine Reports, 12, 7649-7656. https://doi.org/10.3892/mmr.2015.4351
MLA
Syed, H., Ikram, M. F., Yaqinuddin, A., Ahmed, T."Cyclooxygenase I and II inhibitors distinctly enhance hippocampal- and cortex-dependent cognitive functions in mice". Molecular Medicine Reports 12.5 (2015): 7649-7656.
Chicago
Syed, H., Ikram, M. F., Yaqinuddin, A., Ahmed, T."Cyclooxygenase I and II inhibitors distinctly enhance hippocampal- and cortex-dependent cognitive functions in mice". Molecular Medicine Reports 12, no. 5 (2015): 7649-7656. https://doi.org/10.3892/mmr.2015.4351
Copy and paste a formatted citation
x
Spandidos Publications style
Syed H, Ikram MF, Yaqinuddin A and Ahmed T: Cyclooxygenase I and II inhibitors distinctly enhance hippocampal- and cortex-dependent cognitive functions in mice. Mol Med Rep 12: 7649-7656, 2015.
APA
Syed, H., Ikram, M.F., Yaqinuddin, A., & Ahmed, T. (2015). Cyclooxygenase I and II inhibitors distinctly enhance hippocampal- and cortex-dependent cognitive functions in mice. Molecular Medicine Reports, 12, 7649-7656. https://doi.org/10.3892/mmr.2015.4351
MLA
Syed, H., Ikram, M. F., Yaqinuddin, A., Ahmed, T."Cyclooxygenase I and II inhibitors distinctly enhance hippocampal- and cortex-dependent cognitive functions in mice". Molecular Medicine Reports 12.5 (2015): 7649-7656.
Chicago
Syed, H., Ikram, M. F., Yaqinuddin, A., Ahmed, T."Cyclooxygenase I and II inhibitors distinctly enhance hippocampal- and cortex-dependent cognitive functions in mice". Molecular Medicine Reports 12, no. 5 (2015): 7649-7656. https://doi.org/10.3892/mmr.2015.4351
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