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Molecular characteristics of recurrent triple-negative breast cancer

  • Authors:
    • Chung‑Hsin Tsai
    • Jen‑Hwey Chiu
    • Chu‑Wen Yang
    • Jir‑You Wang
    • Yi‑Fang Tsai
    • Ling‑Ming Tseng
    • Wei‑Shone Chen
    • Yi‑Ming Shyr
  • View Affiliations / Copyright

    Affiliations: Institute of Traditional Medicine, School of Medicine, National Yang‑Ming University, Taipei 112, Taiwan, R.O.C., Department of Microbiology, Soochow University, Tapei 111, Taiwan, R.O.C., Department of Orthopedics, Taipei Veterans General Hospital, Tapei 112, Taiwan, R.O.C., Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Tapei 112, Taiwan, R.O.C., Division of Colorectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Tapei 112, Taiwan, R.O.C.
    Copyright: © Tsai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7326-7334
    |
    Published online on: September 24, 2015
       https://doi.org/10.3892/mmr.2015.4360
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Abstract

Due to the fact that the treatment of breast cancer depends significantly on the molecular markers present in the cancer, including estrogen receptor (+), progesterone receptor (+) or erbB2 receptor (+), further investigation targeting triple‑negative breast cancer (TNBC) subtypes may assist in elucidating the mechanisms of recurrence of TNBC and enable the identification of novel therapeutic strategies for patients with TNBC. The aim of the present study was to compare the gene expression profiles between TNBC samples that were identified as having recurrent and non‑recurrent statuses. Between June 2011 and May 2012, a total of 30 patients with TNBC were examined using a follow-up period of at least 5 years. Their clinicopathological information was retrospectively reviewed and they were classified with a status either of recurrence [n=15 stage II (9), IIIA (2), IIIC (4)] or non‑recurrence [n=15 stage II (6), IIIA (1), IIIC (8)]. The total RNA from tissue samples obtained from the recurrent and non‑recurrent TNBC patients were used to performed oligonucleotide microarray analysis. The dataset was analyzed using GeneSpring software and validated using reverse transcription-quantitative polymerase chain reaction. Principal component analysis demonstrated that there was a marked difference in the gene expression distribution between the stage IIIc recurrent samples and early stage (stages IIa, IIb and IIIa) recurrent samples. In early stage recurrence, the significant pathway‑associated upregulated genes were matrix metalloproteinases (MMPs) and genes associated with cancer cell migration (CDH2) and cell adhesion/motility (KRAS, CDC42, RAC1, ICAM and SRGAP2). By contrast, during stage IIIc recurrence, the significant pathway‑associated upregulated genes in the recurrent samples were WNT signaling genes, including WNT 4 and WNT 16. It was concluded that there were markedly different distributions and gene expression profiles between stage IIIc recurrent TNBC tumors and early stage (IIa, IIb, IIIa) recurrent TNBC tumors, which provides important information for the development of effective treatment strategies for TNBC.
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Copy and paste a formatted citation
Spandidos Publications style
Tsai CH, Chiu JH, Yang CW, Wang JY, Tsai YF, Tseng LM, Chen WS and Shyr YM: Molecular characteristics of recurrent triple-negative breast cancer. Mol Med Rep 12: 7326-7334, 2015.
APA
Tsai, C., Chiu, J., Yang, C., Wang, J., Tsai, Y., Tseng, L. ... Shyr, Y. (2015). Molecular characteristics of recurrent triple-negative breast cancer. Molecular Medicine Reports, 12, 7326-7334. https://doi.org/10.3892/mmr.2015.4360
MLA
Tsai, C., Chiu, J., Yang, C., Wang, J., Tsai, Y., Tseng, L., Chen, W., Shyr, Y."Molecular characteristics of recurrent triple-negative breast cancer". Molecular Medicine Reports 12.5 (2015): 7326-7334.
Chicago
Tsai, C., Chiu, J., Yang, C., Wang, J., Tsai, Y., Tseng, L., Chen, W., Shyr, Y."Molecular characteristics of recurrent triple-negative breast cancer". Molecular Medicine Reports 12, no. 5 (2015): 7326-7334. https://doi.org/10.3892/mmr.2015.4360
Copy and paste a formatted citation
x
Spandidos Publications style
Tsai CH, Chiu JH, Yang CW, Wang JY, Tsai YF, Tseng LM, Chen WS and Shyr YM: Molecular characteristics of recurrent triple-negative breast cancer. Mol Med Rep 12: 7326-7334, 2015.
APA
Tsai, C., Chiu, J., Yang, C., Wang, J., Tsai, Y., Tseng, L. ... Shyr, Y. (2015). Molecular characteristics of recurrent triple-negative breast cancer. Molecular Medicine Reports, 12, 7326-7334. https://doi.org/10.3892/mmr.2015.4360
MLA
Tsai, C., Chiu, J., Yang, C., Wang, J., Tsai, Y., Tseng, L., Chen, W., Shyr, Y."Molecular characteristics of recurrent triple-negative breast cancer". Molecular Medicine Reports 12.5 (2015): 7326-7334.
Chicago
Tsai, C., Chiu, J., Yang, C., Wang, J., Tsai, Y., Tseng, L., Chen, W., Shyr, Y."Molecular characteristics of recurrent triple-negative breast cancer". Molecular Medicine Reports 12, no. 5 (2015): 7326-7334. https://doi.org/10.3892/mmr.2015.4360
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