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Article

Effects of skeletal muscle denervation on the potency of succinylcholine

  • Authors:
    • Hong Wang
    • Wei Fu
    • Gang Liu
    • Shi‑Tong Li
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, P.R. China
  • Pages: 7796-7800
    |
    Published online on: September 30, 2015
       https://doi.org/10.3892/mmr.2015.4392
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Abstract

The aim of the present study was to investigate the time‑dependent effects of denervation on the sensitivity of skeletal muscles to the relaxant succinylcholine (SuCh) and to assess the possible association of the de novo expression of γ‑acetylcholine receptor (AChR). Innervated as well as denervated mouse muscle cells and human embryonic kidney (HEK293) cells expressing γ‑AChR and ε‑AChR were used in the present study. The effects of SuCh on the current of nicotinic (n)AChRs were examined using a whole‑cell patch clamp technique. Compared with innervated skeletal muscle cells, the SuCh concentration producing 50% of the maximal response (EC50) were decreased by 20, 56, 73, 66, 60 and 62% (P<0.05), and current responses induced by 30 µM SuCh were increased by 1.9‑, 4.6‑, 9.4‑, 7.1‑, 5.2‑ and 5.1‑fold (P<0.05) at days 1, 4, 7, 14, 21 and 28 after denervation, respectively. However, SuCh was equipotent regarding γ‑AChR and ε‑AChR (P>0.05). These results indicated that short‑term denervation led to a change in the sensitivity of muscle cells to SuCh, which, however, was unlikely to be associated with the de novo expression of γ‑AChR.
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View References

1 

Miller R: Will succinylcholine ever disappear? Anesth Analg. 98:1674–1675. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Caldwell JE: The continuing search for a succinylcholine replacement. Anesthesiology. 100:763–764. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Laurin EG, Sakles JC, Panacek EA, Rantapaa AA and Redd J: A comparison of succinylcholine and rocuronium for rapid-sequence intubation of emergency department patients. Acad Emerg Med. 7:1362–1369. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Marsch SC, Steiner L, Bucher E, Pargger H, Schumann M, Aebi T, Hunziker PR and Siegemund M: Succinylcholine versus rocuronium for rapid sequence intubation in intensive care: A prospective, randomized controlled trial. Crit Care. 15:R1992011. View Article : Google Scholar : PubMed/NCBI

5 

Norwood S, Myers MB and Butler TJ: The safety of emergency neuromuscular blockade and orotracheal intubation in the acutely injured trauma patient. J Am Coll Surg. 179:646–652. 1994.PubMed/NCBI

6 

Ma OJ, Atchley RB, Hatley T, Green M, Young J and Brady W: Intubation success rates improve for an air medical program after implementing the use of neuromuscular blocking agents. Am J Emerg Med. 16:125–127. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Wang H, Yang B, Xu YF, Yan T and Li ST: Different magnitude of resistance to nondepolarizing muscle relaxants in the denervated mouse skeletal mucle. Acta Pharmacol Sin. 31:399–404. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Wang H, Yang B, Han GW and Li ST: Potency of nondepolarizing muscle relaxants at muscle-type acetylcholine receptors in denervated mouse skeletal muscle. Acta Pharmacol Sin. 31:1541–1546. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Martyn JA, White DA, Gronert GA, Jaffe RS and Ward JM: Up-and-down regulation of skeletal muscle acetylcholine receptors. Effects on neuromuscular blockers. Anesthesiology. 76:822–843. 1992. View Article : Google Scholar : PubMed/NCBI

10 

Yanez P and Martyn JA: Prolonged d-tubocurarine infusion and/or immobilization cause upregulation of acetylcholine receptors and hyperkalemia to succinylcholine in rats. Anesthesiology. 84:384–391. 1996. View Article : Google Scholar : PubMed/NCBI

11 

Wang H, Liang QS and Cheng LR: Effects of skeletal muscle denervation on potency of rocuronium. Asian Biomedicine. 5:507–512. 2011.

12 

Ibebunjo C and Martyn JA: Thermal injury induces greater resistance to d-tubocurarine in local rather than in distant muscles in the rat. Anesth Analg. 91:1243–1249. 2000.PubMed/NCBI

13 

Ma J, Shen J, Garrett JP, Lee CA, Li Z, Elsaidi GA, Ritting A, Hick J, Tan KH, Smith TL, et al: Gene expression of myogenic regulatory factors, nicotinic acetylcholine receptor subunits, and GAP-43 in skeletal muscle following denervation in a rat model. J Orthop Res. 25:1498–1505. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Adams L, Carlson BM, Henderson L and Goldman D: Adaptation of nicotinic acetylcholine receptor, myogenin and MRF4 gene expression to long-term muscle denervation. J Cell Biol. 131:1341–1349. 1995. View Article : Google Scholar : PubMed/NCBI

15 

Hamill OP, Marty A, Neher E, Sakmann B and Sigworth FJ: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391:85–100. 1981. View Article : Google Scholar : PubMed/NCBI

16 

Ibebunjo C and Martyn J: Disparate dysfunction of skeletal muscles located near and distant from burn site in the rat. Muscle Nerve. 24:1283–1294. 2001. View Article : Google Scholar : PubMed/NCBI

17 

John DA, Tobey RE, Homer LD and Rice CL: Onset of succinylcholine-induced hyperkalemia following denervation. Anesthesiology. 45:294–299. 1976. View Article : Google Scholar : PubMed/NCBI

18 

Gronert GA: Succinylcholine hyperkalemia after burns. Anesthesiology. 91:320–322. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Witzemann V, Brenner HR and Sakmann B: Neural factors regulate AChR subunit mRNAs at rat neuromuscular synapses. J Cell Biol. 114:125–141. 1991. View Article : Google Scholar : PubMed/NCBI

20 

Yost CS and Winegar BD: Potency of agonists and competitive antagonists on adult- and fetal-type nicotinic acetylcholine receptors. Cell Mol Neurobiol. 17:35–50. 1997. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Fu W, Liu G and Li ST: Effects of skeletal muscle denervation on the potency of succinylcholine. Mol Med Rep 12: 7796-7800, 2015.
APA
Wang, H., Fu, W., Liu, G., & Li, S. (2015). Effects of skeletal muscle denervation on the potency of succinylcholine. Molecular Medicine Reports, 12, 7796-7800. https://doi.org/10.3892/mmr.2015.4392
MLA
Wang, H., Fu, W., Liu, G., Li, S."Effects of skeletal muscle denervation on the potency of succinylcholine". Molecular Medicine Reports 12.5 (2015): 7796-7800.
Chicago
Wang, H., Fu, W., Liu, G., Li, S."Effects of skeletal muscle denervation on the potency of succinylcholine". Molecular Medicine Reports 12, no. 5 (2015): 7796-7800. https://doi.org/10.3892/mmr.2015.4392
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Fu W, Liu G and Li ST: Effects of skeletal muscle denervation on the potency of succinylcholine. Mol Med Rep 12: 7796-7800, 2015.
APA
Wang, H., Fu, W., Liu, G., & Li, S. (2015). Effects of skeletal muscle denervation on the potency of succinylcholine. Molecular Medicine Reports, 12, 7796-7800. https://doi.org/10.3892/mmr.2015.4392
MLA
Wang, H., Fu, W., Liu, G., Li, S."Effects of skeletal muscle denervation on the potency of succinylcholine". Molecular Medicine Reports 12.5 (2015): 7796-7800.
Chicago
Wang, H., Fu, W., Liu, G., Li, S."Effects of skeletal muscle denervation on the potency of succinylcholine". Molecular Medicine Reports 12, no. 5 (2015): 7796-7800. https://doi.org/10.3892/mmr.2015.4392
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