Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2015 Volume 12 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2015 Volume 12 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Chrysin inhibits human airway smooth muscle cells proliferation through the extracellular signal‑regulated kinase 1/2 signaling pathway

  • Authors:
    • Jing Yao
    • Yun‑Shi Zhang
    • Gan‑Zhu Feng
    • Qiang Du
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, P.R. China
  • Pages: 7693-7698
    |
    Published online on: September 30, 2015
       https://doi.org/10.3892/mmr.2015.4401
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Asthma is a chronic airway inflammatory disease characterized by an increased mass of airway smooth muscle (ASM). Chrysin (5,7‑dihydroxyflavone), a natural flavonoid, has been shown to exert multiple biological activities, including anti‑inflammatory, anti‑proliferative and anti‑oxidant effects, as well as the potency to ameliorate asthma in animal models. The objective of the present study was to identify the underlying mechanism of the therapeutic effects of chrysin. The impact of chrysin on basal and platelet‑derived growth factor (PDGF)‑induced proliferation and apoptosis of human airway smooth muscle cells (HASMCs) was investigated. Furthermore, the activation of the extracellular signal-regulated protein kinase (ERK) signaling pathway was evaluated in HASMCs. The results revealed that chrysin significantly inhibited basal as well as PDGF‑induced HASMC proliferation, most likely through the suppression of ERK1/2 phosphorylation. However, chrysin did not significantly reduce PDGF‑induced apoptosis of HASMCs. The present study indicated that chrysin may be a promising medication for controlling airway remodeling and clinical manifestations of asthma.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Al-Muhsen S, Johnson JR and Hamid Q: Remodeling in asthma. J Allergy Clin Immunol. 128:451–462. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Bergeron C and Boulet LP: Structural changes in airway diseases: Characteristics, mechanisms, consequences and pharmacologic modulation. Chest. 129:1068–1087. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Manuyakorn W, Howarth PH and Holgate ST: Airway remodelling in asthma and novel therapy. Asian Pac J Allergy Immunol. 31:3–10. 2013.PubMed/NCBI

4 

Ozier A, Allard B, Bara I, Girodet PO, Trian T, Marthan R and Berger P: The pivotal role of airway smooth muscle in asthma pathophysiology. J Allergy (Cairo). 2011:7427102011.

5 

Bara I, Ozier A, Tunon de Lara JM, Marthan R and Berger P: Pathophysiology of bronchial smooth muscle remodelling in asthma. Eur Respir J. 36:1174–1184. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Damera G, Tliba O and Panettieri RA Jr: Airway smooth muscle as an immunomodulatory cell. Pulm Pharmacol Ther. 22:353–359. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Stewart AG: Airway wall remodelling and hyperresponsiveness: Modelling remodelling in vitro and in vivo. Pulm Pharmacol Ther. 14:255–265. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Girodet PO, Ozier A, Bara I, Tunon de Lara JM, Marthan R and Berger P: Airway remodeling in asthma: New mechanisms and potential for pharmacological intervention. Pharmacol Ther. 130:325–337. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Moon YJ, Wang X and Morris ME: Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro. 20:187–210. 2006. View Article : Google Scholar

10 

Williams CA, Harborne JB, Newman M, Greenham J and Eagles J: Chrysin and other leaf exudate flavonoids in the genus pelargonium. Phytochemistry. 46:1349–1353. 1997. View Article : Google Scholar

11 

Rapta P, Misik V, Stasko A and Vrabel I: Redox intermediates of flavonoids and caffeic acid esters from propolis: An EPR spectroscopy and cyclic voltammetry study. Free Radic Biol Med. 18:901–908. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Cho H, Yun CW, Park WK, Kong JY, Kim KS, Park Y, Lee S and Kim BK: Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives. Pharmacol Res. 49:37–43. 2004. View Article : Google Scholar

13 

Lapidot T, Walker MD and Kanner J: Antioxidant and prooxidant effects of phenolics on pancreatic beta-cells in vitro. J Agric Food Chem. 50:7220–7225. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Phan T, Yu XM, Kunnimalaiyaan M and Chen H: Antiproliferative effect of chrysin on anaplastic thyroid cancer. J Surg Res. 170:84–88. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Du Q, Gu X, Cai J, Huang M and Su M: Chrysin attenuates allergic airway inflammation by modulating the transcription factors T-bet and GATA-3 in mice. Mol Med Rep. 6:100–104. 2012.PubMed/NCBI

16 

Bae Y, Lee S and Kim SH: Chrysin suppresses mast cell-mediated allergic inflammation: Involvement of calcium, caspase-1 and nuclear factor-κB. Toxicol Appl Pharmacol. 254:56–64. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Lommatzsch M: Airway hyperresponsiveness: New insights into the pathogenesis. Semin Respir Crit Care Med. 33:579–587. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Zha WJ, Qian Y, Shen Y, Du Q, Chen FF, Wu ZZ, Li X and Huang M: Galangin abrogates ovalbumin-induced airway inflammation via negative regulation of NF-κB. Evidence-Based Complement Alternat Med. 2013:7676892013. View Article : Google Scholar

19 

Lo HM, Wu MW, Pan SL, Peng CY, Wu PH and Wu WB: Chrysin restores PDGF-induced inhibition on protein tyrosine phosphatase and reduces PDGF signaling in cultured VSMCs. J Nutr Biochem. 23:667–678. 2012. View Article : Google Scholar

20 

Kirkham P and Rahman I: Oxidative stress in asthma and COPD: Antioxidants as a therapeutic strategy. Pharmacol Ther. 111:476–494. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Sugiura H and Ichinose M: Oxidative and nitrative stress in bronchial asthma. Antioxid Redox Signal. 10:785–797. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Lee JY, Kim JM and Kim CJ: Flavones derived from nature attenuate the immediate and late-phase asthmatic responses to aerosolized-ovalbumin exposure in conscious guinea pigs. Inflamm Res. 63:53–60. 2014. View Article : Google Scholar

23 

Shao JJ, Zhang AP, Qin W, Zheng L, Zhu YF and Chen X: AMP-activated protein kinase (AMPK) activation is involved in chrysin-induced growth inhibition and apoptosis in cultured A549 lung cancer cells. Biochem Biophys Res Commun. 423:448–453. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Samarghandian S, Afshari JT and Davoodi S: Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line Pc-3. Clinics (Sao Paulo). 66:1073–1079. 2011. View Article : Google Scholar

25 

Ahn MR, Kunimasa K, Kumazawa S, Nakayama T, Kaji K, Uto Y, Hori H, Nagasawa H and Ohta T: Correlation between antiangiogenic activity and antioxidant activity of various components from propolis. Mol Nutr Food Res. 53:643–651. 2009. View Article : Google Scholar

26 

Barnes PJ: Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol. 8:183–192. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Hirota JA, Ask K, Farkas L, Smith JA, Ellis R, Rodriguez-Lecompte JC, Kolb M and Inman MD: In vivo role of platelet-derived growth factor-BB in airway smooth muscle proliferation in mouse lung. Am J Respir Cell Mol Biol. 45:566–572. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Hirst SJ, Barnes PJ and Twort CH: PDGF isoform-induced proliferation and receptor expression in human cultured airway smooth muscle cells. Am J Physiol. 270:L415–L428. 1996.PubMed/NCBI

29 

Deng X, Zhao X, Lan Z, Jiang J, Yin W and Chen L: Anti-tumor effects of flavonoids from the ethnic medicine docynia delavayi (Franch.) Schneid And its possible mechanism. J Med Food. 17:787–794. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Yu ZH, Wang YX, Song Y, Lu HZ, Hou LN, Cui YY and Chen HZ: Up-regulation of KCa3.1 promotes human airway smooth muscle cell phenotypic modulation. Pharmacol Res. 77:30–38. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Movassagh H, Shan L, Halayko AJ, Roth M, Tamm M, Chakir J and Gounni AS: Neuronal chemorepellent Semaphorin 3E inhibits human airway smooth muscle cell proliferation and migration. J Allergy Clin Immunol. 133:560–567. 2014. View Article : Google Scholar

32 

Lee JH, Johnson PR, Roth M, Hunt NH and Black JL: ERK activation and mitogenesis in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 280:L1019–L1029. 2001.PubMed/NCBI

33 

Pelaia G, Renda T, Gallelli L, Vatrella A, Busceti MT, Agati S, Caputi M, Cazzola M, Maselli R and Marsico SA: Molecular mechanisms underlying airway smooth muscle contraction and proliferation: Implications for asthma. Respir Med. 102:1173–1181. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Pichichero E, Cicconi R, Mattei M and Canini A: Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16–F1 and A375 melanoma cells. Int J Oncol. 38:473–483. 2011.

35 

Tallquist M and Kazlauskas A: PDGF signaling in cells and mice. Cytokine Growth Factor Rev. 15:205–213. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Gosens R, Stelmack GL, Dueck G, McNeill KD, Yamasaki A, Gerthoffer WT, Unruh H, Gounni AS, Zaagsma J and Halayko AJ: Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 291:L523–L534. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Yang B, Huang J, Xiang T, Yin X, Luo X, Huang J, Luo F, Li H, Li H and Ren G: Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition and PI3K/Akt signaling pathway. J Appl Toxicol. 34:105–112. 2014. View Article : Google Scholar

38 

Lin CM, Shyu KG, Wang BW, Chang H, Chen YH and Chiu JH: Chrysin suppresses IL-6-induced angiogenesis via downregulation of JAK1/STAT3 and VEGF: An in vitro and in ovo approach. J Agric Food Chem. 58:7082–7087. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yao J, Zhang YS, Feng GZ and Du Q: Chrysin inhibits human airway smooth muscle cells proliferation through the extracellular signal‑regulated kinase 1/2 signaling pathway. Mol Med Rep 12: 7693-7698, 2015.
APA
Yao, J., Zhang, Y., Feng, G., & Du, Q. (2015). Chrysin inhibits human airway smooth muscle cells proliferation through the extracellular signal‑regulated kinase 1/2 signaling pathway. Molecular Medicine Reports, 12, 7693-7698. https://doi.org/10.3892/mmr.2015.4401
MLA
Yao, J., Zhang, Y., Feng, G., Du, Q."Chrysin inhibits human airway smooth muscle cells proliferation through the extracellular signal‑regulated kinase 1/2 signaling pathway". Molecular Medicine Reports 12.5 (2015): 7693-7698.
Chicago
Yao, J., Zhang, Y., Feng, G., Du, Q."Chrysin inhibits human airway smooth muscle cells proliferation through the extracellular signal‑regulated kinase 1/2 signaling pathway". Molecular Medicine Reports 12, no. 5 (2015): 7693-7698. https://doi.org/10.3892/mmr.2015.4401
Copy and paste a formatted citation
x
Spandidos Publications style
Yao J, Zhang YS, Feng GZ and Du Q: Chrysin inhibits human airway smooth muscle cells proliferation through the extracellular signal‑regulated kinase 1/2 signaling pathway. Mol Med Rep 12: 7693-7698, 2015.
APA
Yao, J., Zhang, Y., Feng, G., & Du, Q. (2015). Chrysin inhibits human airway smooth muscle cells proliferation through the extracellular signal‑regulated kinase 1/2 signaling pathway. Molecular Medicine Reports, 12, 7693-7698. https://doi.org/10.3892/mmr.2015.4401
MLA
Yao, J., Zhang, Y., Feng, G., Du, Q."Chrysin inhibits human airway smooth muscle cells proliferation through the extracellular signal‑regulated kinase 1/2 signaling pathway". Molecular Medicine Reports 12.5 (2015): 7693-7698.
Chicago
Yao, J., Zhang, Y., Feng, G., Du, Q."Chrysin inhibits human airway smooth muscle cells proliferation through the extracellular signal‑regulated kinase 1/2 signaling pathway". Molecular Medicine Reports 12, no. 5 (2015): 7693-7698. https://doi.org/10.3892/mmr.2015.4401
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team