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Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma

  • Authors:
    • Jinghua Yu
    • Peiyou Ren
    • Ting Zhong
    • Yalin Wang
    • Minghui Yan
    • Bianbian Xue
    • Rui Li
    • Chunyan Dai
    • Chunyu Liu
    • Guang Chen
    • Xiao‑Fang Yu
  • View Affiliations / Copyright

    Affiliations: Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, Jilin 130000, P.R. China, Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun, Jilin 130000, P.R. China, Medicinal Chemistry, College of Pharmacy, Changchun University of Chinese Medicine, Changchun, Jilin 130000, P.R. China, Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130000, P.R. China, Department of Biomedical Engineering, College of Pharmacy, Jilin University, Changchun, Jilin 130000, P.R. China, Department of Gastroenterology, The First Hospital of Jilin University, Changchun, Jilin 130000, P.R. China, Acupuncture Department, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin 130000, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7195-7202
    |
    Published online on: October 5, 2015
       https://doi.org/10.3892/mmr.2015.4418
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Abstract

Primary squamous cell carcinoma of the thyroid is a rare and aggressive type of neoplasm, which is routinely treated with surgery; however, despite this, survival time is not commonly more than six months. Thus, the aim of the present study was to determine the efficacy of pseudolaric acid (PAB) as a therapeutic agent. PAB is an antitubulin agent, and in the present study, inhibition of the SW579 thyroid squamous cell carcinoma cell line by PAB was investigated. PAB was found to inhibit SW579 cell growth in a time‑ and dose‑dependent manner via interference in α‑tubulin polymerization. However, the inhibitory role of PAB in SW579 cells was not predominantly due to apoptosis, but was due to the cytostatic status resulting from cell cycle arrest. The present study proposes that this is the underlying mechanism of the antitumor properties of PAB. During cytostatis, autophagy was activated to sustain cell survival and SW579 cell migration was inhibited. Nuclear p53 expression was observed to be reduced, however the role of reduced p53 requires further investigation. Therefore, PAB induced cytostasis, which inhibited SW579 cell growth and therefore may function as an antitubulin therapeutic agent.
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Copy and paste a formatted citation
Spandidos Publications style
Yu J, Ren P, Zhong T, Wang Y, Yan M, Xue B, Li R, Dai C, Liu C, Chen G, Chen G, et al: Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma. Mol Med Rep 12: 7195-7202, 2015.
APA
Yu, J., Ren, P., Zhong, T., Wang, Y., Yan, M., Xue, B. ... Yu, X. (2015). Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma. Molecular Medicine Reports, 12, 7195-7202. https://doi.org/10.3892/mmr.2015.4418
MLA
Yu, J., Ren, P., Zhong, T., Wang, Y., Yan, M., Xue, B., Li, R., Dai, C., Liu, C., Chen, G., Yu, X."Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma". Molecular Medicine Reports 12.5 (2015): 7195-7202.
Chicago
Yu, J., Ren, P., Zhong, T., Wang, Y., Yan, M., Xue, B., Li, R., Dai, C., Liu, C., Chen, G., Yu, X."Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma". Molecular Medicine Reports 12, no. 5 (2015): 7195-7202. https://doi.org/10.3892/mmr.2015.4418
Copy and paste a formatted citation
x
Spandidos Publications style
Yu J, Ren P, Zhong T, Wang Y, Yan M, Xue B, Li R, Dai C, Liu C, Chen G, Chen G, et al: Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma. Mol Med Rep 12: 7195-7202, 2015.
APA
Yu, J., Ren, P., Zhong, T., Wang, Y., Yan, M., Xue, B. ... Yu, X. (2015). Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma. Molecular Medicine Reports, 12, 7195-7202. https://doi.org/10.3892/mmr.2015.4418
MLA
Yu, J., Ren, P., Zhong, T., Wang, Y., Yan, M., Xue, B., Li, R., Dai, C., Liu, C., Chen, G., Yu, X."Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma". Molecular Medicine Reports 12.5 (2015): 7195-7202.
Chicago
Yu, J., Ren, P., Zhong, T., Wang, Y., Yan, M., Xue, B., Li, R., Dai, C., Liu, C., Chen, G., Yu, X."Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma". Molecular Medicine Reports 12, no. 5 (2015): 7195-7202. https://doi.org/10.3892/mmr.2015.4418
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