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Novel insights into a treatment for aplastic anemia based on the advanced proliferation of bone marrow‑derived mesenchymal stem cells induced by fibroblast growth factor 1

  • Authors:
    • Shayi Jiang
    • Min Xia
    • Jingwei Yang
    • Jingbo Shao
    • Xuelian Liao
    • Jiashi Zhu
    • Hui Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai 200040, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7877-7882
    |
    Published online on: October 9, 2015
       https://doi.org/10.3892/mmr.2015.4421
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Abstract

Aplastic anemia (AA) is rare disease that is predominantly observed in adolescents. Without effective management at an early stage, is associated with a high risk of mortality. Bone marrow mesenchymal stem cells (BMSCs) can differentiate into various types of cell, which are able to produce a number of hematopoietic growth factors considered to be important in AA alleviation. However, the mechanism underlying the role of fibroblast growth factor 1 (FGF1) in BMSC differentiation remains unknown. In the current study, the investigation focused on the regulatory role and potential signaling pathway of FGF1 in BMSC differentiation in patients exhibiting AA. BMSCs were infected with Ad‑FGF1 and presented a potent proliferation capability, which was evaluated using Cell Counting kit‑8 analysis. Reverse transcription‑quantitative polymerase chain reaction revealed that long non‑coding (lnc)RNA of testis development related gene 1 (TDRG1) was significantly upregulated, demonstrating high expression at the transcriptional level in the BMSCs that were infected with Ad‑FGF1. The decreased proliferation capability of BMSCs that were treated with Ad‑FGF1 and TDRG1‑small interfering RNA validated the vital effect of TDRG1 on the FGF1 regulatory process of BMSC differentiation. Further experiments revealed that the increase of acetyl‑histones, H3 and H4 was diminished in the TDRG1 promoter of BMSCs that were infected with Ad‑FGF1, which indicated that the process of acetylation was promoted when the BMSCs were infected with Ad-FGF1. Thus, it was inferred that FGF1 induces the proliferation of BMSCs in patients with AA via promoting acetylation in lncRNA of the TDRG1 gene promoter.
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1 

Sheng W, Liu C, Fu R, Wang H, Qu W, Ruan E, Wang G, Liu H, Wu Y, Song J, et al: Abnormalities of quantities and functions of linker for activations of T cells in severe aplastic anemia. Eur J Haemato. 93:214–223. 2014.

2 

Young NS, Scheinberg P and Calado RT: Aplastic anemia. Current Opin Hematol. 15:162–168. 2008. View Article : Google Scholar

3 

Cohen T and Creger WP: Acute myeloid leukemia following seven years of aplastic anemia induced by chloramphenicol. Am J Med. 43:762–770. 1967. View Article : Google Scholar : PubMed/NCBI

4 

Binder D, van den Broek MF, Kägi D, Bluethmann H, Fehr J, Hengartner H and Zinkernagel RM: Aplastic anemia rescued by exhaustion of cytokine-secreting CD8+ T cells in persistent infection with lymphocytic choriomeningitis virus. J Exp Med. 187:1903–1920. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Xing L, Liu C, Fu R, Wang H, Wang J, Liu X, Feng L, Li L, Liu H, Wang H, et al: CD8+HLA-DR+ T cells are increased in patients with severe aplastic anemia. Mol Med Rep. 10:1252–1258. 2014.PubMed/NCBI

6 

Feng X, Scheinberg P, Biancotto A, Rios O, Donaldson S, Wu C, Zheng H, Sato K, Townsley DM, McCoy JP and Young NS: In vivo effects of horse and rabbit antithymocyte globulin in patients with severe aplastic anemia. Haematologica. 99:1433–1440. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Kato RB, Roy B, De Oliveira FS, Ferraz EP, De Oliveira PT, Kemper AG, Hassan MQ, Rosa AL and Beloti MM: Nanotopography directs mesenchymal stem cells to osteoblast lineage through regulation of microRNA-SMAD-BMP-2 circuit. J cell Physiol. 229:1690–1696. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Ding L, Zhu H, Yang Y, Wang ZD, Zheng XL, Yan HM, Dong L, Zhang HH, Han DM, Xue M, et al: Functional mesenchymal stem cells remain present in bone marrow microenvironment of patients with leukemia post-allogeneic hematopoietic stem cell transplant. Leuk lymphoma. 55:1635–1644. 2014. View Article : Google Scholar

9 

Sun ZM, Liu HL, Geng LQ, Wang XB, Yao W, Liu X, Ding KY, Han YS, Yang HZ, Tang BL, et al: HLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemia. J Hematol Oncol. 3:512010. View Article : Google Scholar

10 

Zhao J, Wang C, Song Y and Fang B: Arsenic trioxide and microRNA-204 display contrary effects on regulating adipogenic and osteogenic differentiation of mesenchymal stem cells in aplastic anemia. Acta Biochim Biophys Sin (Shanghai). 46:885–893. 2014. View Article : Google Scholar

11 

Wang X, Ma FX, Lu SH, Chi Y, Chen F, Li X, Li JJ, Du WJ, Feng Y, Cui JJ, et al: Effects of rapamycin on biological characteristics of bone marrow mesenchymal stem cells from patients with aplastic anemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 22:762–766. 2014.In Chinese. PubMed/NCBI

12 

Jiang SY, Xie XT, Jiang H, Zhou J, Li FX and Cao P: Low expression of basic fibroblastic growth factor in mesenchymal stem cells and bone marrow of children with aplastic anemia. Pediatric Hematol Oncol. 31:11–19. 2014. View Article : Google Scholar

13 

Tursi A, Elisei W, Inchingolo CD, Nenna R, Picchio M, Ierardi E and Brandimarte G: Chronic diverticulitis and Crohn's disease share the same expression of basic fibroblastic growth factor, syndecan 1 and tumour necrosis factor-α. J Clin Pathol. 67:844–846. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Marinucci L, Bodo M, Balloni S, Locci P and Baroni T: Sub-toxic nicotine concentrations affect extracellular matrix and growth factor signaling gene expressions in human osteoblasts. J Cell Physiol. 229:2038–2048. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Stegmann TJ: New approaches to coronary heart disease: Induction of neovascularisation by growth factors. Bio Drugs. 11:301–308. 1999.

16 

Cao R, Bråkenhielm E, Pawliuk R, Wariaro D, Post MJ, Wahlberg E, Leboulch P and Cao Y: Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat Med. 9:604–613. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Kapranov P, Willingham AT and Gingeras TR: Genome-wide transcription and the implications for genomic organization. Nat Rev Genet. 8:413–423. 2007. View Article : Google Scholar

18 

Wapinski O and Chang HY: Long noncoding RNAs and human disease. Trends cell Biol. 21:354–361. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Muers M: RNA: Genome-wide views of long non-coding RNAs. Nat Rev Genet. 12:7422011. View Article : Google Scholar : PubMed/NCBI

20 

Yang JH, Li JH, Shao P, Zhou H, Chen YQ and Qu LH: StarBase: A database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res. 39:D202–D209. 2011. View Article : Google Scholar

21 

Yang JH, Li JH, Jiang S, Zhou H and Qu LH: ChIPBase: A database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data. Nucleic Acids Res (Database Issue). 41:D177–D178. 2013. View Article : Google Scholar

22 

Volders PJ, Helsens K, Wang X, Menten B, Martens L, Gevaert K, Vandesompele J and Mestdagh P: LNCipedia: A database for annotated human lncRNA transcript sequences and structures. Nucleic Acids Res (Database Issue). 41:D246–D251. 2013. View Article : Google Scholar

23 

Amaral PP, Clark MB, Gascoigne DK, Dinger ME and Mattick JS: lncRNAdb: A reference database for long noncoding RNAs. Nucleic Acids Res (Database Issue). 39:D146–D151. 2011. View Article : Google Scholar

24 

Bu D, Yu K, Sun S, Xie C, Skogerbø G, Miao R, Xiao H, Liao Q, Luo H, Zhao G, et al: NONCODE v3.0: Integrative annotation of long noncoding RNAs. Nucleic Acids Res (Database Issue). 40:D210–D215. 2012. View Article : Google Scholar

25 

Dinger ME, Pang KC, Mercer TR, Crowe ML, Grimmond SM and Mattick JS: NRED: A database of long noncoding RNA expression. Nucleic Acids Res (Database Issue). 37:D122–D126. 2009. View Article : Google Scholar

26 

Self SG, Longton G, Kopecky KJ and Liang KY: On estimating HLA/disease association with application to a study of aplastic anemia. Biometrics. 47:53–61. 1991. View Article : Google Scholar : PubMed/NCBI

27 

Baldwin JL, Storb R, Thomas ED and Mannik M: Bone marrow transplantation in patients with gold-induced marrow aplasia. Arthritis Rheum. 20:1043–1048. 1997. View Article : Google Scholar

28 

Zhang T, Wang J, Zhou X, Liang R, Bai Q, Yang L, Gu H, Gao G, Dong B, Zhu H and Chen X: Increased Expression of TIGIT on CD4+ T cells ameliorates immune-mediated bone marrow failure of aplastic anemia. J Cell Biochem. 115:1918–1927. 2014.PubMed/NCBI

29 

Wang M, Nie N, Feng S, Shi J, Ge M, Li X, Shao Y, Huang J and Zheng Y: The polymorphisms of human leukocyte antigen loci may contribute to the susceptibility and severity of severe aplastic anemia in Chinese patients. Hum Immunol. 75:867–872. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Eom YW, Oh JE, Lee JI, Baik SK, Rhee KJ, Shin HC, Kim YM, Ahn CM, Kong JH, Kim HS and Shim KY: The role of growth factors in maintenance of stemness in bone marrow-derived mesenchymal stem cells. Biochem Biophys Res Commun. 445:16–22. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Chen P and Zhang L, Weng T, Zhang S, Sun S, Chang M, Li Y, Zhang B and Zhang L: A Ser252Trp mutation in fibroblast growth factor receptor 2 (FGFR2) mimicking human Apert syndrome reveals an essential role for FGF signaling in the regulation of endochondral bone formation. PloS One. 9:e873112014. View Article : Google Scholar : PubMed/NCBI

32 

Tian Y, Zhang X, Hao Y, Fang Z and He Y: Potential roles of abnormally expressed long noncoding RNA UCA1 and Malat-1 in metastasis of melanoma. Melanoma Res. 24:335–341. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Huang YS, Hsieh HY, Shih HM, Sytwu HK and Wu CC: Urinary Xist is a potential biomarker for membranous nephropathy. Biochem Biophys Res Commun. 452:415–421. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Sedaie Bonab A, Pouladi N, Hosseinpourfeizi MA, Ravanbakhsh Gavgani R, Dehghan R, Azarfam P, Montazeri V and Fakhrjou A: Single-strand conformational polymorphism analysis of a common single nucleotide variation in WRAP53 gene, rs2287499 and evaluating its association in relation to breast cancer risk and prognosis among Iranian-Azeri population. Med Oncol. 31:1682014. View Article : Google Scholar

35 

Bilinovich SM, Davis CM, Morris DL, Ray LA, Prokop JW, Buchan GJ and Leeper TC: The C-terminal domain of SRA1p has a fold more similar to PRP18 than to an RRM and does not directly bind to the SRA1 RNA STR7 region. J Mol Biol. 426:1753–1765. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Sciacca L, Cassarino MF, Genua M, Vigneri P, Giovanna Pennisi M, Malandrino P, Squatrito S, Pezzino V and Vigneri R: Biological effects of insulin and its analogs on cancer cells with different insulin family receptor expression. J Cell Physiol. 229:1817–1821. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Chen H, Xin Y, Zhou L, Huang JM, Tao L, Cheng L and Tian J: Cisplatin and paclitaxel target significant long noncoding RNAs in laryngeal squamous cell carcinoma. Med Oncol. 31:2462014. View Article : Google Scholar : PubMed/NCBI

38 

Deb S, Johansson I, Byrne D, Nilsson C, Investigators K, Constable L, Fjällskog ML, Dobrovic A, Hedenfalk I and Fox SB: Nuclear HIF1A expression is strongly prognostic in sporadic but not familial male breast cancer. Mod Pathol. 27:1223–1230. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang S, Xia M, Yang J, Shao J, Liao X, Zhu J and Jiang H: Novel insights into a treatment for aplastic anemia based on the advanced proliferation of bone marrow‑derived mesenchymal stem cells induced by fibroblast growth factor 1. Mol Med Rep 12: 7877-7882, 2015.
APA
Jiang, S., Xia, M., Yang, J., Shao, J., Liao, X., Zhu, J., & Jiang, H. (2015). Novel insights into a treatment for aplastic anemia based on the advanced proliferation of bone marrow‑derived mesenchymal stem cells induced by fibroblast growth factor 1. Molecular Medicine Reports, 12, 7877-7882. https://doi.org/10.3892/mmr.2015.4421
MLA
Jiang, S., Xia, M., Yang, J., Shao, J., Liao, X., Zhu, J., Jiang, H."Novel insights into a treatment for aplastic anemia based on the advanced proliferation of bone marrow‑derived mesenchymal stem cells induced by fibroblast growth factor 1". Molecular Medicine Reports 12.6 (2015): 7877-7882.
Chicago
Jiang, S., Xia, M., Yang, J., Shao, J., Liao, X., Zhu, J., Jiang, H."Novel insights into a treatment for aplastic anemia based on the advanced proliferation of bone marrow‑derived mesenchymal stem cells induced by fibroblast growth factor 1". Molecular Medicine Reports 12, no. 6 (2015): 7877-7882. https://doi.org/10.3892/mmr.2015.4421
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang S, Xia M, Yang J, Shao J, Liao X, Zhu J and Jiang H: Novel insights into a treatment for aplastic anemia based on the advanced proliferation of bone marrow‑derived mesenchymal stem cells induced by fibroblast growth factor 1. Mol Med Rep 12: 7877-7882, 2015.
APA
Jiang, S., Xia, M., Yang, J., Shao, J., Liao, X., Zhu, J., & Jiang, H. (2015). Novel insights into a treatment for aplastic anemia based on the advanced proliferation of bone marrow‑derived mesenchymal stem cells induced by fibroblast growth factor 1. Molecular Medicine Reports, 12, 7877-7882. https://doi.org/10.3892/mmr.2015.4421
MLA
Jiang, S., Xia, M., Yang, J., Shao, J., Liao, X., Zhu, J., Jiang, H."Novel insights into a treatment for aplastic anemia based on the advanced proliferation of bone marrow‑derived mesenchymal stem cells induced by fibroblast growth factor 1". Molecular Medicine Reports 12.6 (2015): 7877-7882.
Chicago
Jiang, S., Xia, M., Yang, J., Shao, J., Liao, X., Zhu, J., Jiang, H."Novel insights into a treatment for aplastic anemia based on the advanced proliferation of bone marrow‑derived mesenchymal stem cells induced by fibroblast growth factor 1". Molecular Medicine Reports 12, no. 6 (2015): 7877-7882. https://doi.org/10.3892/mmr.2015.4421
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