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Brain mechanisms of sympathetic activation in heart failure: Roles of the renin‑angiotensin system, nitric oxide and pro‑inflammatory cytokines (Review)

  • Authors:
    • Bin Xu
    • Hongli Li
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Shanghai First People's Hospital, College of Medicine, Shanghai Jiaotong University, Shanghai 200080, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7823-7829
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    Published online on: October 13, 2015
       https://doi.org/10.3892/mmr.2015.4434
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Abstract

Patients with chronic heart failure (CHF) have an insufficient perfusion to the peripheral tissues due to decreased cardiac output. The compensatory mechanisms are triggered even prior to the occurrence of clinical symptoms, which include activation of the sympathetic nervous system (SNS) and other neurohumoral factors. However, the long‑term activation of the SNS contributes to progressive cardiac dysfunction and has toxic effects on the cardiomyocytes. The mechanisms leading to the activation of SNS include changes in peripheral baroreceptor and chemoreceptor reflexes and the abnormal regulation of sympathetic nerve activity (SNA) in the central nervous system (CNS). Recent studies have focused on the role of brain mechanisms in the regulation of SNA and the progression of CHF. The renin‑angiotensin system, nitric oxide and pro‑inflammatory cytokines were shown to be involved in the abnormal regulation of SNA in the CNS. The alteration of these neurohumoral factors during CHF influences the activity of neurons in the autonomic regions and finally increase the sympathetic outflow. The present review summarizes the brain mechanisms contributing to sympathoexcitation in CHF.
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1 

Azad N and Lemay G: Management of chronic heart failure in the older population. J Geriatr Cardiol. 11:329–337. 2014.

2 

Johansen H, Strauss B, Arnold JM, Moe G and Liu P: On the rise: The current and projected future burden of congestive heart failure hospitalization in Canada. Can J Cardiol. 19:430–435. 2003.PubMed/NCBI

3 

Kishi T: Heart failure as an autonomic nervous system dysfunction. J Cardiol. 59:117–122. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G and Butler J: The sympathetic nervous system in heart failure physiology, pathophysiology and clinical implications. J Am Coll Cardiol. 54:1747–1762. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Guyenet PG: The sympathetic control of blood pressure. Nat Rev Neurosci. 7:335–346. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Potts JT, Paton JF, Mitchell JH, Garry MG, Kline G, Anguelov PT and Lee SM: Contraction-sensitive skeletal muscle afferents inhibit arterial baroreceptor signalling in the nucleus of the solitary tract: Role of intrinsic GABA interneurons. Neuroscience. 119:201–214. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Schreihofer AM and Guyenet PG: The baroreflex and beyond: Control of sympathetic vasomotor tone by GABAergic neurons in the ventrolateral medulla. Clin Exp Pharmacol Physiol. 29:514–521. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Affleck VS, Coote JH and Pyner S: The projection and synaptic organisation of NTS afferent connections with presympathetic neurons, GABA and nNOS neurons in the paraventricular nucleus of the hypothalamus. Neuroscience. 219:48–61. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Braga VA, Medeiros IA, Ribeiro TP, França-Silva MS, Botelho-Ono MS and Guimarães DD: Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: Implications in neurogenic hypertension. Braz J Med Biol Res. 44:871–876. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Kumagai H, Oshima N, Matsuura T, Iigaya K, Imai M, Onimaru H, Sakata K, Osaka M, Onami T, Takimoto C, et al: Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure. Hypertens Res. 35:132–141. 2012. View Article : Google Scholar :

11 

Tagawa T and Dampney RA: AT(1) receptors mediate excitatory inputs to rostral ventrolateral medulla pressor neurons from hypothalamus. Hypertension. 34:1301–1307. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Shafton AD, Ryan A and Badoer E: Neurons in the hypothalamic paraventricular nucleus send collaterals to the spinal cord and to the rostral ventrolateral medulla in the rat. Brain Res. 801:239–243. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Nunn N, Womack M, Dart C and Barrett-Jolley R: Function and pharmacology of spinally-projecting sympathetic pre-autonomic neurones in the paraventricular nucleus of the hypothalamus. Curr Neuropharmacol. 9:262–277. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Sun SY, Wang W, Zucker IH and Schultz HD: Enhanced peripheral chemoreflex function in conscious rabbits with pacing-induced heart failure. J Appl Physiol (1985). 86:1264–1272. 1999.

15 

Reid IA: Interactions between ANG II, sympathetic nervous system and baroreceptor reflexes in regulation of blood pressure. Am J Physiol. 262:E763–E778. 1992.PubMed/NCBI

16 

Liu JL, Murakami H, Sanderford M, Bishop VS and Zucker IH: ANG II and baroreflex function in rabbits with CHF and lesions of the area postrema. Am J Physiol. 277:H342–H350. 1999.PubMed/NCBI

17 

Llewellyn TL, Sharma NM, Zheng H and Patel KP: Effects of exercise training on SFO-mediated sympathoexcitation during chronic heart failure. Am J Physiol Heart Circ Physiol. 306:H121–H131. 2014. View Article : Google Scholar :

18 

Parsons KK and Coffman TM: The reninangiotensin system: It's all in your head. J Clin Invest. 117:873–876. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Lavoie JL, Cassell MD, Gross KW and Sigmund CD: Adjacent expression of renin and angiotensinogen in the rostral ventro-lateral medulla using a dual-reporter transgenic model. Hypertension. 43:1116–1119. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Lavoie JL, Cassell MD, Gross KW and Sigmund CD: Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model. Physiol Genomics. 16:240–246. 2004. View Article : Google Scholar

21 

Veerasingham SJ and Raizada MK: Brain renin-angiotensin system dysfunction in hypertension: Recent advances and perspectives. Br J Pharmacol. 139:191–202. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Zheng H, Li YF, Wang W and Patel KP: Enhanced angiotensin-mediated excitation of renal sympathetic nerve activity within the paraventricular nucleus of anesthetized rats with heart failure. Am J Physiol Regul Integr Comp Physiol. 297:R1364–R1374. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Gao L, Wang WZ, Wang W and Zucker IH: Imbalance of angiotensin type 1 receptor and angiotensin II type 2 receptor in the rostral ventrolateral medulla: Potential mechanism for sympathetic overactivity in heart failure. Hypertension. 52:708–714. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Wang WZ, Gao L, Wang HJ, Zucker IH and Wang W: Interaction between cardiac sympathetic afferent reflex and chemoreflex is mediated by the NTS AT1 receptors in heart failure. Am J Physiol Heart Circ Physiol. 295:H1216–H1226. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Tan J, Wang H and Leenen FH: Increases in brain and cardiac AT1 receptor and ACE densities after myocardial infarct in rats. Am J Physiol Heart Circ Physiol. 286:H1665–H1671. 2004. View Article : Google Scholar

26 

Wei SG, Yu Y, Zhang ZH, Weiss RM and Felder RB: Mitogen-activated protein kinases mediate upregulation of hypothalamic angiotensin II type 1 receptors in heart failure rats. Hypertension. 52:679–686. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Isegawa K, Hirooka Y, Katsuki M, Kishi T and Sunagawa K: Angiotensin II type 1 receptor expression in astrocytes is upregulated leading to increased mortality in mice with myocardial infarction-induced heart failure. Am J Physiol Heart Circ Physiol. 307:H1448–H1455. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Ramchandra R, Hood SG, Watson AM, Allen AM and May CN: Central angiotensin type 1 receptor blockade decreases cardiac but not renal sympathetic nerve activity in heart failure. Hypertension. 59:634–641. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Li Z, Iwai M, Wu L, Shiuchi T, Jinno T, Cui TX and Horiuchi M: Role of AT2 receptor in the brain in regulation of blood pressure and water intake. Am J Physiol Heart Circ Physiol. 284:H116–H121. 2003. View Article : Google Scholar

30 

Gao J, Zhang H, Le KD, Chao J and Gao L: Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats. Am J Hypertens. 24:724–730. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Gao J, Zucker IH and Gao L: Activation of central angiotensin type 2 receptors by compound 21 improves arterial baroreflex sensitivity in rats with heart failure. Am J Hypertens. 27:1248–1256. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Gao L, Wang W, Wang W, Li H, Sumners C and Zucker IH: Effects of angiotensin type 2 receptor overexpression in the rostral ventrolateral medulla on blood pressure and urine excretion in normal rats. Hypertension. 51:521–527. 2008. View Article : Google Scholar

33 

Kang J, Posner P and Sumners C: Angiotensin II type 2 receptor stimulation of neuronal K+ currents involves an inhibitory GTP binding protein. Am J Physiol. 267:C1389–C1397. 1994.PubMed/NCBI

34 

Qi J, Zhang DM, Suo YP, Song XA, Yu XJ, Elks C, Lin YX, Xu YY, Zang WJ, Zhu Z and Kang YM: Renin-angiotensin system modulates neurotransmitters in the paraventricular nucleus and contributes to angiotensin II-induced hypertensive response. Cardiovasc Toxicol. 13:48–54. 2013. View Article : Google Scholar

35 

Chen Q and Pan HL: Signaling mechanisms of angiotensin II-induced attenuation of GABAergic input to hypothalamic presympathetic neurons. J Neurophysiol. 97:3279–3287. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Hu L, Zhu DN, Yu Z, Wang JQ, Sun ZJ and Yao T: Expression of angiotensin II type 1 (AT(1)) receptor in the rostral ventrolateral medulla in rats. J Appl Physiol (1985). 92:2153–2161. 2002. View Article : Google Scholar

37 

Paton JF, Deuchars J, Ahmad Z, Wong LF, Murphy D and Kasparov S: Adenoviral vector demonstrates that angiotensin II-induced depression of the cardiac baroreflex is mediated by endothelial nitric oxide synthase in the nucleus tractus solitarii of the rat. J Physiol. 531:445–458. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Paton JF, Boscan P, Murphy D and Kasparov S: Unravelling mechanisms of action of angiotensin II on cardiorespiratory function using in vivo gene transfer. Acta Physiol Scand. 173:127–137. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Chan SH, Hsu KS, Huang CC, Wang LL, Ou CC and Chan JY: NADPH oxidase-derived superoxide anion mediates angiotensin II-induced pressor effect via activation of p38 mitogen-activated protein kinase in the rostral ventrolateral medulla. Circ Res. 97:772–780. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Gao L, Li Y, Schultz HD, Wang WZ, Wang W, Finch M, Smith LM and Zucker IH: Downregulated Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic heart failure. Am J Physiol Heart Circ Physiol. 298:H945–H955. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Kang YM, Ma Y, Zheng JP, Elks C, Sriramula S, Yang ZM and Francis J: Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Cardiovasc Res. 82:503–512. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Gao L, Wang W, Li YL, Schultz HD, Liu D, Cornish KG and Zucker IH: Superoxide mediates sympathoexcitation in heart failure: Roles of angiotensin II and NAD(P)H oxidase. Circ Res. 95:937–944. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Wang G, Anrather J, Glass MJ, Tarsitano MJ, Zhou P, Frys KA, Pickel VM and Ladecola C: Nox2, Ca2+ and protein kinase C play a role in angiotensin II-induced free radical production in nucleus tractus solitarius. Hypertension. 48:482–489. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Liu D, Gao L, Roy SK, Cornish KG and Zucker IH: Role of oxidant stress on AT1 receptor expression in neurons of rabbits with heart failure and in cultured neurons. Circ Res. 103:186–193. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Nishihara M, Hirooka Y, Matsukawa R, Kishi T and Sunagawa K: Oxidative stress in the rostral ventrolateral medulla modulates excitatory and inhibitory inputs in spontaneously hypertensive rats. J Hypertens. 30:97–106. 2012. View Article : Google Scholar

46 

Gao L, Wang W, Liu DM and Zucker IH: Exercise training normalizes sympathetic outflow by central antioxidant mechanisms in rabbits with pacing-induced chronic heart failure. Circulation. 115:3095–3102. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Li Y, Zhang W and Stern JE: Nitric oxide inhibits the firing activity of hypothalamic paraventricular neurons that innervate the medulla oblongata: Role of GABA. Neuroscience. 118:585–601. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Krukoff TL and Khalili P: Stress-induced activation of nitric oxide-producing neurons in the rat brain. J Comp Neurol. 377:509–519. 1997. View Article : Google Scholar : PubMed/NCBI

49 

Lin LH, Taktakishvili O and Talman WT: Identification and localization of cell types that express endothelial and neuronal nitric oxide synthase in the rat nucleus tractus solitarii. Brain Res. 1171:42–51. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Chan SH, Wang LL and Chan JY: Differential engagements of glutamate and GABA receptors in cardiovascular actions of endogenous nNOS or iNOS at rostral ventrolateral medulla of rats. Br J Pharmacol. 138:584–593. 2003. View Article : Google Scholar : PubMed/NCBI

51 

Patel KP, Li YF and Hirooka Y: Role of nitric oxide in central sympathetic outflow. Exp Biol Med (Maywood). 226:814–824. 2001.

52 

Wang Y, Patel KP, Cornish KG, Channon KM and Zucker IH: nNOS gene transfer to RVLM improves baroreflex function in rats with chronic heart failure. Am J Physiol Heart Circ Physiol. 285:H1660–H1667. 2003. View Article : Google Scholar : PubMed/NCBI

53 

Sakai K, Hirooka Y, Shigematsu H, Kishi T, Ito K, Shimokawa H, Takeshita A and Sunagawa K: Overexpression of eNOS in brain stem reduces enhanced sympathetic drive in mice with myocardial infarction. Am J Physiol Heart Circ Physiol. 289:H2159–H2166. 2005. View Article : Google Scholar : PubMed/NCBI

54 

Wang Y, Liu XF, Cornish KG, Zucker IH and Patel KP: Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure. Am J Physiol Heart Circ Physiol. 288:H205–H213. 2005. View Article : Google Scholar

55 

Zhang K, Li YF and Patel KP: Blunted nitric oxide-mediated inhibition of renal nerve discharge within PVN of rats with heart failure. Am J Physiol Heart Circ Physiol. 281:H995–H1004. 2001.PubMed/NCBI

56 

Hirooka Y, Shigematsu H, Kishi T, Kimura Y, Ueta Y and Takeshita A: Reduced nitric oxide synthase in the brainstem contributes to enhanced sympathetic drive in rats with heart failure. J Cardiovasc Pharmacol. 42(Suppl 1): S111–S115. 2003. View Article : Google Scholar

57 

Zucker IH, Schultz HD, Li YF, Wang Y, Wang W and Patel KP: The origin of sympathetic outflow in heart failure: The roles of angiotensin II and nitric oxide. Prog Biophys Mol Biol. 84:217–232. 2004. View Article : Google Scholar : PubMed/NCBI

58 

Jaffrey SR, Snowman AM, Eliasson MJ, Cohen NA and Snyder SH: CAPON: A protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Neuron. 20:115–124. 1998. View Article : Google Scholar : PubMed/NCBI

59 

Sharma NM, Zheng H, Mehta PP, Li YF and Patel KP: Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: Role for CAPON and Ang II. Cardiovasc Res. 92:348–357. 2011. View Article : Google Scholar : PubMed/NCBI

60 

Sharma NM, Llewellyn TL, Zheng H and Patel KP: Angiotensin II-mediated posttranslational modification of nNOS in the PVN of rats with CHF: Role for PIN. Am J Physiol Heart Circ Physiol. 305:H843–H855. 2013. View Article : Google Scholar : PubMed/NCBI

61 

Horn T, Smith PM, McLaughlin BE, Bauce L, Marks GS, Pittman QJ and Ferguson AV: Nitric oxide actions in paravenstricular nucleus: Cardiovascular and neurochemical implications. Am J Physiol. 266:R306–R313. 1994.PubMed/NCBI

62 

Zhang K and Patel KP: Effect of nitric oxide within the para-ventricular nucleus on renal sympathetic nerve discharge: Role of GABA. Am J Physiol. 275:R728–R734. 1998.

63 

Li YF, Mayhan WG and Patel KP: NMDA-mediated increase in renal sympathetic nerve discharge within the PVN: Role of nitric oxide. Am J Physiol Heart Circ Physiol. 281:H2328–H2336. 2001.

64 

Zheng H, Liu X, Li Y, Sharma NM and Patel KP: Gene transfer of neuronal nitric oxide synthase to the paraventricular nucleus reduces the enhanced glutamatergic tone in rats with chronic heart failure. Hypertension. 58:966–973. 2011. View Article : Google Scholar : PubMed/NCBI

65 

Kishi T, Hirooka Y, Sakai K, Shigematsu H, Shimokawa H and Takeshita A: Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release. Hypertension. 38:896–901. 2001.PubMed/NCBI

66 

Martins-Pinge MC, Garcia MR, Zoccal DB, Crestani CC and Pinge-Filho P: Differential influence of iNOS and nNOS inhibitors on rostral ventrolateral medullary mediated cardiovascular control in conscious rats. Auton Neurosci. 131:65–69. 2007. View Article : Google Scholar

67 

Sharma NM, Zheng H, Li YF and Patel KP: Nitric oxide inhibits the expression of AT1 receptors in neurons. Am J Physiol Cell Physiol. 302:C1162–C1173. 2012. View Article : Google Scholar : PubMed/NCBI

68 

Guo ZL, Tjen-A-Looi SC, Fu LW and Longhurst JC: Nitric oxide in rostral ventrolateral medulla regulates cardiac-sympathetic reflexes: Role of synthase isoforms. Am J Physiol Heart Circ Physiol. 297:H1478–H1486. 2009. View Article : Google Scholar : PubMed/NCBI

69 

Wang S, Paton JF and Kasparov S: Differential sensitivity of excitatory and inhibitory synaptic transmission to modulation by nitric oxide in rat nucleus tractus solitarii. Exp Physiol. 92:371–382. 2007. View Article : Google Scholar

70 

Dias AC, Vitela M, Colombari E and Mifflin SW: Nitric oxide modulation of glutamatergic, baroreflex and cardiopulmonary transmission in the nucleus of the solitary tract. Am J Physiol Heart Circ Physiol. 288:H256–H262. 2005. View Article : Google Scholar

71 

Ramchandra R, Hood SG and May CN: Central exogenous nitric oxide decreases cardiac sympathetic drive and improves baroreflex control of heart rate in ovine heart failure. Am J Physiol Regul Integr Comp Physiol. 307:R271–R280. 2014. View Article : Google Scholar : PubMed/NCBI

72 

Rauchhaus M, Doehner W, Francis DP, Davos C, Kemp M, Liebenthal C, Niebauer J, Hooper J, Volk HD, Coats AJ and Anker SD: Plasma cytokine parameters and mortality in patients with chronic heart failure. Circulation. 102:3060–3067. 2000. View Article : Google Scholar : PubMed/NCBI

73 

Utsuyama M and Hirokawa K: Differential expression of various cytokine receports in the brain after stimulation with LPS in young and old mice. Exp Gerontol. 37:411–420. 2002. View Article : Google Scholar : PubMed/NCBI

74 

Wei SG, Zhang ZH, Beltz TG, Yu Y, Johnson AK and Felder RB: Subfornical organ mediates sympathetic and hemo-dynamic responses to blood-borne proinflammatory cytokines. Hypertension. 62:118–125. 2013. View Article : Google Scholar : PubMed/NCBI

75 

Felder RB, Yu Y, Zhang ZH and Wei SG: Pharmacological treatment for heart failure: A view from the brain. Clin Pharmacol Ther. 86:216–220. 2009. View Article : Google Scholar : PubMed/NCBI

76 

Yu Y, Zhang ZH, Wei SG, Serrats J, Weiss RM and Felder RB: Brain perivascular macrophages and the sympathetic response to inflammation in rats after myocardial infarction. Hypertension. 55:652–659. 2010. View Article : Google Scholar : PubMed/NCBI

77 

Zhang ZH, Yu Y, Wei SG and Felder RB: Centrally administered lipopolysaccharide elicits sympathetic excitation via NAD(P)H oxidase-dependent mitogen-activated protein kinase signaling. J Hypertens. 28:806–816. 2010. View Article : Google Scholar :

78 

Francis J, Zhang ZH, Weiss RM and Felder RB: Neural regulation of the proinflammatory cytokine response to acute myocardial infarction. Am J Physiol Heart Circ Physiol. 287:H791–H797. 2004. View Article : Google Scholar : PubMed/NCBI

79 

Kang YM, Zhang ZH, Xue B, Weiss RM and Felder RB: Inhibition of brain proinflammatory cytokine synthesis reduces hypothalamic excitation in rats with ischemia-induced heart failure. Am J Physiol Heart Circ Physiol. 295:H227–H236. 2008. View Article : Google Scholar : PubMed/NCBI

80 

Kang YM, Ma Y, Elks C, Zheng JP, Yang ZM and Francis J: Cross-talk between cytokines and renin-angiotensin in hypo-thalamic paraventricular nucleus in heart failure: Role of nuclear factor-kappaB. Cardiovasc Res. 79:671–678. 2008. View Article : Google Scholar : PubMed/NCBI

81 

Guggilam A, Cardinale JP, Mariappan N, Sriramula S, Haque M and Francis J: Central TNF inhibition results in attenuated neurohumoral excitation in heart failure: A role for superoxide and nitric oxide. Basic Res Cardiol. 106:273–286. 2011. View Article : Google Scholar : PubMed/NCBI

82 

Allen RG and Tresini M: Oxidative stress and gene regulation. Free Radic Biol Med. 28:463–499. 2000. View Article : Google Scholar : PubMed/NCBI

83 

Akira S and Takeda K: Toll-like receptor signalling. Nat Rev Immunol. 4:499–511. 2004. View Article : Google Scholar : PubMed/NCBI

84 

Ogawa K, Hirooka Y, Kishi T and Sunagawa K: Brain AT1 receptor activates the sympathetic nervous system through toll-like receptor 4 in mice with heart failure. J Cardiovasc Pharmacol. 58:543–549. 2011. View Article : Google Scholar : PubMed/NCBI

85 

Kang YM, He RL, Yang LM, Qin DN, Guggilam A, Elks C, Yan N, Guo Z and Francis J: Brain tumour necrosis factor-alpha modulates neurotransmitters in hypothalamic paraventricular nucleus in heart failure. Cardiovasc Res. 83:737–746. 2009. View Article : Google Scholar : PubMed/NCBI

86 

Wei SG, Zhang ZH, Yu Y and Felder RB: Central SDF-1/CXCL12 expression and its cardiovascular and sympathetic effects: The role of angiotensin II, TNF-α and MAPK signaling. Am J Physiol Heart Circ Physiol. 307:H1643–H1654. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu B and Li H: Brain mechanisms of sympathetic activation in heart failure: Roles of the renin‑angiotensin system, nitric oxide and pro‑inflammatory cytokines (Review). Mol Med Rep 12: 7823-7829, 2015.
APA
Xu, B., & Li, H. (2015). Brain mechanisms of sympathetic activation in heart failure: Roles of the renin‑angiotensin system, nitric oxide and pro‑inflammatory cytokines (Review). Molecular Medicine Reports, 12, 7823-7829. https://doi.org/10.3892/mmr.2015.4434
MLA
Xu, B., Li, H."Brain mechanisms of sympathetic activation in heart failure: Roles of the renin‑angiotensin system, nitric oxide and pro‑inflammatory cytokines (Review)". Molecular Medicine Reports 12.6 (2015): 7823-7829.
Chicago
Xu, B., Li, H."Brain mechanisms of sympathetic activation in heart failure: Roles of the renin‑angiotensin system, nitric oxide and pro‑inflammatory cytokines (Review)". Molecular Medicine Reports 12, no. 6 (2015): 7823-7829. https://doi.org/10.3892/mmr.2015.4434
Copy and paste a formatted citation
x
Spandidos Publications style
Xu B and Li H: Brain mechanisms of sympathetic activation in heart failure: Roles of the renin‑angiotensin system, nitric oxide and pro‑inflammatory cytokines (Review). Mol Med Rep 12: 7823-7829, 2015.
APA
Xu, B., & Li, H. (2015). Brain mechanisms of sympathetic activation in heart failure: Roles of the renin‑angiotensin system, nitric oxide and pro‑inflammatory cytokines (Review). Molecular Medicine Reports, 12, 7823-7829. https://doi.org/10.3892/mmr.2015.4434
MLA
Xu, B., Li, H."Brain mechanisms of sympathetic activation in heart failure: Roles of the renin‑angiotensin system, nitric oxide and pro‑inflammatory cytokines (Review)". Molecular Medicine Reports 12.6 (2015): 7823-7829.
Chicago
Xu, B., Li, H."Brain mechanisms of sympathetic activation in heart failure: Roles of the renin‑angiotensin system, nitric oxide and pro‑inflammatory cytokines (Review)". Molecular Medicine Reports 12, no. 6 (2015): 7823-7829. https://doi.org/10.3892/mmr.2015.4434
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