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Article Open Access

Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway

Corrigendum in: /10.3892/mmr.2016.4972
  • Authors:
    • Wei Zhao
    • Mingshu Lu
    • Qiwen Zhang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, People's Hospital of Laiwu, Laiwu, Shandong 271100, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 8041-8047
    |
    Published online on: October 21, 2015
       https://doi.org/10.3892/mmr.2015.4459
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Abstract

Chloride intracellular channel 1 (CLIC1) has been demonstrated to be overexpressed in gastric cancer, and elevated CLIC1 expression levels are markedly associated with the processes of tumor cell migration and invasion. However, the regulatory mechanism and signaling pathway underlying these processes have remained to be elucidated. The present study examined the impact of N-acetyl cysteine (NAC), indanyloxyacetic acid (IAA)-94 and SB203580, inhibitors of reactive oxygen species (ROS), as well as CLIC1 and p38 mitogen-activated protein kinase (MAPK) on the migration and invasion of SGC-7901 gastric cancer cells in a hypoxia‑reoxygenation (H-R) microenvironment. The results demonstrated that intracellular ROS and CLIC1 levels were increased under H‑R conditions, and that functional inhibition of CLIC1 significantly decreased the H‑R‑elevated ROS generation and p‑p38 MAPK levels in SGC‑7901 cells, as well as inhibited the migration and invasion of SGC‑7901 cells. In addition, the expression levels of MMP‑2 and MMP‑9 were inhibited by NAC, IAA‑94 and SB203580. These results indicated that CLIC1 regulates gastric cancer-cell migration and invasion via the ROS-mediated p38 MAPK signaling pathway.
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1 

Fock KM: Review article: The epidemiology and prevention of gastric cancer. Aliment Pharmacol Ther. 40:250–260. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Lin Y, Ueda J, Kikuchi S, Totsuka Y, Wei WQ, Qiao YL and Inoue M: Comparative epidemiology of gastric cancer between Japan and China. World J Gastroenterol. 17:4421–4428. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Ko JH, Ko EA, Gu W, Lim I, Bang H and Zhou T: Expression profiling of ion channel genes predicts clinical outcome in breast cancer. Mol Cancer. 12(106)2013. View Article : Google Scholar : PubMed/NCBI

4 

Poulsen KA, Andersen EC, Hansen CF, Klausen TK, Hougaard C, Lambert IH and Hoffmann EK: Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: Role of chloride channels. Am J Physiol Cell Physiol. 298:C14–C25. 2010. View Article : Google Scholar

5 

Shiozaki A, Otsuji E and Marunaka Y: Intracellular chloride regulates the G(1)/S cell cycle progression in gastric cancer cells. World J Gastrointest Oncol. 3:119–122. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Ashley RH: Challenging accepted ion channel biology: p64 and the CLIC family of putative intracellular anion channel proteins (Review). Mol Membr Biol. 20:1–11. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Zheng DL, Huang QL, Zhou F, Huang QJ, Lin JY and Lin X: PA28β regulates cell invasion of gastric cancer via modulating the expression of chloride intracellular channel 1. J Cell Biochem. 113:1537–1546. 2012.

8 

Chen CD, Wang CS, Huang YH, Chien KY, Liang Y, Chen WJ and Lin KH: Overexpression of CLIC1 in human gastric carcinoma and its clinicopathological significance. Proteomics. 7:155–167. 2007. View Article : Google Scholar

9 

Ma PF, Chen JQ, Wang Z, Liu JL and Li BP: Function of chloride intracellular channel 1 in gastric cancer cells. World J Gastroenterol. 18:3070–3080. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Averaimo S, Milton RH, Duchen MR and Mazzanti M: Chloride intracellular channel 1 (CLIC1): Sensor and effector during oxidative stress. FEBS Lett. 584:2076–2084. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Costa A, Scholer-Dahirel A and Mechta-Grigoriou F: The role of reactive oxygen species and metabolism on cancer cells and their microenvironment. Semin Cancer Biol. 25:23–32. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Okoh V, Deoraj A and Roy D: Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer. Biochim Biophys Acta. 1815:115–133. 2011.

13 

Son Y, Kim S, Chung HT and Pae HO: Reactive oxygen species in the activation of MAP kinases. Methods Enzymol. 528:27–48. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Son Y, Cheong YK, Kim NH, Chung HT, Kang DG and Pae HO: Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways? J Signal Transduct. 2011(792639)2011. View Article : Google Scholar : PubMed/NCBI

15 

Tormos AM, Taléns-Visconti R, Nebreda AR and Sastre J: p38 MAPK: A dual role in hepatocyte proliferation through reactive oxygen species. Free Radic Res. 47:905–916. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Wang P, Zeng Y, Liu T, Zhang C, Yu PW, Hao YX, Luo HX and Liu G: Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway. World J Gastroenterol. 20:2071–2078. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Li C and Jackson RM: Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol Cell Physiol. 282:C227–C241. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Wang P, Zhang C, Yu P, Tang B, Liu T, Cui H and Xu J: Regulation of colon cancer cell migration and invasion by CLIC1-mediated RVD. Mol Cell Biochem. 365:313–321. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Binker MG, Binker-Cosen AA, Richards D, Gaisano HY, de Cosen RH and Cosen-Binker LI: Hypoxia-reoxygenation increase invasiveness of PANC-1 cells through Rac1/MMP-2. Biochem Biophys Res Commun. 393:371–376. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Kokura S, Yoshida N, Imamoto E, Ueda M, Ishikawa T, Uchiyama K, Kuchide M, Naito Y, Okanoue T and Yoshikawa T: Anoxia/reoxygenation downregulates the expression of E-cadherin in human colon cancer cell lines. Cancer Lett. 211:79–87. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Su HL, Chou CC, Hung DJ, et al: The disruption of bacterial membrane integrity through ROS generation induced by nanohybrids of silver and clay. Biomaterials. 30:5979–5987. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Chaffer CL and Weinberg RA: A perspective on cancer cell metastasis. Science. 331:1559–1564. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Kim MS, Lee EJ, Kim HR and Moon A: p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells. Cancer Res. 63:5454–5461. 2003.PubMed/NCBI

24 

Negus RP and Balkwill FR: Cytokines in tumour growth, migration and metastasis. World J Urol. 14:157–165. 1996. View Article : Google Scholar : PubMed/NCBI

25 

Versteeg HH, Spek CA, Peppelenbosch MP and Richel DJ: Tissue factor and cancer metastasis: The role of intracellular and extracellular signaling pathways. Mol Med. 10:6–11. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Avni R, Cohen B and Neeman M: Hypoxic stress and cancer: Imaging the axis of evil in tumor metastasis. NMR Biomed. 24:569–581. 2011.PubMed/NCBI

27 

Bendinelli P, Maroni P, Matteucci E, Luzzati A, Perrucchini G and Desiderio MA: Microenvironmental stimuli affect Endothelin-1 signaling responsible for invasiveness and osteomimicry of bone metastasis from breast cancer. Biochim Biophys Acta. 1843:815–826. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Quail DF and Joyce JA: Microenvironmental regulation of tumor progression and metastasis. Nat Med. 19:1423–1437. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Postovit LM, Abbott DE, Payne SL, Wheaton WW, Margaryan NV, Sullivan R, Jansen MK, Csiszar K, Hendrix MJ and Kirschmann DA: Hypoxia/reoxygenation: A dynamic regulator of lysyl oxidase-facilitated breast cancer migration. J Cell Biochem. 103:1369–1378. 2008. View Article : Google Scholar

30 

Circu Ml and Aw TY: Reactive oxygen species, cellular redox systems and apoptosis. Free Radic Biol Med. 48:749–762. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Kamata H, Honda S, Maeda S, Chang L, Hirata H and Karin M: Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell. 120:649–661. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Inokuma T, Haraguchi M, Fujita F, Torashima Y, Eguchi S and Kanematsu T: Suppression of reactive oxygen species develops lymph node metastasis in colorectal cancer. Hepatogastroenterology. 59:2480–2483. 2012.PubMed/NCBI

33 

Nishikawa M: Reactive oxygen species in tumor metastasis. Cancer lett. 266:53–59. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Arnold RS, Shi J, Murad E, Whalen AM, Sun CQ, Polavarapu R, Parthasarathy S, Petros JA and Lambeth JD: Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc Natl Acad Sci USA. 98:5550–5555. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Allen RG and Tresini M: Oxidative stress and gene regulation. Free Radic Biol Med. 28:463–499. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Chen PN, Hsieh YS, Chiou HL and Chu SC: Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways. Chem Biol Interact. 156:141–150. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Kwon GT, Cho HJ, Chung WY, Park KK, Moon A and Park JH: Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: Possible mediation by decreased JNK/AP-1 signaling. J Nutr Biochem. 20:663–676. 2009. View Article : Google Scholar

38 

Lee SJ, Park SS, Lee US, Kim WJ and Moon SK: Signaling pathway for TNF-alpha-induced MMP-9 expression: Mediation through p38 MAP kinase and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells. Int Immunopharmacol. 8:1821–1826. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Wang WH, Hullinger RL and Andrisani OM: Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis. J Biol Chem. 283:25455–25467. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Kim MS, Lee EJ, Kim HR and Moon A: p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells. Cancer Res. 63:5454–5461. 2003.PubMed/NCBI

41 

Bernhard EJ, Gruber SB and Muschel RJ: Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc Natl Acad Sci USA. 91:4293–4297. 1994. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao W, Lu M and Zhang Q: Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway Corrigendum in /10.3892/mmr.2016.4972. Mol Med Rep 12: 8041-8047, 2015.
APA
Zhao, W., Lu, M., & Zhang, Q. (2015). Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway Corrigendum in /10.3892/mmr.2016.4972. Molecular Medicine Reports, 12, 8041-8047. https://doi.org/10.3892/mmr.2015.4459
MLA
Zhao, W., Lu, M., Zhang, Q."Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway Corrigendum in /10.3892/mmr.2016.4972". Molecular Medicine Reports 12.6 (2015): 8041-8047.
Chicago
Zhao, W., Lu, M., Zhang, Q."Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway Corrigendum in /10.3892/mmr.2016.4972". Molecular Medicine Reports 12, no. 6 (2015): 8041-8047. https://doi.org/10.3892/mmr.2015.4459
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao W, Lu M and Zhang Q: Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway Corrigendum in /10.3892/mmr.2016.4972. Mol Med Rep 12: 8041-8047, 2015.
APA
Zhao, W., Lu, M., & Zhang, Q. (2015). Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway Corrigendum in /10.3892/mmr.2016.4972. Molecular Medicine Reports, 12, 8041-8047. https://doi.org/10.3892/mmr.2015.4459
MLA
Zhao, W., Lu, M., Zhang, Q."Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway Corrigendum in /10.3892/mmr.2016.4972". Molecular Medicine Reports 12.6 (2015): 8041-8047.
Chicago
Zhao, W., Lu, M., Zhang, Q."Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway Corrigendum in /10.3892/mmr.2016.4972". Molecular Medicine Reports 12, no. 6 (2015): 8041-8047. https://doi.org/10.3892/mmr.2015.4459
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