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Article

Mitochondrial COI/tRNASer(UCN) G7444A mutation may be associated with aminoglycoside-induced and non-syndromic hearing impairment

  • Authors:
    • Qi Liu
    • Ping Liu
    • Yu Ding
    • Xue‑Jun Dong
    • Zong‑Xin Wang
    • Yan‑Er Qian
    • Qing Wang
    • Guo‑Can Yang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory Center, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang 312000, P.R. China, Central Laboratory, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, P.R. China
  • Pages: 8176-8178
    |
    Published online on: October 26, 2015
       https://doi.org/10.3892/mmr.2015.4484
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Abstract

Mutations in mitochondrial DNA (mtDNA) have been reported to have important roles in aminoglycoside-induced hearing impairment; however, the underlying molecular mechanisms have remained largely elusive. The current study presented a case of a Chinese patient with maternally inherited aminoglycoside-induced hearing impairment. A profound hearing impairment was identified by clinical evaluation; furthermore, analysis of the mitochondrial genome sequence of the patient revealed the presence of an A1555G mutation in the 12S rRNA as well as a G7444A mutation in the COI/tRNASer(UCN) gene. As the G7444A mutation is highly conserved between various species, it may be a modifying factor with regard to the pathological effects of the A1555G mutation.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Q, Liu P, Ding Y, Dong XJ, Wang ZX, Qian YE, Wang Q and Yang GC: Mitochondrial COI/tRNASer(UCN) G7444A mutation may be associated with aminoglycoside-induced and non-syndromic hearing impairment. Mol Med Rep 12: 8176-8178, 2015.
APA
Liu, Q., Liu, P., Ding, Y., Dong, X., Wang, Z., Qian, Y. ... Yang, G. (2015). Mitochondrial COI/tRNASer(UCN) G7444A mutation may be associated with aminoglycoside-induced and non-syndromic hearing impairment. Molecular Medicine Reports, 12, 8176-8178. https://doi.org/10.3892/mmr.2015.4484
MLA
Liu, Q., Liu, P., Ding, Y., Dong, X., Wang, Z., Qian, Y., Wang, Q., Yang, G."Mitochondrial COI/tRNASer(UCN) G7444A mutation may be associated with aminoglycoside-induced and non-syndromic hearing impairment". Molecular Medicine Reports 12.6 (2015): 8176-8178.
Chicago
Liu, Q., Liu, P., Ding, Y., Dong, X., Wang, Z., Qian, Y., Wang, Q., Yang, G."Mitochondrial COI/tRNASer(UCN) G7444A mutation may be associated with aminoglycoside-induced and non-syndromic hearing impairment". Molecular Medicine Reports 12, no. 6 (2015): 8176-8178. https://doi.org/10.3892/mmr.2015.4484
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Q, Liu P, Ding Y, Dong XJ, Wang ZX, Qian YE, Wang Q and Yang GC: Mitochondrial COI/tRNASer(UCN) G7444A mutation may be associated with aminoglycoside-induced and non-syndromic hearing impairment. Mol Med Rep 12: 8176-8178, 2015.
APA
Liu, Q., Liu, P., Ding, Y., Dong, X., Wang, Z., Qian, Y. ... Yang, G. (2015). Mitochondrial COI/tRNASer(UCN) G7444A mutation may be associated with aminoglycoside-induced and non-syndromic hearing impairment. Molecular Medicine Reports, 12, 8176-8178. https://doi.org/10.3892/mmr.2015.4484
MLA
Liu, Q., Liu, P., Ding, Y., Dong, X., Wang, Z., Qian, Y., Wang, Q., Yang, G."Mitochondrial COI/tRNASer(UCN) G7444A mutation may be associated with aminoglycoside-induced and non-syndromic hearing impairment". Molecular Medicine Reports 12.6 (2015): 8176-8178.
Chicago
Liu, Q., Liu, P., Ding, Y., Dong, X., Wang, Z., Qian, Y., Wang, Q., Yang, G."Mitochondrial COI/tRNASer(UCN) G7444A mutation may be associated with aminoglycoside-induced and non-syndromic hearing impairment". Molecular Medicine Reports 12, no. 6 (2015): 8176-8178. https://doi.org/10.3892/mmr.2015.4484
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