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Article

Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice

  • Authors:
    • Jin‑Zhong Huang
    • Jian Wu
    • Shoukui Xiang
    • Shiying Sheng
    • Ying Jiang
    • Zhilong Yang
    • Fei Hua
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China, Department of Endocrinology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China
  • Pages: 491-496
    |
    Published online on: November 2, 2015
       https://doi.org/10.3892/mmr.2015.4496
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Abstract

Alzheimer's disease (AD) is the most common form of dementia and there currently are no effective treatment strategies available. Catalpol is an iridoid glucoside, and large quantities can be isolated from the genus Rehmannia (Orobanchaceae). The present study assessed whether catalpol had any protective effects against Alzheimer's disease using a murine model. Reactive oxygen species (ROS)-associated enzymes as well as soluble Aβ40 and Aβ42 were detected using kits. Thioflavin‑S staining was performed to detect senile plaques and reverse-transcription quantitative polymerase chain reaction was used to assess iroquois homeobox protein 3 (IRX3) and obesity‑associated genes, while western blot analysis was used for β‑secretase 1 (BACE1), insulin‑degrading enzyme (IDE) and neprilysin (NEP) detection. The Morris water maze was used to detect the learning ability and spatial memory. The results revealed that catalpol was able to reduce the oxidative stress in the cerebral cortex by regulating the activities and concentration of ROS‑associated enzymes superoxide dismutase, glutathione peroxidase and catalase, however not malondialdehyde. Catalpol was also identified to be able to reduce the levels of soluble Aβ40 and Aβ42 in the cerebral cortex and thus inhibit the formation of senile plaques. These effects were observed to be regulated by IDE, however not by BACE1 or NEP. It is suggested that catalpol is not capable of directly regulating the expression of IRX3 and obesity‑associated genes. Subsequent to the treatment with catalpol, impairments in learning and memory were also observed to be relieved using the Morris water maze test. The results of the present study indicate that catalpol may be a potential drug for the treatment of neurodegenerative diseases such as AD.
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Copy and paste a formatted citation
Spandidos Publications style
Huang JZ, Wu J, Xiang S, Sheng S, Jiang Y, Yang Z and Hua F: Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice. Mol Med Rep 13: 491-496, 2016.
APA
Huang, J., Wu, J., Xiang, S., Sheng, S., Jiang, Y., Yang, Z., & Hua, F. (2016). Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice. Molecular Medicine Reports, 13, 491-496. https://doi.org/10.3892/mmr.2015.4496
MLA
Huang, J., Wu, J., Xiang, S., Sheng, S., Jiang, Y., Yang, Z., Hua, F."Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice". Molecular Medicine Reports 13.1 (2016): 491-496.
Chicago
Huang, J., Wu, J., Xiang, S., Sheng, S., Jiang, Y., Yang, Z., Hua, F."Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice". Molecular Medicine Reports 13, no. 1 (2016): 491-496. https://doi.org/10.3892/mmr.2015.4496
Copy and paste a formatted citation
x
Spandidos Publications style
Huang JZ, Wu J, Xiang S, Sheng S, Jiang Y, Yang Z and Hua F: Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice. Mol Med Rep 13: 491-496, 2016.
APA
Huang, J., Wu, J., Xiang, S., Sheng, S., Jiang, Y., Yang, Z., & Hua, F. (2016). Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice. Molecular Medicine Reports, 13, 491-496. https://doi.org/10.3892/mmr.2015.4496
MLA
Huang, J., Wu, J., Xiang, S., Sheng, S., Jiang, Y., Yang, Z., Hua, F."Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice". Molecular Medicine Reports 13.1 (2016): 491-496.
Chicago
Huang, J., Wu, J., Xiang, S., Sheng, S., Jiang, Y., Yang, Z., Hua, F."Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice". Molecular Medicine Reports 13, no. 1 (2016): 491-496. https://doi.org/10.3892/mmr.2015.4496
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