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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
January-2016 Volume 13 Issue 1

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

IL‑33 and kidney disease (Review)

Feifei Yang, Ping Zhu, Lihua Duan, Lin Yang, Jiajun Wang
Pages: 3-8
Published online on: 06 November 2015

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Review

Activating transcription factor 3 ‑ an endogenous inhibitor of myocardial ischemia-reperfusion injury (Review)

Chao‑Jun Yang, Jun Yang, Zhi‑Xing Fan, Jian Yang
Pages: 9-12
Published online on: 06 November 2015

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Article Open Access

Methylene blue exerts a neuroprotective effect against traumatic brain injury by promoting autophagy and inhibiting microglial activation

Mingfei Zhao, Feng Liang, Hangdi Xu, Wei Yan, Jianmin Zhang
Pages: 13-20
Published online on: 11 November 2015

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Article Open Access

Melatonin attenuates hypertension-induced renal injury partially through inhibiting oxidative stress in rats

Yu‑Feng Qiao, Wen‑Juan Guo, Lu Li, Shan Shao, Xi Qiao, Jin‑Jin Shao, Qiong Zhang, Rong‑Shan Li, Li‑Hua Wang
Pages: 21-26
Published online on: 02 November 2015

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Article Open Access

Long non‑coding RNA‑GAS5 acts as a tumor suppressor in bladder transitional cell carcinoma via regulation of chemokine (C‑C motif) ligand 1 expression

Qifeng Cao, Ning Wang, Juan Qi, Zhengqin Gu, Haibo Shen
Pages: 27-34
Published online on: 05 November 2015

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Article Open Access

Role of histone deacetylase 3 in ankylosing spondylitis via negative feedback loop with microRNA-130a and enhancement of tumor necrosis factor-1α expression in peripheral blood mononuclear cells

Ya Jiang, Lin Wang
Pages: 35-40
Published online on: 02 November 2015

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Article Open Access

Silencing of MAP4K4 by short hairpin RNA suppresses proliferation, induces G1 cell cycle arrest and induces apoptosis in gastric cancer cells

Yuan‑Fei Liu, Guo‑Qiang Qu, Yun‑Min Lu, Wu‑Ming Kong, Yuan Liu, Wei‑Xiong Chen, Xiao‑Hong Liao
Pages: 41-48
Published online on: 06 November 2015

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Article Open Access

Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro

Yang Hu, Yan Zhang, Kang Tian, Chong Xun, Shouyu Wang, Decheng Lv
Pages: 49-58
Published online on: 11 November 2015

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Article Open Access

Downregulation of δ opioid receptor by RNA interference enhances the sensitivity of BEL/FU drug‑resistant human hepatocellular carcinoma cells to 5‑FU Corrigendum in /10.3892/mmr.2018.9415 Retraction in /10.3892/mmr.2023.12974

Bo Tang, Zhigao Hu, Yang Li, Shengguang Yuan, Zhenran Wang, Shuiping Yu, Songqing He
Pages: 59-66
Published online on: 06 November 2015

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Article Open Access

Microfluidics‑based optimization of neuroleukin‑mediated regulation of articular chondrocyte proliferation

Kang Tian, Weiliang Zhong, Yingqiu Zhang, Baosheng Yin, Weiguo Zhang, Han Liu
Pages: 67-74
Published online on: 10 November 2015

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Article Open Access

MicroRNA-21 stimulates epithelial-to-mesenchymal transition and tumorigenesis in clear cell renal cells

Jian Cao, Jun Liu, Ran Xu, Xuan Zhu, Lei Liu, Xiaokun Zhao
Pages: 75-82
Published online on: 13 November 2015

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Article Open Access

MicroRNA-148b enhances proliferation and apoptosis in human renal cancer cells via directly targeting MAP3K9

Fang Nie, Tianming Liu, Liang Zhong, Xianggui Yang, Yunhong Liu, Hongwei Xia, Xiaoqiang Liu, Xiaoyan Wang, Zhicheng Liu, Li Zhou, Zhaomin Mao, Qin Zhou, Tingmei Chen
Pages: 83-90
Published online on: 11 November 2015

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Article Open Access

A comparative analysis of metal allergens associated with dental alloy prostheses and the expression of HLA-DR in gingival tissue

Xin Zhang, Li‑Cheng Wei, Bin Wu, Li‑Ying Yu, Xiao‑Ping Wang, Yue Liu
Pages: 91-98
Published online on: 12 November 2015

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Article Open Access

Abnormal epigenetic regulation of the gene expression levels of Wnt2b and Wnt7b: Implications for neural tube defects

Baoling Bai, Shuyuan Chen, Qin Zhang, Qian Jiang, Huili Li
Pages: 99-106
Published online on: 06 November 2015

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Article Open Access

Identification of hub genes of pneumocyte senescence induced by thoracic irradiation using weighted gene co‑expression network analysis

Yonghua Xing, Junling Zhang, Lu Lu, Deguan Li, Yueying Wang, Song Huang, Chengcheng Li, Zhubo Zhang, Jianguo Li, Aimin Meng
Pages: 107-116
Published online on: 13 November 2015

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Article Open Access

Effects of maslinic acid on the proliferation and apoptosis of A549 lung cancer cells

Xue Bai, Yi Zhang, Hongfang Jiang, Peng Yang, Hui Li, Yue Zhang, Ping He
Pages: 117-122
Published online on: 11 November 2015

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Article Open Access

KiSS‑1‑mediated suppression of the invasive ability of human pancreatic carcinoma cells is not dependent on the level of KiSS‑1 receptor GPR54

Chun‑Hui Wang, Chong Qiao, Ruo‑Chen Wang, Wen‑Ping Zhou
Pages: 123-129
Published online on: 09 November 2015

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Article Open Access

Chromosomal radiosensitivity of human immunodeficiency virus positive/negative cervical cancer patients in South Africa

Olivia Herd, Flavia Francies, Jeffrey Kotzen, Trudy Smith, Zwide Nxumalo, Xanthene Muller, Jacobus Slabbert, Anne Vral, Ans Baeyens
Pages: 130-136
Published online on: 05 November 2015

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Article Open Access

Hippocampal mitogen-activated protein kinase activation is associated with intermittent hypoxia in a rat model of obstructive sleep apnea syndrome

Ya‑Ning Zhao, Hong‑Yang Wang, Jian‑Min Li, Bao‑Yuan Chen, Guo Xia, Pan‑Pan Zhang, Yan‑Lei Ge
Pages: 137-145
Published online on: 05 November 2015

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Article Open Access

Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats

Woori Jo, Eun‑Sil Yu, Minsun Chang, Hyun‑Kyu Park, Hyun‑Ji Choi, Jae‑Eun Ryu, Sungwoong Jang, Hyo‑Ju Lee, Ja‑June Jang, Woo‑Chan Son
Pages: 146-152
Published online on: 06 November 2015

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Article Open Access

Triptolide reverses the Taxol resistance of lung adenocarcinoma by inhibiting the NF-κB signaling pathway and the expression of NF-κB-regulated drug-resistant genes

Ning Jiang, Xiao‑Peng Dong, Suo‑Lin Zhang, Qing‑Yong You, Xing‑Tao Jiang, Xiao‑Gang Zhao
Pages: 153-159
Published online on: 02 November 2015

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Article Open Access

Gene silencing of galectin-3 changes the biological behavior of Eca109 human esophageal cancer cells

Lili Qiao, Ning Liang, Jian Xie, Hui Luo, Jingxin Zhang, Guodong Deng, Yupeng Li, Jiandong Zhang
Pages: 160-166
Published online on: 10 November 2015

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Article Open Access

Downregulation of matrix metalloproteinase‑19 induced by respiratory syncytial viral infection affects the interaction between epithelial cells and fibroblasts

Xiuxiu Wu, Huijuan Qi, Yan Yang, Yunhong Yin, Dedong Ma, Hao Li, Yiqing Qu
Pages: 167-173
Published online on: 06 November 2015

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Article Open Access

Transient transfection of macrophage migration inhibitory factor small interfering RNA disrupts the biological behavior of oral squamous carcinoma cells Corrigendum in /10.3892/mmr.2016.5266

Jie Zeng, Jingjing Quan, Xuefeng Xia
Pages: 174-180
Published online on: 06 November 2015

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Article Open Access

In vitro culture of hFOB1.19 osteoblast cells on TGF-β1-SF-CS three-dimensional scaffolds

Shuang Tong, Lei Xue, Da‑Peng Xu, Zi‑Mei Liu, Yang Du, Xu‑Kai Wang
Pages: 181-187
Published online on: 02 November 2015

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Article Open Access

NRP1 is targeted by miR-130a and miR-130b, and is associated with multidrug resistance in epithelial ovarian cancer based on integrated gene network analysis

Changxian Chen, Yanling Hu, Li Li
Pages: 188-196
Published online on: 11 November 2015

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Article Open Access

Combination of remote ischemic perconditioning and remote ischemic postconditioning fails to increase protection against myocardial ischemia/reperfusion injury, compared with either alone

Kankai Chen, Meiling Yan, Penglong Wu, Yanwei Qing, Shuai Li, Yongguang Li, Zhifeng Dong, Hongjuan Xia, Dong Huang, Ping Xin, Jingbo Li, Meng Wei
Pages: 197-205
Published online on: 09 November 2015

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Article Open Access

NMDA receptors promote neurogenesis in the neonatal rat subventricular zone following hypoxic‑ischemic injury

Qingwei Lai, Peng Hu, Qingyun Li, Xinyu Li, Rui Yuan, Xiaohong Tang, Wei Wang, Xiaoquan Li, Hongbin Fan, Xiaoxing Yin
Pages: 206-212
Published online on: 04 November 2015

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Article Open Access

Irradiation alters the differentiation potential of bone marrow mesenchymal stem cells

Yu Wang, Guoying Zhu, Jianping Wang, Junxiang Chen
Pages: 213-223
Published online on: 10 November 2015

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Article

Resveratrol attenuates the progress of liver fibrosis via the Akt/nuclear factor-κB pathways

Hui Zhang, Qingfeng Sun, Tingyan Xu, Liang Hong, Rongquan Fu, Jinguo Wu, Jiguang Ding
Pages: 224-230
Published online on: 02 November 2015

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Article

Partial deletion of the ROCK2 protein fails to reduce renal fibrosis in a unilateral ureteral obstruction model in mice

Itsuko Baba, Yasuhiro Egi, Kazuo Suzuki
Pages: 231-236
Published online on: 16 November 2015

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Article

YAP overexpression promotes the epithelial-mesenchymal transition and chemoresistance in pancreatic cancer cells

Yanli Yuan, Deyu Li, Haibo Li, Liancai Wang, Guangjin Tian, Yadong Dong
Pages: 237-242
Published online on: 11 November 2015

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Article

Mitogen-activated protein kinase kinase 3 induces cell cycle arrest via p38 activation mediated Bmi-1 downregulation in hepatocellular carcinoma

Lin Wang, Chen Chen, Shuzhi Feng, Ping Lei, Jianli Tian
Pages: 243-248
Published online on: 13 November 2015

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Article

Clinical significance and role of LKB1 in gastric cancer

Shanshan Jiang, Rensheng Chen, Jianan Yu, Nianshuang Li, Rong Ke, Lingyu Luo, Junrong Zou, Jiangnan Zhang, Kunhe Zhang, Nonghua Lu, Deqiang Huang
Pages: 249-256
Published online on: 05 November 2015

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Article

Rapid method of luxS and pfs gene inactivation in enterotoxigenic Escherichia coli and the effect on biofilm formation

Xiaoxu Wang, Shiyu Li, Xiaoran Lu, Pan Hu, Haiyan Chen, Zheng Li, Zhaoyang Bu, Xulong Lang, Xinglong Wang
Pages: 257-264
Published online on: 09 November 2015

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Article

Adenovirus‑mediated overexpression of cystic fibrosis transmembrane conductance regulator enhances invasiveness and motility of serous ovarian cancer cells

Jiao Xu, Liangbo Lin, Min Yong, Xiaojing Dong, Tinghe Yu, Lina Hu
Pages: 265-272
Published online on: 05 November 2015

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Article

MicroRNA-1246 promotes growth and metastasis of colorectal cancer cells involving CCNG2 reduction

Sai Wang, Ya Zeng, Ju‑Mei Zhou, Shao‑Lin Nie, Qiao Peng, Jian Gong, Ji‑Rong Huo
Pages: 273-280
Published online on: 12 November 2015

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Article

Inhibition of the expression of aquaporin‑1 by RNA interference in pulmonary epithelial cells and its effects on water transport

Qiuyue Zhang, Jianhua Fu, Xindong Xue
Pages: 281-286
Published online on: 06 November 2015

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Article

Resveratrol inhibits mucus overproduction and MUC5AC expression in a murine model of asthma

Zhen‑Hua Ni, Ji‑Hong Tang, Guo Chen, Yi‑Min Lai, Qing‑Ge Chen, Zao Li, Wei Yang, Xu‑Min Luo, Xiong‑Biao Wang
Pages: 287-294
Published online on: 06 November 2015

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Article

Microarray expression profiling and gene ontology analysis of long non-coding RNAs in spontaneously hypertensive rats and their potential roles in the pathogenesis of hypertension

Lianglei Hou, Zhenhao Lin, Yunjie Ni, Yihao Wu, Dezhun Chen, Lijuan Song, Xiaoyan Huang, Huanhuan Hu, Deye Yang
Pages: 295-300
Published online on: 11 November 2015

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Article

Hepatitis B virus X protein upregulates DNA methyltransferase 3A/3B and enhances SOCS-1CpG island methylation

Xiaoyu Fu, Xiaoling Song, Yanyan Li, Deming Tan, Guozhen Liu
Pages: 301-308
Published online on: 11 November 2015

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Article

Propofol protects against the neurotoxicity of 1‑methyl‑4‑phenylpyridinium

Shoushi Wang, Tingting Song, Cuibo Leng, Ketao Lan, Jishun Ning, Haichen Chu
Pages: 309-314
Published online on: 16 November 2015

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Article

UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of E‑cadherin in an Rb1‑dependent manner

Wei Liu, Rui Hong Qiao, Dong Ming Wang, Xiao Wei Huang, Bing Li, Dong Wang
Pages: 315-320
Published online on: 06 November 2015

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Article

Overexpression of melanopsin in the retina restores visual function in Royal College of Surgeons rats

Mingming Liu, Jiaman Dai, Wenyi Liu, Chongjian Zhao, Zheng Qin Yin
Pages: 321-326
Published online on: 11 November 2015

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Article

Sequential changes in autophagy in diabetic cardiac fibrosis

Huikuan Gao, Qiong Yang, Ruiqing Dong, Fei Hou, Yongquan Wu
Pages: 327-332
Published online on: 06 November 2015

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Article

PP242 suppresses bladder cancer cell proliferation and migration through deactivating the mammalian target of rapamycin complex 2/AKT1 signaling pathway

Zhe Zhang, Guojun Zhang, Chuize Kong, Daxin Gong
Pages: 333-338
Published online on: 06 November 2015

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Article

Newly synthesized podophyllotoxin derivative, LJ12, induces apoptosis and mitotic catastrophe in non-small cell lung cancer cells in vitro

Ling Hui, Chunyan Sang, Donghong Wang, Xiaohui Wang, Meiliang Wang, Qinghua Jia, Mingren Ma, Shiwu Chen
Pages: 339-346
Published online on: 12 November 2015

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Article

Smith‑Magenis syndrome in monozygotic twin fetuses presenting with discordant phenotypes and uteroplacental insufficiency

Yi Zhou, Yingjun Xie, Yunxiao Zhu, Jianzhu Wu, Meijiao Shang, Baojiang Chen, Qun Fang
Pages: 347-352
Published online on: 09 November 2015

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Article

FAM172A protein promotes the proliferation of human papillary thyroid carcinoma cells via the p38 mitogen-activated protein kinase pathway

Mei‑Fang Li, Rong Zhang, Ming‑Gao Guo, Lian‑Xi Li, Han‑Kui Lu, Jun‑Xi Lu, Wei‑Ping Jia
Pages: 353-358
Published online on: 11 November 2015

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Article

Smac mimetic‑induced caspase‑independent necroptosis requires RIP1 in breast cancer

Gongsheng Jin, Yadong Lan, Fusheng Han, Yiming Sun, Zhe Liu, Mingliang Zhang, Xianfu Liu, Xiaojing Zhang, Jianguo Hu, Hao Liu, Benzhong Wang
Pages: 359-366
Published online on: 10 November 2015

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Article

Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibiting the expression of peroxiredoxin III in H9c2 cells

Mi‑Hua Liu, Xiao‑Long Lin, Cong Yuan, Jun He, Tian‑Ping Tan, Shao‑Jian Wu, Shan Yu, Li Chen, Jun Liu, Wei Tian, Yu‑Dan Chen, Hong‑Yun Fu, Jian Li, Yuan Zhang
Pages: 367-372
Published online on: 11 November 2015

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Article

Catalpol downregulates vascular endothelial‑cadherin expression and induces vascular hyperpermeability

Caiqing Zhang, Qingfa Liu, Fengyun Dong, Liqun Li, Juan Du, Qi Xie, Hesheng Hu, Suhua Yan, Xia Zhou, Changsheng Li, Corrinne G. Lobe, Ju Liu
Pages: 373-378
Published online on: 06 November 2015

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Article

MicroRNA‑566 modulates vascular endothelial growth factor by targeting Von Hippel‑Landau in human glioblastoma in vitro and in vivo

Bing Xiao, Xuan Zhou, Minhua Ye, Shigang Lv, Miaojing Wu, Changchun Liao, Lei Han, Chunsheng Kang, Xingen Zhu
Pages: 379-385
Published online on: 09 November 2015

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Article

Flap endonuclease 1 silencing is associated with increasing the cisplatin sensitivity of SGC‑7901 gastric cancer cells

Chunhong Xie, Kejia Wang, Daorong Chen
Pages: 386-392
Published online on: 13 November 2015

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Article

Imiquimod inhibits the growth of SGC‑7901 cells in vitro through induction of autophagy and apoptosis

Jiong Jiang, Lei Dong, Hai‑Tao Shi, Xiao‑Yan Guo, Bin Qin, Yan Wang, Hong Li
Pages: 393-397
Published online on: 06 November 2015

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Article

Endoplasmic reticulum protein 29 is involved in endoplasmic reticulum stress in islet beta cells

Jialin Gao, Yao Zhang, Lizhuo Wang, Libing Xia, Meiqing Lu, Binghua Zhang, Yueping Chen, Lianzhi He
Pages: 398-402
Published online on: 06 November 2015

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Article

Trichosanthin reduces the viability of SU‑DHL‑2 cells via the activation of the extrinsic and intrinsic apoptotic pathways

Yingjie Zhu, Yueli Sun, Yuchen Cai, Ou Sha, Wenqi Jiang
Pages: 403-411
Published online on: 06 November 2015

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Article

Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia‑reperfusion in rats: The role of the Nrf2/HO‑1 signaling pathway

Xiaofeng Lei, Lijian Lei, Zhelin Zhang, Yan Cheng
Pages: 412-418
Published online on: 09 November 2015

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Article

Protective effects of the Tougu Xiaotong capsule on morphology and osteoprotegerin/nuclear factor-κB ligand expression in rabbits with knee osteoarthritis

Sainan Chen, Yunmei Huang, Wenlie Chen, Guangwen Wu, Naishun Liao, Xihai Li, Meiya Huang, Ruhui Lin, Chao Yu, Xiaodong Li, Xianxiang Liu
Pages: 419-425
Published online on: 11 November 2015

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Article

Inhibitory effects of fermented extract of Ophiopogon japonicas on thrombin-induced vascular smooth muscle cells

Jun‑Hui Song, Gi Hee Jeong, Sung Lyea Park, Se Yeon Won, Nam Soo Paek, Bog‑Hieu Lee, Sung‑Kwon Moon
Pages: 426-432
Published online on: 02 November 2015

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Article

MicroRNA 28-5p regulates ATP-binding cassette transporter A1 via inhibiting extracellular signal-regulated kinase 2

Jia Liu, Xue‑Qing Liu, Ying Liu, Ya‑Nan Sun, Si Li, Chun‑Mei Li, Jie Li, Wei Tian, Xiao‑Ming Shang, Yun‑Tao Zhou
Pages: 433-440
Published online on: 12 November 2015

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Article

MicroRNA‑10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain‑derived neurotrophic factor Retraction in /10.3892/mmr.2021.12208

Abudunaibi Aili, Yong Chen, Hongqi Zhang
Pages: 441-446
Published online on: 05 November 2015

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Article

Unique dose-dependent effects of the human pregnancy hormone estriol on the ratio of blood IgM to IgG in female mice

Jian Ding, Bao‑Ting Zhu
Pages: 447-452
Published online on: 29 October 2015

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Article

Analysis of microRNA and gene networks in human chronic myelogenous leukemia

Kunhao Wang, Zhiwen Xu, Ning Wang, Ye Tian, Xin Sun, Yonggang Ma
Pages: 453-460
Published online on: 05 November 2015

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Article

Effect of vascular endothelial growth factor siRNA and wild‑type p53 co‑expressing plasmid in MDA‑MB‑231 cells

Hua Guo, Yang Li, Junlian Gu, Yue Wang, Lianqin Liu, Ping Zhang, Yanan Liu
Pages: 461-468
Published online on: 16 November 2015

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Article

Effect of GnT-V knockdown on the proliferation, migration and invasion of the SMMC7721/R human hepatocellular carcinoma drug-resistant cell line

Bo Li, Song Su, Meng‑Yu Zhang, Lei He, Qing‑Da Wang, Kai He
Pages: 469-476
Published online on: 29 October 2015

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Article

MicroRNA-148b targets Rho-associated protein kinase 1 to inhibit cell proliferation, migration and invasion in hepatocellular carcinoma

Xian Chen, Lianhua Bo, Wei Lu, Guihua Zhou, Qi Chen
Pages: 477-482
Published online on: 02 November 2015

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Article

A regulatory circuit involving miR-143 and DNMT3a mediates vascular smooth muscle cell proliferation induced by homocysteine

Hui‑Ping Zhang, Yan‑Hua Wang, Cheng‑Jian Cao, Xiao‑Ming Yang, Sheng‑Chao Ma, Xue‑Bo Han, Xiao‑Ling Yang, An‑Ning Yang, Jue Tian, Hua Xu, Ming‑Hao Zhang, Yi‑Deng Jiang
Pages: 483-490
Published online on: 12 November 2015

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Article

Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice

Jin‑Zhong Huang, Jian Wu, Shoukui Xiang, Shiying Sheng, Ying Jiang, Zhilong Yang, Fei Hua
Pages: 491-496
Published online on: 02 November 2015

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Article

SOX18 knockdown suppresses the proliferation and metastasis, and induces the apoptosis of osteosarcoma cells

Zhong Wu, Junjian Liu, Jianguang Wang, Fan Zhang
Pages: 497-504
Published online on: 10 November 2015

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Article

MicroRNA‑1915‑3p prevents the apoptosis of lung cancer cells by downregulating DRG2 and PBX2

Chengshan Xu, Hengheng Li, Ling Zhang, Tianjun Jia, Lianning Duan, Chengrong Lu
Pages: 505-512
Published online on: 13 November 2015

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Article

Expression of HMGB1 in septic serum induces vascular endothelial hyperpermeability

Yun‑Jiang Zheng, Wei‑Ping Xu, Gang Ding, Yu‑Hua Gao, Hai‑Rong Wang, Shu‑Ming Pan
Pages: 513-521
Published online on: 09 November 2015

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Article

NIM811 downregulates transforming growth factor‑β signal transduction in vivo and in vitro

Jing Chen, Dian‑Gang Liu, Hui Wang, Xiao‑Ning Wu, Min Cong, Hong You, Ji‑Dong Jia
Pages: 522-528
Published online on: 16 November 2015

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Article

Rac1 mediates HMGB1‑induced hyperpermeability in pulmonary microvascular endothelial cells via MAPK signal transduction

Min Shao, Song‑Tao Tang, Bao Liu, Hua‑Qing Zhu
Pages: 529-535
Published online on: 06 November 2015

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Article

Sesamin attenuates mast cell-mediated allergic responses by suppressing the activation of p38 and nuclear factor-κB

Liang Chang Li, Hong Mei Piao, Ming Yu Zheng, Zhen Hua Lin, Guangzhao Li, Guang Hai Yan
Pages: 536-542
Published online on: 11 November 2015

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Article

Upregulation of p‑Akt by glial cell line‑derived neurotrophic factor ameliorates cell apoptosis in the hippocampus of rats with streptozotocin‑induced diabetic encephalopathy

Weigang Cui, Yinghua Zhang, Derong Lu, Mingxin Ren, Guoyan Yuan
Pages: 543-549
Published online on: 05 November 2015

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Article

Effects of CDC42 on the proliferation and invasion of gastric cancer cells

Dong‑Shu Du, Xiao‑Zhong Yang, Qiong Wang, Wei‑Jie Dai, Wen‑Xia Kuai, Ye‑Liu Liu, Dechang Chu, Xiao‑Jun Tang
Pages: 550-554
Published online on: 06 November 2015

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Article

Telmisartan prevents proliferation and promotes apoptosis of human ovarian cancer cells through upregulating PPARγ and downregulating MMP‑9 expression

Zhichen Pu, Min Zhu, Fandou Kong
Pages: 555-559
Published online on: 06 November 2015

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Article

Mycophenolic acid inhibits the phosphorylation of nuclear factor‑κB and Akt in renal tubular epithelial cells

Fang Zeng, Hui‑Qun Qin, Wei‑Jia Xu, Ming‑Dan Zheng, Hong‑Tao Hu, Hua Shui
Pages: 560-564
Published online on: 06 November 2015

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Article

Autoimmune regulator‑overexpressing dendritic cells induce T helper 1 and T helper 17 cells by upregulating cytokine expression

Haijun Li, Dongbei Li, Jitong Sun, Yinan Li, Wei Yang, Yi Li
Pages: 565-571
Published online on: 06 November 2015

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Article

MicroRNA-101 induces apoptosis in cisplatin-resistant gastric cancer cells by targeting VEGF-C Retraction in /10.3892/mmr.2021.12333

Guangyan Li, Fang Yang, Shiyu Gu, Zhenjuan Li, Minghui Xue
Pages: 572-578
Published online on: 12 November 2015

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Retraction Open Access

[Retracted] Blockade of 11β-hydroxysteroid dehydrogenase type 1 enzyme inhibits experimental collagenase-induced osteoarthritis

Faxin Li, Chuanwu Qiao, Yi Li, Jie Zhu, Jian Chen, Shuya Guo
Pages: 579-579
Published online on: 12 November 2015

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Review

Extramedullary hematopoiesis: Elucidating the function of the hematopoietic stem cell niche (Review)

Kouhei Yamamoto, Yukako Miwa, Shiho Abe‑Suzuki, Shinya Abe, Susumu Kirimura, Iichiroh Onishi, Masanobu Kitagawa, Morito Kurata
Pages: 587-591
Published online on: 27 November 2015

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Systematic and comprehensive investigation of the toxicity of curcuminoid‑essential oil complex: A bioavailable turmeric formulation

Madan L. Aggarwal, Karampendethu M. Chacko, Binu T. Kuruvilla
Pages: 592-604
Published online on: 19 November 2015

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Article Open Access

Overexpression of TIP30 inhibits the growth and invasion of glioma cells

Yingying Hu, Fengsheng Chen, Feiye Liu, Xinhui Liu, Na Huang, Xiaoli Cai, Yi Sun, Aimin Li, Rongcheng Luo
Pages: 605-612
Published online on: 27 November 2015

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Dose-dependent inhibitory effects of zoledronic acid on osteoblast viability and function in vitro

Xin Huang, Shilong Huang, Fengjin Guo, Fei Xu, Peng Cheng, Yaping Ye, Yonghui Dong, Wei Xiang, Anmin Chen
Pages: 613-622
Published online on: 30 November 2015

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Growth differentiation factor 15 may protect the myocardium from no‑reflow by inhibiting the inflammatory‑like response that predominantly involves neutrophil infiltration

Mei Zhang, Kunying Pan, Qianping Liu, Xin Zhou, Tiemin Jiang, Yuming Li
Pages: 623-632
Published online on: 19 November 2015

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Calycosin‑7‑O‑β‑D‑glucoside attenuates ischemia‑reperfusion injury in vivo via activation of the PI3K/Akt pathway

Min Ren, Xudong Wang, Guoqing Du, Jiawei Tian, Yujie Liu
Pages: 633-640
Published online on: 24 November 2015

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Detection and preliminary screening of the human gene expression profile for Hirschsprung's disease

Xin Wang, Shiqi Wang, Xianqing Jin, Ning Wang, Yuanyuan Luo, Yinping Teng
Pages: 641-650
Published online on: 01 December 2015

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Evaluation of the dynamic pattern of viral evolution in patients with virological breakthrough during treatment with nucleoside/nucleotide analogs by ultra‑deep pyrosequencing

Shaolong Chen, Jing Wu, Erli Gu, Yaojie Shen, Feifei Wang, Wenhong Zhang
Pages: 651-660
Published online on: 19 November 2015

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Valproate attenuates diabetic nephropathy through inhibition of endoplasmic reticulum stress‑induced apoptosis

Xin‑Yi Sun, Han‑Jiao Qin, Ze Zhang, Ye Xu, Xiao‑Chun Yang, Dong‑Ming Zhao, Xiao‑Ning Li, Lian‑Kun Sun
Pages: 661-668
Published online on: 19 November 2015

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Multi‑transgenic minipig models exhibiting potential for hepatic insulin resistance and pancreatic apoptosis

Siyuan Kong, Jinxue Ruan, Leilei Xin, Junhua Fan, Jihan Xia, Zhiguo Liu, Yulian Mu, Shulin Yang, Kui Li
Pages: 669-680
Published online on: 19 November 2015

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Intramuscular injection of bone marrow mononuclear cells contributes to bone repair following midpalatal expansion in rats

Xiaoxia Che, Jie Guo, Xiangdong Li, Lve Wang, Silong Wei
Pages: 681-688
Published online on: 19 November 2015

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Suppression of HSP27 increases the anti‑tumor effects of quercetin in human leukemia U937 cells

Xi Chen, Xiu‑Shuai Dong, Hai‑Yan Gao, Yong‑Fang Jiang, Ying‑Lan Jin, Yu‑Ying Chang, Li‑Yan Chen, Jing‑Hua Wang
Pages: 689-696
Published online on: 23 November 2015

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Effect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice

Hongxia Chen, Qingqing Xia, Xiaoqian Feng, Fangyuan Cao, Hang Yu, Yinli Song, Xiuqin Ni
Pages: 697-704
Published online on: 27 November 2015

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Effects of human vascular endothelial growth factor on reparative dentin formation

Juan Zhang, Xia Liu, Weixian Yu, Yingli Zhang, Ce Shi, Shilei Ni, Qilin Liu, Xiangwei Li, Yingjian Sun, Changyu Zheng, Hongchen Sun
Pages: 705-712
Published online on: 23 November 2015

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Fibroblast growth factor receptor 1 promotes MG63 cell proliferation and is associated with increased expression of cyclin-dependent kinase 1 in osteosarcoma

Wei Zhou, Yue Zhu, Song Chen, Ruijun Xu, Kunzheng Wang
Pages: 713-719
Published online on: 23 November 2015

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Dickkopf Wnt signaling pathway inhibitor 1 regulates the differentiation of mouse embryonic stem cells in vitro and in vivo

Liping Ou, Liaoqiong Fang, Hejing Tang, Hai Qiao, Xiaomei Zhang, Zhibiao Wang
Pages: 720-730
Published online on: 19 November 2015

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Expression of arginase I and inducible nitric oxide synthase in the peripheral blood and lymph nodes of HIV‑positive patients

Naichun Zhang, Jianning Deng, Fengyao Wu, Xiangchan Lu, Lei Huang, Min Zhao
Pages: 731-743
Published online on: 23 November 2015

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Downregulation of caveolin‑1 upregulates the expression of growth factors and regulators in co‑culture of fibroblasts with cancer cells

Xiao‑Yu Shi, Li‑Xia Xiong, Liang Xiao, Chuang Meng, Guan‑Yun Qi, Wen‑Lin Li
Pages: 744-752
Published online on: 24 November 2015

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Peroxiredoxin 6 attenuates ischemia‑ and hypoxia‑induced liver damage of brain‑dead donors

Qiang Tu, Yan Xiong, Lin Fan, Bingbing Qiao, Zhiping Xia, Long Hu, Yanfeng Wang, Guizhu Peng, Qifa Ye
Pages: 753-761
Published online on: 19 November 2015

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Establishment of a dual-color fluorescence tracing orthotopic transplantation model of hepatocellular carcinoma

Qian Chen, Xiaoping Wang, Hao Wu, Hui Wang, Mingao Zhu, Roushu Wang, Ying Wu, Luyao Zhang, Qiao Meng, Ranran Song, Zhixiang Zhuang, Qiang Huang
Pages: 762-768
Published online on: 30 November 2015

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Effect of gallium nitrate on the expression of osteoprotegerin and receptor activator of nuclear factor‑κB ligand in osteoblasts in vivo and in vitro

Jingwu Li, Guang‑Bin Wang, Xue Feng, Jing Zhang, Qin Fu
Pages: 769-777
Published online on: 19 November 2015

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SNAIL transcription factor increases the motility and invasive capacity of prostate cancer cells

Luis A. Osorio, Nancy M. Farfán, Enrique A. Castellón, Héctor R. Contreras
Pages: 778-786
Published online on: 19 November 2015

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Fructus xanthii improves lipid homeostasis in the epididymal adipose tissue of rats fed a high-fat diet

Xiumin Li, Mingxing Yang, Zhipeng Li, Mei Xue, Zhaoshui Shangguan, Zhimin Ou, Ming Liu, Suhuan Liu, Shuyu Yang, Xuejun Li
Pages: 787-795
Published online on: 30 November 2015

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Article

Induction of autophagy by the MG‑132 proteasome inhibitor is associated with endoplasmic reticulum stress in MCF‑7 cells

Wenhua Bao, Yiqi Gu, La Ta, Keren Wang, Zheli Xu
Pages: 796-804
Published online on: 23 November 2015

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Article

Hypoxia‑mediated activation of autophagic flux inhibits apoptosis of keratinocytes via blocking tumor necrosis factor‑related apoptosis‑inducing ligand

Sung‑Wook Kim, Sang‑Youel Park
Pages: 805-810
Published online on: 20 November 2015

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Article

LY294002 prevents lipopolysaccharide‑induced hepatitis in a murine model by suppressing IκB phosphorylation

Zhize Chen, Huimin Liu, Shaoqin Lei, Bo Zhao, Zhongyuan Xia
Pages: 811-816
Published online on: 19 November 2015

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Article

Bufalin induces apoptosis in the U‑2OS human osteosarcoma cell line via triggering the mitochondrial pathway

Ya Chen, Meng Li, Zhongji Li, Peng Gao, Xiao Zhou, Jianxin Zhang
Pages: 817-822
Published online on: 19 November 2015

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Article

Orally administered betaine reduces photodamage caused by UVB irradiation through the regulation of matrix metalloproteinase-9 activity in hairless mice

A‑Rang Im, Hee Jeong Lee, Ui Joung Youn, Jin Won Hyun, Sungwook Chae
Pages: 823-828
Published online on: 24 November 2015

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Article

Epigallocatechin-3-gallate suppresses alveolar epithelial cell apoptosis in seawater aspiration-induced acute lung injury via inhibiting STAT1-caspase-3/p21 associated pathway

Wei Liu, Mingqing Dong, Liyan Bo, Congcong Li, Qingqing Liu, Zhichao Li, Faguang Jin
Pages: 829-836
Published online on: 27 November 2015

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Article

4.1N suppresses hypoxia-induced epithelial-mesenchymal transition in epithelial ovarian cancer cells

Letian Zhang, Ajin Hu, Mengrui Li, Hongquan Zhang, Caixia Ren, Xiuli An, Congrong Liu
Pages: 837-844
Published online on: 01 December 2015

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Article

Trichostatin A inhibits inflammation in phorbol myristate acetate‑induced macrophages by regulating the acetylation of histone and/or non‑histone proteins

Qian Zhang, Fan Yang, Xun Li, Luwen Wang, Xiaogang Chu, Hong Zhang, Zuojiong Gong
Pages: 845-852
Published online on: 20 November 2015

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Article

Correlation between Th17 and nTreg cell frequencies and the stages of progression in chronic hepatitis B

Chun Yang, Fang Cui, Li‑Min Chen, Xue‑Yan Gong, Bo Qin
Pages: 853-859
Published online on: 27 November 2015

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Article

Lentivirus‑mediated knockdown of MeCP2 inhibits the growth of colorectal cancer cells in vitro

Ning Song, Keqiang Li, Yan Wang, Zongyou Chen, Liubin Shi
Pages: 860-866
Published online on: 24 November 2015

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Article

Effects of miR‑590 on oxLDL‑induced endothelial cell apoptosis: Roles of p53 and NF‑κB

Mei‑Hua Bao, Jian‑Ming Li, Qi‑Liang Zhou, Guang‑Yi Li, Jie Zeng, Juan Zhao, Yi‑Wen Zhang
Pages: 867-873
Published online on: 23 November 2015

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Article

Sodium orthovanadate induces the apoptosis of SH-SY5Y cells by inhibiting PIWIL2

Xiaohong Tian, Jun Fan, Weijian Hou, Shuling Bai, Qiang Ao, Hao Tong
Pages: 874-880
Published online on: 26 November 2015

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Article

Capsaicin enhances anti-proliferation efficacy of pirarubicin via activating TRPV1 and inhibiting PCNA nuclear translocation in 5637 cells

Long Zheng, Jiaqi Chen, Zhenkun Ma, Wei Liu, Fei Yang, Zhao Yang, Ke Wang, Xinyang Wang, Dalin He, Lei Li, Jin Zeng
Pages: 881-887
Published online on: 30 November 2015

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Article

Bioinformatic prediction of the antigenic epitopes of recombinant ferritin of Echinococcus granulosus

Xuelei Liu, Hui Zhao, Wenyan Cao, Yumei Liu, Chuntao Zhang, Xi Lan, Shanshan Peng, Hao Wen, Jianbing Ding, Xiumin Ma
Pages: 888-894
Published online on: 19 November 2015

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Article

Connexin43 knockdown in bone marrow‑derived dendritic cells by small interfering RNA leads to a diminished T-cell stimulation

Fuling Yu, Hui Yan, Wencheng Nie, Jianhua Zhu
Pages: 895-900
Published online on: 20 November 2015

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Article

Lefty1 alleviates renal tubulointerstitial injury in mice with unilateral ureteral obstruction

Changgeng Xu, Mingwei Xu, Wei Wang, Jie Zhang
Pages: 901-908
Published online on: 30 November 2015

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Article

Modulation of transforming growth factor‑β signaling transducers in colon adenocarcinoma cells induced by staphylococcal enterotoxin B

Abolfazl Akbari, Gholam Reza Mobini, Reza Maghsoudi, Javad Akhtari, Ebrahim Faghihloo, Zohreh Farahnejad
Pages: 909-914
Published online on: 23 November 2015

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Article

Synthetic innate defense regulator peptide combination using CpG ODN as a novel adjuvant induces long‑lasting and balanced immune responses

Chao‑Heng Yu, Zi‑Chao Luo, Meng Li, Lian Lu, Zhan Li, Xiao‑Zhe Wu, Ying‑Zi Fan, Hai‑Long Zhang, Bai‑Ling Zhou, Yang Wan, Ke Men, Yao‑Mei Tian, Shuang Chen, Feng‑Jiao Yuan, Rong Xiang, Li Yang
Pages: 915-924
Published online on: 19 November 2015

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Article

Indoleamine 2,3‑dioxygenase downregulates T‑cell receptor complex ζ‑chain and c‑Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T‑cells

Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Konstantina Tsogka, Maria Sounidaki, Vassilios Liakopoulos, Ioannis Stefanidis
Pages: 925-932
Published online on: 20 November 2015

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Article

CK0403, a 9‑aminoacridine, is a potent anti‑cancer agent in human breast cancer cells

Yuan‑Wan Sun, Kuen‑Yuan Chen, Chul‑Hoon Kwon, Kun‑Ming Chen
Pages: 933-938
Published online on: 23 November 2015

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Article

Investigation of the antidepressant effects of exopolysaccharides obtained from Marasmius androsaceus fermentation in a mouse model

Jia Song, Gaoyang Xing, Jiaming Cao, Lirong Teng, Chenliang Li, Qingfan Meng, Jiahui Lu, Yulin Zhou, Yang Liu, Di Wang, Lesheng Teng
Pages: 939-946
Published online on: 19 November 2015

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Article

Polymorphisms in the PE35 and PPE68 antigens in Mycobacterium tuberculosis strains may affect strain virulence and reflect ongoing immune evasion

Yi Jiang, Jianhao Wei, Haican Liu, Guilian Li, Qian Guo, Yan Qiu, Lili Zhao, Machao Li, Xiuqin Zhao, Xiangfeng Dou, Kanglin Wan
Pages: 947-954
Published online on: 19 November 2015

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Article

Effects of hesperetin on platelet-derived growth factor-BB-induced pulmonary artery smooth muscle cell proliferation

Li Wei, Wei Deng, Zhihong Cheng, Haipeng Guo, Shihong Wang, Xiao Zhang, Yiyu He, Qizhu Tang
Pages: 955-960
Published online on: 30 November 2015

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Article

Characterization of mitochondrial NADH dehydrogenase 1α subcomplex 10 variants in cardiac muscles from normal Wistar rats and spontaneously hypertensive rats: Implications in the pathogenesis of hypertension

Liying Huang, Xian Jin, Li Xia, Xiaoling Wang, Yun Yu, Cunfei Liu, Dongmin Shao, Ningyuan Fang, Chao Meng
Pages: 961-966
Published online on: 23 November 2015

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Article

Inhibitory effect of withaferin A on Helicobacter pylori‑induced IL‑8 production and NF‑κB activation in gastric epithelial cells

Green Kim, Tae‑Hyoun Kim, Min‑Jung Kang, Jin‑A Choi, Da‑Young Pack, Ik‑Rae Lee, Min‑Gyu Kim, Sang‑Seop Han, Bo‑Yeon Kim, Sang‑Muk Oh, Kyung‑Bok Lee, Dong‑Jae Kim, Jong‑Hwan Park
Pages: 967-972
Published online on: 23 November 2015

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Article

Astaxanthin reduces type 2 diabetic‑associated cognitive decline in rats via activation of PI3K/Akt and attenuation of oxidative stress

Xiaobin Li, Zhonghua Qi, Longshan Zhao, Zhan Yu
Pages: 973-979
Published online on: 25 November 2015

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Article

Shensongyangxin protects against pressure overload‑induced cardiac hypertrophy

Di‑Fei Shen, Qing‑Qing Wu, Jian Ni, Wei Deng, Cong Wei, Zhen‑Hua Jia, Heng Zhou, Meng‑Qiao Zhou, Zhou‑Yan Bian, Qi‑Zhu Tang
Pages: 980-988
Published online on: 23 November 2015

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Article

Effects of total flavones from Dendranthema morifolium on vasocontraction and proliferation of vascular smooth muscle cells

Hong‑Feng Jin, Xiao‑Wei Liu, Yi‑Ming Tang, Li‑Jiang Tang, Ya‑Li Wang, Chang‑Qing Du
Pages: 989-993
Published online on: 19 November 2015

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Article

miR-362-3p targets nemo-like kinase and functions as a tumor suppressor in renal cancer cells

Xiaowen Zou, Jianhua Zhong, Jiaqiang Li, Zhengming Su, Yan Chen, Wanxin Deng, Yuchi Li, Siheng Lu, Youcheng Lin, Liya Luo, Zesong Li, Zhiming Cai, Aifa Tang
Pages: 994-1002
Published online on: 30 November 2015

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Article

Inhibitory effects of tetrandrine on epidermal growth factor-induced invasion and migration in HT29 human colorectal adenocarcinoma cells

Chi‑Ting Horng, Jai‑Sing Yang, Jo‑Hua Chiang, Chi‑Cheng Lu, Chiu‑Fang Lee, Ni‑Na Chiang, Fu‑An Chen
Pages: 1003-1009
Published online on: 01 December 2015

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Article

Lentivirus-mediated TNF-α gene silencing and overexpression of osteoprotegerin inhibit titanium particle-induced inflammatory response and osteoclastogenesis in vitro

Li Peng, Hongzhi Wang, Keguan Song, Hai Wang, Ping Liu
Pages: 1010-1018
Published online on: 27 November 2015

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Article

Rhus javanica Linn protects against hydrogen peroxide‑induced toxicity in human Chang liver cells via attenuation of oxidative stress and apoptosis signaling

Chanjin Yoon, Sushruta Koppula, Seunghoon Yoo, Munjeong Yum, Jinseoub Kim, Jaedong Lee, Mindong Song
Pages: 1019-1025
Published online on: 23 November 2015

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Article Open Access

Survivin is expressed in degenerated nucleus pulposus cells and is involved in proliferation and the prevention of apoptosis in vitro

Yazhou Lin, Bin Yue, Hongfei Xiang, Yong Liu, Xuexiao Ma, Bohua Chen
Pages: 1026-1032
Published online on: 23 November 2015

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Article

MicroRNA‑145 inhibits the malignant phenotypes of gastric carcinoma cells via downregulation of fascin 1 expression Retraction in /10.3892/mmr.2022.12613

Minghui Xue, Lunde Zhao, Fang Yang, Zhenjuan Li, Guangyan Li
Pages: 1033-1039
Published online on: 24 November 2015

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Article

Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility

Adrianna Mostowska, Malgorzata Szczepańska, Przemyslaw Wirstlein, Jana Skrzypczak, Paweł P. Jagodziński
Pages: 1040-1046
Published online on: 30 November 2015

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Article

Morphine-induced delayed pre-conditioning against anoxia/reoxygenation injury in pulmonary artery endothelial cells: The role of mitochondrial KATP channels Retraction in /10.3892/mmr.2023.13030

Wengang Ding, Yueping Guo, Xiaoguang Cui, Bing Zhang, Dongmei Li, Wenzhi Li
Pages: 1047-1053
Published online on: 30 November 2015

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Correction Open Access

[Corrigendum] Cannabinoid WIN55, 212-2 induces cell cycle arrest and inhibits the proliferation and migration of human BEL7402 hepatocellular carcinoma cells

Dacai Xu, Jianglin Wang, Zhenkang Zhou, Zhiwei He, Qing Zhao
Pages: 1054-1054
Published online on: 20 November 2015

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Correction Open Access

[Corrigendum] Naotaifang extract treatment results in increased ferroportin expression in the hippocampus of rats subjected to cerebral ischemia

Jun Liao, Xing Xia, Guo‑Zuo Wang, Yong‑Mei Shi, Jin‑Wen Ge
Pages: 1055-1055
Published online on: 30 November 2015

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Correction Open Access

[Corrigendum] NADPH oxidase 3-associated oxidative stress and caspase 3-dependent apoptosis in the cochleae of D-galactose-induced aged rats

Zhengde Du, Shuo Li, Lin Liu, Qiong Yang, Hongwei Zhang, Chunsheng Gao
Pages: 1056-1056
Published online on: 20 November 2015

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Article Number: 49
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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
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Article Number: 47
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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Article

Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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