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Article

MicroRNA‑10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain‑derived neurotrophic factor

Retraction in: /10.3892/mmr.2021.12208
  • Authors:
    • Abudunaibi Aili
    • Yong Chen
    • Hongqi Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Spinal Surgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 441-446
    |
    Published online on: November 5, 2015
       https://doi.org/10.3892/mmr.2015.4506
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Abstract

MicroRNAs (miRs) can lead to mRNA degradation or inhibit protein translation through directly binding to the 3'‑untranslational region (UTR) of their target mRNAs. Deregulation of miR‑10b has been reported to be associated with chondrosarcoma. However, the role of miR‑10b in chondrosarcoma cell migration and invasion, as well as the underlying mechanisms, has not been investigated. In the present study, it was demonstrated that miR‑10b was notably downregulated in the JJ012 and SW1353 chondrosarcoma cell lines compared with the TC28a2 normal chondrocyte line. Treatment with DNA demethylating agent 5‑aza‑2'‑deoxycytidine and histone deacetylase inhibitor 4‑phenylbutyric acid, or transfection with miR‑10b mimics promoted the expression of miR‑10b, which further suppressed the migratory and invasive capacities of JJ012 chondrosarcoma cells. Moreover, brain‑derived neurotrophic factor (BDNF) was identified as a novel target of miR‑10b, and its protein expression level was negatively regulated by miR‑10b in JJ012 cells. Furthermore, overexpression of BDNF reversed the inhibitory effect of miR‑10b upregulation on the migration and invasion of JJ012 cells. In addition, the data suggest that matrix metalloproteinase 1 (MMP1) may be involved in the miR‑10b/BDNF‑mediated chondrosarcoma cell migration and invasion in JJ012 cells. In conclusion, these findings suggest that miR‑10b/BDNF may serve as a potential therapeutic target for chondrosarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Aili A, Chen Y and Zhang H: MicroRNA‑10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain‑derived neurotrophic factor Retraction in /10.3892/mmr.2021.12208. Mol Med Rep 13: 441-446, 2016.
APA
Aili, A., Chen, Y., & Zhang, H. (2016). MicroRNA‑10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain‑derived neurotrophic factor Retraction in /10.3892/mmr.2021.12208. Molecular Medicine Reports, 13, 441-446. https://doi.org/10.3892/mmr.2015.4506
MLA
Aili, A., Chen, Y., Zhang, H."MicroRNA‑10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain‑derived neurotrophic factor Retraction in /10.3892/mmr.2021.12208". Molecular Medicine Reports 13.1 (2016): 441-446.
Chicago
Aili, A., Chen, Y., Zhang, H."MicroRNA‑10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain‑derived neurotrophic factor Retraction in /10.3892/mmr.2021.12208". Molecular Medicine Reports 13, no. 1 (2016): 441-446. https://doi.org/10.3892/mmr.2015.4506
Copy and paste a formatted citation
x
Spandidos Publications style
Aili A, Chen Y and Zhang H: MicroRNA‑10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain‑derived neurotrophic factor Retraction in /10.3892/mmr.2021.12208. Mol Med Rep 13: 441-446, 2016.
APA
Aili, A., Chen, Y., & Zhang, H. (2016). MicroRNA‑10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain‑derived neurotrophic factor Retraction in /10.3892/mmr.2021.12208. Molecular Medicine Reports, 13, 441-446. https://doi.org/10.3892/mmr.2015.4506
MLA
Aili, A., Chen, Y., Zhang, H."MicroRNA‑10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain‑derived neurotrophic factor Retraction in /10.3892/mmr.2021.12208". Molecular Medicine Reports 13.1 (2016): 441-446.
Chicago
Aili, A., Chen, Y., Zhang, H."MicroRNA‑10b suppresses the migration and invasion of chondrosarcoma cells by targeting brain‑derived neurotrophic factor Retraction in /10.3892/mmr.2021.12208". Molecular Medicine Reports 13, no. 1 (2016): 441-446. https://doi.org/10.3892/mmr.2015.4506
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