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Article

UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of E‑cadherin in an Rb1‑dependent manner

  • Authors:
    • Wei Liu
    • Rui Hong Qiao
    • Dong Ming Wang
    • Xiao Wei Huang
    • Bing Li
    • Dong Wang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Second Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi 215006, P.R. China, Department of Gastroenterology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 226001, P.R. China
  • Pages: 315-320
    |
    Published online on: November 6, 2015
       https://doi.org/10.3892/mmr.2015.4515
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Abstract

Ubiquitin‑like with plant homeodomain (PHD) and RING‑finger domain 1 (UHRF1) maintains methylation patterns following DNA replication and is expressed at high levels in various types of human cancer. UHRF1 has been identified as a novel oncogene involved in the pathogenesis of hepatocellular carcinoma. Previous studies have demonstrated that inhibition of the expression of UHRF1 suppresses the proliferation of cancer cells. However, the role of UHRF1 in human osteosarcoma has not been investigated. The present study examined the expression levels of UHRF1 and retinoblastoma 1 (Rb1) in human osteosarcoma cell lines by western blot analysis. Stable overexpression of UHRF1 or knockdown of Rb1 was achieved by lentiviral transfection. Subsequently, a Cell Counting Kit-8 assay and a cell invasion assay were performed to detect the biological functions of UHRF1 in vitro. The results of the present study demonstrated that UHRF1 promoted the proliferation of human osteosarcoma cells. The present study also reported that UHRF1 was able to enhance the invasion of osteosarcoma cells in a retinoblastoma 1 (Rb1)‑dependent manner. UHRF1 promoted invasion in Rb1‑positive osteosarcoma cells, but not in Saos‑2 cells with homozygous loss of Rb1. Similarly, knockdown of Rb1 in Rb1‑positive osteosarcoma cells enhanced levels of invasion and eliminated the regulation of invasion by UHRF1. UHRF1 was found to inhibit the mRNA and protein expression levels of Rb1. Furthermore, deletion of Rb1 was found to suppress the expression of E‑cadherin and promote epithelial‑to‑mesenchymal transition (EMT). In addition, the overexpression of UHRF1 inhibited the expression of E‑cadherin and promoted EMT via the suppression of Rb1. These data demonstrated that UHRF1 promotes osteosarcoma cell invasion by downregulating the expression of E‑cadherin and increasing EMT in an Rb1‑dependent manner.
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1 

Goguet-Surmenian E, Richard-Fiardo P, Guillemot E, Benchetrit M, Gomez-Brouchet A, Buzzo P, Karimdjee-Soilihi B, Alemanno P, Michiels JF, Schmid-Alliana A and Schmid-Antomarchi H: CXCR7-mediated progression of osteo-sarcoma in the lungs. Br J Cancer. 109:1579–1585. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Kansara M, Teng MW, Smyth MJ and Thomas DM: Translational biology of osteosarcoma. Nat Rev Cancer. 14:722–735. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Liu Y, Wu Y, Gu S, Sun Z, Rui Y, Wang J, Lu Y, Li H, Xu K and Sheng P: Prognostic role of CD44 expression in osteosarcoma: Evidence from six studies. Diagn Pathol. 9:1402014. View Article : Google Scholar : PubMed/NCBI

4 

Chu J, Loughlin EA, Gaur NA, SenBanerjee S, Jacob V, Monson C, Kent B, Oranu A, Ding Y, Ukomadu C and Sadler KC: UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis. Mol Biol Cell. 23:59–70. 2012. View Article : Google Scholar :

5 

Hopfner R, Mousli M, Jeltsch JM, Voulgaris A, Lutz Y, Marin C, Bellocq JP, Oudet P and Bronner C: ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression. Cancer Res. 60:121–128. 2000.PubMed/NCBI

6 

Jeanblanc M, Mousli M, Hopfner R, Bathami K, Martinet N, Abbady AQ, Siffert JC, Mathieu E, Muller CD and Bronner C: The retinoblastoma gene and its product are targeted by ICBP90: A key mechanism in the G1/S transition during the cell cycle. Oncogene. 24:7337–7345. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Benavente CA, Finkelstein D, Johnson DA, Marine JC, Ashery-Padan R and Dyer MA: Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression. Oncotarget. 5:9594–9608. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Arima Y, Inoue Y, Shibata T, Hayashi H, Nagano O, Saya H and Taya Y: Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition. Cancer Res. 68:5104–5112. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Arita K, Ariyoshi M, Tochio H, Nakamura Y and Shirakawa M: Recognition of hemimethylated DNA by the SRA protein UHRF1 by a base-flipping mechanism. Nature. 455:818–821. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Hashimoto H, Vertino PM and Cheng X: Molecular coupling of DNA methylation and histone methylation. Epigenomics. 2:657–669. 2010. View Article : Google Scholar

11 

Rothbart SB, Krajewski K, Nady N, Tempel W, Xue S, Badeaux AI, Barsyte-Lovejoy D, Martinez JY, Bedford MT, Fuchs SM, et al: Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol. 19:1155–1160. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Unoki M: Current and potential anticancer drugs targeting members of the UHRF1 complex including epigenetic modifiers. Recent Pat Anticancer Drug Discov. 6:116–130. 2011. View Article : Google Scholar

13 

Alhosin M, Sharif T, Mousli M, Etienne-Selloum N, Fuhrmann G, Schini-Kerth VB and Bronner C: Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties. J Exp Clin Cancer Res. 30:412011. View Article : Google Scholar : PubMed/NCBI

14 

Li XL, Xu JH, Nie JH and Fan SJ: Exogenous expression of UHRF1 promotes proliferation and metastasis of breast cancer cells. Oncol Rep. 28:375–383. 2012.PubMed/NCBI

15 

Zhang Y, Huang Z, Zhu Z, et al: Upregulated UHRF1 promotes bladder cancer cell invasion by epigenetic silencing of KiSS1. PLoS One. 9:e1042522014. View Article : Google Scholar : PubMed/NCBI

16 

Babbio F, Pistore C, Curti L, et al: The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression. Oncogene. 31:4878–4887. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Daskalos A, Oleksiewicz U, Filia A, et al: UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer. Cancer. 117:1027–1037. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Li XL, Meng QH and Fan SJ: Adenovirus-mediated expression of UHRF1 reduces the radiosensitivity of cervical cancer HeLa cells to gamma-irradiation. Acta Pharmacol Sin. 30:458–466. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Mudbhary R, Hoshida Y, Chernyavskaya Y, Jacob V, Villanueva A, Fiel MI, Chen X, Kojima K, Thung S, Bronson RT, et al: UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma. Cancer Cell. 25:196–209. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Zhuo H, Tang J, Lin Z, et al: The aberrant expression of MEG3 regulated by UHRF1 predicts the prognosis of hepatocellular carcinoma. Mol Carcinog. Jan 16–2015.Epub ahead of print. View Article : Google Scholar

21 

Zhou L, Zhao X, Han Y, Lu Y, Shang Y, Liu C, Li T, Jin Z, Fan D and Wu K: Regulation of UHRF1 by miR-146a/b modulates gastric cancer invasion and metastasis. FASEB J. 27:4929–4939. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Manning AL, Yazinski SA, Nicolay B, Bryll A, Zou L and Dyson NJ: Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion. Mol Cell. 53:993–1004. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Rosemann M, Gonzalez-Vasconcellos I, Domke T, Kuosaite V, Schneider R, Kremer M, Favor J, Nathrath M and Atkinson MJ: A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice. Mol Cancer. 13:1822014. View Article : Google Scholar : PubMed/NCBI

24 

Ory B, Blanchard F, Battaglia S, Gouin F, Rédini F and Heymann D: Zoledronic acid activates the DNA S-phase checkpoint and induces osteosarcoma cell death characterized by apoptosis-inducing factor and endonuclease-G translocation independently of p53 and retinoblastoma status. Mol Pharmacol. 71:333–343. 2007. View Article : Google Scholar

25 

Lau MT, Klausen C and Leung PC: E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression. Oncogene. 30:2753–2766. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Lombaerts M, van Wezel T, Philippo K, Dierssen JW, Zimmerman RM, Oosting J, van Eijk R, Eilers PH, van de Water B, Cornelisse CJ and Cleton-Jansen AM: E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines. Br J Cancer. 94:661–671. 2006.PubMed/NCBI

27 

Cao ZQ, Shen Z and Huang WY: MicroRNA-802 promotes osteosarcoma cell proliferation by targeting p27. Asian Pac J Cancer Prev. 14:7081–7084. 2013. View Article : Google Scholar

28 

Cheng J, Yang Y, Fang J, Xiao J, Zhu T, Chen F, Wang P, Li Z, Yang H and Xu Y: Structural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein. J Biol Chem. 288:1329–1339. 2013. View Article : Google Scholar :

29 

Sharif J, Muto M, Takebayashi S, Suetake I, Iwamatsu A, Endo TA, Shinga J, Mizutani-Koseki Y, Toyoda T, Okamura K, et al: The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature. 450:908–912. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Puisieux A, Brabletz T and Caramel J: Oncogenic roles of EMT-inducing transcription factors. Nat Cell Biol. 16:488–494. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Xiong H, Hong J, Du W, Lin YW, Ren LL, Wang YC, Su WY, Wang JL, Cui Y, Wang ZH and Fang JY: Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition. J Biol Chem. 287:5819–5832. 2012. View Article : Google Scholar :

33 

Sun XJ, Liu H, Zhang P, Zhang XD, Jiang ZW and Jiang CC: miR-10b promotes migration and invasion in nasopharyngeal carcinoma cells. Asian Pac J Cancer Prev. 14:5533–5537. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Wang YP, Wang MZ, Luo YR, Shen Y and Wei ZX: Lentivirus-mediated shRNA interference targeting SLUG inhibits lung cancer growth and metastasis. Asian Pac J Cancer Prev. 13:4947–4951. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Kim JK, Estève PO, Jacobsen SE and Pradhan S: UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. Nucleic Acids Res. 37:493–505. 2009. View Article : Google Scholar :

36 

Guan D, Factor D, Liu Y, Wang Z and Kao HY: The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein. Oncogene. 32:3819–3828. 2013. View Article : Google Scholar :

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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Qiao RH, Wang DM, Huang XW, Li B and Wang D: UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of E‑cadherin in an Rb1‑dependent manner. Mol Med Rep 13: 315-320, 2016.
APA
Liu, W., Qiao, R.H., Wang, D.M., Huang, X.W., Li, B., & Wang, D. (2016). UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of E‑cadherin in an Rb1‑dependent manner. Molecular Medicine Reports, 13, 315-320. https://doi.org/10.3892/mmr.2015.4515
MLA
Liu, W., Qiao, R. H., Wang, D. M., Huang, X. W., Li, B., Wang, D."UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of E‑cadherin in an Rb1‑dependent manner". Molecular Medicine Reports 13.1 (2016): 315-320.
Chicago
Liu, W., Qiao, R. H., Wang, D. M., Huang, X. W., Li, B., Wang, D."UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of E‑cadherin in an Rb1‑dependent manner". Molecular Medicine Reports 13, no. 1 (2016): 315-320. https://doi.org/10.3892/mmr.2015.4515
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Qiao RH, Wang DM, Huang XW, Li B and Wang D: UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of E‑cadherin in an Rb1‑dependent manner. Mol Med Rep 13: 315-320, 2016.
APA
Liu, W., Qiao, R.H., Wang, D.M., Huang, X.W., Li, B., & Wang, D. (2016). UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of E‑cadherin in an Rb1‑dependent manner. Molecular Medicine Reports, 13, 315-320. https://doi.org/10.3892/mmr.2015.4515
MLA
Liu, W., Qiao, R. H., Wang, D. M., Huang, X. W., Li, B., Wang, D."UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of E‑cadherin in an Rb1‑dependent manner". Molecular Medicine Reports 13.1 (2016): 315-320.
Chicago
Liu, W., Qiao, R. H., Wang, D. M., Huang, X. W., Li, B., Wang, D."UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of E‑cadherin in an Rb1‑dependent manner". Molecular Medicine Reports 13, no. 1 (2016): 315-320. https://doi.org/10.3892/mmr.2015.4515
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