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Review

IL‑33 and kidney disease (Review)

  • Authors:
    • Feifei Yang
    • Ping Zhu
    • Lihua Duan
    • Lin Yang
    • Jiajun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The First College of Clinical Medical Science, Three Gorges University, Yichang, Hubei 443003, P.R. China, Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen, Fujian 361000, P.R. China, Department of Immunology, The First College of Clinical Medical Science, Three Gorges University, Yichang, Hubei 443003, P.R. China
  • Pages: 3-8
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    Published online on: November 6, 2015
       https://doi.org/10.3892/mmr.2015.4516
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Abstract

Interleukin (IL)‑33, is a novel member of the IL‑1 superfamily, and act as a dual‑function molecule as a nuclear factor and cytokine. The expression of IL‑33 can be detected in several tissues and cells in humans and in mice. In addition to the conventional secretion approach for cytokines, full‑length IL‑33 can also be released into the extracellular space following cell damage or mechanical injury. IL‑33 mediates its biological effects by interacting with the receptors, suppression of tumorigenicity 2 (ST2) and IL‑1 receptor accessory protein, activating intracellular molecules in the nuclear factor‑κB and mitogen‑activated protein kinase signaling pathways, which drive the production of type 2 cytokines, including IL‑4, IL‑5 and IL‑13, from polarized T helper 2 cells. Increasing evidence indicates that IL‑33 is important in chronic kidney disease, and may be involved in the progression of renal fibrosis associated with systemic lupus erythematosus and renal graft damage. In addition, IL‑33 contributes to acute kidney injury. In the present review, the biology of IL‑33, and the association of IL‑33 with kidney diseases are discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Yang F, Zhu P, Duan L, Yang L and Wang J: IL‑33 and kidney disease (Review). Mol Med Rep 13: 3-8, 2016.
APA
Yang, F., Zhu, P., Duan, L., Yang, L., & Wang, J. (2016). IL‑33 and kidney disease (Review). Molecular Medicine Reports, 13, 3-8. https://doi.org/10.3892/mmr.2015.4516
MLA
Yang, F., Zhu, P., Duan, L., Yang, L., Wang, J."IL‑33 and kidney disease (Review)". Molecular Medicine Reports 13.1 (2016): 3-8.
Chicago
Yang, F., Zhu, P., Duan, L., Yang, L., Wang, J."IL‑33 and kidney disease (Review)". Molecular Medicine Reports 13, no. 1 (2016): 3-8. https://doi.org/10.3892/mmr.2015.4516
Copy and paste a formatted citation
x
Spandidos Publications style
Yang F, Zhu P, Duan L, Yang L and Wang J: IL‑33 and kidney disease (Review). Mol Med Rep 13: 3-8, 2016.
APA
Yang, F., Zhu, P., Duan, L., Yang, L., & Wang, J. (2016). IL‑33 and kidney disease (Review). Molecular Medicine Reports, 13, 3-8. https://doi.org/10.3892/mmr.2015.4516
MLA
Yang, F., Zhu, P., Duan, L., Yang, L., Wang, J."IL‑33 and kidney disease (Review)". Molecular Medicine Reports 13.1 (2016): 3-8.
Chicago
Yang, F., Zhu, P., Duan, L., Yang, L., Wang, J."IL‑33 and kidney disease (Review)". Molecular Medicine Reports 13, no. 1 (2016): 3-8. https://doi.org/10.3892/mmr.2015.4516
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