A comparative analysis of metal allergens associated with dental alloy prostheses and the expression of HLA-DR in gingival tissue

Zhang,Xin; Wei,Li‑Cheng; Wu,Bin; Yu,Li‑Ying; Wang,Xiao‑Ping; Liu,Yue

doi:10.3892/mmr.2015.4562

January-2016 Volume 13 Issue 1

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January-2016 Volume 13 Issue 1

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A comparative analysis of metal allergens associated with dental alloy prostheses and the expression of HLA-DR in gingival tissue

Authors:
- Xin Zhang
- Li‑Cheng Wei
- Bin Wu
- Li‑Ying Yu
- Xiao‑Ping Wang
- Yue Liu
View Affiliations / Copyright

Affiliations: Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Orthopaedics, Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 200052, P.R. China, Department of Stomatology, Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China

Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 91-98
|
Published online on: November 12, 2015

https://doi.org/10.3892/mmr.2015.4562
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Abstract

The present study aimed to provide guidance for the selection of prosthodontic materials and the management of patients with a suspected metal allergy. This included a comparison of the sensitivity of patients to alloys used in prescribed metal‑containing prostheses, and correlation analysis between metal allergy and accompanying clinical symptoms of sensitized patients using a patch test. The results from the patch test and metal component analyses were processed to reach a final diagnosis. In the present study, four dental alloys were assessed. Subsequent to polishing the surface of a metal restoration, the components were analyzed using an X‑ray fluorescence microscopy and spectrometry. Immunohistochemical analysis, reverse transcription‑polymerase chain reaction and western blotting were used to detect the expression levels of human leukocyte antigen (HLA)‑DR in gingival tissues affected by alloy restoration, and in normal gingival tissue samples. Positive allergens identified in the patch test were consistent with the components of the metal prostheses. The prevalence of nickel (Ni) allergy was highest (22.8%), and women were significantly more allergic to palladium and Ni than men (P<0.05). The protein and gene expression levels of HLA‑DR in the Ni‑chromium (Cr) prosthesis group were significantly higher, compared with those in the other groups (P<0.01); followed by cobalt‑Cr alloy, gold alloy and titanium alloy. In conclusion, dentists require an understanding of the corrosion and allergy rates of prescribed alloys, in order to reduce the risk of allergic reactions. Patch testing for hypersensitive patients is recommended and caution is required when planning to use different alloys in the mouth.

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1	Lundström IM: Allergy and corrosion of dental materials in patients with oral lichen planus. Int J Oral Surg. 13:16–24. 1984. View Article : Google Scholar : PubMed/NCBI
2	Magnusson B, Bergman M, Bergman B and Söremark R: Nickel allergy and nickel-containing dental alloys. Scand J Dent Res. 90:163–167. 1982.PubMed/NCBI
3	Gawkrodger DJ: Investigation of reactions to dental materials. Br J Dermatol. 153:479–485. 2005. View Article : Google Scholar : PubMed/NCBI
4	Yanagi T, Shimizu T, Abe R and Shimizu H: Zinc dental fillings and palmoplantar pustulosis. Lancet. 366:10502005. View Article : Google Scholar : PubMed/NCBI
5	Zhu Z and Zhan DS: Mutagenicity of two Ni-Cr porcelain alloys. JMutagenicity of two Ni-Cr porcelain alloys. Journal of Clinical Rehabilitative Tissue Engineering Research. 14:2683–2685. 2008.
6	Bayindir F, Körkut O and Güngör H: Potentiodynamic polarization technique for corrosion testing of Cr-Co and Cr-Ni alloys in artificial saliva and soft drinks. J Mater Res Innov. 14:280–284. 2010. View Article : Google Scholar
7	Danaei SM, Safavi A, Roeinpeikar SM, Oshagh M, Iranpour S and Omidkhoda M: Ion release from orthodontic brackets in 3 mouthwashes: An in-vitro study. Am J Orthod Dentofacial Orthop. 139:730–734. 2011. View Article : Google Scholar : PubMed/NCBI
8	Uter W, Rämsch C, Aberer W, Ayala F, Balato A, Beliauskiene A, Fortina AB, Bircher A, Brasch J, Chowdhury MM, et al: The European baseline series in 10 European countries, 2005/2006 - results of the European Surveillance System on Contact Allergies (ESSCA). Contact Dermatitis. 61:31–38. 2009. View Article : Google Scholar : PubMed/NCBI
9	Zeng J, Wang J, Gao W, Mohammadreza A, Kelbauskas L, Zhang W, Johnson RH and Meldrum DR: Quantitative single-cell gene expression measurements of multiple genes in response to hypoxia treatment. Anal Bioanal Chem. 401:3–13. 2011. View Article : Google Scholar : PubMed/NCBI
10	Lidén C and Norberg K: Nickel on the Swedish market. Follow-up after implementation of the Nickel Directive. Contact Dermatitis. 52:29–35. 2005. View Article : Google Scholar : PubMed/NCBI
11	Nakada T, Iijima M, Nakayama H and Maibach HI: Role of ear piercing in metal allergic contact dermatitis. Contact Dermatitis. 36:233–226. 228–233. 1997. View Article : Google Scholar : PubMed/NCBI
12	Merritt K and Rodrigo JJ: Immune response to synthetic materials. Sensitization of patients receiving orthopaedic implants. Clin Orthop Relat Res. 71–79. 1996. View Article : Google Scholar : PubMed/NCBI
13	Schmidt M, Raghavan B, Müller V, Vogl T, Fejer G, Tchaptchet S, Keck S, Kalis C, Nielsen PJ, Galanos C, et al: Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nat Immunol. 11:814–819. 2010. View Article : Google Scholar : PubMed/NCBI
14	Abraham CM, Ownby DR, Peterson EL, Wegienka G, Zoratti EM, Williams LK, Joseph CL and Johnson CC: The relationship between seroatopy and symptoms of either allergic rhinitis or asthma. J Allergy Clin Immunol. 119:1099–1104. 2007. View Article : Google Scholar : PubMed/NCBI
15	Arshad SH, Tariq SM, Matthews S and Hakim E: Sensitization to common allergens and its association with allergic disorders at age 4 years: A whole population birth cohort study. Pediatrics. 108:E332001. View Article : Google Scholar : PubMed/NCBI
16	Thomas P, Maier S and Summer B: Allergic reactions to metal implants. Materwiss Werksttech. 35:997–1000. 2004. View Article : Google Scholar
17	Forte G, Petrucci F and Bocca B: Metal allergens of growing significance: Epidemiology, immunotoxicology, strategies for testing and prevention. Inflamm Allergy Drug Targets. 7:145–162. 2008. View Article : Google Scholar : PubMed/NCBI
18	Harloff T, Hönle W, Holzwarth U, Bader R, Thomas P and Schuh A: Titanium allergy or not? 'Impurity' of titanium implant materials. Health. 2:306–310. 2010. View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

A comparative analysis of metal allergens associated with dental alloy prostheses and the expression of HLA-DR in gingival tissue

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