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Article

MicroRNA 28-5p regulates ATP-binding cassette transporter A1 via inhibiting extracellular signal-regulated kinase 2

  • Authors:
    • Jia Liu
    • Xue‑Qing Liu
    • Ying Liu
    • Ya‑Nan Sun
    • Si Li
    • Chun‑Mei Li
    • Jie Li
    • Wei Tian
    • Xiao‑Ming Shang
    • Yun‑Tao Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China, Department of Hepatobiliary Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, Department of Clinical Laboratory Center, Tangshan Gongren Hospital, Tangshan, Hebei 063000, P.R. China, Department of Cardiology, Tangshan Gongren Hospital, Tangshan, Hebei 063000, P.R. China
  • Pages: 433-440
    |
    Published online on: November 12, 2015
       https://doi.org/10.3892/mmr.2015.4563
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Abstract

The biological function of the intronic microRNA-28 (miR-28) may be associated with the biological roles of its host gene, LIM domain lipoma‑preferred partner (LPP). LPP has been reported to promote smooth muscle cell migration in arterial injury and atherosclerosis. However, the mechanism of miR‑28 in atherosclerosis remains unclear. In the current study, the aim was to validate the inhibitory effect of miR‑28‑5p on extracellular signal‑regulated kinase 2 (ERK2), to investigate its biological role in atherosclerosis and its association with cardiovascular disease. Western blotting and stem‑loop reverse transcription‑quantitative polymerase chain reaction combined with TaqMAN microRNA analysis was conducted. The current study demonstrated that miR‑28‑5p upregulated the expression of ATP‑binding cassette transporter A1 (ABCA1) via the inhibition of ERK2 in HepG2 cells. In addition, increased levels of plasma miR‑28‑5p were positively correlated with the levels of high‑density lipoprotein cholesterol in patients with unstable angina. This suggests that miR-28-5p participates in atherosclerosis via ERK2-mediated upregulation of the ABCA1 pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Liu XQ, Liu Y, Sun YN, Li S, Li CM, Li J, Tian W, Shang XM, Zhou YT, Zhou YT, et al: MicroRNA 28-5p regulates ATP-binding cassette transporter A1 via inhibiting extracellular signal-regulated kinase 2. Mol Med Rep 13: 433-440, 2016.
APA
Liu, J., Liu, X., Liu, Y., Sun, Y., Li, S., Li, C. ... Zhou, Y. (2016). MicroRNA 28-5p regulates ATP-binding cassette transporter A1 via inhibiting extracellular signal-regulated kinase 2. Molecular Medicine Reports, 13, 433-440. https://doi.org/10.3892/mmr.2015.4563
MLA
Liu, J., Liu, X., Liu, Y., Sun, Y., Li, S., Li, C., Li, J., Tian, W., Shang, X., Zhou, Y."MicroRNA 28-5p regulates ATP-binding cassette transporter A1 via inhibiting extracellular signal-regulated kinase 2". Molecular Medicine Reports 13.1 (2016): 433-440.
Chicago
Liu, J., Liu, X., Liu, Y., Sun, Y., Li, S., Li, C., Li, J., Tian, W., Shang, X., Zhou, Y."MicroRNA 28-5p regulates ATP-binding cassette transporter A1 via inhibiting extracellular signal-regulated kinase 2". Molecular Medicine Reports 13, no. 1 (2016): 433-440. https://doi.org/10.3892/mmr.2015.4563
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Liu XQ, Liu Y, Sun YN, Li S, Li CM, Li J, Tian W, Shang XM, Zhou YT, Zhou YT, et al: MicroRNA 28-5p regulates ATP-binding cassette transporter A1 via inhibiting extracellular signal-regulated kinase 2. Mol Med Rep 13: 433-440, 2016.
APA
Liu, J., Liu, X., Liu, Y., Sun, Y., Li, S., Li, C. ... Zhou, Y. (2016). MicroRNA 28-5p regulates ATP-binding cassette transporter A1 via inhibiting extracellular signal-regulated kinase 2. Molecular Medicine Reports, 13, 433-440. https://doi.org/10.3892/mmr.2015.4563
MLA
Liu, J., Liu, X., Liu, Y., Sun, Y., Li, S., Li, C., Li, J., Tian, W., Shang, X., Zhou, Y."MicroRNA 28-5p regulates ATP-binding cassette transporter A1 via inhibiting extracellular signal-regulated kinase 2". Molecular Medicine Reports 13.1 (2016): 433-440.
Chicago
Liu, J., Liu, X., Liu, Y., Sun, Y., Li, S., Li, C., Li, J., Tian, W., Shang, X., Zhou, Y."MicroRNA 28-5p regulates ATP-binding cassette transporter A1 via inhibiting extracellular signal-regulated kinase 2". Molecular Medicine Reports 13, no. 1 (2016): 433-440. https://doi.org/10.3892/mmr.2015.4563
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