Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2016 Volume 13 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2016 Volume 13 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Peroxiredoxin 6 attenuates ischemia‑ and hypoxia‑induced liver damage of brain‑dead donors

  • Authors:
    • Qiang Tu
    • Yan Xiong
    • Lin Fan
    • Bingbing Qiao
    • Zhiping Xia
    • Long Hu
    • Yanfeng Wang
    • Guizhu Peng
    • Qifa Ye
  • View Affiliations / Copyright

    Affiliations: Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
    Copyright: © Tu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 753-761
    |
    Published online on: November 19, 2015
       https://doi.org/10.3892/mmr.2015.4587
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oxidative stress induced by ischemia and hypoxia in the livers of donors after brain death (DBD) is associated with poor organ function and low patient survival rates in those receiving DBD liver transplants. Peroxiredoxin 6 (Prdx6) can defend cells against liver damage induced by oxidative stress. The present study aimed to investigate the role of Prdx6 in ischemia‑ and hypoxia‑induced liver damage in DBD livers. Liver tissue samples from ten DBD patients were collected. The control group constituted of six liver samples from patients with liver hemangioma that had accepted tumor excision surgery. Protein expression levels were determined by western blotting, cell viability was assessed using a CCK‑8 assay, intracellular reactive oxygen species (ROS) levels were measured using a ROS assay kit, and phospholipase A2 (PLA2) activity was measured using a PLA2 assay kit. In DBD liver samples, Prdx6 expression was downregulated and the nuclear factor‑κB (NF‑κB) signaling pathway was activated. Furthermore, when human liver L02 cells were exposed to ischemia and hypoxia, the expression of Prdx6 was reduced, causing an increase in reactive oxygen species (ROS); this in turn activated NF‑κB signaling and lowered cell viability (P<0.01). In agreement, overexpression of Prdx6 reduced ROS levels and improved cell viability. It was also demonstrated that inhibition of NF‑κB increased Prdx6 expression, while inhibition of Prdx6 limited PLA2 activity, exacerbating ischemia‑ and hypoxia‑induced cell damage. This data suggests that Prdx6 and its PLA2 activity have a protective role in DBD livers, the expression of which is regulated by NF‑κB. Thus, Prdx6 may be a novel target to alleviate liver damage in DBD.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Telles-Correia D and Mega I: Candidates for liver transplantation with alcoholic liver disease: Psychosocial aspects. World J Gastroenterol. 21:11027–11033. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Heimbach JK, Hirose R, Stock PG, Schladt DP, Xiong H, Liu J, Olthoff KM, Harper A, Snyder JJ, Israni AK, et al: Delayed hepatocellular carcinoma model for end-stage liver disease exception score improves disparity in access to liver transplant in the United States. Hepatology. 61:1643–1650. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Park SJ, Lim YS, Hwang S, Heo NY, Lee HC, Suh DJ, Yu E and Lee SG: Emergency adult-to-adult living-donor liver transplantation for acute liver failure in a hepatitis B virus endemic area. Hepatology. 51:903–911. 2010.

4 

Huang JF, Wang HB, Zheng SS, Liu YF, Shi BY, Shen ZY, Hu SS, Ye QF, Xue WJ and He XS: Advances in China's organ transplantation achieved with the guidance of law. Chin Med J (Engl). 128:143–146. 2015. View Article : Google Scholar

5 

Weiss S, Kotsch K, Francuski M, Reutzel-Selke A, Mantouvalou L, Klemz R, Kuecuek O, Jonas S, Wesslau C, Ulrich F, et al: Brain death activates donor organs and is associated with a worse I/R injury after liver transplantation. Am J Transplant. 7:1584–1593. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Barklin A, Larsson A, Vestergaard C, Koefoed-Nielsen J, Bach A, Nyboe R, Wogensen L and Tønnesen E: Does brain death induce a pro-inflammatory response at the organ level in a porcine model? Acta Anaesthesiol Scand. 52:621–627. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Kusaka M, Pratschke J, Wilhelm MJ, Ziai F, Zandi-Nejad K, Mackenzie HS, Hancock WW and Tilney NL: Activation of inflammatory mediators in rat renal isografts by donor brain death. Transplantation. 69:405–410. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Takada M, Nadeau KC, Hancock WW, Mackenzie HS, Shaw GD, Waaga AM, Chandraker A, Sayegh MH and Tilney NL: Effects of explosive brain death on cytokine activation of peripheral organs in the rat. Transplantation. 5:1533–1542. 1998. View Article : Google Scholar

9 

Van Der Hoeven JA, Moshage H, Schuurs T, Nijboer M, Van Schilfgaarde R and Ploeg RJ: Brain death induces apoptosis in donor liver of the rat. Transplantation. 76:1150–1154. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Adrie C, Monchi M, Fulgencio JP, Cottias P, Haouache H, Alvarez-Gonzalvez A, Guerrini P, Cavaillon JM and Adib-Conquy M: Immune status and apoptosis activation during brain death. Shock. 33:353–362. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Golling M, Mehrabi A, Blum K, Jahnke C, Kellner H, Bud O, Hashemi B, Breitkreutz R, Becker-Brandenbutg K, Schemmer P, et al: Effects of hemodynamic instability on brain death-induced prepreservation liver damage. Transplantation. 75:1154–1159. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Dutkiewicz G, Domanski L, Binczak-Kuleta A, Pawlik A, Safranow K, Dziedziejko V, Wisniewska M, Ciechanowicz A and Ciechanowski K: Lack of association of polymorphisms 239+34A/C in the SOD1 gene and 47C/T in the SOD2 gene with delayed graft function and acute and chronic rejection of kidney allografts. Transplant Proc. 41:3701–3703. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Rhee SG, Kang SW, Chang TS, Jeong W and Kim K: Peroxiredoxin, a novel family of peroxidases. IUBMB Life. 52:35–41. 2001. View Article : Google Scholar

14 

Fisher AB: Peroxiredoxin 6: A bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. Antioxid Redox Signal. 15:831–844. 2011. View Article : Google Scholar :

15 

Simeone M and Phelan SA: Transcripts associated with Prdx6 (peroxiredoxin 6) and related genes in mouse. Mamm Genome. 16:103–111. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Eismann T, Huber N Shin T, Kuboki S, Galloway E, Wyder M, Edwards MJ, Greis KD, Shertzer HG, Fisher AB and Lentsch AB: Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice. Am J Physiol Gastrointest Liver Physiol. 296:G266–G274. 2009. View Article : Google Scholar :

17 

Fisher AB, Dodia C, Feinstein SI and Ho YS: Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A2. J Lipid Res. 46:1248–1256. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Ambruso DR, Ellison MA, Thurman GW and Leto TL: Peroxiredoxin 6 translocates to the plasma membrane during neutrophil activation and is required for optimal NADPH oxidase activity. Biochim Biophys Acta. 1823.306–315. 2012.

19 

Lien YC, Feinstein SI, Dodia C and Fisher AB: The roles of peroxidase and phospholipase A2 activities of peroxiredoxin 6 in protecting pulmonary microvascular endothelial cells against peroxidative stress. Antioxid Redox Signal. 16:440–451. 2012. View Article : Google Scholar :

20 

Chhunchha B, Fatma N, Kubo E, Rai P, Singh SP and Singh DP: Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation. Am J Physiol Cell Physiol. 304:C636–C655. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Chowdhury I, Fisher AB, Christofidou-Solomidou M, Gao L, Tao JQ, Sorokina EM, Lien YC, Bates SR and Feinstein SI: Keratinocyte growth factor and glucocorticoid induction of human peroxiredoxin 6 gene expression occur by independent mechanisms that are synergistic. Antioxid Redox Signal. 20:391–402. 2014. View Article : Google Scholar :

22 

Paula FM, Ferreira SM, Boschero AC and Souza KL: Modulation of the peroxiredoxin system by cytokines in insulin-producing RINm5F cells: Down-regulation of PRDX6 increases susceptibility of beta cells to oxidative stress. Mol Cell Endocrinol. 374:56–64. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Chen K, Li YH, Xu SQ, Hu SH and Zhang L: Protective effects of peroxisome proliferator-activated receptor-α agonist, Wy14643, on hypoxia/reoxygenation injury in primary rat hepatocytes. PPAR Res. 2012:5479802012. View Article : Google Scholar

24 

Chhunchha B, Fatma N, Bhargavan B, Kubo E, Kumar A and Singh DP: Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress. Cell Death Dis. 2:e2342011. View Article : Google Scholar : PubMed/NCBI

25 

Gallagher BM and Phelan SA: Investigating transcriptional regulation of Prdx6 in mouse liver cells. Free Radic Biol Med. 42:1270–1277. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Tulsawani R, Kelly LS, Fatma N, Chhunchha B, Kubo E, Kumar A and Singh DP: Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage. BMC Neurosci. 11:1252010. View Article : Google Scholar : PubMed/NCBI

27 

Wang Y, Xu Y, Wang H, Xue P, Li X, Li B, Zheng Q and Sun G: Arsenic induces mitochondria-dependent apoptosis by reactive oxygen species generation rather than glutathione depletion in Chang human hepatocytes. Arch Toxicol. 83:899–908. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Fatma N, Kubo E, Sen M, Agarwal N, Thoreson WB, Camras CB and Singh DP: Peroxiredoxin 6 delivery attenuates TNF-alpha-and glutamate-induced retinal ganglion cell death by limiting ROS levels and maintaining Ca2+ homeostasis. Brain Res. 1233:63–78. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Sun XG, Fu XQ, Cai HB, Liu Q, Li CH, Liu YW, Li YJ, Liu ZF, Song YH and Lv ZP: Proteomic analysis of protective effects of polysaccharides from Salvia miltiorrhiza against immunological liver injury in mice. Phytother Res. 25:1087–1094. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Roede JR, Stewart BJ and Petersen DR: Decreased expression of peroxiredoxin 6 in a mouse model of ethanol consumption. Free Radic Biol Med. 45:1551–1558. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Gloire G, Legrand-Poels S and Piette J: NF-kappaB activation by reactive oxygen species: Fifteen years later. Biochem Pharmacol. 72:1493–1505. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Zhang H, Wang ZW, Wu HB, Li Z, Li LC, Hu XP, Ren ZL, Li BJ and Hu ZP: Transforming growth factor-β1 induces matrix metal-loproteinase-9 expression in rat vascular smooth muscle cells via ROS-dependent ERK-NF-κB pathways. Mol Cell Biochem. 375:11–21. 2013.PubMed/NCBI

33 

Girotti AW: Lipid hydroperoxide generation, turnover, and effector action in biological systems. J Lipid Res. 39:1529–1542. 1998.PubMed/NCBI

34 

Schaloske RH and Dennis EA: The phospholipase A2 superfamily and its group numbering system. Biochim Biophys Acta. 1761:1246–1259. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Winstead MV, Balsinde J and Dennis EA: Calcium-independent phospholipase A(2): Structure and function. Biochim Biophys Acta. 1488:28–39. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Manevich Y, Shuvaeva T, Dodia C, Kazi A, Feinstein SI and Fisher AB: Binding of peroxiredoxin 6 to substrate determines differential phospholipid hydroperoxide peroxidase and phospholipase A(2) activities. Arch Biochem Biophys. 485:139–149. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tu Q, Xiong Y, Fan L, Qiao B, Xia Z, Hu L, Wang Y, Peng G and Ye Q: Peroxiredoxin 6 attenuates ischemia‑ and hypoxia‑induced liver damage of brain‑dead donors. Mol Med Rep 13: 753-761, 2016.
APA
Tu, Q., Xiong, Y., Fan, L., Qiao, B., Xia, Z., Hu, L. ... Ye, Q. (2016). Peroxiredoxin 6 attenuates ischemia‑ and hypoxia‑induced liver damage of brain‑dead donors. Molecular Medicine Reports, 13, 753-761. https://doi.org/10.3892/mmr.2015.4587
MLA
Tu, Q., Xiong, Y., Fan, L., Qiao, B., Xia, Z., Hu, L., Wang, Y., Peng, G., Ye, Q."Peroxiredoxin 6 attenuates ischemia‑ and hypoxia‑induced liver damage of brain‑dead donors". Molecular Medicine Reports 13.1 (2016): 753-761.
Chicago
Tu, Q., Xiong, Y., Fan, L., Qiao, B., Xia, Z., Hu, L., Wang, Y., Peng, G., Ye, Q."Peroxiredoxin 6 attenuates ischemia‑ and hypoxia‑induced liver damage of brain‑dead donors". Molecular Medicine Reports 13, no. 1 (2016): 753-761. https://doi.org/10.3892/mmr.2015.4587
Copy and paste a formatted citation
x
Spandidos Publications style
Tu Q, Xiong Y, Fan L, Qiao B, Xia Z, Hu L, Wang Y, Peng G and Ye Q: Peroxiredoxin 6 attenuates ischemia‑ and hypoxia‑induced liver damage of brain‑dead donors. Mol Med Rep 13: 753-761, 2016.
APA
Tu, Q., Xiong, Y., Fan, L., Qiao, B., Xia, Z., Hu, L. ... Ye, Q. (2016). Peroxiredoxin 6 attenuates ischemia‑ and hypoxia‑induced liver damage of brain‑dead donors. Molecular Medicine Reports, 13, 753-761. https://doi.org/10.3892/mmr.2015.4587
MLA
Tu, Q., Xiong, Y., Fan, L., Qiao, B., Xia, Z., Hu, L., Wang, Y., Peng, G., Ye, Q."Peroxiredoxin 6 attenuates ischemia‑ and hypoxia‑induced liver damage of brain‑dead donors". Molecular Medicine Reports 13.1 (2016): 753-761.
Chicago
Tu, Q., Xiong, Y., Fan, L., Qiao, B., Xia, Z., Hu, L., Wang, Y., Peng, G., Ye, Q."Peroxiredoxin 6 attenuates ischemia‑ and hypoxia‑induced liver damage of brain‑dead donors". Molecular Medicine Reports 13, no. 1 (2016): 753-761. https://doi.org/10.3892/mmr.2015.4587
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team