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Article

Shensongyangxin protects against pressure overload‑induced cardiac hypertrophy

  • Authors:
    • Di‑Fei Shen
    • Qing‑Qing Wu
    • Jian Ni
    • Wei Deng
    • Cong Wei
    • Zhen‑Hua Jia
    • Heng Zhou
    • Meng‑Qiao Zhou
    • Zhou‑Yan Bian
    • Qi‑Zhu Tang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, The Integration of Traditional and Western Medical Research Academy of Hebei, Shijiazhuang, Hebei 050035, P.R. China
  • Pages: 980-988
    |
    Published online on: November 23, 2015
       https://doi.org/10.3892/mmr.2015.4598
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Abstract

Shensongyangxin (SSYX) is a medicinal herb, which has long been used in traditional Chinese medicine. Various pharmacological activities of SSYX have been identified. However, the role of SSYX in cardiac hypertrophy remains to be fully elucidated. In present study, aortic banding (AB) was performed to induce cardiac hypertrophy in mice. SSYX (520 mg/kg) was administered by daily gavage between 1 and 8 weeks following surgery. The extent of cardiac hypertrophy was then evaluated by pathological and molecular analyses of heart tissue samples. In addition, in vitro experiments were performed to confirm the in vivo results. The data of the present study demonstrated that SSYX prevented the cardiac hypertrophy and fibrosis induced by AB, as assessed by measurements of heart weight and gross heart size, hematoxylin and eosin staining, cross‑sectional cardiomyocyte area and the mRNA expression levels of hypertrophic markers. SSYX also inhibited collagen deposition and suppressed the expression of transforming growth factor β (TGFβ), connective tissue growth factor, fibronectin, collagen Ⅰα and collagen Ⅲα, which was mediated by the inhibition of the TGFβ/small mothers against decapentaplegic (Smad) signaling pathway. The inhibitory action of SSYX on cardiac hypertrophy was mediated by the inhibition of Akt signaling. In vitro investigations in the rat H9c2 cardiac cells also demonstrated that SSYX attenuated angiotensin II‑induced cardiomyocyte hypertrophy. These findings suggested that SSYX attenuated cardiac hypertrophy and fibrosis in the pressure overloaded mouse heart. Therefore, the cardioprotective effect of SSYX is associated with inhibition of the Akt and TGFβ/Smad signaling pathways.
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Copy and paste a formatted citation
Spandidos Publications style
Shen DF, Wu QQ, Ni J, Deng W, Wei C, Jia ZH, Zhou H, Zhou MQ, Bian ZY, Tang QZ, Tang QZ, et al: Shensongyangxin protects against pressure overload‑induced cardiac hypertrophy. Mol Med Rep 13: 980-988, 2016.
APA
Shen, D., Wu, Q., Ni, J., Deng, W., Wei, C., Jia, Z. ... Tang, Q. (2016). Shensongyangxin protects against pressure overload‑induced cardiac hypertrophy. Molecular Medicine Reports, 13, 980-988. https://doi.org/10.3892/mmr.2015.4598
MLA
Shen, D., Wu, Q., Ni, J., Deng, W., Wei, C., Jia, Z., Zhou, H., Zhou, M., Bian, Z., Tang, Q."Shensongyangxin protects against pressure overload‑induced cardiac hypertrophy". Molecular Medicine Reports 13.1 (2016): 980-988.
Chicago
Shen, D., Wu, Q., Ni, J., Deng, W., Wei, C., Jia, Z., Zhou, H., Zhou, M., Bian, Z., Tang, Q."Shensongyangxin protects against pressure overload‑induced cardiac hypertrophy". Molecular Medicine Reports 13, no. 1 (2016): 980-988. https://doi.org/10.3892/mmr.2015.4598
Copy and paste a formatted citation
x
Spandidos Publications style
Shen DF, Wu QQ, Ni J, Deng W, Wei C, Jia ZH, Zhou H, Zhou MQ, Bian ZY, Tang QZ, Tang QZ, et al: Shensongyangxin protects against pressure overload‑induced cardiac hypertrophy. Mol Med Rep 13: 980-988, 2016.
APA
Shen, D., Wu, Q., Ni, J., Deng, W., Wei, C., Jia, Z. ... Tang, Q. (2016). Shensongyangxin protects against pressure overload‑induced cardiac hypertrophy. Molecular Medicine Reports, 13, 980-988. https://doi.org/10.3892/mmr.2015.4598
MLA
Shen, D., Wu, Q., Ni, J., Deng, W., Wei, C., Jia, Z., Zhou, H., Zhou, M., Bian, Z., Tang, Q."Shensongyangxin protects against pressure overload‑induced cardiac hypertrophy". Molecular Medicine Reports 13.1 (2016): 980-988.
Chicago
Shen, D., Wu, Q., Ni, J., Deng, W., Wei, C., Jia, Z., Zhou, H., Zhou, M., Bian, Z., Tang, Q."Shensongyangxin protects against pressure overload‑induced cardiac hypertrophy". Molecular Medicine Reports 13, no. 1 (2016): 980-988. https://doi.org/10.3892/mmr.2015.4598
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