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Orally administered betaine reduces photodamage caused by UVB irradiation through the regulation of matrix metalloproteinase-9 activity in hairless mice

  • Authors:
    • A‑Rang Im
    • Hee Jeong Lee
    • Ui Joung Youn
    • Jin Won Hyun
    • Sungwook Chae

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  • Published online on: November 24, 2015     https://doi.org/10.3892/mmr.2015.4613
  • Pages: 823-828
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Betaine is widely distributed in plants, microorganisms, in several types of food and in medical herbs, including Lycium chinense. The administration of 100 mg betaine/kg body weight/day is an effective strategy for preventing ultraviolet irradiation‑induced skin damage. The present study aimed to determine the preventive effects of betaine on ultraviolet B (UVB) irradiation‑induced skin damage in hairless mice. The mice were divided into three groups: Control (n=5), UVB‑treated vehicle (n=5) and UVB‑treated betaine (n=5) groups. The level of irradiation was progressively increased between 60 mJ/cm2 per exposure at week 1 (one minimal erythematous dose = 60 mJ/cm2) and 90 mJ/cm2 per exposure at week 7. The formation of wrinkles significantly increased following UVB exposure in the UVB‑treated vehicle group. However, treatment with betaine suppressed UVB‑induced wrinkle formation, as determined by the mean length, mean depth, number, epidermal thickness and collagen damage. Furthermore, oral administration of betaine also inhibited the UVB‑induced expression of mitogen‑activated protein kinase kinase (MEK), extracellular signal‑regulated kinase (ERK), and matrix metalloproteinase‑9 (MMP‑9). These findings suggested that betaine inhibits UVB‑induced skin damage by suppressing increased expression of MMP‑9 through the inhibition of MEK and ERK.
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January-2016
Volume 13 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 6.9
  • CiteScore Rank: Q2: #98/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.721
  • SCImago Journal Rank (SJR): 0.65
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Spandidos Publications style
Im AR, Lee HJ, Youn UJ, Hyun JW and Chae S: Orally administered betaine reduces photodamage caused by UVB irradiation through the regulation of matrix metalloproteinase-9 activity in hairless mice. Mol Med Rep 13: 823-828, 2016
APA
Im, A., Lee, H.J., Youn, U.J., Hyun, J.W., & Chae, S. (2016). Orally administered betaine reduces photodamage caused by UVB irradiation through the regulation of matrix metalloproteinase-9 activity in hairless mice. Molecular Medicine Reports, 13, 823-828. https://doi.org/10.3892/mmr.2015.4613
MLA
Im, A., Lee, H. J., Youn, U. J., Hyun, J. W., Chae, S."Orally administered betaine reduces photodamage caused by UVB irradiation through the regulation of matrix metalloproteinase-9 activity in hairless mice". Molecular Medicine Reports 13.1 (2016): 823-828.
Chicago
Im, A., Lee, H. J., Youn, U. J., Hyun, J. W., Chae, S."Orally administered betaine reduces photodamage caused by UVB irradiation through the regulation of matrix metalloproteinase-9 activity in hairless mice". Molecular Medicine Reports 13, no. 1 (2016): 823-828. https://doi.org/10.3892/mmr.2015.4613