Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2016 Volume 13 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2016 Volume 13 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Correlation between Th17 and nTreg cell frequencies and the stages of progression in chronic hepatitis B

  • Authors:
    • Chun Yang
    • Fang Cui
    • Li‑Min Chen
    • Xue‑Yan Gong
    • Bo Qin
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China, Department of Clinical Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario M5S 2J7, Canada
  • Pages: 853-859
    |
    Published online on: November 27, 2015
       https://doi.org/10.3892/mmr.2015.4618
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Several studies have suggested that the balance of T helper 17 (Th17) and natural regulatory T (nTreg) cells in the Th17‑mediated immune response are critical in the pathogenesis of viral hepatitis. The aim of the present study was to examine the role of circulating Th17 and nTreg cells in the disease progression of hepatitis B virus (HBV) infection. A total of 40 patients with chronic HBV (CHB), 27 patients with HBV‑associated cirrhosis, 20 patients with HBV‑associated liver failure and 20 healthy controls were enrolled in the present study. The frequencies of Th17 and nTreg cells in the peripheral blood were examined using flow cytometry. Th17‑associated serum cytokine levels were measured using an enzyme‑linked immunosorbent assay. The results revealed a significantly higher frequency of circulating Th17 cells in the patients with CHB, cirrhosis and liver failure compared, with the normal controls, particularly in the patients with liver failure. The same trend was observed in the serum levels of interleukin (IL)‑17. The frequency of Th17 cells and the serum levels of IL‑17 were positively correlated with the levels of alanine aminotransferase and the prothrombin times. There was a significantly higher frequency of circulating nTreg cells in the patients with CHB, compared with the normal controls. The nTreg cell frequencies were significantly and positively correlated with plasma HBV DNA load, and were negatively correlated with Th17 frequencies in the cohort of patients with HBV. Taken together, the results suggested that Th17 cell‑mediated inflammation is associated with progression from CHB to cirrhosis, and to liver failure. Peripheral Th17 cell frequency and serum levels of IL‑17 may assisting in predicting the severity of liver damage and fibrosis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Ganem D and Prince AM: Hepatitis B virus infection-natural history and clinical consequences. New Engl J Med. 350:1118–1129. 2004. View Article : Google Scholar

2 

Hernandez-Gea V and Friedman SL: Pathogenesis of liver fibrosis. Annu Rev Pathol. 6:425–456. 2011. View Article : Google Scholar

3 

Friedman SL: Evolving challenges in hepatic fibrosis. Nat Rev Gastroenterol Hepatol. 7:425–436. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Wang FS and Zhang Z: Host immunity influences disease progression and antiviral efficacy in humans infected with hepatitis B virus. Expert Rev Gastroenterol Hepatol. 3:499–512. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Dancygier H and Schirmacher P: Immune mediated liver injury. Clinical Hepatology. Dancygier H: Springer; Berlin, Germany: pp. 191–196. 2010

6 

Jung MC and Pape GR: Immunology of hepatitis B infection. Lancet Infect Dis. 2:43–50. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Wang FS: Clinical immune characterization of hepatitis B virus infection and implications for immune intervention: Progress and challenges. Hepatol Res. 37(Suppl 3): S339–S346. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy KM and Weaver CT: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 6:1123–1132. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Shi M, Wei J, Dong J, Meng W, Ma J, Wang T, Wang N and Wang Y: Function of interleukin-17 and -35 in the blood of patients with hepatitis B-related liver cirrhosis. Mol Med Rep. 11:121–126. 2015.

10 

Jaeschke H and Hasegawa T: Role of neutrophils in acute inflammatory liver injury. Liver Int. 26:912–919. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Zhang JY, Zhang Z, Lin F, Zou ZS, Xu RN, Jin L, Fu JL, Shi F, Shi M, Wang HF and Wang FS: Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B. Hepatology. 51:81–91. 2010. View Article : Google Scholar

12 

Zhang Z, Zou ZS, Fu JL, Cai L, Jin L, Liu YJ and Wang FS: Severe dendritic cell perturbation is actively involved in the pathogenesis of acute-on-chronic hepatitis B liver failure. J Hepatol. 49:396–406. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Szabo G, Mandrekar P and Dolganiuc A: Innate immune response and hepatic inflammation. Semin Liver Dis. 27:339–350. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Ge J, Wang K, Meng QH, Qi ZX, Meng FL and Fan YC: Implication of Th17 and Th1 cells in patients with chronic active hepatitis B. J Clin Immunol. 30:60–67. 2010. View Article : Google Scholar

15 

Zhao RR, Yang XF, Dong J, Zhao YY, Wei X, Huang CX, Lian JQ and Zhang Y: Toll-like receptor 2 promotes T helper 17 cells response in hepatitis B virus infection. Int J Clin Exp Med. 8:7315–7323. 2015.PubMed/NCBI

16 

Li X, Liu X, Tian L and Chen Y: Cytokine-mediated immuno-pathogenesis of hepatitis B virus infections. Clin Rev Allergy Immunol. 1–14, epub. 2014.

17 

Kondo Y, Ueno Y and Shimosegawa T: Immunopathogenesis of hepatitis B persistent infection: Implications for immunothera-peutic strategies. Clin J Gastroenterol. 2:71–79. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Kondo Y, Ueno Y, Kobayashi K, Kakazu E, Shiina M, Inoue J, Tamai K, Wakui Y, Tanaka Y, Ninomiya M, et al: Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes. J Infect Dis. 202:202–213. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Yuan Q, Hong S, Shi B, Kers J, Li Z, Pei X, Xu L, Wei X and Cai M: CD4(+)CD25(-)Nrp1(+) T cells synergize with rapamycin to prevent murine cardiac allorejection in immunocompetent recipients. PLoS One. 8:e611512013. View Article : Google Scholar : PubMed/NCBI

20 

Voelkl S, Gary R and Mackensen A: Characterization of the immunoregulatory function of human TCR-αβ+ CD4- CD8-double-negative T cells. Eur J Immunol. 41:739–748. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Wang BL, Su H, Chen Y, Wang J and Xu GL: A role for tricho-santhin in the expansion of CD4CD25 regulatory T cells. Scand J Immunol. 71:258–266. 2015. View Article : Google Scholar

22 

Lambotin M, Raghuraman S, Stoll-Keller F, Baumert TF and Barth H: A look behind closed doors: Interaction of persistent viruses with dendritic cells. Nat Rev Microbiol. 8:350–360. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Xie Q, Shen HC, Jia NN, Wang H, Lin LY, An BY, Gui HL, Guo SM, Cai W, Yu H, et al: Patients with chronic hepatitis B infection display deficiency of plasmacytoid dendritic cells with reduced expression of TLR9. Microbes Infect. 11:515–523. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Carotenuto P, Artsen A, Niesters HG, Osterhaus AD and Pontesilli O: In vitro use of autologous dendritic cells improves detection of T cell responses to hepatitis B virus (HBV) antigens. J Med Virol. 81:332–339. 2009. View Article : Google Scholar

25 

Sakaguchi S, Yamaguchi T, Nomura T and Ono M: Regulatory T cells and immune tolerance. Cell. 133:775–787. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Thimme R, Wieland S, Steiger C, Ghrayeb J, Reimann KA, Purcell RH and Chisari FV: CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol. 77:68–76. 2003. View Article : Google Scholar :

27 

Pawlotsky JM: EASL Clinical Practice Guidelines. J Hepatol. 50:2432009. View Article : Google Scholar

28 

Bettelli E, Korn T, Oukka M and Kuchroo VK: Induction and effector functions of T(H)17 cells. Nature. 453:1051–1057. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Zhou L, Lopes JE, Chong MM, Ivanov II, Min R, Victora GD, Shen Y, Du J, Rubtsov YP, Rudensky AY, et al: TGF-β-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature. 453:236–240. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL and Kuchroo VK: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 441:235–238. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM and Stockinger B: TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 24:179–189. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Ando DG, Clayton J, Kono D, Urban JL and Sercarz EE: Encephalitogenic T cells in the B10. PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell Immunol. 124:132–143. 1989. View Article : Google Scholar : PubMed/NCBI

33 

Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q and Dong C: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 6:1133–1141. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Bouchliou I, Miltiades P, Nakou E, Spanoudakis E, Goutzouvelidis A, Vakalopoulou S, Garypidou V, Kotoula V, Bourikas G, Tsatalas C and Kotsianidis I: Th17 and Foxp3(+) T regulatory cell dynamics and distribution in myelodysplastic syndromes. Clin Immunol. 139:350–359. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Maek-A-Nantawat W, Buranapraditkun S, Klaewsongkram J and Ruxrungthum K: Increased interleukin-17 production both in helper T cell subset Th17 and CD4-negative T cells in human immunodeficiency virus infection. Viral Immunol. 20:66–75. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Acosta-Rodriguez EV, Rivino L, Geginat J, Jarrossay D, Gattorno M, Lanzavecchia A, Sallusto F and Napolitani G: Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol. 8:639–646. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM and Weaver CT: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 6:1123–1132. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Lemmers A, Moreno C, Gustot T, Maréchal R, Degré D, Demetter P, de Nadai P, Geerts A, Quertinmont E, Vercruysse V, et al: The interleukin-17 pathway is involved in human alcoholic liver disease. Hepatology. 49:646–657. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Harada K, Shimoda S, Sato Y, Isse K, Ikeda H and Nakanuma Y: Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis. Clin Exp Immunol. 157:261–270. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Wang R, Kozhaya L, Mercer F, Khaitan A, Fujii H and Unutmaz D: Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A. 106:13439–13444. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Peng G, Li S, Wu W, Sun Z, Chen Y and Chen Z: Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection. Immunology. 123:57–65. 2008. View Article : Google Scholar

42 

Niu Y, Liu H, Yin D, Yi R, Chen T, Xue H, Zhang S, Lin S and Zhao Y: The balance between intrahepatic IL-17(+) T cells and Foxp3(+) regulatory T cells plays an important role in HBV-related end-stage liver disease. BMC Immunol. 12:472011. View Article : Google Scholar : PubMed/NCBI

43 

Zhang JY, Song CH, Shi F, Zhang Z, Fu JL and Wang FS: Decreased ratio of Treg cells to Th17 cells correlates with HBV DNA suppression in chronic hepatitis B patients undergoing entecavir treatment. PLoS One. 5:e138692010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang C, Cui F, Chen LM, Gong XY and Qin B: Correlation between Th17 and nTreg cell frequencies and the stages of progression in chronic hepatitis B. Mol Med Rep 13: 853-859, 2016.
APA
Yang, C., Cui, F., Chen, L., Gong, X., & Qin, B. (2016). Correlation between Th17 and nTreg cell frequencies and the stages of progression in chronic hepatitis B. Molecular Medicine Reports, 13, 853-859. https://doi.org/10.3892/mmr.2015.4618
MLA
Yang, C., Cui, F., Chen, L., Gong, X., Qin, B."Correlation between Th17 and nTreg cell frequencies and the stages of progression in chronic hepatitis B". Molecular Medicine Reports 13.1 (2016): 853-859.
Chicago
Yang, C., Cui, F., Chen, L., Gong, X., Qin, B."Correlation between Th17 and nTreg cell frequencies and the stages of progression in chronic hepatitis B". Molecular Medicine Reports 13, no. 1 (2016): 853-859. https://doi.org/10.3892/mmr.2015.4618
Copy and paste a formatted citation
x
Spandidos Publications style
Yang C, Cui F, Chen LM, Gong XY and Qin B: Correlation between Th17 and nTreg cell frequencies and the stages of progression in chronic hepatitis B. Mol Med Rep 13: 853-859, 2016.
APA
Yang, C., Cui, F., Chen, L., Gong, X., & Qin, B. (2016). Correlation between Th17 and nTreg cell frequencies and the stages of progression in chronic hepatitis B. Molecular Medicine Reports, 13, 853-859. https://doi.org/10.3892/mmr.2015.4618
MLA
Yang, C., Cui, F., Chen, L., Gong, X., Qin, B."Correlation between Th17 and nTreg cell frequencies and the stages of progression in chronic hepatitis B". Molecular Medicine Reports 13.1 (2016): 853-859.
Chicago
Yang, C., Cui, F., Chen, L., Gong, X., Qin, B."Correlation between Th17 and nTreg cell frequencies and the stages of progression in chronic hepatitis B". Molecular Medicine Reports 13, no. 1 (2016): 853-859. https://doi.org/10.3892/mmr.2015.4618
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team