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Article

4.1N suppresses hypoxia-induced epithelial-mesenchymal transition in epithelial ovarian cancer cells

  • Authors:
    • Letian Zhang
    • Ajin Hu
    • Mengrui Li
    • Hongquan Zhang
    • Caixia Ren
    • Xiuli An
    • Congrong Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China, Department of Histology and Embryology, Peking University Health Science Center, Beijing 100191, P.R. China, College of Life Science, Zhengzhou University, Zhengzhou, Henan 450051, P.R. China, Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University Health Science Center, Beijing 100191, P.R. China
  • Pages: 837-844
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    Published online on: December 1, 2015
       https://doi.org/10.3892/mmr.2015.4634
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Abstract

Protein 4.1N (4.1N) is a member of the protein 4.1 family and is essential for the regulation of cell adhesion, motility and signaling. Previous studies have suggested that 4.1N may serve a tumor suppressor role. However, the molecular mechanisms remain unclear. In the current study, the role of 4.1N in the downregulation of hypoxia‑induced factor 1α (HIF‑1α) under hypoxic conditions and therefore the suppression of hypoxia induced epithelial‑mesenchymal transition (EMT) was investigated. The data were obtained from overexpressed and knockdown 4.1N epithelial ovarian cancer (EOC) cell lines. It was identified that 4.1N was capable of regulating the sub‑cellular localization and expression levels of HIF‑1α, by which 4.1N served a dominant role in the suppression of hypoxia‑induced EMT and associated genes. Collectively, the data of the current study identified 4.1N as an inhibitor of hypoxia‑induced tumor progression in EOC cells and highlighted its potential role in EOC therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Hu A, Li M, Zhang H, Ren C, An X and Liu C: 4.1N suppresses hypoxia-induced epithelial-mesenchymal transition in epithelial ovarian cancer cells. Mol Med Rep 13: 837-844, 2016.
APA
Zhang, L., Hu, A., Li, M., Zhang, H., Ren, C., An, X., & Liu, C. (2016). 4.1N suppresses hypoxia-induced epithelial-mesenchymal transition in epithelial ovarian cancer cells. Molecular Medicine Reports, 13, 837-844. https://doi.org/10.3892/mmr.2015.4634
MLA
Zhang, L., Hu, A., Li, M., Zhang, H., Ren, C., An, X., Liu, C."4.1N suppresses hypoxia-induced epithelial-mesenchymal transition in epithelial ovarian cancer cells". Molecular Medicine Reports 13.1 (2016): 837-844.
Chicago
Zhang, L., Hu, A., Li, M., Zhang, H., Ren, C., An, X., Liu, C."4.1N suppresses hypoxia-induced epithelial-mesenchymal transition in epithelial ovarian cancer cells". Molecular Medicine Reports 13, no. 1 (2016): 837-844. https://doi.org/10.3892/mmr.2015.4634
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Hu A, Li M, Zhang H, Ren C, An X and Liu C: 4.1N suppresses hypoxia-induced epithelial-mesenchymal transition in epithelial ovarian cancer cells. Mol Med Rep 13: 837-844, 2016.
APA
Zhang, L., Hu, A., Li, M., Zhang, H., Ren, C., An, X., & Liu, C. (2016). 4.1N suppresses hypoxia-induced epithelial-mesenchymal transition in epithelial ovarian cancer cells. Molecular Medicine Reports, 13, 837-844. https://doi.org/10.3892/mmr.2015.4634
MLA
Zhang, L., Hu, A., Li, M., Zhang, H., Ren, C., An, X., Liu, C."4.1N suppresses hypoxia-induced epithelial-mesenchymal transition in epithelial ovarian cancer cells". Molecular Medicine Reports 13.1 (2016): 837-844.
Chicago
Zhang, L., Hu, A., Li, M., Zhang, H., Ren, C., An, X., Liu, C."4.1N suppresses hypoxia-induced epithelial-mesenchymal transition in epithelial ovarian cancer cells". Molecular Medicine Reports 13, no. 1 (2016): 837-844. https://doi.org/10.3892/mmr.2015.4634
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