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4‑Phenylbutyrate protects rat skin flaps against ischemia‑reperfusion injury and apoptosis by inhibiting endoplasmic reticulum stress

  • Authors:
    • Zhen‑Shuang Yue
    • Lin‑Ru Zeng
    • Ren‑Fu Quan
    • Yang‑Hua Tang
    • Wen‑Jie Zheng
    • Gang Qu
    • Can‑Da Xu
    • Fang‑Bing Zhu
    • Zhong‑Ming Huang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Xiaoshan Traditional Chinese Medical Hospital, Hangzhou, Zhejiang 311201, P.R. China
    Copyright: © Yue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1227-1233
    |
    Published online on: December 4, 2015
       https://doi.org/10.3892/mmr.2015.4636
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Abstract

4‑phenylbutyrate (4‑PBA) is a low molecular weight fatty acid, which has been demonstrated to regulate endoplasmic reticulum (ER) stress. ER stress‑induced cell apoptosis has an important role in skin flap ischemia; however, a pharmacological approach for treating ischemia‑induced ER dysfunction has yet to be reported. In the present study, the effects of 4‑PBA‑induced ER stress inhibition on ischemia‑reperfusion injury were investigated in the skin flap of rats, and transcriptional regulation was examined. 4‑PBA attenuated ischemia‑reperfusion injury and inhibited cell apoptosis in the skin flap. Furthermore, 4‑PBA reversed the increased expression levels of two ER stress markers: CCAAT/enhancer-binding protein‑homologous protein and glucose‑regulated protein 78. These results suggested that 4‑PBA was able to protect rat skin flaps against ischemia‑reperfusion injury and apoptosis by inhibiting ER stress marker expression and ER stress‑mediated apoptosis. The beneficial effects of 4‑PBA may prove useful in the treatment of skin flap ischemia‑reperfusion injury.
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Copy and paste a formatted citation
Spandidos Publications style
Yue ZS, Zeng LR, Quan RF, Tang YH, Zheng WJ, Qu G, Xu CD, Zhu FB and Huang ZM: 4‑Phenylbutyrate protects rat skin flaps against ischemia‑reperfusion injury and apoptosis by inhibiting endoplasmic reticulum stress. Mol Med Rep 13: 1227-1233, 2016.
APA
Yue, Z., Zeng, L., Quan, R., Tang, Y., Zheng, W., Qu, G. ... Huang, Z. (2016). 4‑Phenylbutyrate protects rat skin flaps against ischemia‑reperfusion injury and apoptosis by inhibiting endoplasmic reticulum stress. Molecular Medicine Reports, 13, 1227-1233. https://doi.org/10.3892/mmr.2015.4636
MLA
Yue, Z., Zeng, L., Quan, R., Tang, Y., Zheng, W., Qu, G., Xu, C., Zhu, F., Huang, Z."4‑Phenylbutyrate protects rat skin flaps against ischemia‑reperfusion injury and apoptosis by inhibiting endoplasmic reticulum stress". Molecular Medicine Reports 13.2 (2016): 1227-1233.
Chicago
Yue, Z., Zeng, L., Quan, R., Tang, Y., Zheng, W., Qu, G., Xu, C., Zhu, F., Huang, Z."4‑Phenylbutyrate protects rat skin flaps against ischemia‑reperfusion injury and apoptosis by inhibiting endoplasmic reticulum stress". Molecular Medicine Reports 13, no. 2 (2016): 1227-1233. https://doi.org/10.3892/mmr.2015.4636
Copy and paste a formatted citation
x
Spandidos Publications style
Yue ZS, Zeng LR, Quan RF, Tang YH, Zheng WJ, Qu G, Xu CD, Zhu FB and Huang ZM: 4‑Phenylbutyrate protects rat skin flaps against ischemia‑reperfusion injury and apoptosis by inhibiting endoplasmic reticulum stress. Mol Med Rep 13: 1227-1233, 2016.
APA
Yue, Z., Zeng, L., Quan, R., Tang, Y., Zheng, W., Qu, G. ... Huang, Z. (2016). 4‑Phenylbutyrate protects rat skin flaps against ischemia‑reperfusion injury and apoptosis by inhibiting endoplasmic reticulum stress. Molecular Medicine Reports, 13, 1227-1233. https://doi.org/10.3892/mmr.2015.4636
MLA
Yue, Z., Zeng, L., Quan, R., Tang, Y., Zheng, W., Qu, G., Xu, C., Zhu, F., Huang, Z."4‑Phenylbutyrate protects rat skin flaps against ischemia‑reperfusion injury and apoptosis by inhibiting endoplasmic reticulum stress". Molecular Medicine Reports 13.2 (2016): 1227-1233.
Chicago
Yue, Z., Zeng, L., Quan, R., Tang, Y., Zheng, W., Qu, G., Xu, C., Zhu, F., Huang, Z."4‑Phenylbutyrate protects rat skin flaps against ischemia‑reperfusion injury and apoptosis by inhibiting endoplasmic reticulum stress". Molecular Medicine Reports 13, no. 2 (2016): 1227-1233. https://doi.org/10.3892/mmr.2015.4636
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