Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February-2016 Volume 13 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2016 Volume 13 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Integrative genomic analysis of interleukin‑36RN and its prognostic value in cancer

  • Authors:
    • Zhilei Lv
    • Jinshuo Fan
    • Xiuxiu Zhang
    • Qi Huang
    • Jieli Han
    • Feng Wu
    • Guorong Hu
    • Mengfei Guo
    • Yang Jin
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of the Ministry of Health, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
  • Pages: 1404-1412
    |
    Published online on: December 9, 2015
       https://doi.org/10.3892/mmr.2015.4667
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Interleukin (IL)‑36RN, previously known as IL1‑F5 and IL‑1δ, shares a 360‑kb region of chromosome 2q13 with members of IL‑1 systems. IL‑36RN encodes an anti‑inflammatory cytokine, IL‑36 receptor antagonist (IL‑36Ra). In spite of IL‑36Ra showing the highest homology to IL‑1 receptor (IL‑1R) antagonist, it differs from the latter in aspects including its binding to IL‑lRrp2 but not to IL‑1R1. IL‑36RN is mainly expressed in epithelial cells and has important roles in inflammatory diseases. In the present study, IL‑36RN was identified in the genomes of 27 species, including human, chimpanzee, mouse, horse and dolphin. Human IL‑36RN was mainly expressed in the eye, head and neck, fetal heart, lung, testis, cervix and placenta; furthermore, it was highly expressed in bladder and parathyroid tumors. Furthermore, a total of 30 single nucleotide polymorphisms causing missense mutations were determined, which are considered to be the causes of various diseases, such as generalized pustular psoriasis. In addition, the link between IL‑36RN and the prognosis of certain cancer types was revealed through meta‑analysis. Tumor‑associated transcriptional factors c‑Fos, activator protein‑1, c‑Jun and nuclear factor κB were found to bind to the upstream region in the IL‑36RN gene. This may indicate that IL‑36RN is involved in tumorigenesis and tumor progression through the regulation of tumor‑associated transcriptional factors. The present study identified IL-36RN in various species and investigated the associations between IL-36RN and cancer prognosis, which would determine whether IL-36RN drove the evolution of the various species with regard to tumorigenesis.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, Kastelein RA, Kumar S, Lin H, Mulero JJ, et al: A new nomenclature for IL-1-family genes. Trends Immunol. 22:536–537. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Dinarello C, Arend W, Sims J, Smith D, Blumberg H, O'Neill L, Goldbach-Mansky R, Pizarro T, Hoffman H, Bufler P, et al: IL-1 family nomenclature. Nat Immunol. 11:9732010. View Article : Google Scholar : PubMed/NCBI

3 

Sharaf N, Nicklin MJ and di Giovine FS: Long-range DNA interactions at the IL-1/IL-36/IL-37 gene cluster (2q13) are induced by activation of monocytes. Cytokine. 68:16–22. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R and Ford JE: IL1HY1: A novel interleukin-1 receptor antagonist gene. Biochem Biophys Res Commun. 263:702–706. 1999. View Article : Google Scholar : PubMed/NCBI

5 

Towne JE, Renshaw BR, Douangpanya J, Lipsky BP, Shen M, Gabel CA and Sims JE: Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β and IL-36γ) or antagonist (IL-36Ra) activity. J Biol Chem. 286:42594–42602. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME, Garlanda C, Mantovani A, O'Neill LA, Mills KH and Lynch MA: IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8. J Neurochem. 105:1960–1969. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Gresnigt MS and van de Veerdonk FL: Biology of IL-36 cytokines and their role in disease. Semin Immunol. 25:458–465. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Chen H, Wang Y, Bai C and Wang X: Alterations of plasma inflammatory biomarkers in the healthy and chronic obstructive pulmonary disease patients with or without acute exacerbation. J Proteomics. 75:2835–2843. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Ramadas RA, Li X, Shubitowski DM, Samineni S, Wills-Karp M and Ewart SL: IL-1 Receptor antagonist as a positional candidate gene in a murine model of allergic asthma. Immunogenetics. 58:851–855. 2006. View Article : Google Scholar : PubMed/NCBI

10 

van Asseldonk EJ, Stienstra R, Koenen TB, van Tits LJ, Joosten LA, Tack CJ and Netea MG: The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation. Obesity (Silver Spring). 18:2234–2236. 2010. View Article : Google Scholar

11 

Kim TJ, Kim TH, Lee HJ, Peddle L, Rahman P, Hu P, Greenwood CM and Inman RD: Interleukin 1 polymorphisms in patients with ankylosing spondylitis in Korea. J Rheumatol. 35:1603–1608. 2008.PubMed/NCBI

12 

Frey S, Derer A, Messbacher ME, Baeten DL, Bugatti S, Montecucco C, Schett G and Hueber AJ: The novel cytokine interleukin-36α is expressed in psoriatic and rheumatoid arthritis synovium. Ann Rheum Dis. 72:1569–1574. 2013. View Article : Google Scholar

13 

Mattii M, Ayala F, Balato N, Filotico R, Lembo S, Schiattarella M, Patruno C, Marone G and Balato A: The balance between pro-and anti-inflammatory cytokines is crucial in human allergic contact dermatitis pathogenesis: The role of IL-1 family members. Exp Dermatol. 22:813–819. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Heinemann A, He Y, Zimina E, Boerries M, Busch H, Chmel N, Kurz T, Bruckner-Tuderman L and Has C: Induction of phenotype modifying cytokines by FERMT1 mutations. Hum Mutat. 32:397–406. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Karumbaiah L, Norman SE, Rajan NB, Anand S, Saxena T, Betancur M, Patkar R and Bellamkonda RV: The upregulation of specific interleukin (IL) receptor antagonists and paradoxical enhancement of neuronal apoptosis due to electrode induced strain and brain micromotion. Biomaterials. 33:5983–5996. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Towne JE and Sims JE: IL-36 in psoriasis. Curr Opin Pharmacol. 12:486–490. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Marrakchi S, Guigue P, Renshaw BR, Puel A, Pei XY, Fraitag S, Zribi J, Bal E, Cluzeau C, Chrabieh M, et al: Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis. N Engl J Med. 365:620–628. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Sugiura K, Takeichi T, Kono M, Ogawa Y, Shimoyama Y, Muro Y and Akiyama M: A novel IL36RN/IL1F5 homozygous nonsense mutation, p.Arg10X, in a Japanese patient with adult-onset generalized pustular psoriasis. Br J Dermatol. 167:699–701. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Onoufriadis A, Simpson MA, Pink AE, Di Meglio P, Smith CH, Pullabhatla V, Knight J, Spain SL, Nestle FO, Burden AD, et al: Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis. Am J Hum Genet. 89:432–437. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Kanazawa N, Nakamura T, Mikita N and Furukawa F: Novel IL36RN mutation in a Japanese case of early onset generalized pustular psoriasis. J Dermatol. 40:749–751. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Kumar S, Nei M, Dudley J and Tamura K: MEGA: A biologist-centric software for evolutionary analysis of DNA and protein sequences. Brief Bioinform. 9:299–306. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Yang Z, Nielsen R, Goldman N and Pedersen AM: Codon-substitution models for heterogeneous selection pressure at amino acid sites. Genetics. 155:431–449. 2000.PubMed/NCBI

23 

Yang Z: PAML 4: Phylogenetic analysis by maximum likelihood. Mol Biol Evol. 24:1586–1591. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Wang B, Chen K, Xu W, Chen D, Tang W and Xia TS: Integrative genomic analyses of secreted protein acidic and rich in cysteine and its role in cancer prediction. Mol Med Rep. 10:1461–1468. 2014.PubMed/NCBI

25 

Kolker E, Higdon R, Morgan P, Sedensky M, Welch D, Bauman A, Stewart E, Haynes W, Broomall W and Kolker N: SPIRE: Systematic protein investigative research environment. J Proteomics. 75:122–126. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Kolker E, Higdon R, Haynes W, Welch D, Broomall W, Lancet D, Stanberry L and Kolker N: MOPED: Model organism protein expression database. Nucleic Acids Res. 40:D1093–D1099. 2012. View Article : Google Scholar :

27 

Wang B, Xu W, Tan M, Xiao Y, Yang H and Xia TS: Integrative genomic analyses of a novel cytokine, interleukin-34 and its potential role in cancer prediction. Int J Mol Med. 35:92–102. 2015.

28 

Wang M, Wei X, Shi L, Chen B, Zhao G and Yang H: Integrative genomic analyses of the histamine H1 receptor and its role in cancer prediction. Int J Mol Med. 33:1019–1026. 2014.PubMed/NCBI

29 

Forbes SA, Bindal N, Bamford S, Cole C, Kok CY, Beare D, Jia M, Shepherd R, Leung K, Menzies A, et al: COSMIC: Mining complete cancer genomes in the catalogue of somatic mutations in cancer. Nucleic Acids Res. 39:D945–D950. 2011. View Article : Google Scholar :

30 

Mizuno H, Kitada K, Nakai K and Sarai A: PrognoScan: A new database for meta-analysis of the prognostic value of genes. BMC Med Genomics. 2:182009. View Article : Google Scholar : PubMed/NCBI

31 

Sugiura K, Takemoto A, Yamaguchi M, Takahashi H, Shoda Y, Mitsuma T, Tsuda K, Nishida E, Togawa Y, Nakajima K, et al: The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist. J Invest Dermatol. 133:2514–2521. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Kim WJ, Kim EJ, Kim SK, Kim YJ, Ha YS, Jeong P, Kim MJ, Yun SJ, Lee KM, Moon SK, et al: Predictive value of progression-related gene classifier in primary non-muscle invasive bladder cancer. Mol Cancer. 9:32010. View Article : Google Scholar : PubMed/NCBI

33 

Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens JA and Massagué J: Genes that mediate breast cancer metastasis to the brain. Nature. 459:1005–1009. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Smith JJ, Deane NG, Wu F, Merchant NB, Zhang B, Jiang A, Lu P, Johnson JC, Schmidt C, Bailey CE, et al: Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Gastroenterology. 138:958–968. 2010. View Article : Google Scholar

35 

Okayama H, Kohno T, Ishii Y, Shimada Y, Shiraishi K, Iwakawa R, Furuta K, Tsuta K, Shibata T, Yamamoto S, et al: Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas. Cancer Res. 72:100–111. 2012. View Article : Google Scholar

36 

Yoshihara K, Tajima A, Yahata T, Kodama S, Fujiwara H, Suzuki M, Onishi Y, Hatae M, Sueyoshi K, Fujiwara H, et al: Gene expression profile for predicting survival in advanced-stage serous ovarian cancer across two independent datasets. PLoS One. 5:e96152010. View Article : Google Scholar : PubMed/NCBI

37 

Shaulian E and Karin M: AP-1 as a regulator of cell life and death. Nat Cell Biol. 4:E131–E136. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Kappelmann M, Bosserhoff A and Kuphal S: AP-1/c-Jun transcription factors: Regulation and function in malignant melanoma. Eur J Cell Biol. 93:76–81. 2014. View Article : Google Scholar

39 

Karamouzis MV, Konstantinopoulos PA and Papavassiliou AG: The activator protein-1 transcription factor in respiratory epithelium carcinogenesis. Mol Cancer Res. 5:109–120. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Caputto BL, Cardozo Gizzi AM and Gil GA: C-Fos: an AP-1 transcription factor with an additional cytoplasmic, non-genomic lipid synthesis activation capacity. Biochim Biophys Acta. 1841:1241–1246. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Milde-Langosch K: The Fos family of transcription factors and their role in tumourigenesis. Eur J Cancer. 41:2449–2461. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Motrich RD, Castro GM and Caputto BL: Old players with a newly defined function: Fra-1 and c-Fos support growth of human malignant breast tumors by activating membrane biogenesis at the cytoplasm. PLoS One. 8:e532112013. View Article : Google Scholar : PubMed/NCBI

43 

Bakiri L, Lallemand D, Bossy-Wetzel E and Yaniv M: Cell cycle-dependent variations in c-Jun and JunB phosphorylation: A role in the control of cyclin D1 expression. EMBO J. 19:2056–2068. 2000. View Article : Google Scholar : PubMed/NCBI

44 

Zenz R, Scheuch H, Martin P, Frank C, Eferl R, Kenner L, Sibilia M and Wagner EF: C-Jun regulates eyelid closure and skin tumor development through EGFR signaling. Dev Cell. 4:879–889. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Mils V, Piette J, Barette C, Veyrune J, Tesnière A, Escot C, Guilhou JJ and Basset-Séguin N: The proto-oncogene c-fos increases the sensitivity of keratinocytes to apoptosis. Oncogene. 14:1555–1561. 1997. View Article : Google Scholar : PubMed/NCBI

46 

Schreiber M, Kolbus A, Piu F, Szabowski kA, Möhle-Steinlein U, Tian J, Karin M, Angel P and Wagner EF: Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev. 13:607–619. 1999. View Article : Google Scholar : PubMed/NCBI

47 

Chen F and Castranova V: Nuclear factor-kappaB, an unappreciated tumor suppressor. Cancer Res. 67:11093–11098. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Horst D, Budczies J, Brabletz T, Kirchner T and Hlubek F: Invasion associated up-regulation of nuclear factor kappaB target genes in colorectal cancer. Cancer. 115:4946–4958. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Zubair A and Frieri M: Role of nuclear factor-kB in breast and colorectal cancer. Curr Allergy Asthma Rep. 13:44–49. 2013. View Article : Google Scholar

50 

Yu LL, Yu HG, Yu JP, Luo HS, Xu XM and Li JH: Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human colorectal carcinoma tissue. World J Gastroenterol. 10:3255–3260. 2004. View Article : Google Scholar : PubMed/NCBI

51 

Vainer GW, Pikarsky E and Ben-Neriah Y: Contradictory functions of NF-kappaB in liver physiology and cancer. Cancer Lett. 267:182–188. 2008. View Article : Google Scholar : PubMed/NCBI

52 

Arsura M and Cavin LG: Nuclear factor-kappaB and liver carcinogenesis. Cancer Lett. 229:157–169. 2005. View Article : Google Scholar : PubMed/NCBI

53 

Karin M: Nuclear factor-kappaB in cancer development and progression. Nature. 441:431–436. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lv Z, Fan J, Zhang X, Huang Q, Han J, Wu F, Hu G, Guo M and Jin Y: Integrative genomic analysis of interleukin‑36RN and its prognostic value in cancer. Mol Med Rep 13: 1404-1412, 2016.
APA
Lv, Z., Fan, J., Zhang, X., Huang, Q., Han, J., Wu, F. ... Jin, Y. (2016). Integrative genomic analysis of interleukin‑36RN and its prognostic value in cancer. Molecular Medicine Reports, 13, 1404-1412. https://doi.org/10.3892/mmr.2015.4667
MLA
Lv, Z., Fan, J., Zhang, X., Huang, Q., Han, J., Wu, F., Hu, G., Guo, M., Jin, Y."Integrative genomic analysis of interleukin‑36RN and its prognostic value in cancer". Molecular Medicine Reports 13.2 (2016): 1404-1412.
Chicago
Lv, Z., Fan, J., Zhang, X., Huang, Q., Han, J., Wu, F., Hu, G., Guo, M., Jin, Y."Integrative genomic analysis of interleukin‑36RN and its prognostic value in cancer". Molecular Medicine Reports 13, no. 2 (2016): 1404-1412. https://doi.org/10.3892/mmr.2015.4667
Copy and paste a formatted citation
x
Spandidos Publications style
Lv Z, Fan J, Zhang X, Huang Q, Han J, Wu F, Hu G, Guo M and Jin Y: Integrative genomic analysis of interleukin‑36RN and its prognostic value in cancer. Mol Med Rep 13: 1404-1412, 2016.
APA
Lv, Z., Fan, J., Zhang, X., Huang, Q., Han, J., Wu, F. ... Jin, Y. (2016). Integrative genomic analysis of interleukin‑36RN and its prognostic value in cancer. Molecular Medicine Reports, 13, 1404-1412. https://doi.org/10.3892/mmr.2015.4667
MLA
Lv, Z., Fan, J., Zhang, X., Huang, Q., Han, J., Wu, F., Hu, G., Guo, M., Jin, Y."Integrative genomic analysis of interleukin‑36RN and its prognostic value in cancer". Molecular Medicine Reports 13.2 (2016): 1404-1412.
Chicago
Lv, Z., Fan, J., Zhang, X., Huang, Q., Han, J., Wu, F., Hu, G., Guo, M., Jin, Y."Integrative genomic analysis of interleukin‑36RN and its prognostic value in cancer". Molecular Medicine Reports 13, no. 2 (2016): 1404-1412. https://doi.org/10.3892/mmr.2015.4667
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team