Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February-2016 Volume 13 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2016 Volume 13 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells

  • Authors:
    • Zhongyuan Qu
    • Xiang Zou
    • Xiujuan Zhang
    • Jiejing Sheng
    • Yumeng Wang
    • Jiaqi Wang
    • Chao Wang
    • Yubin Ji
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, Harbin University of Commerce, Harbin, Heilongjiang 150076, P.R. China, Engineering Research Center of Natural Antineoplastic Drugs, Harbin University of Commerce, Harbin, Heilongjiang 150076, P.R. China
  • Pages: 1336-1344
    |
    Published online on: December 14, 2015
       https://doi.org/10.3892/mmr.2015.4683
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the effect of chelidonine on mitotic slippage and apoptotic-like death in SGC-7901 human gastric cancer cells. The MTT assay was performed to detect the antiproliferative effect of chelidonine. Following treatment with chelidonine (10 µmol/l), the ultrastructure changes in SGC‑7901, MCF‑7 and HepG2 cells were observed by transmission electron microscopy. The effects of chelidonine on G2/M phase arrest and apoptosis of SGC‑7901 cells were determined by flow cytometry. Indirect immunofluorescence assay and laser scanning confocal microscopy (LSCM) were used to detect the phosphorylation level of histone H3 (Ser10) and microtubule formation was detected using LSCM following immunofluorescent labeling. Subsequent to treatment with chelidonine (10 µmol/l), expression levels of mitotic slippage‑associated proteins, including BUB1 mitotic checkpoint serine/threonine kinase B (BubR1), cyclin‑dependent kinase 1 (Cdk1) and cyclin B1, and apoptosis‑associated protein, caspase‑3 were examined by western blotting at 24, 48 and 72 h. The half maximal inhibitory concentration of chelidonine was 23.13 µmol/l over 48 h and chelidonine induced G2/M phase arrest of cells. The phosphorylation of histone H3 at Ser10 was significantly increased following treatment with chelidonine for 24 h, indicating that chelidonine arrested the SGC‑7901 cells in the M phase. Chelidonine inhibited microtubule polymerization, destroyed microtubule structures and induced cell cycle arrest in the M phase. Giant cells were observed with multiple micronuclei of varying sizes, which indicated that following a prolonged arrest in the M phase, the cells underwent mitotic catastrophe. Western blotting demonstrated that the protein expression levels of BubR1, cyclin B1 and Cdk1 decreased significantly between 48 and 72 h. Low expression levels of BubR1 and inactivation of the cyclin B1‑Cdk1 complex results in the cells being arrested at mitosis and leads to mitotic slippage. In addition, apoptotic morphological changes in multinucleated cells were observed, the apoptosis rates increased gradually with administration of chelidonine in a time‑dependent manner and the protein levels of caspase‑3 increased significantly between 24 and 72 h. Thus, chelidonine induces mitotic slippage, and apoptotic‑like death occurs in SGC‑7901 cells undergoing mitotic catastrophe. Gastric cancer is a common malignancy, and ranks second in overall cancer‑associated mortalities worldwide. The present study demonstrated that chelidonine induces M phase arrest and mitotic slippage of SGC‑7901 human gastric carcinoma cells via downregulating the expression of BubR1, Cdk1 and cyclin B1 proteins. With the prolongation of chelidonine treatment, the giant cells with multiple micronuclei underwent mitotic slippage and were maintained in the G1 phase and did not survive. A number of multinucleated cells underwent apoptosis via a caspase‑dependent signaling pathway. The current study proposes that chelidonine induces mitotic slippage and apoptotic-like death of SGC-7901 cells.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

De Vita F, Di Martino N, Fabozzi A, Laterza MM, Ventriglia J, Savastano B, Petrillo A, Gambardella V, Sforza V, Marano L, et al: Clinical management of advanced gastric cancer: The role of new molecular drugs. World J Gastroenterol. 20:14537–14558. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Cives M, Ciavarella S, Rizzo FM, De Matteo M, Dammacco F and Silvestris F: Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 25:1108–1117. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Zhao GP, Dai S, Chen RS, Wen HM, Yin L, Shi LW, Shi XD, Liu WL, Liu XH, Li Y, et al: Dictionary Chinese materia medica. Dictionary Chinese Materia Medica. Yu HA and Liu SF: 1. 2nd edition. Shanghai Science and Technology Press; Shanghai: pp. p10002006

4 

Chinese Pharmacopoeia Commission: Pharmacopoeia of the People's Republic of China. Pharmacopoeia of the People's Republic of China. Zhao YY: 1. 10th edition. Medicine Science and Technology Press of China; Beijing: pp. p1092015

5 

He ZM, Tong JM and Gong FC: Study on the analgesic effect of Chelidonium majus L. Chin Tradit Herb Drugs. 34:837–838. 2003.

6 

Colombo ML and Bosisio E: Pharmacological activities of Chelidonium majus L. (Papaveraceae). Pharmacol Res. 33:127–134. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Noureini SK and Wink M: Transcriptional down regulation of hTERT and senescence induction in HepG2 cells by chelidonine. World J Gastroenterol. 15:3603–3610. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Paul A, Bishayee K, Ghosh S, Mukherjee A, Sikdar S, Chakraborty D, Boujedaini N and Khuda-Bukhsh AR: Chelidonine isolated from ethanolic extract of Chelidonium majus promotes apoptosis in HeLa cells through p38-p53 and PI3K/AKT signalling pathways. J Chin Integ Med. 10:1025–1038. 2012. View Article : Google Scholar

9 

Paul A, Das S, Das J, Samadder A and Khuda-Bukhsh AR: Cytotoxicity and apoptotic signalling cascade induced by chelidonine-loaded PLGA nanoparticles in HepG2 cells in vitro and bioavailability of nano-chelidonine in mice in vivo. Toxicol Lett. 222:10–22. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Park JE, Cuong TD, Hung TM, Lee I, Na M, Kim JC, Ryoo S, Lee JH, Choi JS, Woo MH and Min BS: Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cells. Bioorg Med Chem Lett. 21:6960–6963. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Heinle H, Hagelauer D, Pascht U, Kelber O and Weiser D: Intestinal spasmolytic effects of STW 5 (Iberogast) and its components. Phytomedicine. 13(Suppl 5): 75–79. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Iagodina OV, Niko'/skaia EB and Faddeeva MD: Inhibition of liver mitochondrial monoamine oxidase activity by alkaloids isolated from Chelidonium and Macleaya and by their derivative drugs. Tsitologiia. 45:1032–1037. 2003.In Russian.

13 

Paul A, Das J, Das S, Samadder A and Khuda-Bukhsh AR: Poly (lactide-co-glycolide) nano-encapsulation of chelidonine, an active bioingredient of greater celandine (Chelidonium majus), enhances its ameliorative potential against cadmium induced oxidative stress and hepatic injury in mice. Environ Toxicol Pharmacol. 36:937–947. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Koriem KM, Arbid MS and Asaad GF: Chelidonium majus leaves methanol extract and its chelidonine alkaloid ingredient reduce cadmium-induced nephrotoxicity in rats. J Nat Med. 67:159–167. 2013. View Article : Google Scholar

15 

Staniszewski A, Slesak B, Kołodziej J, Harłozińska-Szmyrka A and Nowicky JW: Lymphocyte subsets in patients with lung cancer treated with thiophosphoric acid alkaloid derivatives from Chelidonium majus L. (Ukrain). Drugs Exp Clin Res. 18(Suppl): 63–67. 1992.PubMed/NCBI

16 

Kadan P, Korsh OB and Melnyk A: Ukrain therapy of recurrent breast cancer with lung metastases (case report). Drugs Exp Clin Res. 22:243–245. 1996.PubMed/NCBI

17 

Uglyanitsa KN, Nechiporenko NA, Nefyodov LI, Doroshenko YM, Brzosko W and Nowicky W: Results of Ukrain monotherapy of prostate cancer. Drugs Exp Clin Res. 26:191–193. 2000.

18 

Zemskov V, Prokopchuk O, Susak Y, Zemskov S, Tkachenko O, Hodysh Y and Nowicky W: Efficacy of ukrain in the treatment of pancreatic cancer. Langenbecks Arch Surg. 387:84–89. 2002. View Article : Google Scholar : PubMed/NCBI

19 

El-Readi MZ, Eid S, Ashour ML, Tahrani A and Wink M: Modulation of multidrug resistance in cancer cells by cheli-donine and Chelidonium majus alkaloids. Phytomedicine. 20:282–294. 2013. View Article : Google Scholar

20 

Hammerová J, Uldrijan S, Táborská E and Slaninová I: Benzo[c] phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status. J Dermatol Sci. 62:22–35. 2011.

21 

Kaminskyy V, Kulachkovskyy O and Stoika R: A decisive role of mitochondria in defining rate and intensity of apoptosis induction by different alkaloids. Toxicol Lett. 177:168–181. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Vitale I, Galluzzi L, Castedo M and Kroemer G: Mitotic catastrophe: A mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol. 12:385–392. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Caruso R, Fedele F, Lucianò R, Branca G, Parisi C, Paparo D and Parisi A: Mitotic catastrophe in malignant epithelial tumors: The pathologis'/s viewpoint. Ultrastruct Pathol. 35:66–71. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Lindgren T, Stigbrand T, Johansson L, Riklund K and Eriksson D: Alterations in gene expression during radiation-induced mitotic catastrophe in HeLa Hep2 cells. Anticancer Res. 34:3875–3880. 2014.PubMed/NCBI

25 

Grzanka D, Marszałek A, Izdebska M, Gackowska L, Andrzej Szczepanski M and Grzanka A: Actin cytoskeleton reorganization correlates with cofilin nuclear expression and ultrastructural changes in cho aa8 cell line after apoptosis and mitotic catastrophe induction by doxorubicin. Ultrastruct Pathol. 35:130–138. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Wang X, Wu E, Wu J, Wang TL, Hsieh HP and Liu X: An antimitotic and antivascular agent BPR0L075 overcomes multidrug resistance and induces mitotic catastrophe in paclitaxel-resistant ovarian cancer cells. PLoS One. 8:e656862013. View Article : Google Scholar : PubMed/NCBI

27 

Magalska A, Sliwinska M, Szczepanowska J, Salvioli S, Franceschi C and Sikora E: Resistance to apoptosis of HCW-2 cells can be overcome by curcumin- or vincristine-induced mitotic catastrophe. Int J Cancer. 119:1811–1818. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Mansilla S, Bataller M and Portugal J: Mitotic catastrophe as a consequence of chemotherapy. Anticancer Agents Med Chem. 6:589–602. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Kemény-Beke A, Aradi J, Damjanovich J, Beck Z, Facskó A, Berta A and Bodnár A: Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine. Cancer Lett. 237:67–75. 2006. View Article : Google Scholar

30 

Philchenkov A, Kaminskyy V, Zavelevich M and Stoika R: Apoptogenic activity of two benzophenanthridine alkaloids from Chelidonium majus L. does not correlate with their DNA damaging effects. Toxicol In Vitro. 22:287–295. 2008. View Article : Google Scholar

31 

Panzer A, Joubert AM, Bianchi PC, Hamel E and Seegers JC: The effects of chelidonine on tubulin polymerisation, cell cycle progression and selected signal transmission pathways. Eur J Cell Biol. 80:111–118. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Ji YB, Qu ZY and Zou X: Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway. Exp Toxicol Pathol. 63:69–78. 2011. View Article : Google Scholar

33 

Kundu S, Kim TH, Yoon JH, Shin HS, Lee J, Jung JH and Kim HS: Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells. Int J Oncol. 45:2331–2340. 2014.PubMed/NCBI

34 

Roy RV, Suman S, Das TP, Luevano JE and Damodaran C: Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells. J Nat Prod. 76:1909–1915. 2013. View Article : Google Scholar : PubMed/NCBI

35 

de-Sá-Júnior PL, Pasqualoto KF, Ferreira AK, Tavares MT, Damião MC, de Azevedo RA, Câmara DA, Pereira A, de Souza DM and Parise Filho R: RPF101, a new capsaicin-like analogue, disrupts the microtubule network accompanied by arrest in the G2/M phase, inducing apoptosis and mitotic catastrophe in the MCF-7 breast cancer cells. Toxicol Appl Pharmacol. 266:385–398. 2013. View Article : Google Scholar

36 

Suematsu T, Li Y, Kojima H, Nakajima K, Oshimura M and Inoue T: Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition. Biochem Biophys Res Commun. 453:588–594. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Yu H: Regulation of APC-Cdc20 by the spindle checkpoint. Curr Opin Cell Biol. 14:706–714. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Lane SI and Jones KT: Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes. Nat Commun. 5:34442014. View Article : Google Scholar : PubMed/NCBI

39 

Kapanidou M, Lee S and Bolanos-Garcia VM: BubR1 kinase: Protection against aneuploidy and premature aging. Trends Mol Med. 21:364–372. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Bolanos-Garcia VM, Nilsson J and Blundell TL: The architecture of the BubR1 tetratricopeptide tandem repeat defines a protein motif underlying mitotic checkpoint-kinetochore communication. Bioarchitecture. 2:23–27. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Ibrahim B: Systems biology modeling of five pathways for regulation and potent inhibition of the anaphase-promoting complex (APC/C): Pivotal roles for MCC and BubR1. OMICS. 19:294–305. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Lentini L, Piscitello D, Veneziano L and Di Leonardo A: Simultaneous reduction of MAD2 and BUBR1 expression induces mitotic spindle alterations associated with p53 dependent cell cycle arrest and death. Cell Biol Int. 38:933–941. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Patel D and McCance DJ: Compromised spindle assembly checkpoint due to altered expression of Ubch10 and Cdc20 in human papillomavirus type 16 E6- and E7-expressing keratinocytes. J Virol. 84:10956–10964. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Lara-Gonzalez P, Scott MI, Diez M, Sen O and Taylor SS: BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. J Cell Sci. 124:4332–4345. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Brito DA and Rieder CL: Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Curr Biol. 16:1194–1200. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Galán-Malo P, Vela L, Gonzalo O, Calvo-Sanjuán R, Gracia-Fleta L, Naval J and Marzo I: Cell fate after mitotic arrest in different tumor cells is determined by the balance between slippage and apoptotic threshold. Toxicol Appl Pharmacol. 258:384–393. 2012. View Article : Google Scholar

47 

Qi M, Yao G, Fan S, Cheng W, Tashiro S, Onodera S and Ikejima T: Pseudolaric acid B induces mitotic catastrophe followed by apoptotic cell death in murine fibrosarcoma L929 cells. Eur J Pharmacol. 683:16–26. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Liu WT, Chen C, Lu IC, Kuo SC, Lee KH, Chen TL, Song TS, Lu YL, Gean PW and Hour MJ: MJ-66 induces malignant glioma cells G2/M phase arrest and mitotic catastrophe through regulation of cyclin B1/Cdk1 complex. Neuropharmacology. 86:219–227. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Jin SQ and Zhan QM: Cell cycle checkpoint and tumour. Molecular Oncology. Liu S: People's Medical Publishing House; Beijing: pp. p3642005

50 

Giovinazzi S, Bellapu D, Morozov VM and Ishov AM: Targeting mitotic exit with hyperthermia or APC/C inhibition to increase paclitaxel efficacy. Cell Cycle. 12:2598–2607. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Castedo M, Perfettini JL, Roumier T, Valent A, Raslova H, Yakushijin K, Horne D, Feunteun J, Lenoir G, Medema R, et al: Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy. Oncogene. 23:4362–4370. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Qu Z, Zou X, Zhang X, Sheng J, Wang Y, Wang J, Wang C and Ji Y: Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells. Mol Med Rep 13: 1336-1344, 2016.
APA
Qu, Z., Zou, X., Zhang, X., Sheng, J., Wang, Y., Wang, J. ... Ji, Y. (2016). Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells. Molecular Medicine Reports, 13, 1336-1344. https://doi.org/10.3892/mmr.2015.4683
MLA
Qu, Z., Zou, X., Zhang, X., Sheng, J., Wang, Y., Wang, J., Wang, C., Ji, Y."Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells". Molecular Medicine Reports 13.2 (2016): 1336-1344.
Chicago
Qu, Z., Zou, X., Zhang, X., Sheng, J., Wang, Y., Wang, J., Wang, C., Ji, Y."Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells". Molecular Medicine Reports 13, no. 2 (2016): 1336-1344. https://doi.org/10.3892/mmr.2015.4683
Copy and paste a formatted citation
x
Spandidos Publications style
Qu Z, Zou X, Zhang X, Sheng J, Wang Y, Wang J, Wang C and Ji Y: Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells. Mol Med Rep 13: 1336-1344, 2016.
APA
Qu, Z., Zou, X., Zhang, X., Sheng, J., Wang, Y., Wang, J. ... Ji, Y. (2016). Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells. Molecular Medicine Reports, 13, 1336-1344. https://doi.org/10.3892/mmr.2015.4683
MLA
Qu, Z., Zou, X., Zhang, X., Sheng, J., Wang, Y., Wang, J., Wang, C., Ji, Y."Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells". Molecular Medicine Reports 13.2 (2016): 1336-1344.
Chicago
Qu, Z., Zou, X., Zhang, X., Sheng, J., Wang, Y., Wang, J., Wang, C., Ji, Y."Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells". Molecular Medicine Reports 13, no. 2 (2016): 1336-1344. https://doi.org/10.3892/mmr.2015.4683
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team