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Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer

  • Authors:
    • Yutaka Kimura
    • Satoko Morohashi
    • Tadashi Yoshizawa
    • Takahiro Suzuki
    • Hajime Morohashi
    • Yoshiyuki Sakamoto
    • Motoi Koyama
    • Akihiko Murata
    • Hiroshi Kijima
    • Kenichi Hakamada
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine and Hospital, Hirosaki, Aomori 036‑8562, Japan, Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine and Hospital, Hirosaki, Aomori 036‑8562, Japan
    Copyright: © Kimura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1551-1557
    |
    Published online on: December 17, 2015
       https://doi.org/10.3892/mmr.2015.4687
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Abstract

Colorectal cancer is a common malignant disease, the incidence of which is increasing worldwide, therefore, identifying novel prognostic factors to improve adjuvant therapeutic strategies or postoperative monitoring is required. Angiogenesis, which is assessed by microvessel density (MVD), is significant in tumor growth and metastasis. However, the association between angiogenesis and clinical outcome remains controversial. In the present study, 84 surgically resected cases of colorectal cancer were examined to clarify the clinicopathological significance of vascular endothelial growth factor (VEGF), thymidine phosphorylase (TP) and cluster of differentiation (CD)34 expression levels. VEGF expression was identified to be significantly correlated with TP expression (r=0.45; P<0.0001) and MVD in the high VEGF expression group was observed to be significantly greater than that in the low VEGF expression group (P=0.0194). In the Dukes' stage D group, the MVD in the high TP expression group was significantly greater than that in the low TP expression group (P=0.0149). High VEGF expression was subsequently correlated with a short overall survival rate for patients exhibiting lymph node metastasis (P=0.0128); however, there was no significant difference in overall survival rate regarding the expression levels of TP and CD34. The results of the present study indicate that VEGF expression may serve as a prognostic factor for colorectal cancer patients exhibiting lymph node metastasis. Furthermore, angiogenesis, as assessed by MVD, is an important prognostic factor for tumor growth at the primary site.
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Copy and paste a formatted citation
Spandidos Publications style
Kimura Y, Morohashi S, Yoshizawa T, Suzuki T, Morohashi H, Sakamoto Y, Koyama M, Murata A, Kijima H, Hakamada K, Hakamada K, et al: Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer. Mol Med Rep 13: 1551-1557, 2016.
APA
Kimura, Y., Morohashi, S., Yoshizawa, T., Suzuki, T., Morohashi, H., Sakamoto, Y. ... Hakamada, K. (2016). Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer. Molecular Medicine Reports, 13, 1551-1557. https://doi.org/10.3892/mmr.2015.4687
MLA
Kimura, Y., Morohashi, S., Yoshizawa, T., Suzuki, T., Morohashi, H., Sakamoto, Y., Koyama, M., Murata, A., Kijima, H., Hakamada, K."Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer". Molecular Medicine Reports 13.2 (2016): 1551-1557.
Chicago
Kimura, Y., Morohashi, S., Yoshizawa, T., Suzuki, T., Morohashi, H., Sakamoto, Y., Koyama, M., Murata, A., Kijima, H., Hakamada, K."Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer". Molecular Medicine Reports 13, no. 2 (2016): 1551-1557. https://doi.org/10.3892/mmr.2015.4687
Copy and paste a formatted citation
x
Spandidos Publications style
Kimura Y, Morohashi S, Yoshizawa T, Suzuki T, Morohashi H, Sakamoto Y, Koyama M, Murata A, Kijima H, Hakamada K, Hakamada K, et al: Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer. Mol Med Rep 13: 1551-1557, 2016.
APA
Kimura, Y., Morohashi, S., Yoshizawa, T., Suzuki, T., Morohashi, H., Sakamoto, Y. ... Hakamada, K. (2016). Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer. Molecular Medicine Reports, 13, 1551-1557. https://doi.org/10.3892/mmr.2015.4687
MLA
Kimura, Y., Morohashi, S., Yoshizawa, T., Suzuki, T., Morohashi, H., Sakamoto, Y., Koyama, M., Murata, A., Kijima, H., Hakamada, K."Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer". Molecular Medicine Reports 13.2 (2016): 1551-1557.
Chicago
Kimura, Y., Morohashi, S., Yoshizawa, T., Suzuki, T., Morohashi, H., Sakamoto, Y., Koyama, M., Murata, A., Kijima, H., Hakamada, K."Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer". Molecular Medicine Reports 13, no. 2 (2016): 1551-1557. https://doi.org/10.3892/mmr.2015.4687
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