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Article

Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways

  • Authors:
    • Shengqin Li
    • Guangju Zhao
    • Longwang Chen
    • Yinwei Ding
    • Jie Lian
    • Guangliang Hong
    • Zhongqiu Lu
  • View Affiliations / Copyright

    Affiliations: Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
  • Pages: 1833-1838
    |
    Published online on: December 23, 2015
       https://doi.org/10.3892/mmr.2015.4710
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Abstract

Sirtuin 1 (SIRT1) acts via the deacetylation of a number of crucial transcription factors and has been implicated in various biological processes, including oxidative stress. Previous studies have indicated that nuclear factor, erythroid 2‑like 2 (NRF2) is an effective target of antioxidant therapy for paraquat (PQ) poisoning. However, the association between SIRT1 and NRF2 and their effects in PQ‑induced oxidative stress remains to be elucidated. The current study demonstrated that PQ exposure upregulated the expression of SIRT1 and NRF2 following 6‑ and 24‑h exposure in the lungs of mice. However, long‑term exposure to PQ significantly decreased the expression of SIRT1 and NRF2. Resveratrol is a SIRT1 activator, and strongly enhanced SIRT1 expression and attenuated the lung injury resulting from PQ exposure in the current study. Additionally, treatment with resveratrol upregulated the expression of NRF2 and glutathione, increased the activity of heme oxygenase‑1, superoxide dismutase and catalase, but depleted the expression of malondialdehyde. The present results demonstrated that resveratrol reduced PQ‑induced oxidative stress and lung injury, potentially through the positive feedback signaling loop between SIRT1 and NRF2.
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View References

1 

Gawarammana IB and Buckley NA: Medical management of paraquat ingestion. Br J Clin Pharmacol. 72:745–757. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Blanco-Ayala T, Andérica-Romero AC and Pedraza-Chaverri J: New insights into antioxidant strategies against paraquat toxicity. Free Radic Res. 48:623–640. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Hong GL, Liu JM, Zhao GJ, Wang L, Liang G, Wu B, Li MF, Qiu QM and Lu ZQ: The reversal of paraquat-induced mitochondria-mediated apoptosis by cycloartenyl ferulate, the important role of Nrf2 pathway. Exp Cell Res. 319:2845–2855. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Caito S, Rajendrasozhan S, Cook S, Chung S, Yao H, Friedman AE, Brookes PS and Rahman I: SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J. 24:3145–3159. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Salminen A, Kaarniranta K and Kauppinen A: Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process. Int J Mol Sci. 14:3834–3859. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Hong GL, Cai QQ, Tan JP, Jiang XZ, Zhao GJ, Wu B, Li MF, Qiu QM and Lu ZQ: Mifepristone-inducible recombinant adenovirus attenuates paraquat-induced lung injury in rats. Hum Exp Toxicol. 34:32–43. 2015. View Article : Google Scholar

7 

Kawai Y, Garduño L, Theodore M, Yang J and Arinze IJ: Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. J Biol Chem. 286:7629–7640. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Huang K, Huang J, Xie X, Wang S, Chen C, Shen X, Liu P and Huang H: Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells. Free Radic Biol Med. 65:528–540. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Huang K, Chen C, Hao J, Huang J, Wang S, Liu P and Huang H: Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells. Mol Cell Endocrinol. 399:178–189. 2015. View Article : Google Scholar

10 

Leonard SS, Xia C, Jiang BH, Stinefelt B, Klandorf H, Harris GK and Shi X: Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses. Biochem Biophys Res Commun. 309:1017–1026. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Borra MT, Smith BC and Denu JM: Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 280:17187–17195. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Novelle MG, Wahl D, Diéguez C, Bernier M and de Cabo R: Resveratrol supplementation: Where are we now and where should we go? Ageing Res Rev. 21:1–15. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Rivera H, Shibayama M, Tsutsumi V, Perez-Alvarez V and Muriel P: Resveratrol and trimethylated resveratrol protect from acute liver damage induced by CCl4 in the rat. J Appl Toxicol. 28:147–155. 2008. View Article : Google Scholar

14 

Hoet PHM and Nemery B: Polyamines in the lung: Polyamine uptake and polyamine-linked pathological or toxicological conditions. Am J Physiol Lung Cell Mol Physiol. 278:L417–L433. 2000.PubMed/NCBI

15 

Dinis-Oliveira RJ, Pontes H, Bastos ML, Remião F, Duarte JA and Carvalho F: An effective antidote for paraquat poisonings: The treatment with lysine acetylsalicylate. Toxicology. 255:187–193. 2009. View Article : Google Scholar

16 

Cantó C and Auwerx J: Targeting sirtuin 1 to improve metabolism: All you need is NAD(+)? Pharmacol Rev. 64:166–187. 2012. View Article : Google Scholar

17 

Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF and Sadoshima J: Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res. 100:1512–1521. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Cao C, Lu S, Kivlin R, Wallin B, Card E, Bagdasarian A, Tamakloe T, Wang WJ, Song X, Chu WM, et al: SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes. J Cell Mol Med. 13(9B): 3632–3643. 2009. View Article : Google Scholar

19 

Hasegawa K, Wakino S, Yoshioka K, Tatematsu S, Hara Y, Minakuchi H, Washida N, Tokuyama H, Hayashi K and Itoh H: Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression. Biochem Biophys Res Commun. 372:51–56. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Cho HY, Reddy SP and Kleeberger SR: Nrf2 defends the lung from oxidative stress. Antioxid Redox Signal. 8:76–87. 2006. View Article : Google Scholar : PubMed/NCBI

21 

He XY, Zhao GJ, Lu ZQ, Hong GL, He F, Liang H, Qiu QM and Li JR: Oxidative stress of acute paraquat poisoned rats and sodium dimercaptopropane sulfonate intervention. Chin J Ind Hyg Occup Dis. 27:476–479. 2009.

22 

Jiang XZ, Song Q, Xu XP, Cai QQ, Hong GL, Liang H and Lu ZQ: The effects of Nrf2 gene expression induced by RU486 at different doses on A549 cell damage induced by paraquat. Chin J Ind Hyg Occup Dis. 30:268–272. 2012.

23 

Yang Y, Li W, Liu Y, Sun Y, Li Y, Yao Q, Li J, Zhang Q, Gao Y, Gao L, et al: Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 25:1207–1217. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Mercado N, Thimmulappa R, Thomas CM, Fenwick PS, Chana KK, Donnelly LE, Biswal S, Ito K and Barnes PJ: Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress. Biochem Biophys Res Commun. 406:292–298. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li S, Zhao G, Chen L, Ding Y, Lian J, Hong G and Lu Z: Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways. Mol Med Rep 13: 1833-1838, 2016.
APA
Li, S., Zhao, G., Chen, L., Ding, Y., Lian, J., Hong, G., & Lu, Z. (2016). Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways. Molecular Medicine Reports, 13, 1833-1838. https://doi.org/10.3892/mmr.2015.4710
MLA
Li, S., Zhao, G., Chen, L., Ding, Y., Lian, J., Hong, G., Lu, Z."Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways". Molecular Medicine Reports 13.2 (2016): 1833-1838.
Chicago
Li, S., Zhao, G., Chen, L., Ding, Y., Lian, J., Hong, G., Lu, Z."Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways". Molecular Medicine Reports 13, no. 2 (2016): 1833-1838. https://doi.org/10.3892/mmr.2015.4710
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Zhao G, Chen L, Ding Y, Lian J, Hong G and Lu Z: Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways. Mol Med Rep 13: 1833-1838, 2016.
APA
Li, S., Zhao, G., Chen, L., Ding, Y., Lian, J., Hong, G., & Lu, Z. (2016). Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways. Molecular Medicine Reports, 13, 1833-1838. https://doi.org/10.3892/mmr.2015.4710
MLA
Li, S., Zhao, G., Chen, L., Ding, Y., Lian, J., Hong, G., Lu, Z."Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways". Molecular Medicine Reports 13.2 (2016): 1833-1838.
Chicago
Li, S., Zhao, G., Chen, L., Ding, Y., Lian, J., Hong, G., Lu, Z."Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways". Molecular Medicine Reports 13, no. 2 (2016): 1833-1838. https://doi.org/10.3892/mmr.2015.4710
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