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Review

Adenosine triphosphate-sensitive potassium channels and cardiomyopathies (Review)

  • Authors:
    • Zhongwei Liu
    • Hui Cai
    • Yonghui Dang
    • Chuan Qiu
    • Junkui Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China, Department of Anesthesiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, College of Medicine and Forensics, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, P.R. China, Department of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans 70112‑2705, LA, USA
  • Pages: 1447-1454
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    Published online on: December 23, 2015
       https://doi.org/10.3892/mmr.2015.4714
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Abstract

Cardiomyopathies have been indicated to be one of the leading causes of heart failure. Though it was indicated that genetic defects, viral infection and trace element deficiency were among the causes of cardiomyopathy, the etiology has remained to be fully elucidated. Cardiomyocytes require large amounts of energy to maintain their normal biological functions. Adenosine triphosphate‑sensitive potassium channels (KATP), composed of inward‑rectifier potassium ion channel and sulfonylurea receptor subunits, are present on the cell surface and mitochondrial membrane of cardiac muscle cells. As metabolic sensors sensitive to changes in intracellular energy levels, KATP adapt electrical activities to metabolic challenges, maintaining normal biological functions of myocytes. It is implied that malfunctions, mutations and altered expression of KATP are associated with the pathogenesis of conditions including c hypertrophy, diabetes as well as dilated, ischemic and endemic cardiomyopathy. However, the current knowledge is only the tip of the iceberg and the roles of KATP in cardiomyopathies largely remain to be elucidated in future studies.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Cai H, Dang Y, Qiu C and Wang J: Adenosine triphosphate-sensitive potassium channels and cardiomyopathies (Review). Mol Med Rep 13: 1447-1454, 2016.
APA
Liu, Z., Cai, H., Dang, Y., Qiu, C., & Wang, J. (2016). Adenosine triphosphate-sensitive potassium channels and cardiomyopathies (Review). Molecular Medicine Reports, 13, 1447-1454. https://doi.org/10.3892/mmr.2015.4714
MLA
Liu, Z., Cai, H., Dang, Y., Qiu, C., Wang, J."Adenosine triphosphate-sensitive potassium channels and cardiomyopathies (Review)". Molecular Medicine Reports 13.2 (2016): 1447-1454.
Chicago
Liu, Z., Cai, H., Dang, Y., Qiu, C., Wang, J."Adenosine triphosphate-sensitive potassium channels and cardiomyopathies (Review)". Molecular Medicine Reports 13, no. 2 (2016): 1447-1454. https://doi.org/10.3892/mmr.2015.4714
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Cai H, Dang Y, Qiu C and Wang J: Adenosine triphosphate-sensitive potassium channels and cardiomyopathies (Review). Mol Med Rep 13: 1447-1454, 2016.
APA
Liu, Z., Cai, H., Dang, Y., Qiu, C., & Wang, J. (2016). Adenosine triphosphate-sensitive potassium channels and cardiomyopathies (Review). Molecular Medicine Reports, 13, 1447-1454. https://doi.org/10.3892/mmr.2015.4714
MLA
Liu, Z., Cai, H., Dang, Y., Qiu, C., Wang, J."Adenosine triphosphate-sensitive potassium channels and cardiomyopathies (Review)". Molecular Medicine Reports 13.2 (2016): 1447-1454.
Chicago
Liu, Z., Cai, H., Dang, Y., Qiu, C., Wang, J."Adenosine triphosphate-sensitive potassium channels and cardiomyopathies (Review)". Molecular Medicine Reports 13, no. 2 (2016): 1447-1454. https://doi.org/10.3892/mmr.2015.4714
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