Effect of bone marrow-derived stem cells on chondrocytes from patients with osteoarthritis

  • Authors:
    • Qiangzhi Zhang
    • Yong Chen
    • Qiang Wang
    • Chaoyong Fang
    • Yu Sun
    • Tao Yuan
    • Yuebei Wang
    • Rongni Bao
    • Ningjian Zhao
  • View Affiliations

  • Published online on: December 28, 2015     https://doi.org/10.3892/mmr.2015.4720
  • Pages: 1795-1800
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Increasing numbers of individuals are suffering from osteoarthritis every year, and the directed intra‑articular injection of bone marrow stem cells has provided a promising treatment strategy for osteoarthritis. Although a number of studies have demonstrated that intra‑articular injection of bone marrow stem cells produced desirable results, the mechanism underlying this effect has not been elucidated. In the current study, the effect of bone marrow stem cells on chondrocytes from patients with osteoarthritis was observed in a co‑culture system. Human chondrocytes were obtained from patients with osteoarthritis who underwent surgical procedures and bone marrow stem cells were obtained from bone marrow aspirates, and then the chondrocytes were then cultured alone or cocultured with bone marrow stem cells in 0.4-µm Transwell inserts. The differentiation and biological activity of chondrocytes in the culture system were measured, and the inflammatory factors and OA‑associated markers were also measured. The results indicated that coculture with human bone marrow stem cells increases cell proliferation of chondrocytes and inhibits inflammatory activity in osteoarthritis.
View Figures
View References

Related Articles

Journal Cover

February-2016
Volume 13 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Chen Y, Wang Q, Fang C, Sun Y, Yuan T, Wang Y, Bao R and Zhao N: Effect of bone marrow-derived stem cells on chondrocytes from patients with osteoarthritis. Mol Med Rep 13: 1795-1800, 2016
APA
Zhang, Q., Chen, Y., Wang, Q., Fang, C., Sun, Y., Yuan, T. ... Zhao, N. (2016). Effect of bone marrow-derived stem cells on chondrocytes from patients with osteoarthritis. Molecular Medicine Reports, 13, 1795-1800. https://doi.org/10.3892/mmr.2015.4720
MLA
Zhang, Q., Chen, Y., Wang, Q., Fang, C., Sun, Y., Yuan, T., Wang, Y., Bao, R., Zhao, N."Effect of bone marrow-derived stem cells on chondrocytes from patients with osteoarthritis". Molecular Medicine Reports 13.2 (2016): 1795-1800.
Chicago
Zhang, Q., Chen, Y., Wang, Q., Fang, C., Sun, Y., Yuan, T., Wang, Y., Bao, R., Zhao, N."Effect of bone marrow-derived stem cells on chondrocytes from patients with osteoarthritis". Molecular Medicine Reports 13, no. 2 (2016): 1795-1800. https://doi.org/10.3892/mmr.2015.4720