bZIP transmembrane transcription factor CREBH: Potential role in non‑alcoholic fatty liver disease (Review)

  • Authors:
    • Min Wang
    • Shuiping Zhao
    • Mingyue Tan
  • View Affiliations

  • Published online on: December 30, 2015     https://doi.org/10.3892/mmr.2015.4749
  • Pages: 1455-1462
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Abstract

The cyclic adenosine monophosphate (cAMP)‑responsive element‑binding protein H (CREBH) is a transcription factor localized to the endoplasmic reticulum (ER) membrane. Previous studies have demonstrated that CREBH is activated by ER stress, hepatic glucose and lipid metabolism signaling, and inflammation. Thus, it may be critical in the regulation of various physiological functions associated with the development of non‑alcoholic fatty liver disease (NAFLD), which results from inflammation and disorder of hepatic glucose and lipid metabolism. Therefore, CREBH may have potential as a pharmacological target for NAFLD. This review summarizes recent scientific developments and the biological actions of CREBH with a particular focus on its involvement in NAFLD.
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February-2016
Volume 13 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang M, Zhao S and Tan M: bZIP transmembrane transcription factor CREBH: Potential role in non‑alcoholic fatty liver disease (Review). Mol Med Rep 13: 1455-1462, 2016
APA
Wang, M., Zhao, S., & Tan, M. (2016). bZIP transmembrane transcription factor CREBH: Potential role in non‑alcoholic fatty liver disease (Review). Molecular Medicine Reports, 13, 1455-1462. https://doi.org/10.3892/mmr.2015.4749
MLA
Wang, M., Zhao, S., Tan, M."bZIP transmembrane transcription factor CREBH: Potential role in non‑alcoholic fatty liver disease (Review)". Molecular Medicine Reports 13.2 (2016): 1455-1462.
Chicago
Wang, M., Zhao, S., Tan, M."bZIP transmembrane transcription factor CREBH: Potential role in non‑alcoholic fatty liver disease (Review)". Molecular Medicine Reports 13, no. 2 (2016): 1455-1462. https://doi.org/10.3892/mmr.2015.4749