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Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain‑derived neurotrophic factor in APP/PS1 transgenic mice

  • Authors:
    • Ruhui Lin
    • Jixiang Chen
    • Xiaojie Li
    • Jingjie Mao
    • Yunan Wu
    • Peiyuan Zhuo
    • Yinzheng Zhang
    • Weilin Liu
    • Jia Huang
    • Jing Tao
    • Li‑Dian Chen
  • View Affiliations / Copyright

    Affiliations: College of Rehabilitation Medicine, Fujian University of Traditional Medicine, Fuzhou, Fujian 350122, P.R. China, Academy of Integrative Medicine Biomedical Research Center, Fuzhou, Fujian 350122, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1611-1617
    |
    Published online on: December 31, 2015
       https://doi.org/10.3892/mmr.2015.4751
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Abstract

Alzheimer's disease (AD) is a common human neurodegenerative disorder characterized by progressive deterioration of cognition and memory. Acupuncture at the Baihui (DU20) acupoint has long been used in China to clinically treat cognitive impairment. However, the precise mechanism underlying its neuroprotective effects remains to be elucidated. In the present study, electroacupuncture (EA) at the Baihui (DU20) acupoint was observed to markedly ameliorate cognitive impairments, reduce the aberrant overexpression of β‑amyloid(1‑42), and inhibit neuronal apoptosis in APP/PS1 mice. As brain‑derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of AD, the expression and processing of BDNF in APP/PS1 mice was investigated. EA at the Baihui (DU20) acupoint was indicated to significantly enhance the expression levels of mature BDNF and proBDNF in APP/PS1 mice. Furthermore, an increase in the BDNF/proBDNF ratio, upregulation of the expression levels of phosphorylated tropomyosin receptor kinase B and a decrease in the expression level of p75 neurotrophin receptor were also observed in the APP/PS1 mice. The present study demonstrates the efficacy of EA at the Baihui (DU20) acupoint in the treatment of cognitive impairments in APP/PS1 transgenic mice. The present study hypothesized that modulation of BDNF expression and processing may be the underlying mechanism by which stimulation of the Baihui (DU20) acupoint exerts its neuroprotective effect.
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1 

Mayeux R: Clinical practice. Early Alzheimer's disease. N Engl J Med. 362:2194–2201. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Querfurth HW and LaFerla FM: Alzheimer's disease. N Engl J Med. 362:329–344. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Serrano-Pozo A, Frosch MP, Masliah E and Hyman BT: Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med. 1:a0061892011. View Article : Google Scholar :

4 

Phillips HS, Hains JM, Armanini M, Laramee GR, Johnson SA and Winslow JW: BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron. 7:695–702. 1991. View Article : Google Scholar : PubMed/NCBI

5 

Lee J, Fukumoto H, Orne J, Klucken J, Raju S, Vanderburg CR, Irizarry MC, Hyman BT and Ingelsson M: Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. Exp Neurol. 194:91–96. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Peng S, Wuu J, Mufson EJ and Fahnestock M: Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J Neurochem. 93:1412–1421. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Weinstein G, Beiser AS, Choi SH, Preis SR, Chen TC, Vorgas D, Au R, Pikula A, Wolf PA, DeStefano AL, et al: Serum brain-derived neurotrophic factor and the risk for dementia: The Framingham Heart Study. JAMA Neurol. 71:55–61. 2014. View Article : Google Scholar :

8 

Barker PA: Whither proBDNF? Nat Neurosci. 12:105–106. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Greenberg ME, Xu B, Lu B and Hempstead BL: New insights in the biology of BDNF synthesis and release: Implications in CNS function. J Neurosci. 29:12764–12767. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Yang J, Harte-Hargrove LC, Siao CJ, Marinic T, Clarke R, Ma Q, Jing D, Lafrancois JJ, Bath KG, Mark W, et al: proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus. Cell Reports. 7:796–806. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Minichiello L: TrkB signalling pathways in LTP and learning. Nat Rev Neurosci. 10:850–860. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Arancibia S, Silhol M, Moulière F, Meffre J, Höllinger I, Maurice T and Tapia-Arancibia L: Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats. Neurobiol Dis. 31:316–326. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Kemppainen S, Rantamäki T, Jerónimo-Santos A, Lavasseur G, Autio H, Karpova N, Kärkkäinen E, Stavén S, Vicente Miranda H, Outeiro TF, et al: Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice. Neurobiol Aging. 33:2012.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

14 

Xu ZQ, Li J, Deng J, Jiang XJ and Zhou HD: Effects of proBDNF on cell proliferation and differentiation in hippocampal dentate gyrus in Alzheimer's disease rat model. Chin Med J. 90:1353–1356. 2010.In Chinese.

15 

Feng X, Yang S, Liu J, Huang J, Peng J, Lin J, Tao J and Chen L: Electroacupuncture ameliorates cognitive impairment through inhibition of NF-κB-mediated neuronal cell apoptosis in cerebral ischemia-reperfusion injured rats. Mol Med Rep. 7:1516–1522. 2013.PubMed/NCBI

16 

International Ethical Guidelines for Biomedical Research Involving Human Subjects. WHO/CIOMS; Geneva: 1993

17 

Vorhees CV and Williams MT: Morris water maze: Procedures for assessing spatial and related forms of learning and memory. Nat Protoc. 1:848–858. 2006. View Article : Google Scholar

18 

Selkoe DJ: Alzheimer's disease is a synaptic failure. Science. 298:789–791. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Haas HL, Sergeeva OA and Selbach O: Histamine in the nervous system. Physiol Rev. 88:1183–1241. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Brioni JD, Esbenshade TA, Garrison TR, Bitner SR and Cowart MD: Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. J Pharmacol Exp Ther. 336:38–46. 2011. View Article : Google Scholar

21 

Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D and Jones E: Alzheimer's disease. Lancet. 377:1019–1031. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jäggi F, Wolburg H, Gengler S, et al: Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep. 7:940–946. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL and Sisodia SS: Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron. 19:939–945. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Bilkei-Gorzo A: Genetic mouse models of brain ageing and Alzheimer's disease. Pharmacol Ther. 142:244–257. 2014. View Article : Google Scholar

25 

Binder DK and Scharfman HE: Brain-derived neurotrophic factor. Growth Factors. 22:123–131. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Cosker KE, Courchesne SL and Segal RA: Action in the axon: generation and transport of signaling endosomes. Curr Opin Neurobiol. 18:270–275. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Schindowski K, Belarbi K and Buée L: Neurotrophic factors in Alzheimer's disease: role of axonal transport. Genes, Brain Behav. 7(suppl 1): 43–56. 2008. View Article : Google Scholar

28 

Tapia-Arancibia L, Aliaga E, Silhol M and Arancibia S: New insights into brain BDNF function in normal aging and Alzheimer disease. Brain Res Rev. 59:201–220. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Castello NA, Nguyen MH, Tran JD, Cheng D, Green KN and LaFerla FM: 7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss. PLoS One. 9:e914532014. View Article : Google Scholar : PubMed/NCBI

30 

Lu B, Pang PT and Woo NH: The yin and yang of neurotrophin action. Nat Rev Neurosci. 6:603–614. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, Hempstead BL and Lu B: Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci. 8:1069–1077. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Teng HK, Teng KK, Lee R, Wright S, Tevar S, Almeida RD, Kermani P, Torkin R, Chen ZY, Lee FS, et al: ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci. 25:5455–5463. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lin R, Chen J, Li X, Mao J, Wu Y, Zhuo P, Zhang Y, Liu W, Huang J, Tao J, Tao J, et al: Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain‑derived neurotrophic factor in APP/PS1 transgenic mice. Mol Med Rep 13: 1611-1617, 2016.
APA
Lin, R., Chen, J., Li, X., Mao, J., Wu, Y., Zhuo, P. ... Chen, L. (2016). Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain‑derived neurotrophic factor in APP/PS1 transgenic mice. Molecular Medicine Reports, 13, 1611-1617. https://doi.org/10.3892/mmr.2015.4751
MLA
Lin, R., Chen, J., Li, X., Mao, J., Wu, Y., Zhuo, P., Zhang, Y., Liu, W., Huang, J., Tao, J., Chen, L."Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain‑derived neurotrophic factor in APP/PS1 transgenic mice". Molecular Medicine Reports 13.2 (2016): 1611-1617.
Chicago
Lin, R., Chen, J., Li, X., Mao, J., Wu, Y., Zhuo, P., Zhang, Y., Liu, W., Huang, J., Tao, J., Chen, L."Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain‑derived neurotrophic factor in APP/PS1 transgenic mice". Molecular Medicine Reports 13, no. 2 (2016): 1611-1617. https://doi.org/10.3892/mmr.2015.4751
Copy and paste a formatted citation
x
Spandidos Publications style
Lin R, Chen J, Li X, Mao J, Wu Y, Zhuo P, Zhang Y, Liu W, Huang J, Tao J, Tao J, et al: Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain‑derived neurotrophic factor in APP/PS1 transgenic mice. Mol Med Rep 13: 1611-1617, 2016.
APA
Lin, R., Chen, J., Li, X., Mao, J., Wu, Y., Zhuo, P. ... Chen, L. (2016). Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain‑derived neurotrophic factor in APP/PS1 transgenic mice. Molecular Medicine Reports, 13, 1611-1617. https://doi.org/10.3892/mmr.2015.4751
MLA
Lin, R., Chen, J., Li, X., Mao, J., Wu, Y., Zhuo, P., Zhang, Y., Liu, W., Huang, J., Tao, J., Chen, L."Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain‑derived neurotrophic factor in APP/PS1 transgenic mice". Molecular Medicine Reports 13.2 (2016): 1611-1617.
Chicago
Lin, R., Chen, J., Li, X., Mao, J., Wu, Y., Zhuo, P., Zhang, Y., Liu, W., Huang, J., Tao, J., Chen, L."Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain‑derived neurotrophic factor in APP/PS1 transgenic mice". Molecular Medicine Reports 13, no. 2 (2016): 1611-1617. https://doi.org/10.3892/mmr.2015.4751
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