|
1
|
Goodenberger ML and Jenkins RB: Genetics
of adult glioma. Cancer Genet. 205:613–621. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Stewart LA: Chemotherapy in adult
high-grade glioma: A systematic review and meta-analysis of
individual patient data from 12 randomised trials. Lancet.
359:1011–1018. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Zhu VF, Yang J, Lebrun DG and Li M:
Understanding the role of cytokines in glioblastoma multiforme
pathogenesis. Cancer Lett. 316:139–150. 2012. View Article : Google Scholar
|
|
4
|
Sathornsumetee S, Reardon DA, Desjardins
A, Quinn JA, Vredenburgh JJ and Rich JN: Molecularly targeted
therapy for malignant glioma. Cancer. 110:13–24. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Pulkkanen KJ and Yla-Herttuala S: Gene
therapy for malignant glioma: Current clinical status. Mol Ther.
12:585–598. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Danielsen SA, Eide PW, Nesbakken A, Guren
T, Leithe E and Lothe RA: Portrait of the PI3K/AKT pathway in
colorectal cancer. Biochim Biophys Acta. 1855:104–121. 2015.
|
|
7
|
Follo MY, Manzoli L, Poli A, McCubrey JA
and Cocco L: PLC and PI3K/Akt/mTOR signalling in disease and
cancer. Adv Biol Regul. 57:10–16. 2015. View Article : Google Scholar
|
|
8
|
Carnero A and Paramio JM: The
PTEN/PI3K/AKT pathway in vivo, cancer mouse models. Front Oncol.
4:2522014. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Fine B, Hodakoski C, Koujak S, Su T, Saal
LH, Maurer M, Hopkins B, Keniry M, Sulis ML, Mense S, et al:
Activation of the PI3K pathway in cancer through inhibition of PTEN
by exchange factor P-REX2a. Science. 325:1261–1265. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Joseph RE and Norris FA: Substrate
specificity and recognition is conferred by the pleckstrin homology
domain of the Dbl family guanine nucleotide exchange factor P-Rex2.
J Biol Chem. 280:27508–27512. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Rosenfeldt H, Vázquez-Prado J and Gutkind
JS: P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. FEBS
Lett. 572:167–171. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Pandiella A and Montero JC: Molecular
pathways: P-Rex in cancer. Clin Cancer Res. 19:4564–4569. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Guo B, Liu L, Yao J, Ma R, Chang D, Li Z,
Song T and Huang C: miR-338–3p suppresses gastric cancer
progression through a PTEN-AKT axis by targeting P-REX2a. Mol
Cancer Res. 12:313–321. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Louis DN, Ohgaki H, Wiestler OD, Cavenee
WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007
WHO Classification of Tumours of the Central Nervous System. Acta
Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
16
|
Auffinger B, Thaci B, Ahmed A, Ulasov I
and Lesniak MS: MicroRNA targeting as a therapeutic strategy
against glioma. Curr Mol Med. 13:535–542. 2013. View Article : Google Scholar
|
|
17
|
Marumoto T and Saya H: Molecular biology
of glioma. Adv Exp Med Biol. 746:2–11. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Cantley LC: The phosphoinositide 3-kinase
pathway. Science. 296:1655–1657. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Qin J, Xie Y, Wang B, Hoshino M, Wolff DW,
Zhao J, Scofield MA, Dowd FJ, Lin MF and Tu Y: Upregulation of
PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer
metastasis. Oncogene. 28:1853–1863. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Welch HC, Coadwell WJ, Ellson CD, Ferguson
GJ, Andrews SR, Erdjument-Bromage H, Tempst P, Hawkins PT and
Stephens LR: P-Rex1, a PtdIns (3,4,5)P3- and Gbetagamma-regulated
guanine-nucleotide exchange factor for Rac. Cell. 108:809–821.
2002. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Li Z, Paik JH, Wang Z, Hla T and Wu D:
Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine
1-phosphate-induced Rac1 activation and cell migration in
endothelial cells. Prostaglandins Other Lipid Mediat. 76:95–104.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Chen X, Pan M, Han L, Lu H, Hao X and Dong
Q: miR-338-3p suppresses neuroblastoma proliferation, invasion and
migration through targeting PREX2a. FEBS Lett. 587:3729–3737. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Leslie NR and Downes CP: PTEN function:
How normal cells control it and tumour cells lose it. Biochem J.
382(Pt 1): 1–11. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Yuan TL and Cantley LC: PI3K pathway
alterations in cancer: Variations on a theme. Oncogene.
27:5497–5510. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Barrio-Real L and Kazanietz MG: Rho GEFs
and cancer: Linking gene expression and metastatic dissemination.
Sci Signal. 5:pe432012. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Salmena L, Carracedo A and Pandolfi PP:
Tenets of PTEN tumor suppression. Cell. 133:403–414. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Kwabi-Addo B, Giri D, Schmidt K,
Podsypanina K, Parsons R, Greenberg N and Ittmann M:
Haploinsufficiency of the Pten tumor suppressor gene promotes
prostate cancer progression. Proc Natl Acad Sci USA.
98:11563–11568. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Kwon CH, Zhao D, Chen J, Alcantara S, Li
Y, Burns DK, Mason RP, Lee EY, Wu H and Parada LF: Pten
haploinsufficiency accelerates formation of high-grade
astrocytomas. Cancer Res. 68:3286–3294. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Trotman LC, Niki M, Dotan ZA, Koutcher JA,
Di Cristofano A, Xiao A, Khoo AS, Roy-Burman P, Greenberg NM, Van
Dyke T, et al: Pten dose dictates cancer progression in the
prostate. PLoS Biol. 1:E592003. View Article : Google Scholar : PubMed/NCBI
|
