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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
March-2016 Volume 13 Issue 3

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Identification of diagnostic and prognostic biomarkers for cancer: Focusing on genetic variations in microRNA regulatory pathways (Review)

Zhen Guo, Yan Shu, Honghao Zhou, Wei Zhang
Pages: 1943-1952
Published online on: 14 January 2016

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Article Open Access

Hypoxic preconditioning increases the protective effect of bone marrow mesenchymal stem cells on spinal cord ischemia/reperfusion injury

Zhilin Wang, Bo Fang, Zhibin Tan, Dong Zhang, Hong Ma
Pages: 1953-1960
Published online on: 11 January 2016

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Article Open Access

MicroRNA-610 suppresses the proliferation of human glioblastoma cells by repressing CCND2 and AKT3

Xiaomei Mo, Qian Cao, Hui Liang, Jianmin Liu, Huahui Li, Fenghai Liu
Pages: 1961-1966
Published online on: 12 January 2016

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Article Open Access

Genetic counseling for patients with nonsyndromic hearing impairment directed by gene analysis

Dingyuan Ma, Jingjing Zhang, Chunyu Luo, Ying Lin, Xiuqing Ji, Ping Hu, Zhengfeng Xu
Pages: 1967-1974
Published online on: 13 January 2016

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Article Open Access

Identification of potential therapeutic targets for lung cancer by bioinformatics analysis

Li‑Quan Wang, Lan‑Hua Zhao, Yi‑Ze Qiao
Pages: 1975-1982
Published online on: 31 December 2015

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Article Open Access

Clinical and genetic investigation of families with type II Waardenburg syndrome

Yong Chen, Fuwei Yang, Hexin Zheng, Jianda Zhou, Ganghua Zhu, Peng Hu, Weijing Wu
Pages: 1983-1988
Published online on: 13 January 2016

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Article Open Access

Activation of TRPV1-dependent calcium oscillation exacerbates seawater inhalation-induced acute lung injury

Congcong Li, Liyan Bo, Qingqing Liu, Wei Liu, Xiangjun Chen, Dunquan Xu, Faguang Jin
Pages: 1989-1998
Published online on: 20 January 2016

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Article Open Access

Abnormal expression of key genes and proteins in the canonical Wnt/β-catenin pathway of articular cartilage in a rat model of exercise-induced osteoarthritis

Shen‑Shen Liu, Pu Zhou, Yanqiu Zhang
Pages: 1999-2006
Published online on: 19 January 2016

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Article Open Access

Treatment with the herbal medicine, naoxintong improves the protective effect of high‑density lipoproteins on endothelial function in patients with type 2 diabetes

Pu Lv, Xunliang Tong, Qing Peng, Yuanyuan Liu, Haiqiang Jin, Ran Liu, Wei Sun, Bing Pan, Lemin Zheng, Yining Huang
Pages: 2007-2016
Published online on: 18 January 2016

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Article Open Access

Effects of CCN3 on rat cartilage endplate chondrocytes cultured under serum deprivation in vitro

Lei Ding, Jingping Wu, Defang Li, Houlei Wang, Bin Zhu, Wei Lu, Guoxiong Xu
Pages: 2017-2022
Published online on: 20 January 2016

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Article Open Access

Establishment of mesenchymal stem cell lines derived from the bone marrow of green fluorescent protein‑transgenic mice exhibiting a diversity in intracellular transforming growth factor‑β and bone morphogenetic protein signaling

Shunsuke Sawada, Naoyuki Chosa, Naoki Takizawa, Jun Yokota, Yasuyuki Igarashi, Koichi Tomoda, Hisatomo Kondo, Takashi Yaegashi, Akira Ishisaki
Pages: 2023-2031
Published online on: 18 January 2016

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Article Open Access

Downregulation of B7-H4 in the MHCC97-H hepatocellular carcinoma cell line by arsenic trioxide

Liming Cui, Bo Gao, Zhigang Cao, Xiaoying Chen, Shide Zhang, Weizhe Zhang
Pages: 2032-2038
Published online on: 12 January 2016

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Article Open Access

Knockout of phospholipase Cε attenuates N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder tumorigenesis

Taimao Jiang, Tao Liu, Lin Li, Zhijun Yang, Yunfeng Bai, Dongye Liu, Chuize Kong
Pages: 2039-2045
Published online on: 12 January 2016

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Article Open Access

Inhibition of Rho‑associated protein kinase increases the ratio of formation of blastocysts from single human blastomeres

Sunxing Huang, Chenhui Ding, Qingyun Mai, Yanwen Xu, Canquan Zhou
Pages: 2046-2052
Published online on: 13 January 2016

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Article Open Access

Autologous adipose tissue‑derived mesenchymal stem cells are involved in rat liver regeneration following repeat partial hepatectomy

Tao Liu, Hong Mu, Zhongyang Shen, Zhuolun Song, Xiaobo Chen, Yuliang Wang
Pages: 2053-2059
Published online on: 13 January 2016

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Article Open Access

Opposing needling promotes behavior recovery and exerts neuroprotection via the cAMP/PKA/CREB signal transduction pathway in transient MCAO rats

Yijing Jiang, Shanli Yang, Jing Tao, Zhicheng Lin, Xiaoqian Ye, Yongmei You, Jun Peng, Zhenfeng Hong, Lidian Chen
Pages: 2060-2070
Published online on: 13 January 2016

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Article Open Access

Osteochondral repair with synovial membrane‑derived mesenchymal stem cells

Hong Li, Junchao Qian, Jiwu Chen, Kai Zhong, Shiyi Chen
Pages: 2071-2077
Published online on: 18 January 2016

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Article Open Access

Interruptin B induces brown adipocyte differentiation and glucose consumption in adipose-derived stem cells

Sireewan Kaewsuwan, Anuchit Plubrukarn, Maleeruk Utsintong, Seok‑Ho Kim, Jin‑Hyun Jeong, Jin Gu Cho, Sang Gyu Park, Jong‑Hyuk Sung
Pages: 2078-2086
Published online on: 12 January 2016

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Article Open Access

Native low density lipoprotein promotes lipid raft formation in macrophages

Jian Song, Ling‑Yan Ping, Duc M. Duong, Xiao‑Yan Gao, Chun‑Yan He, Lei Wei, Jun‑Zhu Wu
Pages: 2087-2093
Published online on: 14 January 2016

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Article Open Access

Myricetin induces apoptosis via endoplasmic reticulum stress and DNA double-strand breaks in human ovarian cancer cells

Ye Xu, Qi Xie, Shaohua Wu, Dan Yi, Yang Yu, Shibing Liu, Songyan Li, Zhixin Li
Pages: 2094-2100
Published online on: 12 January 2016

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Article Open Access

RNA sequencing reveals retinal transcriptome changes in STZ‑induced diabetic rats

Yuan‑Jie Liu, Zhi‑Yun Lian, Geng Liu, Hong‑Ying Zhou, Hui‑Jun Yang
Pages: 2101-2109
Published online on: 18 January 2016

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Article Open Access

Gene expression profiling analysis contributes to understanding the association between non-syndromic cleft lip and palate, and cancer

Hongyi Wang, Tao Qiu, Jie Shi, Jiulong Liang, Yang Wang, Liangliang Quan, Yu Zhang, Qian Zhang, Kai Tao
Pages: 2110-2116
Published online on: 20 January 2016

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Article Open Access

Genotype‑phenotype analysis of CYP2C19 in the Tibetan population and its potential clinical implications in drug therapy

Tianbo Jin, Xiyang Zhang, Tingting Geng, Xugang Shi, Li Wang, Dongya Yuan, Longli Kang
Pages: 2117-2123
Published online on: 13 January 2016

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Article

Antitumor effect of dendritic cells transfected with prostate-specific membrane antigen recombinant adenovirus on prostate cancer: An in vitro study

Fan‑Dong Meng, Shuai Wang, You‑Hong Jiang, Cheng‑Guang Sui
Pages: 2124-2134
Published online on: 11 January 2016

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Article

Beneficial effect of farnesoid X receptor activation on metabolism in a diabetic rat model

Hong‑Mei Zhang, Xuan Wang, Zhao‑Hong Wu, Hui‑Ling Liu, Wei Chen, Zhong‑Zhi Zhang, Dan Chen, Tian‑Shu Zeng
Pages: 2135-2142
Published online on: 12 January 2016

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Article

Vaccarin attenuates high glucose-induced human EA•hy926 endothelial cell injury through inhibition of Notch signaling

Yuyu Qiu, Bin Du, Fengshan Xie, Weiwei Cai, Yanling Liu, Yue Li, Lei Feng, Liying Qiu
Pages: 2143-2150
Published online on: 20 January 2016

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Article

Carboxymethylated chitosan protects rat chondrocytes from NO‑induced apoptosis via inhibition of the p38/MAPK signaling pathway

Bin He, Haiying Tao, Shiqing Liu, Ailin Wei, Feng Pan, Ren Chen, Xiaohai Li
Pages: 2151-2158
Published online on: 13 January 2016

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Article

TLR4‑dependent signaling pathway modulation: A novel mechanism by which pioglitazone protects against nutritional fibrotic steatohepatitis in mice

Jinghua Du, Xuemin Niu, Rongqi Wang, Suxian Zhao, Lingbo Kong, Yuguo Zhang, Yuemin Nan
Pages: 2159-2166
Published online on: 13 January 2016

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Article

Human cytomegalovirus RL13 protein interacts with host NUDT14 protein affecting viral DNA replication

Guili Wang, Gaowei Ren, Xin Cui, Zhitao Lu, Yanping Ma, Ying Qi, Yujing Huang, Zhongyang Liu, Zhengrong Sun, Qiang Ruan
Pages: 2167-2174
Published online on: 13 January 2016

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Article

Netrin-1 prevents the development of cardiac hypertrophy and heart failure

Nan Wang, Yunshan Cao, Yan Zhu
Pages: 2175-2181
Published online on: 11 January 2016

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Article

Identification of candidate target genes of pituitary adenomas based on the DNA microarray

Wei Zhou, Chun-Xiao Ma, Ya-Zhou Xing, Zhao-Yue Yan
Pages: 2182-2186
Published online on: 14 January 2016

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Article

Curcumin activates autophagy and attenuates oxidative damage in EA.hy926 cells via the Akt/mTOR pathway

Shouyu Guo, Mingzhi Long, Xiuzhen Li, Shushu Zhu, Min Zhang, Zhijian Yang
Pages: 2187-2193
Published online on: 18 January 2016

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Article

MicroRNA-378 promotes myogenic differentiation by targeting BMP4

Huiming Ju, Yuefei Yang, Anzhi Sheng, Yuyu Qi
Pages: 2194-2200
Published online on: 12 January 2016

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Article

Targeting peroxiredoxin I potentiates 1,25‑dihydroxyvitamin D3‑induced cell differentiation in leukemia cells

Wei Wei, Chuanxu Liu, Dongjun Qin, Lili Song, Li Xia, Hu Lei, Yun Yu, Weiwei Wang, Jianxin Pu, Handong Sun, Yingli Wu, Hanzhang Xu, Siguo Hao
Pages: 2201-2207
Published online on: 14 January 2016

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Article

NS‑398 promotes pancreatic cancer cell invasion by CD147 and MMP‑2 via the activation of P38

Hua Liu, Xuan‑Fu Xu, Yan Zhao, Mao‑Chun Tang, Ying‑Qun Zhou, Feng‑Hou Gao
Pages: 2208-2214
Published online on: 14 January 2016

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Article

Stimulus-dependent neuronal cell responses in SH-SY5Y neuroblastoma cells

Xiguang Sun, Xu Shi, Laijing Lu, Yanfang Jiang, Bin Liu
Pages: 2215-2220
Published online on: 12 January 2016

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Article

MicroRNA-155 enhances the activation of Wnt/β-catenin signaling in colorectal carcinoma by suppressing HMG-box transcription factor 1 Retraction in /10.3892/mmr.2022.12597

Ying‑Chun Wan, Tao Li, Yang‑Dong Han, Hai‑Yan Zhang, Hai Lin, Bin Zhang
Pages: 2221-2228
Published online on: 15 January 2016

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Article

Overexpression of FOXO4 induces apoptosis of clear-cell renal carcinoma cells through downregulation of Bim

Wei Wang, Pang‑Hu Zhou, Wei Hu
Pages: 2229-2234
Published online on: 15 January 2016

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Article

Eriocalyxin B blocks human SW1116 colon cancer cell proliferation, migration, invasion, cell cycle progression and angiogenesis via the JAK2/STAT3 signaling pathway

Yun‑Min Lu, Wei Chen, Jin‑Shui Zhu, Wei‑Xiong Chen, Ni‑Wei Chen
Pages: 2235-2240
Published online on: 19 January 2016

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Article

Association of HNF4α gene polymorphisms with susceptibility to type 2 diabetes

Run Ma, Hongying Yang, Jingfang Li, Xu Yang, Xiaohong Chen, Ying Hu, Zhou Wang, Li Xue, Wei Zhou
Pages: 2241-2246
Published online on: 13 January 2016

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Article

Protective effect of paeoniflorin on inflammation and apoptosis in the cerebral cortex of a transgenic mouse model of Alzheimer's disease

Xinyi Gu, Zhengxu Cai, Ming Cai, Kun Liu, Dan Liu, Qinsong Zhang, Jing Tan, Qiang Ma
Pages: 2247-2252
Published online on: 20 January 2016

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Article

MicroRNA‑451 inhibits neuroblastoma proliferation, invasion and migration by targeting macrophage migration inhibitory factor

Geng Liu, Zhengwei Xu, Dingjun Hao
Pages: 2253-2260
Published online on: 13 January 2016

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Article

Inhibition of WWP2 suppresses proliferation, and induces G1 cell cycle arrest and apoptosis in liver cancer cells

Sheng‑Qian Xu, Yong Qin, De‑Biao Pan, Guan‑Xiong Ye, Cheng‑Jun Wu, Shi Wang, Jin‑Yan Jiang, Jing Fu, Chao‑Jun Wang
Pages: 2261-2266
Published online on: 13 January 2016

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Article

Upregulation of microRNA‑27b contributes to the migration and invasion of gastric cancer cells via the inhibition of sprouty2‑mediated ERK signaling Retraction in /10.3892/mmr.2021.12366

Juan Jiang, Bo Yi, Chunxiang Qin, Siqing Ding, Wei Cao
Pages: 2267-2272
Published online on: 13 January 2016

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Article

Validation of downregulated microRNAs during osteoclast formation and osteoporosis progression

Yan Ma, Zhi Shan, Jianjun Ma, Qiang Wang, Junjie Chu, Peiwei Xu, An Qin, Shunwu Fan
Pages: 2273-2280
Published online on: 12 January 2016

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Article

Resveratrol‑4‑O‑D‑(2'‑galloyl)‑glucopyranoside exerts an anticancer effect on leukemia cells via inducing apoptosis

Pu Chen, Beili Wang, Baishen Pan, Wei Guo
Pages: 2281-2286
Published online on: 13 January 2016

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Article

MicroRNA-497 targets hepatoma-derived growth factor and suppresses human prostate cancer cell motility

Deyao Wu, Xiaobing Niu, Huixing Pan, Zichun Zhang, Yunfeng Zhou, Ping Qu, Jian Zhou
Pages: 2287-2292
Published online on: 11 January 2016

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Article

c‑Jun N‑terminal kinase‑mediated anti‑inflammatory effects of Garcinia subelliptica in macrophages

Young‑Chang Cho, Sayeon Cho
Pages: 2293-2300
Published online on: 18 January 2016

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Article

Knockdown of PREX2a inhibits the malignant phenotype of glioma cells Retraction in /10.3892/mmr.2021.12184

Liang Liu, Zhixiong Liu, Hao Wang, Long Chen, Fuqiang Ruan, Jihui Zhang, Yi Hu, Hengshan Luo, Shuai Wen
Pages: 2301-2307
Published online on: 19 January 2016

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Article

Occult macular dystrophy in an Italian family carrying a mutation in the RP1L1 gene

Stefano Piermarocchi, Tatiana Segato, Alberta Leon, Davide Colavito, Stefania Miotto
Pages: 2308-2312
Published online on: 14 January 2016

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Article

Matrine inhibits the expression of adhesion molecules in activated vascular smooth muscle cells

Jun Liu, Lihua Zhang, Yingang Ren, Yanli Gao, Li Kang, Shaoping Lu
Pages: 2313-2319
Published online on: 13 January 2016

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Article

Allicin attenuates H2O2‑induced cytotoxicity in retinal pigmented epithelial cells by regulating the levels of reactive oxygen species

Gerile Tu, Yu‑Feng Zhang, Wei Wei, Langen Li, Yanmei Zhang, Jia Yang, Yiqiao Xing
Pages: 2320-2326
Published online on: 18 January 2016

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Article

Identification of key pathways and genes in psoriasis via gene microarray analysis

Wei Chen, Kuixia Xie, Xinhua Liu, Hong Chen
Pages: 2327-2337
Published online on: 15 January 2016

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Article

Co-treatment of wild‑type EGFR head and neck cancer cell lines with afatinib and cisplatin

Roman C. Brands, Urs D.A. Müller‑Richter, Francesco De Donno, Axel Seher, Grit Mutzbauer, Christian Linz, Alexander C. Kübler, Stefan Hartmann
Pages: 2338-2344
Published online on: 14 January 2016

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Review

MicroRNA expression pattern in pre-eclampsia (Review)

Deeba S. Jairajpuri, Wassim Y. Almawi
Pages: 2351-2358
Published online on: 02 February 2016

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Review

Regulatory roles of microRNA-21 in fibrosis through interaction with diverse pathways (Review)

Rong‑Han Liu, Bin Ning, Xiao‑En Ma, Wei‑Ming Gong, Tang‑Hong Jia
Pages: 2359-2366
Published online on: 29 January 2016

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Article Open Access

Identification and characterization of an anti-oxidative stress-associated mutant of Aspergillus fumigatus transformed by Agrobacterium tumefaciens

Zhongqi Fan, Huimei Yu, Qi Guo, Dan He, Baiji Xue, Xiangli Xie, Koji Yokoyama, Li Wang
Pages: 2367-2376
Published online on: 01 February 2016

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Article Open Access

Prognostic value of legumain in uveal melanoma

Tong Wu, Lei Sun, Ying Wu, Rong Xiang, Yuwei Li, Weining Rong, Fengyuan Sun, Ningli Wang
Pages: 2377-2384
Published online on: 29 January 2016

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Article Open Access

Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy

Xinlin Wu, Jianxiang Liu, Jianqing Zhang, Heng Liu, Miansheng Yan, Birong Liang, Hongbo Xie, Shijun Zhang, Baoguo Sun, Houming Zhou
Pages: 2385-2392
Published online on: 29 January 2016

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Article Open Access

Chronic sciatic nerve compression induces fibrosis in dorsal root ganglia

Qinwen Li, Jianghai Chen, Yanhua Chen, Xiaobin Cong, Zhenbing Chen
Pages: 2393-2400
Published online on: 27 January 2016

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Article Open Access

Diosmetin inhibits the metastasis of hepatocellular carcinoma cells by downregulating the expression levels of MMP‑2 and MMP‑9

Jie Liu, Xiaojun Wen, Bin Liu, Qingyu Zhang, Jingjing Zhang, Huilai Miao, Runzhi Zhu
Pages: 2401-2408
Published online on: 05 February 2016

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Article Open Access

Age-dependent changes in the protein expression levels of Redd1 and mTOR in the gerbil hippocampus during normal aging

Hee‑Soo Choi, Ji Hyeon Ahn, Joon Ha Park, Moo‑Ho Won, Choong‑Hyun Lee
Pages: 2409-2414
Published online on: 29 January 2016

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Article Open Access

Sinomenine attenuates airway inflammation and remodeling in a mouse model of asthma

Hai‑Rong Bao, Xiao‑Ju Liu, Yun‑Lin Li, Xiang Men, Xiao‑Li Zeng
Pages: 2415-2422
Published online on: 28 January 2016

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Article Open Access

Expression of programmed death 1 ligand 1 on periodontal tissue cells as a possible protective feedback mechanism against periodontal tissue destruction

Jiehua Zhang, Chieh‑Mei Wang, Ping Zhang, Xiaoqian Wang, Jiao Chen, Jun Yang, Wanlu Lu, Wenjie Zhou, Wenwen Yuan, Yun Feng
Pages: 2423-2430
Published online on: 28 January 2016

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Increased expression of dermatopontin and its implications for testicular dysfunction in mice

Jun Cai, Weijia Liu, Jie Hao, Maoxin Chen, Gang Li
Pages: 2431-2438
Published online on: 05 February 2016

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Wnt3a suppresses Pseudomonas aeruginosa‑induced inflammation and promotes bacterial killing in macrophages

Kang Chen, Qiang Fu, Dandan Li, Yongjian Wu, Shijun Sun, Xiuming Zhang
Pages: 2439-2446
Published online on: 05 February 2016

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Effects of different shear rates on the attachment and detachment of platelet thrombi

Xiaofeng Shi, Jichun Yang, Jiansong Huang, Zhangbiao Long, Zheng Ruan, Bing Xiao, Xiaodong Xi
Pages: 2447-2456
Published online on: 28 January 2016

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Clinical features and survival in individuals with trisomy 18: A retrospective one-center study of 44 patients who received intensive care treatments

George Imataka, Hiroshi Suzumura, Osamu Arisaka
Pages: 2457-2466
Published online on: 22 January 2016

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Association of the hERG mutation with long‑QT syndrome type 2, syncope and epilepsy

Guoliang Li, Rui Shi, Jine Wu, Wenqi Han, Aifeng Zhang, Gong Cheng, Xiaolin Xue, Chaofeng Sun
Pages: 2467-2475
Published online on: 04 February 2016

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Targeting of cancer‑associated fibroblasts enhances the efficacy of cancer chemotherapy by regulating the tumor microenvironment

Minmin Li, Mei Li, Tao Yin, Huashan Shi, Yuan Wen, Binglan Zhang, Meihua Chen, Guangchao Xu, Kexin Ren, Yuquan Wei
Pages: 2476-2484
Published online on: 04 February 2016

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Electroacupuncture stimulation at CV4 prevents ovariectomy‑induced osteoporosis in rats via Wnt‑β‑catenin signaling

Huailing Fan, Feng Ji, Ying Lin, Mulan Zhang, Wei Qin, Qi Zhou, Qiang Wu
Pages: 2485-2491
Published online on: 03 February 2016

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Downregulated microRNA-23b promotes BMP9-mediated osteogenesis in C2C12 myoblast cells by targeting Runx2

Chu Chen, Zuchuan Tang, Qiling Song, Min Yang, Qiong Shi, Yaguang Weng
Pages: 2492-2498
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Effect of glutamate on lysosomal membrane permeabilization in primary cultured cortical neurons

Min Yan, Wenbo Zhu, Xiaoke Zheng, Yuan Li, Lipeng Tang, Bingzheng Lu, Wenli Chen, Pengxin Qiu, Tiandong Leng, Suizhen Lin, Guangmei Yan, Wei Yin
Pages: 2499-2505
Published online on: 28 January 2016

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Ultraviolet light-emitting diode irradiation-induced cell death in HL-60 human leukemia cells in vitro

Dong Xie, Yan Sun, Lingzhen Wang, Xiaoling Li, Chuannong Zang, Yunlai Zhi, Lirong Sun
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Intestinal ischemic preconditioning reduces liver ischemia reperfusion injury in rats

Tong‑Min Xue, Li‑De Tao, Jie Zhang, Pei‑Jian Zhang, Xia Liu, Guo‑Feng Chen, Yi‑Jia Zhu
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Anti‑angiogenic therapy for normalization of tumor vasculature: A potential effect of Buyang Huanwu decoction on nude mice bearing human hepatocellular carcinoma xenografts with high metastatic potential

Liang Min, Wei Ling, Rong Hua, Hong Qi, Shenxu Chen, Haiqiao Wang, Lumen Tang, Wenji Shangguan
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Inhibition of miR-29c promotes proliferation, and inhibits apoptosis and differentiation in P19 embryonic carcinoma cells

Bin Chen, Guixian Song, Ming Liu, Lingmei Qian, Lihua Wang, Haitao Gu, Yahui Shen
Pages: 2527-2535
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Nitidine chloride inhibits proliferation and induces apoptosis in colorectal cancer cells by suppressing the ERK signaling pathway

Huiyuan Zhai, Sanyuan Hu, Tongxiang Liu, Feng Wang, Xixun Wang, Guochang Wu, Yifei Zhang, Minghua Sui, Huantao Liu, Lixin Jiang
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β‑catenin signaling pathway regulates cisplatin resistance in lung adenocarcinoma cells by upregulating Bcl‑xl

Jin Zhang, Jie Liu, Hui Li, Jun Wang
Pages: 2543-2551
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Age‑related changes in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats

Yali Li, Jian Liu, Dengfeng Gao, Jin Wei, Haifeng Yuan, Xiaolin Niu, Qiaojun Zhang
Pages: 2552-2560
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Dynamic changes in the gene expression profile during rat oral carcinogenesis induced by 4‑nitroquinoline 1‑oxide

Shuyun Ge, Ji Zhang, Yanzhi Du, Bin Hu, Zengtong Zhou, Jianing Lou
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A novel dermal matrix generated from burned skin as a promising substitute for deep‑degree burns therapy

Guanying Yu, Lan Ye, Wei Tan, Xuguo Zhu, Yaonan Li, Duyin Jiang
Pages: 2570-2582
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The hypoxia-mimetic agent CoCl2 induces chemotherapy resistance in LOVO colorectal cancer cells

Guanglei Yang, Shuqing Xu, Lintao Peng, Hui Li, Yan Zhao, Yanfang Hu
Pages: 2583-2589
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Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase

Qianqian Guo, Zhiyan Liu, Lili Jiang, Mengjie Liu, Jiequn Ma, Chengcheng Yang, Lili Han, Kejun Nan, Xuan Liang
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Cilostazol suppresses angiotensin II‑induced apoptosis in endothelial cells

Miao‑Qian Shi, Fei‑Fei Su, Xuan Xu, Xiong‑Tao Liu, Hong‑Tao Wang, Wei Zhang, Xue Li, Cheng Lian, Qiang‑Sun Zheng, Zhi‑Chun Feng
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Superoxide dismutase activity and gene expression levels in Saudi women with recurrent miscarriage

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Echinacoside suppresses pancreatic adenocarcinoma cell growth by inducing apoptosis via the mitogen‑activated protein kinase pathway

Wei Wang, Jinbin Luo, Yinghui Liang, Xinfeng Li
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Macrophage migration inhibitory factor induces autophagy to resist hypoxia/serum deprivation‑induced apoptosis via the AMP‑activated protein kinase/mammalian target of rapamycin signaling pathway

Wenzheng Xia, Meng Hou
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Transcriptomic study of high‑glucose effects on human skin fibroblast cells

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Complete cytogenetic response to Nilotinib in a chronic myeloid leukemia case with a rare e13a3(b2a3) BCR-ABL fusion transcript: A case report

Bei Liu, Wei Zhang, Haizhen Ma
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MicroRNA-98 suppresses cell proliferation, migration and invasion by targeting collagen triple helix repeat containing 1 in hepatocellular carcinoma

Chen‑Yu Wang, Jun‑Jie Zhang, Long Hua, Kun‑Hou Yao, Jiang‑Tao Chen, Xue‑Qun Ren
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Suicide gene-modified killer cells as an allogeneic alternative to autologous cytokine-induced killer cell immunotherapy of hepatocellular carcinoma

Tao Wu, Céline Leboeuf, Sarah Durand, Bin Su, Marina Deschamps, Xiaowen Zhang, Christophe Ferrand, Patrick Pessaux, Eric Robinet
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Electroacupuncture improves cognitive function through Rho GTPases and enhances dendritic spine plasticity in rats with cerebral ischemia‑reperfusion

Ruhui Lin, Yunan Wu, Jing Tao, Bin Chen, Jixiang Chen, Congkuai Zhao, Kunqiang Yu, Xiaojie Li, Li‑Dian Chen
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Effects of autophagy regulation of tumor‑associated macrophages on radiosensitivity of colorectal cancer cells

Le‑Ning Shao, Bao‑Song Zhu, Chun‑Gen Xing, Xiao‑Dong Yang, Wu Young, Jian‑Ping Cao
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Retinal and choroidal expression of BMP-2 in lens-induced myopia and recovery from myopia in guinea pigs

Honghui Li, Juan Wu, Dongmei Cui, Junwen Zeng
Pages: 2671-2676
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The MAPK pathway is involved in the regulation of rapid pacing‑induced ionic channel remodeling in rat atrial myocytes

Wei Cheng, Yun Zhu, Haidong Wang
Pages: 2677-2682
Published online on: 04 February 2016

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Downregulation of let‑7b promotes COL1A1 and COL1A2 expression in dermis and skin fibroblasts during heat wound repair Retraction in /10.3892/mmr.2023.13144

Jinyan Liu, Chengqun Luo, Zhaoqi Yin, Ping Li, Shaohua Wang, Jia Chen, Quanyong He, Jianda Zhou
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Poly (I:C) transfection induces mitochondrial‑mediated apoptosis in cervical cancer

Hui Chen, Dong‑Liang Wang, Yu‑Ling Liu
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Overexpressed transcription factor FOXM1 contributes to the progression of colorectal cancer

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MicroRNA‑21 expression is associated with the clinical features of patients with gastric carcinoma and affects the proliferation, invasion and migration of gastric cancer cells by regulating Noxa

Haibin Sun, Panzhi Wang, Qiangnu Zhang, Xiaoyan He, Guozhen Zai, Xudong Wang, Mei Ma, Xiaoli Sun
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MicroRNA-let-7f-1 is induced by lycopene and inhibits cell proliferation and triggers apoptosis in prostate cancer

Danbin Li, Lina Chen, Wenran Zhao, Jianbing Hao, Ruihua An
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Effects of the tumor suppressor PTEN on the pathogenesis of idiopathic pulmonary fibrosis in Chinese patients

Baosong Xie, Guanying Zheng, Hongru Li, Xiujuan Yao, Rujun Hong, Ruihui Li, Wenxiang Yue, Yusheng Chen
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Enhancer of zeste homolog 2 depletion arrests the proliferation of hepatoblastoma cells

Yue Wang, Yongtao Xiao, Kai Chen, Sheng Chen, Min Zhang, Zhixiang Wu, Yeming Wu
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Gene expression alterations in inflamed and unaffected colon mucosa from patients with mild inflammatory bowel disease

Lili Xu, Lili Ma, Jingjing Lian, Jiayin Yang, Shiyao Chen
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Anti-inflammatory potential of ursolic acid in Mycobacterium tuberculosis-sensitized and Concanavalin A-stimulated cells

Tamanna Zerin, Minjung Lee, Woong Sik Jang, Kung‑Woo Nam, Ho‑Yeon Song
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Histone deacetylase 5 promotes Wilms' tumor cell proliferation through the upregulation of c-Met

Xu Cao, De‑Hong Liu, Yun Zhou, Xiang‑Ming Yan, Li‑Qun Yuan, Jian Pan, Ming‑Cui Fu, Ting Zhang, Jian Wang
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TGF‑β1 inhibits the apoptosis of pulmonary arterial smooth muscle cells and contributes to pulmonary vascular medial thickening via the PI3K/Akt pathway

Limin Li, Xiaoqian Zhang, Xiaoxia Li, Chengfang Lv, Hongjuan Yu, Mengyuan Xu, Mingwen Zhang, Yueyue Fu, Hongbin Meng, Jin Zhou
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Isatin inhibits the proliferation and invasion of SH‑SY5Y neuroblastoma cells

Pingping Xu, Lin Hou, Chuanxia Ju, Zheng Zhang, Wenyan Sun, Li Zhang, Jinlian Song, Yuqiang Lv, Lu Liu, Zhixiang Chen, Yanhui Wang
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Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN by targeting miR-21

Xiaofang Li, Aimin Zang, Youchao Jia, Jinchao Zhang, Wufang Fan, Jia Feng, Mindan Duan, Lei Zhang, Ran Huo, Jin Jiao, Xiaowei Zhu
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Overexpression of microRNA‑210 promotes chondrocyte proliferation and extracellular matrix deposition by targeting HIF‑3α in osteoarthritis

Zhifu Li, Dongdong Meng, Guangheng Li, Jianzhong Xu, Ke Tian, Yu Li
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Clinical significance of microRNA‑34b expression in pediatric acute leukemia

Lan Cao, Na Wang, Jian Pan, Shaoyan Hu, Wenli Zhao, Hailong He, Yi Wang, Guixiong Gu, Yihuan Chai
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Effects of T cell immunoglobulin and mucin domain-containing molecule-3 signaling molecule on human monocyte-derived dendritic cells with hepatitis B virus surface antigen stimulation in vitro

Zhenjun Yu, Ting Jiang, Min Zhu, Kechuan Pan, Fei Yan, Jiansheng Zhu
Pages: 2785-2790
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Kaempferol induces apoptosis in HepG2 cells via activation of the endoplasmic reticulum stress pathway

Haiqing Guo, Feng Ren, Li Zhang, Xiangying Zhang, Rongrong Yang, Bangxiang Xie, Zhuo Li, Zhongjie Hu, Zhongping Duan, Jing Zhang
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Expression and function of microRNA‑27b in hepatocellular carcinoma

Shujie He, Jingyuan Zhang, Juan Lin, Cuisheng Zhang, Shijie Sun
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MicroRNA‑26b is upregulated in a double transgenic mouse model of Alzheimer's disease and promotes the expression of amyloid‑β by targeting insulin‑like growth factor 1

Hong Liu, Wenzheng Chu, Li Gong, Xiaoyu Gao, Wei Wang
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Antidepressant-like effect of Ikwitang involves modulation of monoaminergic systems

Hee‑Yun Kim, Hyun‑Ja Jeong, Hyung‑Min Kim
Pages: 2815-2820
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5‑Fluorouracil attenuates dextran sodium sulfate‑induced acute colitis in mice

Junhua Xiao, Zhanjun Lu, Jiaqing Sheng, Yunna Song, Weiliang Jiang, Fei Liu, Ping Zheng
Pages: 2821-2828
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High expression of piwi-like RNA-mediated gene silencing 1 is associated with poor prognosis via regulating transforming growth factor-β receptors and cyclin-dependent kinases in breast cancer

Jiwei Cao, Gang Xu, Jing Lan, Qingqing Huang, Zuxiong Tang, Liping Tian
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Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats

Hui Liu, Hong‑Yang Liu, Yi‑Nong Jiang, Nan Li
Pages: 2836-2842
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A‑769662, a direct AMPK activator, attenuates lipopolysaccharide‑induced acute heart and lung inflammation in rats

Maryam Rameshrad, Hamid Soraya, Nasrin Maleki‑Dizaji, Haleh Vaez, Alireza Garjani
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Monoacylglycerol lipase inhibitor JZL184 regulates apoptosis and migration of colorectal cancer cells

Muyuan Ma, Jie Bai, Ye Ling, Weilong Chang, Gengchen Xie, Ruidong Li, Guobin Wang, Kaixiong Tao
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GRHL2 genetic polymorphisms may confer a protective effect against sudden sensorineural hearing loss

Xiaojiang Lin, Yaoshu Teng, Jinshan Lan, Benjun He, Huijuan Sun, Fenglin Xu
Pages: 2857-2863
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Thioredoxin 1 protects astrocytes from oxidative stress by maintaining peroxiredoxin activity

Mengfei Wang, Kunting Zhu, Luyu Zhang, Lingyu Li, Jing Zhao
Pages: 2864-2870
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A novel virulence-associated protein, vapE, in Streptococcus suis serotype 2

Xue Ji, Yang Sun, Jun Liu, Lingwei Zhu, Xuejun Guo, Xulong Lang, Shuzhang Feng
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Published online on: 28 January 2016

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Paris Saponins enhance radiosensitivity in a gefitinib‑resistant lung adenocarcinoma cell line by inducing apoptosis and G2/M cell cycle phase arrest

Peng‑Jun Zhao, Shui‑Chuan Song, Lei‑Wen Du, Guo‑Hua Zhou, Sheng‑Lin Ma, Jin‑Hui Li, Jian‑Guo Feng, Xin‑Hai Zhu, Hao Jiang
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Overexpression of SCARA5 inhibits tumor proliferation and invasion in osteosarcoma via suppression of the FAK signaling pathway

Xinzhu Wen, Nan Wang, Fanfan Zhang, Chunjiao Dong
Pages: 2885-2891
Published online on: 03 February 2016

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17β-estradiol suppresses hyperoxia-induced apoptosis of oligodendrocytes through paired-immunoglobulin-like receptor B

Hua Wang, Jinlin Wu
Pages: 2892-2898
Published online on: 27 January 2016

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Icariin inhibits oxidized low-density lipoprotein-induced proliferation of vascular smooth muscle cells by suppressing activation of extracellular signal-regulated kinase 1/2 and expression of proliferating cell nuclear antigen

Yanwu Hu, Kai Liu, Mengtong Yan, Yang Zhang, Yadi Wang, Liqun Ren
Pages: 2899-2903
Published online on: 27 January 2016

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Suppression of c‑FLIPL promotes JNK activation in malignant melanoma cells

Fen Tian, Yange Hu, Xixi Sun, Gaihui Lu, Yan Li, Jing Yang, Juan Tao
Pages: 2904-2908
Published online on: 03 February 2016

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Time‑dependent homeostasis between glucose uptake and consumption in astrocytes exposed to CoCl2 treatment

Peng Wang, Ling Li, Zhenxiang Zhang, Quancheng Kan, Suyan Chen, Feng Gao
Pages: 2909-2917
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Cardiopulmonary bypass increases pulmonary microvascular permeability through the Src kinase pathway: Involvement of caveolin-1 and vascular endothelial cadherin

Junwen Zhang, Zhaolei Jiang, Chunrong Bao, Ju Mei, Jiaquan Zhu
Pages: 2918-2924
Published online on: 29 January 2016

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Bioinformatics analysis of molecular mechanisms involved in intervertebral disc degeneration induced by TNF‑α and IL‑1β

Feng Xu, Feng Gao, Yadong Liu, Zhenyu Wang, Xinming Zhuang, Zhigang Qu, Hui Ma, Yi Liu, Changfeng Fu, Qi Zhang, Xiaoying Duan
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Published online on: 04 February 2016

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[Expression of Concern] MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA

Shijuan Zhan, Chunfeng Wang, Fangqing Yin
Article Number: 75
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Melatonin induces autophagy in neuroblastoma by alleviating Pak2‑mediated endoplasmic reticulum stress

Qian-Qi Qiu, Na Zhang, Ying-Yi Xu, Jing-Wen Qin, Gao-Feng Yu, Xing-Rong Song
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ST3Gal1 modulates intestinal barrier function and impacts human ulcerative colitis

Yin Tian, Yun Liu, Yangyang Shang, Lijian Ran, Li Liu, Rongquan Wang, Jun Ye
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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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March-2026 Volume 33 Issue 3

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Converting ‘cold’ to ‘hot’ hepatocellular carcinoma for improved immunotherapy (Review)

Ching-Hua Hsieh, Pei-Chin Chuang
Article Number: 93
Published online on: 15 January 2026

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Pathological mechanism of ferroptosis in a rat model of α‑naphthyl isothiocyanate‑induced chronic cholestasis

Zhen Guo, Jiaxuan Wang, Yiwen Wang, Xinzhu Liu, Yubing Xia, Ping Liu, Li Qi, Jia Liu, Xiaoning Wang
Article Number: 92
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] Role of hypoxia‑inducible factor‑1α and CD146 in epidermal growth factor receptor‑mediated angiogenesis in salivary gland adenoid cystic carcinom

Wei-Ming Wang, Zhi-Li Zhao, Wen-Feng Zhang, Yi-Fang Zhao, Lu Zhang, Zhi-Jun Sun
Article Number: 91
Published online on: 13 January 2026

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Klebsiella pneumoniae and pyogenic liver abscess: Emerging clinical threats, virulence mechanisms and therapeutic strategies (Review)

Gulam Mustafa Hasan, Taj Mohammad, Sobia Zaidi, Anas Shamsi, Sukhwinder Singh Sohal, Md. Imtaiyaz Hassan
Article Number: 90
Published online on: 13 January 2026

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Collagen III regulates the termination of liver regeneration by suppressing hepatocyte proliferation and promoting functional recovery

Haiyang Peng, Zhiyong Chen, Qiwei Zhang, Yuezhou Zhang, Peng Yang, Jianping Gong, Andong Zhao
Article Number: 89
Published online on: 13 January 2026

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Review Open Access

Application of extracellular vesicles in the diagnosis and treatment of chronic obstructive pulmonary disease (Review)

Yixin Zhang, Tong Ren, Jianbo Xue, Yan Yu, Xianqiang Zhou, Xiaoyi Hu, Wenyi Yu, Zhancheng Gao, Cuiling Feng
Article Number: 88
Published online on: 13 January 2026

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Cigarette smoke combined with Klebsiella pneumoniae induce damage to the air‑blood barrier in chronic obstructive pulmonary disease rats via the MAPK/NF‑κB/IκBα pathway

Yange Tian, Kexin Xu, Ruilong Lu, Kangchen Li, Xuejie Shao, Yixi Liao, Yakun Zhao, Zhiguang Qiu, Haoran Dong, Xuefang Liu
Article Number: 87
Published online on: 12 January 2026

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Retraction Open Access

[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells

Qing Ding, Yi Chen, Qing Zhang, Yanling Guo, Zhi Huang, Liqing Dai, Sudan Cao
Article Number: 86
Published online on: 12 January 2026

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Anxiety‑induced overactive bladder: The role of oxidative stress and NF‑κB signaling pathway with Hsp90 as a potential biomarker

Zhipeng Zhou, Lina Xu, Han Wu, Huaishan Hong
Article Number: 85
Published online on: 12 January 2026

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Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene

Zi-Run Jin, Yong-Wei Huo, Bo-Heng Liu, Hong Tian, Shuo Yuan, Yue Tian, Ke Xi, Jie Cai, Hui Jiang, Yong Jiang, Guo-Gang Xing
Article Number: 84
Published online on: 12 January 2026

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Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway

Pei Li, Xinyu Wan, Wenjie Li, Ding Cheng, Ying Yang, Yuhan Wang, Ruyuan Zhu, Yanjing Chen, Haixia Liu, Zhiguo Zhang
Article Number: 83
Published online on: 12 January 2026

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Review Open Access

Prolyl hydroxylase domain proteins: Localization, regulation, function and their role in erythropoiesis (Review)

Yan Hou, Zhao-Hua Zhang, Wen-Qian Li, Guo-Xiong Han, Kuo Shen, You-Bang Xie
Article Number: 82
Published online on: 12 January 2026

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Review Open Access

Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review)

Bing-Yu Liang, Zi-Yue Fu, Fen-Fen Li, Ping-Ting Zhou, Zi-Hui Xie, Ke Han, Yan-Xun Han, Shan-Wen Chen, Yi Zhao, Hai-Feng Pan, Ye-Hai Liu, Yu-Chen Liu
Article Number: 81
Published online on: 07 January 2026

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Review Open Access

Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)

Xinyue Wang, Xiaohang Zhang, Jianing Lin, Ping Lin
Article Number: 80
Published online on: 05 January 2026

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Article Open Access

Preliminary exploration of the putative function of SF3A2 in clear cell renal cell carcinoma

Ru Chen, Jie Xu
Article Number: 79
Published online on: 05 January 2026

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Retraction Open Access

[Retracted] TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway

Lin Wang, Chen Chen, Shuzhi Feng, Jianli Tian
Article Number: 78
Published online on: 05 January 2026

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