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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
March-2016 Volume 13 Issue 3

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Identification of diagnostic and prognostic biomarkers for cancer: Focusing on genetic variations in microRNA regulatory pathways (Review)

Zhen Guo, Yan Shu, Honghao Zhou, Wei Zhang
Pages: 1943-1952
Published online on: 14 January 2016

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Article Open Access

Hypoxic preconditioning increases the protective effect of bone marrow mesenchymal stem cells on spinal cord ischemia/reperfusion injury

Zhilin Wang, Bo Fang, Zhibin Tan, Dong Zhang, Hong Ma
Pages: 1953-1960
Published online on: 11 January 2016

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Article Open Access

MicroRNA-610 suppresses the proliferation of human glioblastoma cells by repressing CCND2 and AKT3

Xiaomei Mo, Qian Cao, Hui Liang, Jianmin Liu, Huahui Li, Fenghai Liu
Pages: 1961-1966
Published online on: 12 January 2016

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Article Open Access

Genetic counseling for patients with nonsyndromic hearing impairment directed by gene analysis

Dingyuan Ma, Jingjing Zhang, Chunyu Luo, Ying Lin, Xiuqing Ji, Ping Hu, Zhengfeng Xu
Pages: 1967-1974
Published online on: 13 January 2016

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Article Open Access

Identification of potential therapeutic targets for lung cancer by bioinformatics analysis

Li‑Quan Wang, Lan‑Hua Zhao, Yi‑Ze Qiao
Pages: 1975-1982
Published online on: 31 December 2015

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Article Open Access

Clinical and genetic investigation of families with type II Waardenburg syndrome

Yong Chen, Fuwei Yang, Hexin Zheng, Jianda Zhou, Ganghua Zhu, Peng Hu, Weijing Wu
Pages: 1983-1988
Published online on: 13 January 2016

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Article Open Access

Activation of TRPV1-dependent calcium oscillation exacerbates seawater inhalation-induced acute lung injury

Congcong Li, Liyan Bo, Qingqing Liu, Wei Liu, Xiangjun Chen, Dunquan Xu, Faguang Jin
Pages: 1989-1998
Published online on: 20 January 2016

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Article Open Access

Abnormal expression of key genes and proteins in the canonical Wnt/β-catenin pathway of articular cartilage in a rat model of exercise-induced osteoarthritis

Shen‑Shen Liu, Pu Zhou, Yanqiu Zhang
Pages: 1999-2006
Published online on: 19 January 2016

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Article Open Access

Treatment with the herbal medicine, naoxintong improves the protective effect of high‑density lipoproteins on endothelial function in patients with type 2 diabetes

Pu Lv, Xunliang Tong, Qing Peng, Yuanyuan Liu, Haiqiang Jin, Ran Liu, Wei Sun, Bing Pan, Lemin Zheng, Yining Huang
Pages: 2007-2016
Published online on: 18 January 2016

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Article Open Access

Effects of CCN3 on rat cartilage endplate chondrocytes cultured under serum deprivation in vitro

Lei Ding, Jingping Wu, Defang Li, Houlei Wang, Bin Zhu, Wei Lu, Guoxiong Xu
Pages: 2017-2022
Published online on: 20 January 2016

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Article Open Access

Establishment of mesenchymal stem cell lines derived from the bone marrow of green fluorescent protein‑transgenic mice exhibiting a diversity in intracellular transforming growth factor‑β and bone morphogenetic protein signaling

Shunsuke Sawada, Naoyuki Chosa, Naoki Takizawa, Jun Yokota, Yasuyuki Igarashi, Koichi Tomoda, Hisatomo Kondo, Takashi Yaegashi, Akira Ishisaki
Pages: 2023-2031
Published online on: 18 January 2016

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Article Open Access

Downregulation of B7-H4 in the MHCC97-H hepatocellular carcinoma cell line by arsenic trioxide

Liming Cui, Bo Gao, Zhigang Cao, Xiaoying Chen, Shide Zhang, Weizhe Zhang
Pages: 2032-2038
Published online on: 12 January 2016

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Article Open Access

Knockout of phospholipase Cε attenuates N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder tumorigenesis

Taimao Jiang, Tao Liu, Lin Li, Zhijun Yang, Yunfeng Bai, Dongye Liu, Chuize Kong
Pages: 2039-2045
Published online on: 12 January 2016

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Article Open Access

Inhibition of Rho‑associated protein kinase increases the ratio of formation of blastocysts from single human blastomeres

Sunxing Huang, Chenhui Ding, Qingyun Mai, Yanwen Xu, Canquan Zhou
Pages: 2046-2052
Published online on: 13 January 2016

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Article Open Access

Autologous adipose tissue‑derived mesenchymal stem cells are involved in rat liver regeneration following repeat partial hepatectomy

Tao Liu, Hong Mu, Zhongyang Shen, Zhuolun Song, Xiaobo Chen, Yuliang Wang
Pages: 2053-2059
Published online on: 13 January 2016

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Article Open Access

Opposing needling promotes behavior recovery and exerts neuroprotection via the cAMP/PKA/CREB signal transduction pathway in transient MCAO rats

Yijing Jiang, Shanli Yang, Jing Tao, Zhicheng Lin, Xiaoqian Ye, Yongmei You, Jun Peng, Zhenfeng Hong, Lidian Chen
Pages: 2060-2070
Published online on: 13 January 2016

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Article Open Access

Osteochondral repair with synovial membrane‑derived mesenchymal stem cells

Hong Li, Junchao Qian, Jiwu Chen, Kai Zhong, Shiyi Chen
Pages: 2071-2077
Published online on: 18 January 2016

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Article Open Access

Interruptin B induces brown adipocyte differentiation and glucose consumption in adipose-derived stem cells

Sireewan Kaewsuwan, Anuchit Plubrukarn, Maleeruk Utsintong, Seok‑Ho Kim, Jin‑Hyun Jeong, Jin Gu Cho, Sang Gyu Park, Jong‑Hyuk Sung
Pages: 2078-2086
Published online on: 12 January 2016

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Article Open Access

Native low density lipoprotein promotes lipid raft formation in macrophages

Jian Song, Ling‑Yan Ping, Duc M. Duong, Xiao‑Yan Gao, Chun‑Yan He, Lei Wei, Jun‑Zhu Wu
Pages: 2087-2093
Published online on: 14 January 2016

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Article Open Access

Myricetin induces apoptosis via endoplasmic reticulum stress and DNA double-strand breaks in human ovarian cancer cells

Ye Xu, Qi Xie, Shaohua Wu, Dan Yi, Yang Yu, Shibing Liu, Songyan Li, Zhixin Li
Pages: 2094-2100
Published online on: 12 January 2016

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Article Open Access

RNA sequencing reveals retinal transcriptome changes in STZ‑induced diabetic rats

Yuan‑Jie Liu, Zhi‑Yun Lian, Geng Liu, Hong‑Ying Zhou, Hui‑Jun Yang
Pages: 2101-2109
Published online on: 18 January 2016

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Article Open Access

Gene expression profiling analysis contributes to understanding the association between non-syndromic cleft lip and palate, and cancer

Hongyi Wang, Tao Qiu, Jie Shi, Jiulong Liang, Yang Wang, Liangliang Quan, Yu Zhang, Qian Zhang, Kai Tao
Pages: 2110-2116
Published online on: 20 January 2016

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Article Open Access

Genotype‑phenotype analysis of CYP2C19 in the Tibetan population and its potential clinical implications in drug therapy

Tianbo Jin, Xiyang Zhang, Tingting Geng, Xugang Shi, Li Wang, Dongya Yuan, Longli Kang
Pages: 2117-2123
Published online on: 13 January 2016

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Article

Antitumor effect of dendritic cells transfected with prostate-specific membrane antigen recombinant adenovirus on prostate cancer: An in vitro study

Fan‑Dong Meng, Shuai Wang, You‑Hong Jiang, Cheng‑Guang Sui
Pages: 2124-2134
Published online on: 11 January 2016

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Article

Beneficial effect of farnesoid X receptor activation on metabolism in a diabetic rat model

Hong‑Mei Zhang, Xuan Wang, Zhao‑Hong Wu, Hui‑Ling Liu, Wei Chen, Zhong‑Zhi Zhang, Dan Chen, Tian‑Shu Zeng
Pages: 2135-2142
Published online on: 12 January 2016

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Article

Vaccarin attenuates high glucose-induced human EA•hy926 endothelial cell injury through inhibition of Notch signaling

Yuyu Qiu, Bin Du, Fengshan Xie, Weiwei Cai, Yanling Liu, Yue Li, Lei Feng, Liying Qiu
Pages: 2143-2150
Published online on: 20 January 2016

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Article

Carboxymethylated chitosan protects rat chondrocytes from NO‑induced apoptosis via inhibition of the p38/MAPK signaling pathway

Bin He, Haiying Tao, Shiqing Liu, Ailin Wei, Feng Pan, Ren Chen, Xiaohai Li
Pages: 2151-2158
Published online on: 13 January 2016

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Article

TLR4‑dependent signaling pathway modulation: A novel mechanism by which pioglitazone protects against nutritional fibrotic steatohepatitis in mice

Jinghua Du, Xuemin Niu, Rongqi Wang, Suxian Zhao, Lingbo Kong, Yuguo Zhang, Yuemin Nan
Pages: 2159-2166
Published online on: 13 January 2016

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Article

Human cytomegalovirus RL13 protein interacts with host NUDT14 protein affecting viral DNA replication

Guili Wang, Gaowei Ren, Xin Cui, Zhitao Lu, Yanping Ma, Ying Qi, Yujing Huang, Zhongyang Liu, Zhengrong Sun, Qiang Ruan
Pages: 2167-2174
Published online on: 13 January 2016

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Article

Netrin-1 prevents the development of cardiac hypertrophy and heart failure

Nan Wang, Yunshan Cao, Yan Zhu
Pages: 2175-2181
Published online on: 11 January 2016

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Article

Identification of candidate target genes of pituitary adenomas based on the DNA microarray

Wei Zhou, Chun-Xiao Ma, Ya-Zhou Xing, Zhao-Yue Yan
Pages: 2182-2186
Published online on: 14 January 2016

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Article

Curcumin activates autophagy and attenuates oxidative damage in EA.hy926 cells via the Akt/mTOR pathway

Shouyu Guo, Mingzhi Long, Xiuzhen Li, Shushu Zhu, Min Zhang, Zhijian Yang
Pages: 2187-2193
Published online on: 18 January 2016

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Article

MicroRNA-378 promotes myogenic differentiation by targeting BMP4

Huiming Ju, Yuefei Yang, Anzhi Sheng, Yuyu Qi
Pages: 2194-2200
Published online on: 12 January 2016

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Article

Targeting peroxiredoxin I potentiates 1,25‑dihydroxyvitamin D3‑induced cell differentiation in leukemia cells

Wei Wei, Chuanxu Liu, Dongjun Qin, Lili Song, Li Xia, Hu Lei, Yun Yu, Weiwei Wang, Jianxin Pu, Handong Sun, Yingli Wu, Hanzhang Xu, Siguo Hao
Pages: 2201-2207
Published online on: 14 January 2016

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Article

NS‑398 promotes pancreatic cancer cell invasion by CD147 and MMP‑2 via the activation of P38

Hua Liu, Xuan‑Fu Xu, Yan Zhao, Mao‑Chun Tang, Ying‑Qun Zhou, Feng‑Hou Gao
Pages: 2208-2214
Published online on: 14 January 2016

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Article

Stimulus-dependent neuronal cell responses in SH-SY5Y neuroblastoma cells

Xiguang Sun, Xu Shi, Laijing Lu, Yanfang Jiang, Bin Liu
Pages: 2215-2220
Published online on: 12 January 2016

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Article

MicroRNA-155 enhances the activation of Wnt/β-catenin signaling in colorectal carcinoma by suppressing HMG-box transcription factor 1 Retraction in /10.3892/mmr.2022.12597

Ying‑Chun Wan, Tao Li, Yang‑Dong Han, Hai‑Yan Zhang, Hai Lin, Bin Zhang
Pages: 2221-2228
Published online on: 15 January 2016

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Article

Overexpression of FOXO4 induces apoptosis of clear-cell renal carcinoma cells through downregulation of Bim

Wei Wang, Pang‑Hu Zhou, Wei Hu
Pages: 2229-2234
Published online on: 15 January 2016

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Article

Eriocalyxin B blocks human SW1116 colon cancer cell proliferation, migration, invasion, cell cycle progression and angiogenesis via the JAK2/STAT3 signaling pathway

Yun‑Min Lu, Wei Chen, Jin‑Shui Zhu, Wei‑Xiong Chen, Ni‑Wei Chen
Pages: 2235-2240
Published online on: 19 January 2016

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Article

Association of HNF4α gene polymorphisms with susceptibility to type 2 diabetes

Run Ma, Hongying Yang, Jingfang Li, Xu Yang, Xiaohong Chen, Ying Hu, Zhou Wang, Li Xue, Wei Zhou
Pages: 2241-2246
Published online on: 13 January 2016

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Article

Protective effect of paeoniflorin on inflammation and apoptosis in the cerebral cortex of a transgenic mouse model of Alzheimer's disease

Xinyi Gu, Zhengxu Cai, Ming Cai, Kun Liu, Dan Liu, Qinsong Zhang, Jing Tan, Qiang Ma
Pages: 2247-2252
Published online on: 20 January 2016

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Article

MicroRNA‑451 inhibits neuroblastoma proliferation, invasion and migration by targeting macrophage migration inhibitory factor

Geng Liu, Zhengwei Xu, Dingjun Hao
Pages: 2253-2260
Published online on: 13 January 2016

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Article

Inhibition of WWP2 suppresses proliferation, and induces G1 cell cycle arrest and apoptosis in liver cancer cells

Sheng‑Qian Xu, Yong Qin, De‑Biao Pan, Guan‑Xiong Ye, Cheng‑Jun Wu, Shi Wang, Jin‑Yan Jiang, Jing Fu, Chao‑Jun Wang
Pages: 2261-2266
Published online on: 13 January 2016

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Article

Upregulation of microRNA‑27b contributes to the migration and invasion of gastric cancer cells via the inhibition of sprouty2‑mediated ERK signaling Retraction in /10.3892/mmr.2021.12366

Juan Jiang, Bo Yi, Chunxiang Qin, Siqing Ding, Wei Cao
Pages: 2267-2272
Published online on: 13 January 2016

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Article

Validation of downregulated microRNAs during osteoclast formation and osteoporosis progression

Yan Ma, Zhi Shan, Jianjun Ma, Qiang Wang, Junjie Chu, Peiwei Xu, An Qin, Shunwu Fan
Pages: 2273-2280
Published online on: 12 January 2016

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Article

Resveratrol‑4‑O‑D‑(2'‑galloyl)‑glucopyranoside exerts an anticancer effect on leukemia cells via inducing apoptosis

Pu Chen, Beili Wang, Baishen Pan, Wei Guo
Pages: 2281-2286
Published online on: 13 January 2016

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Article

MicroRNA-497 targets hepatoma-derived growth factor and suppresses human prostate cancer cell motility

Deyao Wu, Xiaobing Niu, Huixing Pan, Zichun Zhang, Yunfeng Zhou, Ping Qu, Jian Zhou
Pages: 2287-2292
Published online on: 11 January 2016

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Article

c‑Jun N‑terminal kinase‑mediated anti‑inflammatory effects of Garcinia subelliptica in macrophages

Young‑Chang Cho, Sayeon Cho
Pages: 2293-2300
Published online on: 18 January 2016

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Article

Knockdown of PREX2a inhibits the malignant phenotype of glioma cells Retraction in /10.3892/mmr.2021.12184

Liang Liu, Zhixiong Liu, Hao Wang, Long Chen, Fuqiang Ruan, Jihui Zhang, Yi Hu, Hengshan Luo, Shuai Wen
Pages: 2301-2307
Published online on: 19 January 2016

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Article

Occult macular dystrophy in an Italian family carrying a mutation in the RP1L1 gene

Stefano Piermarocchi, Tatiana Segato, Alberta Leon, Davide Colavito, Stefania Miotto
Pages: 2308-2312
Published online on: 14 January 2016

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Article

Matrine inhibits the expression of adhesion molecules in activated vascular smooth muscle cells

Jun Liu, Lihua Zhang, Yingang Ren, Yanli Gao, Li Kang, Shaoping Lu
Pages: 2313-2319
Published online on: 13 January 2016

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Article

Allicin attenuates H2O2‑induced cytotoxicity in retinal pigmented epithelial cells by regulating the levels of reactive oxygen species

Gerile Tu, Yu‑Feng Zhang, Wei Wei, Langen Li, Yanmei Zhang, Jia Yang, Yiqiao Xing
Pages: 2320-2326
Published online on: 18 January 2016

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Article

Identification of key pathways and genes in psoriasis via gene microarray analysis

Wei Chen, Kuixia Xie, Xinhua Liu, Hong Chen
Pages: 2327-2337
Published online on: 15 January 2016

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Article

Co-treatment of wild‑type EGFR head and neck cancer cell lines with afatinib and cisplatin

Roman C. Brands, Urs D.A. Müller‑Richter, Francesco De Donno, Axel Seher, Grit Mutzbauer, Christian Linz, Alexander C. Kübler, Stefan Hartmann
Pages: 2338-2344
Published online on: 14 January 2016

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Review

MicroRNA expression pattern in pre-eclampsia (Review)

Deeba S. Jairajpuri, Wassim Y. Almawi
Pages: 2351-2358
Published online on: 02 February 2016

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Review

Regulatory roles of microRNA-21 in fibrosis through interaction with diverse pathways (Review)

Rong‑Han Liu, Bin Ning, Xiao‑En Ma, Wei‑Ming Gong, Tang‑Hong Jia
Pages: 2359-2366
Published online on: 29 January 2016

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Article Open Access

Identification and characterization of an anti-oxidative stress-associated mutant of Aspergillus fumigatus transformed by Agrobacterium tumefaciens

Zhongqi Fan, Huimei Yu, Qi Guo, Dan He, Baiji Xue, Xiangli Xie, Koji Yokoyama, Li Wang
Pages: 2367-2376
Published online on: 01 February 2016

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Article Open Access

Prognostic value of legumain in uveal melanoma

Tong Wu, Lei Sun, Ying Wu, Rong Xiang, Yuwei Li, Weining Rong, Fengyuan Sun, Ningli Wang
Pages: 2377-2384
Published online on: 29 January 2016

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Article Open Access

Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy

Xinlin Wu, Jianxiang Liu, Jianqing Zhang, Heng Liu, Miansheng Yan, Birong Liang, Hongbo Xie, Shijun Zhang, Baoguo Sun, Houming Zhou
Pages: 2385-2392
Published online on: 29 January 2016

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Article Open Access

Chronic sciatic nerve compression induces fibrosis in dorsal root ganglia

Qinwen Li, Jianghai Chen, Yanhua Chen, Xiaobin Cong, Zhenbing Chen
Pages: 2393-2400
Published online on: 27 January 2016

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Article Open Access

Diosmetin inhibits the metastasis of hepatocellular carcinoma cells by downregulating the expression levels of MMP‑2 and MMP‑9

Jie Liu, Xiaojun Wen, Bin Liu, Qingyu Zhang, Jingjing Zhang, Huilai Miao, Runzhi Zhu
Pages: 2401-2408
Published online on: 05 February 2016

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Article Open Access

Age-dependent changes in the protein expression levels of Redd1 and mTOR in the gerbil hippocampus during normal aging

Hee‑Soo Choi, Ji Hyeon Ahn, Joon Ha Park, Moo‑Ho Won, Choong‑Hyun Lee
Pages: 2409-2414
Published online on: 29 January 2016

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Article Open Access

Sinomenine attenuates airway inflammation and remodeling in a mouse model of asthma

Hai‑Rong Bao, Xiao‑Ju Liu, Yun‑Lin Li, Xiang Men, Xiao‑Li Zeng
Pages: 2415-2422
Published online on: 28 January 2016

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Article Open Access

Expression of programmed death 1 ligand 1 on periodontal tissue cells as a possible protective feedback mechanism against periodontal tissue destruction

Jiehua Zhang, Chieh‑Mei Wang, Ping Zhang, Xiaoqian Wang, Jiao Chen, Jun Yang, Wanlu Lu, Wenjie Zhou, Wenwen Yuan, Yun Feng
Pages: 2423-2430
Published online on: 28 January 2016

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Increased expression of dermatopontin and its implications for testicular dysfunction in mice

Jun Cai, Weijia Liu, Jie Hao, Maoxin Chen, Gang Li
Pages: 2431-2438
Published online on: 05 February 2016

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Wnt3a suppresses Pseudomonas aeruginosa‑induced inflammation and promotes bacterial killing in macrophages

Kang Chen, Qiang Fu, Dandan Li, Yongjian Wu, Shijun Sun, Xiuming Zhang
Pages: 2439-2446
Published online on: 05 February 2016

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Effects of different shear rates on the attachment and detachment of platelet thrombi

Xiaofeng Shi, Jichun Yang, Jiansong Huang, Zhangbiao Long, Zheng Ruan, Bing Xiao, Xiaodong Xi
Pages: 2447-2456
Published online on: 28 January 2016

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Clinical features and survival in individuals with trisomy 18: A retrospective one-center study of 44 patients who received intensive care treatments

George Imataka, Hiroshi Suzumura, Osamu Arisaka
Pages: 2457-2466
Published online on: 22 January 2016

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Association of the hERG mutation with long‑QT syndrome type 2, syncope and epilepsy

Guoliang Li, Rui Shi, Jine Wu, Wenqi Han, Aifeng Zhang, Gong Cheng, Xiaolin Xue, Chaofeng Sun
Pages: 2467-2475
Published online on: 04 February 2016

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Targeting of cancer‑associated fibroblasts enhances the efficacy of cancer chemotherapy by regulating the tumor microenvironment

Minmin Li, Mei Li, Tao Yin, Huashan Shi, Yuan Wen, Binglan Zhang, Meihua Chen, Guangchao Xu, Kexin Ren, Yuquan Wei
Pages: 2476-2484
Published online on: 04 February 2016

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Electroacupuncture stimulation at CV4 prevents ovariectomy‑induced osteoporosis in rats via Wnt‑β‑catenin signaling

Huailing Fan, Feng Ji, Ying Lin, Mulan Zhang, Wei Qin, Qi Zhou, Qiang Wu
Pages: 2485-2491
Published online on: 03 February 2016

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Downregulated microRNA-23b promotes BMP9-mediated osteogenesis in C2C12 myoblast cells by targeting Runx2

Chu Chen, Zuchuan Tang, Qiling Song, Min Yang, Qiong Shi, Yaguang Weng
Pages: 2492-2498
Published online on: 27 January 2016

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Effect of glutamate on lysosomal membrane permeabilization in primary cultured cortical neurons

Min Yan, Wenbo Zhu, Xiaoke Zheng, Yuan Li, Lipeng Tang, Bingzheng Lu, Wenli Chen, Pengxin Qiu, Tiandong Leng, Suizhen Lin, Guangmei Yan, Wei Yin
Pages: 2499-2505
Published online on: 28 January 2016

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Ultraviolet light-emitting diode irradiation-induced cell death in HL-60 human leukemia cells in vitro

Dong Xie, Yan Sun, Lingzhen Wang, Xiaoling Li, Chuannong Zang, Yunlai Zhi, Lirong Sun
Pages: 2506-2510
Published online on: 27 January 2016

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Intestinal ischemic preconditioning reduces liver ischemia reperfusion injury in rats

Tong‑Min Xue, Li‑De Tao, Jie Zhang, Pei‑Jian Zhang, Xia Liu, Guo‑Feng Chen, Yi‑Jia Zhu
Pages: 2511-2517
Published online on: 28 January 2016

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Anti‑angiogenic therapy for normalization of tumor vasculature: A potential effect of Buyang Huanwu decoction on nude mice bearing human hepatocellular carcinoma xenografts with high metastatic potential

Liang Min, Wei Ling, Rong Hua, Hong Qi, Shenxu Chen, Haiqiao Wang, Lumen Tang, Wenji Shangguan
Pages: 2518-2526
Published online on: 03 February 2016

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Inhibition of miR-29c promotes proliferation, and inhibits apoptosis and differentiation in P19 embryonic carcinoma cells

Bin Chen, Guixian Song, Ming Liu, Lingmei Qian, Lihua Wang, Haitao Gu, Yahui Shen
Pages: 2527-2535
Published online on: 29 January 2016

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Nitidine chloride inhibits proliferation and induces apoptosis in colorectal cancer cells by suppressing the ERK signaling pathway

Huiyuan Zhai, Sanyuan Hu, Tongxiang Liu, Feng Wang, Xixun Wang, Guochang Wu, Yifei Zhang, Minghua Sui, Huantao Liu, Lixin Jiang
Pages: 2536-2542
Published online on: 29 January 2016

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β‑catenin signaling pathway regulates cisplatin resistance in lung adenocarcinoma cells by upregulating Bcl‑xl

Jin Zhang, Jie Liu, Hui Li, Jun Wang
Pages: 2543-2551
Published online on: 05 February 2016

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Age‑related changes in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats

Yali Li, Jian Liu, Dengfeng Gao, Jin Wei, Haifeng Yuan, Xiaolin Niu, Qiaojun Zhang
Pages: 2552-2560
Published online on: 03 February 2016

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Dynamic changes in the gene expression profile during rat oral carcinogenesis induced by 4‑nitroquinoline 1‑oxide

Shuyun Ge, Ji Zhang, Yanzhi Du, Bin Hu, Zengtong Zhou, Jianing Lou
Pages: 2561-2569
Published online on: 08 February 2016

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A novel dermal matrix generated from burned skin as a promising substitute for deep‑degree burns therapy

Guanying Yu, Lan Ye, Wei Tan, Xuguo Zhu, Yaonan Li, Duyin Jiang
Pages: 2570-2582
Published online on: 04 February 2016

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The hypoxia-mimetic agent CoCl2 induces chemotherapy resistance in LOVO colorectal cancer cells

Guanglei Yang, Shuqing Xu, Lintao Peng, Hui Li, Yan Zhao, Yanfang Hu
Pages: 2583-2589
Published online on: 29 January 2016

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Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase

Qianqian Guo, Zhiyan Liu, Lili Jiang, Mengjie Liu, Jiequn Ma, Chengcheng Yang, Lili Han, Kejun Nan, Xuan Liang
Pages: 2590-2596
Published online on: 29 January 2016

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Cilostazol suppresses angiotensin II‑induced apoptosis in endothelial cells

Miao‑Qian Shi, Fei‑Fei Su, Xuan Xu, Xiong‑Tao Liu, Hong‑Tao Wang, Wei Zhang, Xue Li, Cheng Lian, Qiang‑Sun Zheng, Zhi‑Chun Feng
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Superoxide dismutase activity and gene expression levels in Saudi women with recurrent miscarriage

Hazem K. Ghneim, Yazeed A. Al‑Sheikh, Mashael M. Alshebly, Mourad A. M. Aboul‑Soud
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Echinacoside suppresses pancreatic adenocarcinoma cell growth by inducing apoptosis via the mitogen‑activated protein kinase pathway

Wei Wang, Jinbin Luo, Yinghui Liang, Xinfeng Li
Pages: 2613-2618
Published online on: 04 February 2016

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Macrophage migration inhibitory factor induces autophagy to resist hypoxia/serum deprivation‑induced apoptosis via the AMP‑activated protein kinase/mammalian target of rapamycin signaling pathway

Wenzheng Xia, Meng Hou
Pages: 2619-2626
Published online on: 03 February 2016

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Transcriptomic study of high‑glucose effects on human skin fibroblast cells

Lingxia Pang, Youpei Wang, Meiqin Zheng, Qing Wang, Hong Lin, Liqing Zhang, Lingjian Wu
Pages: 2627-2634
Published online on: 28 January 2016

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Case Report

Complete cytogenetic response to Nilotinib in a chronic myeloid leukemia case with a rare e13a3(b2a3) BCR-ABL fusion transcript: A case report

Bei Liu, Wei Zhang, Haizhen Ma
Pages: 2635-2638
Published online on: 29 January 2016

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Article

MicroRNA-98 suppresses cell proliferation, migration and invasion by targeting collagen triple helix repeat containing 1 in hepatocellular carcinoma

Chen‑Yu Wang, Jun‑Jie Zhang, Long Hua, Kun‑Hou Yao, Jiang‑Tao Chen, Xue‑Qun Ren
Pages: 2639-2644
Published online on: 29 January 2016

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Article

Suicide gene-modified killer cells as an allogeneic alternative to autologous cytokine-induced killer cell immunotherapy of hepatocellular carcinoma

Tao Wu, Céline Leboeuf, Sarah Durand, Bin Su, Marina Deschamps, Xiaowen Zhang, Christophe Ferrand, Patrick Pessaux, Eric Robinet
Pages: 2645-2654
Published online on: 27 January 2016

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Article

Electroacupuncture improves cognitive function through Rho GTPases and enhances dendritic spine plasticity in rats with cerebral ischemia‑reperfusion

Ruhui Lin, Yunan Wu, Jing Tao, Bin Chen, Jixiang Chen, Congkuai Zhao, Kunqiang Yu, Xiaojie Li, Li‑Dian Chen
Pages: 2655-2660
Published online on: 05 February 2016

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Article

Effects of autophagy regulation of tumor‑associated macrophages on radiosensitivity of colorectal cancer cells

Le‑Ning Shao, Bao‑Song Zhu, Chun‑Gen Xing, Xiao‑Dong Yang, Wu Young, Jian‑Ping Cao
Pages: 2661-2670
Published online on: 28 January 2016

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Article

Retinal and choroidal expression of BMP-2 in lens-induced myopia and recovery from myopia in guinea pigs

Honghui Li, Juan Wu, Dongmei Cui, Junwen Zeng
Pages: 2671-2676
Published online on: 02 February 2016

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Article

The MAPK pathway is involved in the regulation of rapid pacing‑induced ionic channel remodeling in rat atrial myocytes

Wei Cheng, Yun Zhu, Haidong Wang
Pages: 2677-2682
Published online on: 04 February 2016

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Article

Downregulation of let‑7b promotes COL1A1 and COL1A2 expression in dermis and skin fibroblasts during heat wound repair Retraction in /10.3892/mmr.2023.13144

Jinyan Liu, Chengqun Luo, Zhaoqi Yin, Ping Li, Shaohua Wang, Jia Chen, Quanyong He, Jianda Zhou
Pages: 2683-2688
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Poly (I:C) transfection induces mitochondrial‑mediated apoptosis in cervical cancer

Hui Chen, Dong‑Liang Wang, Yu‑Ling Liu
Pages: 2689-2695
Published online on: 03 February 2016

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Overexpressed transcription factor FOXM1 contributes to the progression of colorectal cancer

Hongmei Zhang, Hua Zhong, Lei Li, Wansheng Ji, Xiaoqian Zhang
Pages: 2696-2700
Published online on: 05 February 2016

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Article

MicroRNA‑21 expression is associated with the clinical features of patients with gastric carcinoma and affects the proliferation, invasion and migration of gastric cancer cells by regulating Noxa

Haibin Sun, Panzhi Wang, Qiangnu Zhang, Xiaoyan He, Guozhen Zai, Xudong Wang, Mei Ma, Xiaoli Sun
Pages: 2701-2707
Published online on: 04 February 2016

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Article

MicroRNA-let-7f-1 is induced by lycopene and inhibits cell proliferation and triggers apoptosis in prostate cancer

Danbin Li, Lina Chen, Wenran Zhao, Jianbing Hao, Ruihua An
Pages: 2708-2714
Published online on: 02 February 2016

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Effects of the tumor suppressor PTEN on the pathogenesis of idiopathic pulmonary fibrosis in Chinese patients

Baosong Xie, Guanying Zheng, Hongru Li, Xiujuan Yao, Rujun Hong, Ruihui Li, Wenxiang Yue, Yusheng Chen
Pages: 2715-2723
Published online on: 03 February 2016

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Article

Enhancer of zeste homolog 2 depletion arrests the proliferation of hepatoblastoma cells

Yue Wang, Yongtao Xiao, Kai Chen, Sheng Chen, Min Zhang, Zhixiang Wu, Yeming Wu
Pages: 2724-2728
Published online on: 04 February 2016

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Gene expression alterations in inflamed and unaffected colon mucosa from patients with mild inflammatory bowel disease

Lili Xu, Lili Ma, Jingjing Lian, Jiayin Yang, Shiyao Chen
Pages: 2729-2735
Published online on: 05 February 2016

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Article

Anti-inflammatory potential of ursolic acid in Mycobacterium tuberculosis-sensitized and Concanavalin A-stimulated cells

Tamanna Zerin, Minjung Lee, Woong Sik Jang, Kung‑Woo Nam, Ho‑Yeon Song
Pages: 2736-2744
Published online on: 01 February 2016

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Article

Histone deacetylase 5 promotes Wilms' tumor cell proliferation through the upregulation of c-Met

Xu Cao, De‑Hong Liu, Yun Zhou, Xiang‑Ming Yan, Li‑Qun Yuan, Jian Pan, Ming‑Cui Fu, Ting Zhang, Jian Wang
Pages: 2745-2750
Published online on: 29 January 2016

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Article

TGF‑β1 inhibits the apoptosis of pulmonary arterial smooth muscle cells and contributes to pulmonary vascular medial thickening via the PI3K/Akt pathway

Limin Li, Xiaoqian Zhang, Xiaoxia Li, Chengfang Lv, Hongjuan Yu, Mengyuan Xu, Mingwen Zhang, Yueyue Fu, Hongbin Meng, Jin Zhou
Pages: 2751-2756
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Article

Isatin inhibits the proliferation and invasion of SH‑SY5Y neuroblastoma cells

Pingping Xu, Lin Hou, Chuanxia Ju, Zheng Zhang, Wenyan Sun, Li Zhang, Jinlian Song, Yuqiang Lv, Lu Liu, Zhixiang Chen, Yanhui Wang
Pages: 2757-2762
Published online on: 03 February 2016

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Article

Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN by targeting miR-21

Xiaofang Li, Aimin Zang, Youchao Jia, Jinchao Zhang, Wufang Fan, Jia Feng, Mindan Duan, Lei Zhang, Ran Huo, Jin Jiao, Xiaowei Zhu
Pages: 2763-2768
Published online on: 02 February 2016

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Article

Overexpression of microRNA‑210 promotes chondrocyte proliferation and extracellular matrix deposition by targeting HIF‑3α in osteoarthritis

Zhifu Li, Dongdong Meng, Guangheng Li, Jianzhong Xu, Ke Tian, Yu Li
Pages: 2769-2776
Published online on: 05 February 2016

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Article

Clinical significance of microRNA‑34b expression in pediatric acute leukemia

Lan Cao, Na Wang, Jian Pan, Shaoyan Hu, Wenli Zhao, Hailong He, Yi Wang, Guixiong Gu, Yihuan Chai
Pages: 2777-2784
Published online on: 05 February 2016

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Article

Effects of T cell immunoglobulin and mucin domain-containing molecule-3 signaling molecule on human monocyte-derived dendritic cells with hepatitis B virus surface antigen stimulation in vitro

Zhenjun Yu, Ting Jiang, Min Zhu, Kechuan Pan, Fei Yan, Jiansheng Zhu
Pages: 2785-2790
Published online on: 27 January 2016

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Article

Kaempferol induces apoptosis in HepG2 cells via activation of the endoplasmic reticulum stress pathway

Haiqing Guo, Feng Ren, Li Zhang, Xiangying Zhang, Rongrong Yang, Bangxiang Xie, Zhuo Li, Zhongjie Hu, Zhongping Duan, Jing Zhang
Pages: 2791-2800
Published online on: 02 February 2016

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Article

Expression and function of microRNA‑27b in hepatocellular carcinoma

Shujie He, Jingyuan Zhang, Juan Lin, Cuisheng Zhang, Shijie Sun
Pages: 2801-2808
Published online on: 03 February 2016

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MicroRNA‑26b is upregulated in a double transgenic mouse model of Alzheimer's disease and promotes the expression of amyloid‑β by targeting insulin‑like growth factor 1

Hong Liu, Wenzheng Chu, Li Gong, Xiaoyu Gao, Wei Wang
Pages: 2809-2814
Published online on: 04 February 2016

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Antidepressant-like effect of Ikwitang involves modulation of monoaminergic systems

Hee‑Yun Kim, Hyun‑Ja Jeong, Hyung‑Min Kim
Pages: 2815-2820
Published online on: 27 January 2016

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Article

5‑Fluorouracil attenuates dextran sodium sulfate‑induced acute colitis in mice

Junhua Xiao, Zhanjun Lu, Jiaqing Sheng, Yunna Song, Weiliang Jiang, Fei Liu, Ping Zheng
Pages: 2821-2828
Published online on: 03 February 2016

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Article

High expression of piwi-like RNA-mediated gene silencing 1 is associated with poor prognosis via regulating transforming growth factor-β receptors and cyclin-dependent kinases in breast cancer

Jiwei Cao, Gang Xu, Jing Lan, Qingqing Huang, Zuxiong Tang, Liping Tian
Pages: 2829-2835
Published online on: 02 February 2016

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Article

Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats

Hui Liu, Hong‑Yang Liu, Yi‑Nong Jiang, Nan Li
Pages: 2836-2842
Published online on: 28 January 2016

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Article

A‑769662, a direct AMPK activator, attenuates lipopolysaccharide‑induced acute heart and lung inflammation in rats

Maryam Rameshrad, Hamid Soraya, Nasrin Maleki‑Dizaji, Haleh Vaez, Alireza Garjani
Pages: 2843-2849
Published online on: 28 January 2016

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Article

Monoacylglycerol lipase inhibitor JZL184 regulates apoptosis and migration of colorectal cancer cells

Muyuan Ma, Jie Bai, Ye Ling, Weilong Chang, Gengchen Xie, Ruidong Li, Guobin Wang, Kaixiong Tao
Pages: 2850-2856
Published online on: 29 January 2016

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Article

GRHL2 genetic polymorphisms may confer a protective effect against sudden sensorineural hearing loss

Xiaojiang Lin, Yaoshu Teng, Jinshan Lan, Benjun He, Huijuan Sun, Fenglin Xu
Pages: 2857-2863
Published online on: 05 February 2016

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Article Open Access

Thioredoxin 1 protects astrocytes from oxidative stress by maintaining peroxiredoxin activity

Mengfei Wang, Kunting Zhu, Luyu Zhang, Lingyu Li, Jing Zhao
Pages: 2864-2870
Published online on: 03 February 2016

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Article

A novel virulence-associated protein, vapE, in Streptococcus suis serotype 2

Xue Ji, Yang Sun, Jun Liu, Lingwei Zhu, Xuejun Guo, Xulong Lang, Shuzhang Feng
Pages: 2871-2877
Published online on: 28 January 2016

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Article

Paris Saponins enhance radiosensitivity in a gefitinib‑resistant lung adenocarcinoma cell line by inducing apoptosis and G2/M cell cycle phase arrest

Peng‑Jun Zhao, Shui‑Chuan Song, Lei‑Wen Du, Guo‑Hua Zhou, Sheng‑Lin Ma, Jin‑Hui Li, Jian‑Guo Feng, Xin‑Hai Zhu, Hao Jiang
Pages: 2878-2884
Published online on: 04 February 2016

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Article

Overexpression of SCARA5 inhibits tumor proliferation and invasion in osteosarcoma via suppression of the FAK signaling pathway

Xinzhu Wen, Nan Wang, Fanfan Zhang, Chunjiao Dong
Pages: 2885-2891
Published online on: 03 February 2016

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Article

17β-estradiol suppresses hyperoxia-induced apoptosis of oligodendrocytes through paired-immunoglobulin-like receptor B

Hua Wang, Jinlin Wu
Pages: 2892-2898
Published online on: 27 January 2016

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Article

Icariin inhibits oxidized low-density lipoprotein-induced proliferation of vascular smooth muscle cells by suppressing activation of extracellular signal-regulated kinase 1/2 and expression of proliferating cell nuclear antigen

Yanwu Hu, Kai Liu, Mengtong Yan, Yang Zhang, Yadi Wang, Liqun Ren
Pages: 2899-2903
Published online on: 27 January 2016

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Article

Suppression of c‑FLIPL promotes JNK activation in malignant melanoma cells

Fen Tian, Yange Hu, Xixi Sun, Gaihui Lu, Yan Li, Jing Yang, Juan Tao
Pages: 2904-2908
Published online on: 03 February 2016

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Article

Time‑dependent homeostasis between glucose uptake and consumption in astrocytes exposed to CoCl2 treatment

Peng Wang, Ling Li, Zhenxiang Zhang, Quancheng Kan, Suyan Chen, Feng Gao
Pages: 2909-2917
Published online on: 05 February 2016

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Cardiopulmonary bypass increases pulmonary microvascular permeability through the Src kinase pathway: Involvement of caveolin-1 and vascular endothelial cadherin

Junwen Zhang, Zhaolei Jiang, Chunrong Bao, Ju Mei, Jiaquan Zhu
Pages: 2918-2924
Published online on: 29 January 2016

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Bioinformatics analysis of molecular mechanisms involved in intervertebral disc degeneration induced by TNF‑α and IL‑1β

Feng Xu, Feng Gao, Yadong Liu, Zhenyu Wang, Xinming Zhuang, Zhigang Qu, Hui Ma, Yi Liu, Changfeng Fu, Qi Zhang, Xiaoying Duan
Pages: 2925-2931
Published online on: 04 February 2016

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
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Correction Open Access

[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
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Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
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Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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