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Article Open Access

Intestinal ischemic preconditioning reduces liver ischemia reperfusion injury in rats

  • Authors:
    • Tong‑Min Xue
    • Li‑De Tao
    • Jie Zhang
    • Pei‑Jian Zhang
    • Xia Liu
    • Guo‑Feng Chen
    • Yi‑Jia Zhu
  • View Affiliations / Copyright

    Affiliations: Institute of General Surgical Research, Second Affiliated Hospital, Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China
    Copyright: © Xue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2511-2517
    |
    Published online on: January 28, 2016
       https://doi.org/10.3892/mmr.2016.4817
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Abstract

The aim of the current study was to investigate whether intestinal ischemic preconditioning (IP) reduces damage to the liver during hepatic ischemia reperfusion (IR). Sprague Dawley rats were used to model liver IR injury, and were divided into the sham operation group (SO), IR group and IP group. The results indicated that IR significantly increased Bax, caspase 3 and NF‑κBp65 expression levels, with reduced expression of Bcl‑2 compared with the IP group. Compared with the IR group, the levels of AST, ALT, MPO, MDA, TNF‑α and IL‑1 were significantly reduced in the IP group. Immunohistochemistry for Bcl‑2 and Bax indicated that Bcl‑2 expression in the IP group was significantly increased compared with the IR group. In addition, IP reduced Bax expression compared with the IR group. The average liver injury was worsened in the IR group and improved in the IP group, as indicated by the morphological evaluation of liver tissues. The present study suggested that IP may alleviates apoptosis, reduce the release of pro‑inflammatory cytokines, ameloriate reductions in liver function and reduce liver tissue injury. To conclude, IP provided protection against hepatic IR injury.
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Copy and paste a formatted citation
Spandidos Publications style
Xue TM, Tao LD, Zhang J, Zhang PJ, Liu X, Chen GF and Zhu YJ: Intestinal ischemic preconditioning reduces liver ischemia reperfusion injury in rats. Mol Med Rep 13: 2511-2517, 2016.
APA
Xue, T., Tao, L., Zhang, J., Zhang, P., Liu, X., Chen, G., & Zhu, Y. (2016). Intestinal ischemic preconditioning reduces liver ischemia reperfusion injury in rats. Molecular Medicine Reports, 13, 2511-2517. https://doi.org/10.3892/mmr.2016.4817
MLA
Xue, T., Tao, L., Zhang, J., Zhang, P., Liu, X., Chen, G., Zhu, Y."Intestinal ischemic preconditioning reduces liver ischemia reperfusion injury in rats". Molecular Medicine Reports 13.3 (2016): 2511-2517.
Chicago
Xue, T., Tao, L., Zhang, J., Zhang, P., Liu, X., Chen, G., Zhu, Y."Intestinal ischemic preconditioning reduces liver ischemia reperfusion injury in rats". Molecular Medicine Reports 13, no. 3 (2016): 2511-2517. https://doi.org/10.3892/mmr.2016.4817
Copy and paste a formatted citation
x
Spandidos Publications style
Xue TM, Tao LD, Zhang J, Zhang PJ, Liu X, Chen GF and Zhu YJ: Intestinal ischemic preconditioning reduces liver ischemia reperfusion injury in rats. Mol Med Rep 13: 2511-2517, 2016.
APA
Xue, T., Tao, L., Zhang, J., Zhang, P., Liu, X., Chen, G., & Zhu, Y. (2016). Intestinal ischemic preconditioning reduces liver ischemia reperfusion injury in rats. Molecular Medicine Reports, 13, 2511-2517. https://doi.org/10.3892/mmr.2016.4817
MLA
Xue, T., Tao, L., Zhang, J., Zhang, P., Liu, X., Chen, G., Zhu, Y."Intestinal ischemic preconditioning reduces liver ischemia reperfusion injury in rats". Molecular Medicine Reports 13.3 (2016): 2511-2517.
Chicago
Xue, T., Tao, L., Zhang, J., Zhang, P., Liu, X., Chen, G., Zhu, Y."Intestinal ischemic preconditioning reduces liver ischemia reperfusion injury in rats". Molecular Medicine Reports 13, no. 3 (2016): 2511-2517. https://doi.org/10.3892/mmr.2016.4817
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