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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-2016 Volume 13 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Case Report

Complete cytogenetic response to Nilotinib in a chronic myeloid leukemia case with a rare e13a3(b2a3) BCR-ABL fusion transcript: A case report

  • Authors:
    • Bei Liu
    • Wei Zhang
    • Haizhen Ma
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital, Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Central Laboratory, The First Affiliated Hospital, Lanzhou University, Lanzhou, Gansu 730000, P.R. China
  • Pages: 2635-2638
    |
    Published online on: January 29, 2016
       https://doi.org/10.3892/mmr.2016.4826
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Abstract

In the present study, an atypical case of chronic myeloid leukemia (CML) in a 32-year-old male was reported. CML cases with e13a3 breakpoint cluster region (BCR)-ABL transcripts are extremely rare. Reverse transcription quantitative‑polymerase chain reaction (RT-qPCR) was initially negative due to the primer corresponding to ABL a2 sequences and diagnosis was based upon analysis of the bone marrow smear, fluorescence in situ hybridization and karyotype analysis. RT‑qPCR analysis with the ABL primer, which was located in ABL exon 3 to enable the detection of fusions with either ABL a2 or exon a3 demonstrated the presence of the BCR‑ABL fusion transcript e13a3. The patient responded well to Nilotinib and achieved a complete cytogenetic response after 3 months.
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Copy and paste a formatted citation
Spandidos Publications style
Liu B, Zhang W and Ma H: Complete cytogenetic response to Nilotinib in a chronic myeloid leukemia case with a rare e13a3(b2a3) BCR-ABL fusion transcript: A case report. Mol Med Rep 13: 2635-2638, 2016.
APA
Liu, B., Zhang, W., & Ma, H. (2016). Complete cytogenetic response to Nilotinib in a chronic myeloid leukemia case with a rare e13a3(b2a3) BCR-ABL fusion transcript: A case report. Molecular Medicine Reports, 13, 2635-2638. https://doi.org/10.3892/mmr.2016.4826
MLA
Liu, B., Zhang, W., Ma, H."Complete cytogenetic response to Nilotinib in a chronic myeloid leukemia case with a rare e13a3(b2a3) BCR-ABL fusion transcript: A case report". Molecular Medicine Reports 13.3 (2016): 2635-2638.
Chicago
Liu, B., Zhang, W., Ma, H."Complete cytogenetic response to Nilotinib in a chronic myeloid leukemia case with a rare e13a3(b2a3) BCR-ABL fusion transcript: A case report". Molecular Medicine Reports 13, no. 3 (2016): 2635-2638. https://doi.org/10.3892/mmr.2016.4826
Copy and paste a formatted citation
x
Spandidos Publications style
Liu B, Zhang W and Ma H: Complete cytogenetic response to Nilotinib in a chronic myeloid leukemia case with a rare e13a3(b2a3) BCR-ABL fusion transcript: A case report. Mol Med Rep 13: 2635-2638, 2016.
APA
Liu, B., Zhang, W., & Ma, H. (2016). Complete cytogenetic response to Nilotinib in a chronic myeloid leukemia case with a rare e13a3(b2a3) BCR-ABL fusion transcript: A case report. Molecular Medicine Reports, 13, 2635-2638. https://doi.org/10.3892/mmr.2016.4826
MLA
Liu, B., Zhang, W., Ma, H."Complete cytogenetic response to Nilotinib in a chronic myeloid leukemia case with a rare e13a3(b2a3) BCR-ABL fusion transcript: A case report". Molecular Medicine Reports 13.3 (2016): 2635-2638.
Chicago
Liu, B., Zhang, W., Ma, H."Complete cytogenetic response to Nilotinib in a chronic myeloid leukemia case with a rare e13a3(b2a3) BCR-ABL fusion transcript: A case report". Molecular Medicine Reports 13, no. 3 (2016): 2635-2638. https://doi.org/10.3892/mmr.2016.4826
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