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Article

Histone deacetylase 5 promotes Wilms' tumor cell proliferation through the upregulation of c-Met

  • Authors:
    • Xu Cao
    • De‑Hong Liu
    • Yun Zhou
    • Xiang‑Ming Yan
    • Li‑Qun Yuan
    • Jian Pan
    • Ming‑Cui Fu
    • Ting Zhang
    • Jian Wang
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Childrens' Hospital Affiliated to Soochow University, Soochow University, Suzhou, Jiangsu 215003, P.R. China, Department of Pediatric Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China, Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, P.R. China
  • Pages: 2745-2750
    |
    Published online on: January 29, 2016
       https://doi.org/10.3892/mmr.2016.4828
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Abstract

The histone deacetylase (HDAC) family is comprised of enzymes, which are involved in modulating the majority of critical cellular processes, including transcriptional regulation, apoptosis, proliferation and cell cycle progression. However, the biological function of HDAC5 in Wilms' tumor remains to be fully elucidated. The present study aimed to investigate the expression and function of HDAC5 in Wilm's tumor. It was demonstrated that the mRNA and protein levels of HDAC5 were upregulated in human Wilms' tumor tissues. Overexpression of HDAC5 in G401 cells was observed to significantly promote cellular proliferation, as demonstrated by the results of an MTT assay and bromodeoxyuridine incorporation assay. By contrast, HDAC5 knockdown using small interfering RNA suppressed the proliferation of the G401 cells. At the molecular level, the present study demonstrated that HDAC5 promoted the expression of c‑Met, which has been previously identified as an oncogene. In addition, downregulation of c‑Met inhibited the proliferative effects of HDAC5 in human Wilms' tumor cells. Taken together, these results suggested that HDAC5 promotes cellular proliferation through the upregulation of c‑Met, and may provide a novel therapeutic target for the treatment of patients with Wilms' tumor.
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1 

Turnbull C, Perdeaux ER, Pernet D, Naranjo A, Renwick A, Seal S, Munoz-Xicola RM, Hanks S, Slade I, Zachariou A, et al: A genome-wide association study identifies susceptibility loci for Wilms tumor. Nat Genet. 44:681–684. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Wegert J, Bausenwein S, Kneitz S, Roth S, Graf N, Geissinger E and Gessler M: Retinoic acid pathway activity in Wilms tumors and characterization of biological responses in vitro. Mol Cancer. 10:1362011. View Article : Google Scholar : PubMed/NCBI

3 

Tian F, Yourek G, Shi X and Yang Y: The development of Wilms tumor: From WT1 and microRNA to animal models. Biochim Biophys Acta. 1846:180–187. 2014.PubMed/NCBI

4 

Sonn G and Shortliffe LM: Management of Wilms tumor: Current standard of care. Nat Clin Pract Urol. 5:551–560. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Acipayam C, Sezgin G, Bayram İ, Yılmaz S, Özkan A, Tuncel DA, Tanyeli A and Küpeli S: Treatment of Wilms tumor using carboplatin compared to therapy without carboplatin. Pediatr Blood Cancer. 61:1578–1583. 2014. View Article : Google Scholar : PubMed/NCBI

6 

West AC, Mattarollo SR, Shortt J, Cluse LA, Christiansen AJ, Smyth MJ and Johnstone RW: An intact immune system is required for the anticancer activities of histone deacetylase inhibitors. Cancer Res. 73:7265–7276. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Wagner JM, Hackanson B, Lübbert M and Jung M: Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy. Clin Epigenetics. 1:117–136. 2010. View Article : Google Scholar

8 

Witt O, Deubzer HE, Milde T and Oehme I: HDAC family: What are the cancer relevant targets? Cancer Lett. 277:8–21. 2009. View Article : Google Scholar

9 

Song SH, Han SW and Bang YJ: Epigenetic-based therapies in cancer: Progress to date. Drugs. 71:2391–2403. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Vigushin DM and Coombes RC: Histone deacetylase inhibitors in cancer treatment. Anticancer Drugs. 13:1–13. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Khan O and La Thangue NB: HDAC inhibitors in cancer biology: Emerging mechanisms and clinical applications. Immunol Cell Biol. 90:85–94. 2012. View Article : Google Scholar

12 

Cao B, Li J, Zhu J, Shen M, Han K, Zhang Z, Yu Y, Wang Y, Wu D, Chen S, et al: The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity. J Biol Chem. 288:34181–34189. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Lai F, Jin L, Gallagher S, Mijatov B, Zhang XD and Hersey P: Histone deacetylases (HDACs) as mediators of resistance to apoptosis in melanoma and as targets for combination therapy with selective BRAF inhibitors. Adv Pharmacol. 65:27–43. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Zhang Y, Matkovich SJ, Duan X, Diwan A, Kang MY and Dorn GN II: Receptor-independent protein kinase C alpha (PKCalpha) signaling by calpain-generated free catalytic domains induces HDAC5 nuclear export and regulates cardiac transcription. J Biol Chem. 286:26943–26951. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Feng GW, Dong LD, Shang WJ, Pang XL, Li JF, Liu L and Wang Y: HDAC5 promotes cell proliferation in human hepatocellular carcinoma by up-regulating Six1 expression. Eur Rev Med Pharmacol Sci. 18:811–816. 2014.PubMed/NCBI

16 

Milde T, Oehme I, Korshunov A, Kopp-Schneider A, Remke M, Northcott P, Deubzer HE, Lodrini M, Taylor MD, von Deimling A, et al: HDAC5 and HDAC9 in medulloblastoma: Novel markers for risk stratification and role in tumor cell growth. Clin Cancer Res. 16:3240–3252. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Actis M, Inoue A, Evison B, Perry S, Punchihewa C and Fujii N: Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis. Bioorg Med Chem. 21:1972–1977. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Li Z and Zhu WG: Targeting histone deacetylases for cancer therapy: From molecular mechanisms to clinical implications. Int J Biol Sci. 10:757–770. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Rincon-Arano H, Halow J, Delrow JJ, Parkhurst SM and Groudine M: UpSET recruits HDAC complexes and restricts chromatin accessibility and acetylation at promoter regions. Cell. 151:1214–1228. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Marek L, Hamacher A, Hansen FK, Kuna K, Gohlke H, Kassack MU and Kurz T: Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. J Med Chem. 56:427–436. 2013. View Article : Google Scholar

21 

Peixoto P, Castronovo V, Matheus N, Polese C, Peulen O, Gonzalez A, Boxus M, Verdin E, Thiry M, Dequiedt F and Mottet D: HDAC5 is required for maintenance of pericentric heterochromatin and controls cell-cycle progression and survival of human cancer cells. Cell Death Differ. 19:1239–1252. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Chen J, Xia J, Yu YL, Wang SQ, Wei YB, Chen FY, Huang GY and Shi JS: HDAC5 promotes osteosarcoma progression by upregulation of Twist 1 expression. Tumour Biol. 35:1383–1387. 2014. View Article : Google Scholar

23 

Kondo S, Ojima H, Tsuda H, Hashimoto J, Morizane C, Ikeda M, Ueno H, Tamura K, Shimada K, Kanai Y and Okusaka T: Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma. Int J Clin Oncol. 18:207–213. 2013. View Article : Google Scholar

24 

Lee JM, Yoo JK, Yoo H, Jung HY, Lee DR, Jeong HC, Oh SH, Chung HM and Kim JK: The novel miR-7515 decreases the proliferation and migration of human lung cancer cells by targeting c-Met. Mol Cancer Res. 11:43–53. 2013. View Article : Google Scholar

25 

Koon EC, Ma PC, Salgia R, Christensen JG, Berkowitz RS and Mok SC: Effect of a c-Met-specific, ATP-competitive small-molecule inhibitor SU11274 on human ovarian carcinoma cell growth, motility and invasion. Int J Gynecol Cancer. 18:976–984. 2008. View Article : Google Scholar

26 

Goetsch L, Caussanel V and Corvaia N: Biological significance and targeting of c-Met tyrosine kinase receptor in cancer. Front Biosci (Landmark Ed). 18:454–473. 2013. View Article : Google Scholar

27 

Lee YY, Kim HP, Kang MJ, Cho BK, Han SW, Kim TY and Yi EC: Phosphoproteomic analysis identifies activated MET-axis PI3K/AKT and MAPK/ERK in lapatinib-resistant cancer cell line. Exp Mol Med. 45:e642013. View Article : Google Scholar : PubMed/NCBI

28 

Nam HJ, Chae S, Jang SH, Cho H and Lee JH: The PI3K-Akt mediates oncogenic Met-induced centrosome amplification and chromosome instability. Carcinogenesis. 31:1531–1540. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Guessous F, Yang Y, Johnson E, Marcinkiewicz L, Smith M, Zhang Y, Kofman A, Schiff D, Christensen J and Abounader R: Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy. Mol Cancer Ther. 11:288–297. 2012. View Article : Google Scholar :

30 

Hong SW, Jung KH, Park BH, Zheng HM, Lee HS, Choi MJ, Yun JI, Kang NS, Lee J and Hong SS: KRC-408, a novel c-Met inhibitor, suppresses cell proliferation and angiogenesis of gastric cancer. Cancer Lett. 332:74–82. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Yang X, Yang Y, Tang S, Tang H, Yang G, Xu Q and Wu J: Anti-tumor effect of polysaccharides from Scutellaria barbata D. Don on the 95-D xenograft model via inhibition of the C-met pathway. J Pharmacol Sci. 125:255–263. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Zhang HT, Wang L, Ai J, Chen Y, He CX, Ji YC, Huang M, Yang JY, Zhang A, Ding J and Geng MY: SOMG-833, a novel selective c-MET inhibitor, blocks c-MET-dependent neoplastic effects and exerts antitumor activity. J Pharmacol Exp Ther. 350:36–45. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cao X, Liu DH, Zhou Y, Yan XM, Yuan LQ, Pan J, Fu MC, Zhang T and Wang J: Histone deacetylase 5 promotes Wilms' tumor cell proliferation through the upregulation of c-Met. Mol Med Rep 13: 2745-2750, 2016.
APA
Cao, X., Liu, D., Zhou, Y., Yan, X., Yuan, L., Pan, J. ... Wang, J. (2016). Histone deacetylase 5 promotes Wilms' tumor cell proliferation through the upregulation of c-Met. Molecular Medicine Reports, 13, 2745-2750. https://doi.org/10.3892/mmr.2016.4828
MLA
Cao, X., Liu, D., Zhou, Y., Yan, X., Yuan, L., Pan, J., Fu, M., Zhang, T., Wang, J."Histone deacetylase 5 promotes Wilms' tumor cell proliferation through the upregulation of c-Met". Molecular Medicine Reports 13.3 (2016): 2745-2750.
Chicago
Cao, X., Liu, D., Zhou, Y., Yan, X., Yuan, L., Pan, J., Fu, M., Zhang, T., Wang, J."Histone deacetylase 5 promotes Wilms' tumor cell proliferation through the upregulation of c-Met". Molecular Medicine Reports 13, no. 3 (2016): 2745-2750. https://doi.org/10.3892/mmr.2016.4828
Copy and paste a formatted citation
x
Spandidos Publications style
Cao X, Liu DH, Zhou Y, Yan XM, Yuan LQ, Pan J, Fu MC, Zhang T and Wang J: Histone deacetylase 5 promotes Wilms' tumor cell proliferation through the upregulation of c-Met. Mol Med Rep 13: 2745-2750, 2016.
APA
Cao, X., Liu, D., Zhou, Y., Yan, X., Yuan, L., Pan, J. ... Wang, J. (2016). Histone deacetylase 5 promotes Wilms' tumor cell proliferation through the upregulation of c-Met. Molecular Medicine Reports, 13, 2745-2750. https://doi.org/10.3892/mmr.2016.4828
MLA
Cao, X., Liu, D., Zhou, Y., Yan, X., Yuan, L., Pan, J., Fu, M., Zhang, T., Wang, J."Histone deacetylase 5 promotes Wilms' tumor cell proliferation through the upregulation of c-Met". Molecular Medicine Reports 13.3 (2016): 2745-2750.
Chicago
Cao, X., Liu, D., Zhou, Y., Yan, X., Yuan, L., Pan, J., Fu, M., Zhang, T., Wang, J."Histone deacetylase 5 promotes Wilms' tumor cell proliferation through the upregulation of c-Met". Molecular Medicine Reports 13, no. 3 (2016): 2745-2750. https://doi.org/10.3892/mmr.2016.4828
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