Regulatory roles of microRNA-21 in fibrosis through interaction with diverse pathways (Review)

  • Authors:
    • Rong‑Han Liu
    • Bin Ning
    • Xiao‑En Ma
    • Wei‑Ming Gong
    • Tang‑Hong Jia
  • View Affiliations

  • Published online on: January 29, 2016     https://doi.org/10.3892/mmr.2016.4834
  • Pages: 2359-2366
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Abstract

MicroRNA-21 (miR-21) is a small, non-coding RNA which can regulate gene expression at the post‑transcriptional level. While the fibrogenic process is vital in tissue repair, proliferation and transition of fibrogenic cells combined with an imbalance of secretion and degradation of the extracellular matrix results in excessive tissue remodeling and fibrosis. Recent studies have indicated that miR‑21 is overexpressed during fibrosis and can regulate the fibrogenic process in a variety of organs and tissues via diverse pathways. The present review summarized the significant roles of miR-21 in fibrosis and discussed the underlying key pathways.
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March-2016
Volume 13 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Liu RH, Ning B, Ma XE, Gong WM and Jia TH: Regulatory roles of microRNA-21 in fibrosis through interaction with diverse pathways (Review). Mol Med Rep 13: 2359-2366, 2016
APA
Liu, R., Ning, B., Ma, X., Gong, W., & Jia, T. (2016). Regulatory roles of microRNA-21 in fibrosis through interaction with diverse pathways (Review). Molecular Medicine Reports, 13, 2359-2366. https://doi.org/10.3892/mmr.2016.4834
MLA
Liu, R., Ning, B., Ma, X., Gong, W., Jia, T."Regulatory roles of microRNA-21 in fibrosis through interaction with diverse pathways (Review)". Molecular Medicine Reports 13.3 (2016): 2359-2366.
Chicago
Liu, R., Ning, B., Ma, X., Gong, W., Jia, T."Regulatory roles of microRNA-21 in fibrosis through interaction with diverse pathways (Review)". Molecular Medicine Reports 13, no. 3 (2016): 2359-2366. https://doi.org/10.3892/mmr.2016.4834