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Article

Retinal and choroidal expression of BMP-2 in lens-induced myopia and recovery from myopia in guinea pigs

  • Authors:
    • Honghui Li
    • Juan Wu
    • Dongmei Cui
    • Junwen Zeng
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat‑Sen University, Guangzhou, Guangdong 510060, P.R. China
  • Pages: 2671-2676
    |
    Published online on: February 2, 2016
       https://doi.org/10.3892/mmr.2016.4843
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Abstract

The present study investigated the retinal and choroidal expression of bone morphogenetic protein-2 (BMP-2) in myopia and in myopia recovery in a guinea pig model. For this investigation, two groups of guinea pigs, lens‑induced myopia and recovery from myopia, were used, and defocused myopia was induced the guinea pigs wearing ‑4.00 D lenses on the right eyes for 3 weeks, with the left eyes serving as the contralateral. In the following week, the lenses of the guinea pigs in the recovery group were removed, and the refractive power and axial length were measured. The expression of BMP‑2 in the eyeballs was observed using immunohistochemistry and analyzed using Western blot analysis. After 3 weeks, the eyes acquired relative myopia and longer axial lengths in the two groups of guinea pigs. After 1 week without lenses in the recovery group, the myopia and axial lengths regressed. Immunofluorescence staining showed that BMP‑2 was expressed in the posterior retina, RPE, choroid and sclera. The expression of BMP‑2 decreased in the myopic retina of the guinea pigs. Following the regression of myopia in the recovery group, no difference in the expression of BMP‑2 was observed between the recovered treated eyes and the contralateral eyes. The choroidal expression level of BMP‑2 in the treated eyes showed no significant changes in either group. Therefore, BMP‑2 may be involved in the development of myopia, however, it does not have a primary role in the retinal and choroidal signals regulating scleral remodeling.
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Copy and paste a formatted citation
Spandidos Publications style
Li H, Wu J, Cui D and Zeng J: Retinal and choroidal expression of BMP-2 in lens-induced myopia and recovery from myopia in guinea pigs. Mol Med Rep 13: 2671-2676, 2016.
APA
Li, H., Wu, J., Cui, D., & Zeng, J. (2016). Retinal and choroidal expression of BMP-2 in lens-induced myopia and recovery from myopia in guinea pigs. Molecular Medicine Reports, 13, 2671-2676. https://doi.org/10.3892/mmr.2016.4843
MLA
Li, H., Wu, J., Cui, D., Zeng, J."Retinal and choroidal expression of BMP-2 in lens-induced myopia and recovery from myopia in guinea pigs". Molecular Medicine Reports 13.3 (2016): 2671-2676.
Chicago
Li, H., Wu, J., Cui, D., Zeng, J."Retinal and choroidal expression of BMP-2 in lens-induced myopia and recovery from myopia in guinea pigs". Molecular Medicine Reports 13, no. 3 (2016): 2671-2676. https://doi.org/10.3892/mmr.2016.4843
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Wu J, Cui D and Zeng J: Retinal and choroidal expression of BMP-2 in lens-induced myopia and recovery from myopia in guinea pigs. Mol Med Rep 13: 2671-2676, 2016.
APA
Li, H., Wu, J., Cui, D., & Zeng, J. (2016). Retinal and choroidal expression of BMP-2 in lens-induced myopia and recovery from myopia in guinea pigs. Molecular Medicine Reports, 13, 2671-2676. https://doi.org/10.3892/mmr.2016.4843
MLA
Li, H., Wu, J., Cui, D., Zeng, J."Retinal and choroidal expression of BMP-2 in lens-induced myopia and recovery from myopia in guinea pigs". Molecular Medicine Reports 13.3 (2016): 2671-2676.
Chicago
Li, H., Wu, J., Cui, D., Zeng, J."Retinal and choroidal expression of BMP-2 in lens-induced myopia and recovery from myopia in guinea pigs". Molecular Medicine Reports 13, no. 3 (2016): 2671-2676. https://doi.org/10.3892/mmr.2016.4843
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