1
|
Gay SE, Kazerooni EA, Toews GB, Lynch JP
III, Gross BH, Cascade PN, Spizarny DL, Flint A, Schork MA, Whyte
RI, et al: Idiopathic pulmonary fibrosis: Predicting response to
therapy and survival. Am J Respir Crit Care Med. 157:1063–1072.
1998. View Article : Google Scholar : PubMed/NCBI
|
2
|
Baumgartner KB, Samet JM, Stidley CA,
Colby TV and Waldron JA: Cigarette smoking: A risk factor for
idiopathic pulmonary fibrosis. Am J Respir Crit Care Med.
155:242–248. 1997. View Article : Google Scholar : PubMed/NCBI
|
3
|
Iwai K, Mori T, Yamada N, Yamaguchi M and
Hosoda Y: Idiopathic pulmonary fibrosis. Epidemiologic approaches
to occupational exposure. Am J Respir Crit Care Med. 150:670–675.
1994. View Article : Google Scholar : PubMed/NCBI
|
4
|
Taskar VS and Coultas DB: Is idiopathic
pulmonary fibrosis an environmental disease? Proc Am Thorac Soc.
3:293–298. 2006. View Article : Google Scholar : PubMed/NCBI
|
5
|
Quan J, Zhang Q, He H, Liu J, Huang M and
Jin H: Analysis of the formation of fog and haze in North China
Plain (NCP). Atmos Chem Phys. 11:8205–8214. 2011. View Article : Google Scholar
|
6
|
Todd NW, Luzina IG and Atamas SP:
Molecular and cellular mechanisms of pulmonary fibrosis.
Fibrogenesis Tissue Repair. 5:112012. View Article : Google Scholar : PubMed/NCBI
|
7
|
King TE Jr, Schwarz MI, Brown K, Tooze JA,
Colby TV, Waldron JA Jr, Flint A, Thurlbeck W and Cherniack RM:
Idiopathic pulmonary fibrosis: Relationship between histopathologic
features and mortality. Am J Respir Crit Care Med. 164:1025–1032.
2001. View Article : Google Scholar : PubMed/NCBI
|
8
|
Tamura M, Gu J, Matsumoto K, Aota S,
Parsons R and Yamada KM: Inhibition of cell migration, spreading,
and focal adhesions by tumor suppressor PTEN. Science.
280:1614–1617. 1998. View Article : Google Scholar : PubMed/NCBI
|
9
|
Stambolic V, Suzuki A, de la Pompa JL,
Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM,
Siderovski DP and Mak TW: Negative regulation of PKB/Akt-dependent
cell survival by the tumor suppressor PTEN. Cell. 95:29–39. 1998.
View Article : Google Scholar : PubMed/NCBI
|
10
|
Tamura M, Gu J, Takino T and Yamada KM:
Tumor suppressor PTEN inhibition of cell invasion, migration, and
growth: Differential involvement of focal adhesion kinase and
p130Cas. Cancer Res. 59:442–449. 1999.PubMed/NCBI
|
11
|
Vancheri C, Failla M, Crimi N and Raghu G:
Idiopathic pulmonary fibrosis: A disease with similarities and
links to cancer biology. Eur Respir J. 35:496–504. 2010. View Article : Google Scholar : PubMed/NCBI
|
12
|
Rabinovich EI, Kapetanaki MG, Steinfeld I,
Gibson KF, Pandit KV, Yu G, Yakhini Z and Kaminski N: Global
methylation patterns in idiopathic pulmonary fibrosis. PLoS One.
7:e337702012. View Article : Google Scholar : PubMed/NCBI
|
13
|
Vancheri C: Common pathways in idiopathic
pulmonary fibrosis and cancer. Eur Respir Rev. 22:265–272. 2013.
View Article : Google Scholar : PubMed/NCBI
|
14
|
White ES, Thannickal VJ, Carskadon SL,
Dickie EG, Livant DL, Markwart S, Toews GB and Arenberg DA:
Integrin alpha4beta1 regulates migration across basement membranes
by lung fibroblasts: A role for phosphatase and tensin homologue
deleted on chromosome 10. Am J Respir Crit Care Med. 168:436–442.
2003. View Article : Google Scholar : PubMed/NCBI
|
15
|
White ES, Atrasz RG, Hu B, Phan SH,
Stambolic V, Mak TW, Hogaboam CM, Flaherty KR, Martinez FJ, Kontos
CD and Toews GB: Negative regulation of myofibroblast
differentiation by PTEN (phosphatase and tensin homolog deleted on
chromosome 10). Am J Respir Crit Care Med. 173:112–121. 2006.
View Article : Google Scholar :
|
16
|
Miyoshi K, Yanagi S, Kawahara K, Nishio M,
Tsubouchi H, Imazu Y, Koshida R, Matsumoto N, Taguchi A, Yamashita
S, et al: Epithelial Pten controls acute lung injury and fibrosis
by regulating alveolar epithelial cell integrity. Am J Respir Crit
Care Med. 187:262–275. 2013. View Article : Google Scholar
|
17
|
Xia H, Khalil W, Kahm J, Jessurun J,
Kleidon J and Henke CA: Pathologic caveolin-1 regulation of PTEN in
idiopathic pulmonary fibrosis. Am J Pathol. 176:2626–2637. 2010.
View Article : Google Scholar : PubMed/NCBI
|
18
|
Xia H, Diebold D, Nho R, Perlman D,
Kleidon J, Kahm J, Avdulov S, Peterson M, Nerva J, Bitterman P and
Henke C: Pathological integrin signaling enhances proliferation of
primary lung fibroblasts from patients with idiopathic pulmonary
fibrosis. J Exp Med. 205:1659–1672. 2008. View Article : Google Scholar : PubMed/NCBI
|
19
|
Fagone E, Conte E, Gili E, Fruciano M,
Pistorio MP, Lo Furno D, Giuffrida R, Crimi N and Vancheri C:
Resveratrol inhibits transforming growth factor-β-induced
proliferation and differentiation of ex vivo human lung fibroblasts
into myofibroblasts through ERK/Akt inhibition and PTEN
restoration. Exp Lung Res. 37:162–174. 2011. View Article : Google Scholar : PubMed/NCBI
|
20
|
Desmoulière A, Geinoz A, Gabbiani F and
Gabbiani G: Transforming growth factor-beta 1 induces alpha-smooth
muscle actin expression in granulation tissue myofibroblasts and in
quiescent and growing cultured fibroblasts. J Cell Biol.
122:103–111. 1993. View Article : Google Scholar : PubMed/NCBI
|
21
|
Sime PJ and O'Reilly KM: Fibrosis of the
lung and other tissues: New concepts in pathogenesis and treatment.
Clin Immunol. 99:308–319. 2001. View Article : Google Scholar : PubMed/NCBI
|
22
|
Leask A and Abraham DJ: TGF-beta signaling
and the fibrotic response. FASEB J. 18:816–827. 2004. View Article : Google Scholar : PubMed/NCBI
|
23
|
Kulkarni AA, Thatcher TH, Olsen KC,
Maggirwar SB, Phipps RP and Sime PJ: PPAR-γ ligands repress
TGFβ-induced myofibroblast differentiation by targeting the
PI3K/Akt pathway: Implications for therapy of fibrosis. PLoS One.
6:e159092011. View Article : Google Scholar
|
24
|
Caraci F, Gili E, Calafiore M, Failla M,
La Rosa C, Crimi N, Sortino MA, Nicoletti F, Copani A and Vancheri
C: TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK
activation in the transition of human lung fibroblasts into
myofibroblasts. Pharmacol Res. 57:274–282. 2008. View Article : Google Scholar : PubMed/NCBI
|
25
|
Gauldie J, Bonniaud P, Sime P, Ask K and
Kolb M: TGF-beta, Smad3 and the process of progressive fibrosis.
Biochem Soc Trans. 35:661–664. 2007. View Article : Google Scholar : PubMed/NCBI
|
26
|
Li DM and Sun H: TEP1, encoded by a
candidate tumor suppressor locus, is a novel protein tyrosine
phosphatase regulated by transforming growth factor beta. Cancer
Res. 57:2124–2129. 1997.PubMed/NCBI
|
27
|
Raghu G, Collard HR, Egan JJ, Martinez FJ,
Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, et
al ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis: An
official ATS/ERS/JRS/ALAT statement: Idiopathic pulmonary fibrosis:
Evidence-based guidelines for diagnosis and management. Am J Respir
Crit Care Med. 183:788–824. 2011. View Article : Google Scholar : PubMed/NCBI
|
28
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
29
|
Nathan SD, Basavaraj A, Reichner C,
Shlobin OA, Ahmad S, Kiernan J, Burton N and Barnett SD: Prevalence
and impact of coronary artery disease in idiopathic pulmonary
fibrosis. Respir Med. 104:1035–1041. 2010. View Article : Google Scholar : PubMed/NCBI
|
30
|
Nho RS: Current concept for the
pathogenesis of idiopathic pulmonary fibrosis (IPF). Clin Res
Pulmono. 1:1006–1008. 2013.
|
31
|
Nho RS, Hergert P, Kahm J, Jessurun J and
Henke C: Pathological alteration of FoxO3a activity promotes
idiopathic pulmonary fibrosis fibroblast proliferation on type I
collagen matrix. Am J Pathol. 179:2420–30. 2011. View Article : Google Scholar : PubMed/NCBI
|
32
|
Ihn H: Pathogenesis of fibrosis: Role of
TGF-beta and CTGF. Curr Opin Rheumatol. 14:681–685. 2002.
View Article : Google Scholar : PubMed/NCBI
|
33
|
Conte E, Fruciano M, Fagone E, Gili E,
Caraci F, Iemmolo M, Crimi N and Vancheri C: Inhibition of PI3K
prevents the proliferation and differentiation of human lung
fibroblasts into myofibroblasts: The role of class I P110 isoforms.
PLoS One. 6:e246632011. View Article : Google Scholar : PubMed/NCBI
|
34
|
Wilkes MC, Mitchell H, Penheiter SG, Doré
JJ, Suzuki K, Edens M, Sharma DK, Pagano RE and Leof EB:
Transforming growth factor-beta activation of phosphatidylinositol
3-kinase is independent of Smad2 and Smad3 and regulates fibroblast
responses via p21-activated kinase-2. Cancer Res. 65:10431–10440.
2005. View Article : Google Scholar : PubMed/NCBI
|
35
|
Gu L, Zhu YJ, Yang X, Guo ZJ, Xu WB and
Tian XL: Effect of TGF-beta/Smad signaling pathway on lung
myofibroblast differentiation. Acta Pharmacol Sin. 28:382–391.
2007. View Article : Google Scholar : PubMed/NCBI
|
36
|
Chilosi M, Poletti V, Zamò A, Lestani M,
Montagna L, Piccoli P, Pedron S, Bertaso M, Scarpa A, Murer B, et
al: Aberrant Wnt/beta-catenin pathway activation in idiopathic
pulmonary fibrosis. Am J Pathol. 162:1495–1502. 2003. View Article : Google Scholar : PubMed/NCBI
|
37
|
Amini Nik S, Ebrahim RP, Van Dam K,
Cassiman JJ and Tejpar S: TGF-beta modulates beta-Catenin stability
and signaling in mesenchymal proliferations. Exp Cell Res.
313:2887–2895. 2007. View Article : Google Scholar : PubMed/NCBI
|
38
|
Baarsma HA, Spanjer AI, Haitsma G,
Engelbertink LH, Meurs H, Jonker MR, Timens W, Postma DS, Kerstjens
HA and Gosens R: Activation of WNT/β-catenin signaling in pulmonary
fibroblasts by TGF-β1 is increased in chronic
obstructive pulmonary disease. PLoS One. 6:e254502011. View Article : Google Scholar
|
39
|
Pardo A and Selman M: Matrix
metalloproteases in aberrant fibrotic tissue remodeling. Proc Am
Thorac Soc. 3:383–388. 2006. View Article : Google Scholar : PubMed/NCBI
|
40
|
Jarman ER, Khambata VS, Yun Ye L, Cheung
K, Thomas M, Duggan N and Jarai G: A translational preclinical
model of interstitial pulmonary fibrosis and pulmonary
hypertension: mechanistic pathways driving disease pathophysiology.
Physiol Rep. 2:e121332014. View Article : Google Scholar : PubMed/NCBI
|