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Article Open Access

Age‑related changes in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats

  • Authors:
    • Yali Li
    • Jian Liu
    • Dengfeng Gao
    • Jin Wei
    • Haifeng Yuan
    • Xiaolin Niu
    • Qiaojun Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Rehabilitation, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China, Department of Physiology, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2552-2560
    |
    Published online on: February 3, 2016
       https://doi.org/10.3892/mmr.2016.4853
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Abstract

The aim of the present study was to investigate the age‑related alterations in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats (SHR) and the underlying mechanisms. Aging resulted in a significant increase in the number of activated astrocytes and apoptotic cells in the SHR group, which was accompanied by increased expression of oxidative stress markers (iNOS and gp47phox) and apoptotic regulatory proteins (Bax and caspase‑3). In addition, the expression of PPAR‑γ and Bcl‑2 were progressively reduced with increasing age in the SHR group. The 32 and 64‑week‑old SHRs exhibited significantly increased numbers of apoptotic cells, oxidative stress markers and pro‑apoptotic proteins compared with age‑matched WKY rats, which was accompanied by reduced expression of PPAR‑γ. Compared with the 16 and 32‑week‑old WKY group, the 64‑week‑old WKY rats exhibited increased oxidative stress and pro‑apoptotic markers, and increased levels apoptotic cells. In conclusion, the present study indicated that both aging and hypertension enhanced brain damage and oxidative stress injury in the hippocampi of SHRs, indicated by an increased presence of apoptotic cells and astrocytes. In addition, reduced expression of PPAR‑γ may contribute to the age‑related brain damage in SHRs.
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1 

Blackwood WS, Maudgal DP, Pickard RG, Lawrence D and Northfield TC: Cimetidine in duodenal ulcer. Controlled trial Lancet. 2:174–176. 1976.

2 

Kilander L, Nyman H, Boberg M, Hansson L and Lithell H: Hypertension is related to cognitive impairment: A 20-year follow-up of 999 men. Hypertension. 31:780–786. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Sabbatini M, Tomassoni D and Amenta F: Hypertensive brain damage: Comparative evaluation of protective effect of treatment with dihydropyridine derivatives in spontaneously hypertensive rats. Mech Ageing Dev. 122:2085–2105. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Harrison DG and Gongora MC: Oxidative stress and hypertension. Med Clin North Am. 93:621–635. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Brown RC and Davis TP: Calcium modulation of adherens and tight junction function: A potential mechanism for blood-brain barrier disruption after stroke. Stroke. 33:1706–1711. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Sabbatini M, Strocchi P, Vitaioli L and Amenta F: The hippocampus in spontaneously hypertensive rats: A quantitative microanatomical study. Neuroscience. 100:251–258. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Geinisman Y, Detoledo-Morrell L, Morrell F and Heller RE: Hippocampal markers of age-related memory dysfunction: Behavioral, electrophysiological and morphological perspectives. Prog Neurobiol. 45:223–252. 1995. View Article : Google Scholar : PubMed/NCBI

8 

Schmidt-Kastner R, Ophoff BG and Hossmann KA: Pattern of neuronal vulnerability in the cat hippocampus after one hour of global cerebral ischemia. Acta Neuropathol. 79:444–455. 1990. View Article : Google Scholar : PubMed/NCBI

9 

Barone FC, Price WJ, White RF, Willette RN and Feuerstein GZ: Genetic hypertension and increased susceptibility to cerebral ischemia. Neurosci Biobehav Rev. 16:219–233. 1992. View Article : Google Scholar : PubMed/NCBI

10 

Touyz RM: Reactive oxygen species, vascular oxidative stress and redox signaling in hypertension: What is the clinical significance? Hypertension. 44:248–252. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Amoureux S, Lorgis L, Sicard P, Girard C, Rochette L and Vergerly C: Vascular BDNF expression and oxidative stress during aging and the development of chronic hypertension. Fundam Clin Pharmacol. 26:227–234. 2012. View Article : Google Scholar

12 

Fuenzalida K, Quintanilla R, Ramos P, Piderit D, Fuentealba RA, Martinez G, Inestrosa NC and Bronfman M: Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. J Biol Chem. 282:37006–37015. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Blanquicett C, Kang BY, Ritzenthaler JD, Jones DP and Hart CM: Oxidative stress modulates PPAR gamma in vascular endothelial cells. Free Radic Biol Med. 48:1618–1625. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Li WL, Liang X, Wang X, Zhang XD, Liu R, Zhang W, Chen HL, Qin XJ, Bai H and Hai CX: Protective effect of the peroxisome proliferator-activated receptor (PPAR)-γ, ligand rosiglitazone on tert-butyl hydroperoxide-induced QZG cell injury. Exp Toxicol Pathol. 63:527–533. 2011. View Article : Google Scholar

15 

Fleige S, Walf V, Huch S, Prgomet C, Sehm J and Pfaffl MW: Comparison of relative mRNA quantification models and the impact of RNA integrity in quantitative real-time RT-PCR. Biotechnol Lett. 28:1601–1613. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Lehr RP Jr, Browning RA and Myers JH: Gross morphological brain differences between Wistar-Kyoto and spontaneously hypertensive rats. Clin Exp Hypertens. 2:123–127. 1980. View Article : Google Scholar : PubMed/NCBI

17 

Tajima A, Hans FJ, Livingstone D, Wei L, Finnegan W, Demaro J and Fenstermacher J: Smaller local brain volumes and cerebral atrophy in spontaneously hypertensive rats. Hypertension. 21:105–111. 1993. View Article : Google Scholar : PubMed/NCBI

18 

Sabbatini M, Catalani Å, Consoli C, Marletta N, Tomassoni D and Avola R: The hippocampus in spontaneously hypertensive rats: An animal model of vascular dementia? Mech Ageing Dev. 123:547–559. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Tomassoni D, Avola R, Mignini F, Parnetti L and Amenta F: Effect of treatment with choline alphoscerate on hippocampus microanatomy and glial reaction in spontaneously hypertensive rats. Brain Res. 1120:183–190. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Napoleone P, Ferrante F, Ghirardi O, Ramacci MT and Amenta F: Age-dependent nerve cell loss in the brain of Sprague-Dawley rats: Effect of long term acetyl-L-carnitine treatment. Arch Gerontol Geriatr. 10:173–185. 1990. View Article : Google Scholar : PubMed/NCBI

21 

Charriaut-Marlangue C and Ben-Ari Y: A cautionary note on the use of the TUNEL stain to determine apoptosis. Neuroreport. 7:61–64. 1995. View Article : Google Scholar : PubMed/NCBI

22 

Hamet P, Richard L, Dam TV, Teiger E, Orlov SN, Gaboury L, Gossard F and Tremblay J: Apoptosis in target organs of hypertension. Hypertension. 26:642–648. 1995. View Article : Google Scholar : PubMed/NCBI

23 

Lo EH, Dalkara T and Moskowitz MA: Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci. 4:399–415. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Takamiya Y, Kohsaka S, Toya S, Otani M and Tsukada Y: Immunohistochemical studies on the proliferation of reactive astrocytes and the expression of cytoskeletal proteins following brain injury in rats. Brain Res. 466:201–210. 1988. View Article : Google Scholar : PubMed/NCBI

25 

Kregel KC and Zhang HJ: An integrated view of oxidative stress in aging: Basic mechanisms, functional effects and pathological considerations. Am J Physiol Regul Integr Comp Physiol. 292:R18–R36. 2007. View Article : Google Scholar

26 

Tanito M, Nakamura H, Kwon YW, Teratani A, Masutani H, Shioji K, Kishimoto C, Ohira A, Horie R and Yodoi J: Enhanced oxidative stress and impaired thioredoxin expression in spontaneously hypertensive rats. Antioxid Redox Signal. 6:89–97. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Higashi Y, Sasaki S, Nakagawa K, Matsuura H, Oshima T and Chayama K: Endothelial function and oxidative stress in renovascular hypertension. N Engl J Med. 346:1954–1962. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Zhou L, Xiang W, Potts J, Floyd M, Sharan C, Yang H, Ross J, Nyanda AM and Guo Z: Reduction in extracellular superoxide dismutase activity in African-American patients with hypertension. Free Radic Biol Med. 41:1384–1391. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Dobrian AD, Schriver SD, Khraibi AA and Prewitt RL: Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesity. Hypertension. 43:48–56. 2004. View Article : Google Scholar

30 

Nishiyama A, Yao L, Nagai Y, Miyata K, Yoshizumi M, Kagami S, Kondo S, Kiyomoto H, Shokoji T, Kimura S, et al: Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats. Hypertension. 43:841–848. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Pechanova O, Zicha J, Kojsova S, Dobesová Z, Jendeková L and Kunes J: Effect of chronic N-acetylcysteine treatment on the development of spontaneous hypertension. Clin Sci (Lond). 110:235–242. 2006. View Article : Google Scholar

32 

Kushiro T, Fujita H, Hisaki R, Asai T, Ichiyama I, Kitahara Y, Koike M, Sugiura H, Saito F, Otsuka Y and Kanmatsuse K: Oxidative stress in the Dahl salt-sensitive hypertensive rat. Clin Exp Hypertens. 27:9–15. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Poulet R, Gentile MT, Vecchione C, Distaso M, Aretini A, Fratta L, Russo G, Echart C, Maffei A, De Simoni MG and Lembo G: Acute hypertension induces oxidative stress in brain tissues. J Cereb Blood Flow Metab. 26:253–262. 2006. View Article : Google Scholar

34 

Yamamoto E, Tamamaki N, Nakamura T, Kataoka K, Tokutomi Y, Dong YF, Fukuda M, Matsuba S, Ogawa H and Kim-Mitsuyama S: Excess salt causes cerebral cellular apoptosis and inflammation in stroke-prone hypertensive rats through angiotensin II-induced NADPH oxidase activation. Stroke. 39:3049–3056. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Infanger DW, Sharma RV and Davisson RL: NADPH oxidases of the brain: Distribution, regulation and function. Antioxid Redox Signal. 8:1583–1596. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Jiang T, Gao L, Shi J, Lu J, Wang Y and Zhang Y: Angiotensin-(1-7) modulates renin-angiotensin system associated with reducing oxidative stress and attenuating cellular apoptosis in the brain of hypertensive rats. Pharmacol Res. 67:84–93. 2013. View Article : Google Scholar

37 

Yamagata K, Tagami M and Yamori Y: Neuronal vulnerability of stroke-prone spontaneously hypertensive rats to ischemia and its prevention with antioxidants such as vitamin E. Neuroscience. 170:1–7. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Narala VR, Subramani PA, Narasimha VR, Shaik FB and Panati K: The role of nitrated fatty acids and peroxisome proliferator-activated receptor gamma in modulating inflammation. Int Immunopharmacol. 23:283–287. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Diep QN and Schiffrin EL: Increased expression of peroxisome proliferator-activated receptor-alpha and -gamma in blood vessels of spontaneously hypertensive rats. Hypertension. 38:249–254. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Wu L, Wang R, De Champlain J and Wilson TW: Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats. Am J Hypertens. 17:749–756. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Sun L, Gao YH, Tian DK, Zheng JP, Zhu CY, Ke Y and Bian K: Inflammation of different tissues in spontaneously hypertensive rats. Sheng Li Xue Bao. 58:318–323. 2006.PubMed/NCBI

42 

Youle RJ and Strasser A: The BCL-2 protein family: Opposing activities that mediate cell death. Nat Rev Mol Cell Biol. 9:47–59. 2008. View Article : Google Scholar

43 

Li Y, Duan Z, Gao D, Huang S, Yuan H and Niu X: The new role of LOX-1 in hypertension induced cellular apoptosis. Biochem Biophys Res Commun. 425:735–740. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Simao S, Gomes P, Pinto V, Silva E, Amaral JS, Igreja B, Afonso J, Serrão MP, Pinho MJ and Soares-da-Silva P: Age-related changes in renal expression of oxidant and antioxidant enzymes and oxidative stress markers in male SHR and WKY rats. Exp Gerontol. 46:468–474. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Liu J, Gao D, Wei J, Yuan H, Niu X and Zhang Q: Age‑related changes in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats. Mol Med Rep 13: 2552-2560, 2016.
APA
Li, Y., Liu, J., Gao, D., Wei, J., Yuan, H., Niu, X., & Zhang, Q. (2016). Age‑related changes in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats. Molecular Medicine Reports, 13, 2552-2560. https://doi.org/10.3892/mmr.2016.4853
MLA
Li, Y., Liu, J., Gao, D., Wei, J., Yuan, H., Niu, X., Zhang, Q."Age‑related changes in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats". Molecular Medicine Reports 13.3 (2016): 2552-2560.
Chicago
Li, Y., Liu, J., Gao, D., Wei, J., Yuan, H., Niu, X., Zhang, Q."Age‑related changes in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats". Molecular Medicine Reports 13, no. 3 (2016): 2552-2560. https://doi.org/10.3892/mmr.2016.4853
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Liu J, Gao D, Wei J, Yuan H, Niu X and Zhang Q: Age‑related changes in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats. Mol Med Rep 13: 2552-2560, 2016.
APA
Li, Y., Liu, J., Gao, D., Wei, J., Yuan, H., Niu, X., & Zhang, Q. (2016). Age‑related changes in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats. Molecular Medicine Reports, 13, 2552-2560. https://doi.org/10.3892/mmr.2016.4853
MLA
Li, Y., Liu, J., Gao, D., Wei, J., Yuan, H., Niu, X., Zhang, Q."Age‑related changes in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats". Molecular Medicine Reports 13.3 (2016): 2552-2560.
Chicago
Li, Y., Liu, J., Gao, D., Wei, J., Yuan, H., Niu, X., Zhang, Q."Age‑related changes in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats". Molecular Medicine Reports 13, no. 3 (2016): 2552-2560. https://doi.org/10.3892/mmr.2016.4853
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