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A novel dermal matrix generated from burned skin as a promising substitute for deep‑degree burns therapy

  • Authors:
    • Guanying Yu
    • Lan Ye
    • Wei Tan
    • Xuguo Zhu
    • Yaonan Li
    • Duyin Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Burns and Plastic Surgery, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Department of Gastrointestinal Surgery, Jinan Central Hospital, Jinan, Shandong 250013, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2570-2582
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    Published online on: February 4, 2016
       https://doi.org/10.3892/mmr.2016.4866
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Abstract

The extensive skin defects induced by severe burns are dangerous and can be fatal. Currently, the most common therapy is tangential excision to remove the necrotic or denatured areas of skin, followed by skin grafting. Xenogeneic dermal substitutes, such as porcine acellular dermal matrix (ADM), are typically used to cover the burn wounds, and may accelerate wound healing. It is assumed that burned skin that still maintains partial biological activity may be recycled to construct an autologous acellular dermal matrix, termed ‘deep‑degree burned dermal matrix (DDBDM)’. In theory, DDBDM may avoid the histoincompatibility issues associated with foreign or xenogeneic dermal matrices, and reduce therapy costs by making full use of discarded skin. In the present study, the collagens within prepared DDBDM were thickened, disorganized and partially fractured, however, they still maintained their reticular structure and tensile strength (P<0.01). Through microarray analysis of the cytokines present in ADM and DDBDM, it was determined that the DDBDM did not produce excessive levels of harmful burn toxins. Following 4 weeks of subcutaneous implantation, ADM and DDBDM were incompletely degraded and maintained good integrity. No significant inflammatory reaction or rejection were observed, which indicated that ADM and DDBDM have good histocompatibility. Therefore, DDBDM may be a useful material for the treatment of deep‑degree burns.
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Copy and paste a formatted citation
Spandidos Publications style
Yu G, Ye L, Tan W, Zhu X, Li Y and Jiang D: A novel dermal matrix generated from burned skin as a promising substitute for deep‑degree burns therapy. Mol Med Rep 13: 2570-2582, 2016.
APA
Yu, G., Ye, L., Tan, W., Zhu, X., Li, Y., & Jiang, D. (2016). A novel dermal matrix generated from burned skin as a promising substitute for deep‑degree burns therapy. Molecular Medicine Reports, 13, 2570-2582. https://doi.org/10.3892/mmr.2016.4866
MLA
Yu, G., Ye, L., Tan, W., Zhu, X., Li, Y., Jiang, D."A novel dermal matrix generated from burned skin as a promising substitute for deep‑degree burns therapy". Molecular Medicine Reports 13.3 (2016): 2570-2582.
Chicago
Yu, G., Ye, L., Tan, W., Zhu, X., Li, Y., Jiang, D."A novel dermal matrix generated from burned skin as a promising substitute for deep‑degree burns therapy". Molecular Medicine Reports 13, no. 3 (2016): 2570-2582. https://doi.org/10.3892/mmr.2016.4866
Copy and paste a formatted citation
x
Spandidos Publications style
Yu G, Ye L, Tan W, Zhu X, Li Y and Jiang D: A novel dermal matrix generated from burned skin as a promising substitute for deep‑degree burns therapy. Mol Med Rep 13: 2570-2582, 2016.
APA
Yu, G., Ye, L., Tan, W., Zhu, X., Li, Y., & Jiang, D. (2016). A novel dermal matrix generated from burned skin as a promising substitute for deep‑degree burns therapy. Molecular Medicine Reports, 13, 2570-2582. https://doi.org/10.3892/mmr.2016.4866
MLA
Yu, G., Ye, L., Tan, W., Zhu, X., Li, Y., Jiang, D."A novel dermal matrix generated from burned skin as a promising substitute for deep‑degree burns therapy". Molecular Medicine Reports 13.3 (2016): 2570-2582.
Chicago
Yu, G., Ye, L., Tan, W., Zhu, X., Li, Y., Jiang, D."A novel dermal matrix generated from burned skin as a promising substitute for deep‑degree burns therapy". Molecular Medicine Reports 13, no. 3 (2016): 2570-2582. https://doi.org/10.3892/mmr.2016.4866
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