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Article

Echinacoside suppresses pancreatic adenocarcinoma cell growth by inducing apoptosis via the mitogen‑activated protein kinase pathway

  • Authors:
    • Wei Wang
    • Jinbin Luo
    • Yinghui Liang
    • Xinfeng Li
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China
  • Pages: 2613-2618
    |
    Published online on: February 4, 2016
       https://doi.org/10.3892/mmr.2016.4867
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Abstract

The clinical application of natural products derived from traditional Chinese medicine has gained attention in cancer chemotherapeutics. Echinacoside (ECH), one of the phenylethanoids, isolated from the stems of Cistanches salsa (a Chinese herbal medicine) has tissue‑protective and anti‑apoptotic effects on the central nervous system. However, it remains largely elusive whether ECH possesses tumor suppressive activity. In the present study, it was demonstrated that ECH can markedly inhibit the proliferation of pancreatic adenocarcinoma cells by inducing the production of reactive oxygen species and the perturbation of mitochondrial membrane potential and thus triggering apoptosis. Furthermore, it was elucidated that ECH represses tumor cell growth through modulating MAPK activity. In conclusion, this study reveals an novel function of ECH in preventing cancer development, and implies that the usage of ECH could be a potential chemotherapeutic strategy for cancer.
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1 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Alderton GK: Transcription: The transcriptional effects of MYC. Nat Rev Cancer. 14:5132014. View Article : Google Scholar : PubMed/NCBI

3 

Zindy F, Eischen CM, Randle DH, Kamijo T, Cleveland JL, Sherr CJ and Roussel MF: Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev. 12:2424–2433. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K and Mo YY: p53 represses c-Myc through induction of the tumor suppressor miR-145. Proc Natl Acad Sci USA. 106:3207–3212. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Liao JM, Cao B, Zhou X and Lu H: New insights into p53 functions through its target microRNAs. J Mol Cell Biol. 6:206–213. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Zamble DB and Lippard SJ: Cisplatin and DNA repair in cancer chemotherapy. Trends Biochem Sci. 20:435–439. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Kleeff J, Kornmann M, Sawhney H and Korc M: Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells. Int J Cancer. 86:399–407. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Tacar O, Sriamornsak P and Dass CR: Doxorubicin: An update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol. 65:157–170. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Efferth T, Li PC, Konkimalla VS and Kaina B: From traditional Chinese medicine to rational cancer therapy. Trends Mol Med. 13:353–361. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Yim H, Lee YH, Lee CH and Lee SK: Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor. Planta Med. 65:9–13. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Zhang L, Chang CJ, Bacus SS and Hung MC: Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin. Cancer Res. 55:3890–3896. 1995.PubMed/NCBI

12 

Pommier Y: Topoisomerase I inhibitors: Camptothecins and beyond. Nat Rev Cancer. 6:789–802. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Lee YW, Chen TL, Shih YR, Tsai CL, Chang CC, Liang HH, Tseng SH, Chien SC and Wang CC: Adjunctive traditional Chinese medicine therapy improves survival in patients with advanced breast cancer: A population-based study. Cancer. 120:1338–1344. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Xiong Q, Hase K, Tezuka Y, Namba T and Kadota S: Acteoside inhibits apoptosis in D-galactosamine and lipopolysaccharide-induced liver injury. Life Sci. 65:421–430. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Gao JJ, Igalashi K and Nukina M: Radical scavenging activity of phenylpropanoid glycosides in Caryopteris incana. Biosci Biotechnol Biochem. 63:983–988. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Zhang Y, Xing J, Ai T, Wen T, Guan L and Zhao J: Protection of echinacoside against acute lung injury caused by oleic acid in rats. Free Radic Res. 41:798–805. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Li X, Gou C, Yang H, Qiu J, Gu T and Wen T: Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation. Scand J Gastroenterol. 49:993–1000. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Zhao Q, Gao J, Li W and Cai D: Neurotrophic and neurorescue effects of Echinacoside in the subacute MPTP mouse model of Parkinson's disease. Brain Res. 1346:224–236. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Jia Y, Guan Q, Guo Y and Du C: Echinacoside stimulates cell proliferation and prevents cell apoptosis in intestinal epithelial MODE-K cells by up-regulation of transforming growth factor-β1 expression. J Pharmacol Sci. 118:99–108. 2012. View Article : Google Scholar

20 

Liao P, Wang W, Shen M, Pan W, Zhang K, Wang R, Chen T, Chen Y, Chen H and Wang P: A positive feedback loop between EBP2 and c-Myc regulates rDNA transcription, cell proliferation and tumorigenesis. Cell Death Dis. 5:e10322014. View Article : Google Scholar

21 

Westphal S and Kalthoff H: Apoptosis: Targets in pancreatic cancer. Mol Cancer. 2:62003. View Article : Google Scholar : PubMed/NCBI

22 

Simon HU, Haj-Yehia A and Levi-Schaffer F: Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis. 5:415–418. 2000. View Article : Google Scholar

23 

Ly JD, Grubb DR and Lawen A: The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update. Apoptosis. 8:115–128. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Munshi A and Ramesh R: Mitogen-activated protein kinases and their role in radiation response. Genes Cancer. 4:401–408. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Abraham AG and O'Neill E: PI3K/Akt-mediated regulation of p53 in cancer. Biochem Soc Trans. 42:798–803. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Tournier C: The 2 Faces of JNK Signaling in Cancer. Genes Cancer. 4:397–400. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Koul HK, Pal M and Koul S: Role of p38 MAP kinase signal transduction in solid tumors. Genes Cancer. 4:342–359. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Brady CA and Attardi LD: p53 at a glance. J Cell Sci. 123:2527–2532. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Carvajal LA and Manfredi JJ: Another fork in the road-life or death decisions by the tumour suppressor p53. EMBO Rep. 14:414–421. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Miyashita T and Reed JC: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 80:293–299. 1995. View Article : Google Scholar : PubMed/NCBI

31 

Morton JP, Timpson P, Karim SA, Ridgway RA, Athineos D, Doyle B, Jamieson NB, Oien KA, Lowy AM, Brunton VG, et al: Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci USA. 107:246–251. 2010. View Article : Google Scholar :

32 

Schieber M and Chandel NS: ROS function in redox signaling and oxidative stress. Curr Biol. 24:R453–R462. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Li J, O W, Li W, Jiang ZG and Ghanbari HA: Oxidative stress and neurodegenerative disorders. Int J Mol Sci. 14:24438–24475. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang W, Luo J, Liang Y and Li X: Echinacoside suppresses pancreatic adenocarcinoma cell growth by inducing apoptosis via the mitogen‑activated protein kinase pathway. Mol Med Rep 13: 2613-2618, 2016.
APA
Wang, W., Luo, J., Liang, Y., & Li, X. (2016). Echinacoside suppresses pancreatic adenocarcinoma cell growth by inducing apoptosis via the mitogen‑activated protein kinase pathway. Molecular Medicine Reports, 13, 2613-2618. https://doi.org/10.3892/mmr.2016.4867
MLA
Wang, W., Luo, J., Liang, Y., Li, X."Echinacoside suppresses pancreatic adenocarcinoma cell growth by inducing apoptosis via the mitogen‑activated protein kinase pathway". Molecular Medicine Reports 13.3 (2016): 2613-2618.
Chicago
Wang, W., Luo, J., Liang, Y., Li, X."Echinacoside suppresses pancreatic adenocarcinoma cell growth by inducing apoptosis via the mitogen‑activated protein kinase pathway". Molecular Medicine Reports 13, no. 3 (2016): 2613-2618. https://doi.org/10.3892/mmr.2016.4867
Copy and paste a formatted citation
x
Spandidos Publications style
Wang W, Luo J, Liang Y and Li X: Echinacoside suppresses pancreatic adenocarcinoma cell growth by inducing apoptosis via the mitogen‑activated protein kinase pathway. Mol Med Rep 13: 2613-2618, 2016.
APA
Wang, W., Luo, J., Liang, Y., & Li, X. (2016). Echinacoside suppresses pancreatic adenocarcinoma cell growth by inducing apoptosis via the mitogen‑activated protein kinase pathway. Molecular Medicine Reports, 13, 2613-2618. https://doi.org/10.3892/mmr.2016.4867
MLA
Wang, W., Luo, J., Liang, Y., Li, X."Echinacoside suppresses pancreatic adenocarcinoma cell growth by inducing apoptosis via the mitogen‑activated protein kinase pathway". Molecular Medicine Reports 13.3 (2016): 2613-2618.
Chicago
Wang, W., Luo, J., Liang, Y., Li, X."Echinacoside suppresses pancreatic adenocarcinoma cell growth by inducing apoptosis via the mitogen‑activated protein kinase pathway". Molecular Medicine Reports 13, no. 3 (2016): 2613-2618. https://doi.org/10.3892/mmr.2016.4867
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