Open Access

Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice

  • Authors:
    • Sang‑Mi Woo
    • Youn Kyung Choi
    • Ah‑Jeong Kim
    • Yee Jin Yun
    • Yong Cheol Shin
    • Sung‑Gook Cho
    • Seong Gyu Ko
  • View Affiliations

  • Published online on: February 15, 2016     https://doi.org/10.3892/mmr.2016.4889
  • Pages: 2967-2972
  • Copyright: © Woo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Despite its therapeutic advantages, chemotherapy can also cause adverse effects, including anorexia and loss of appetite. Although numerous patients with cancer have been reported to suffer from anorexia during or following chemotherapy, treatment options for anorexia remain to be determined. In Asian countries, traditional medicines are widely used to treat problems with appetite; sip-jeon-dea-bo-tang (SJDBT) is one of those medicines used for the treatment of anorexia. The present study demonstrated that SJDBT ameliorated cisplatin-induced anorexia. In a mouse model of chemotherapy-induced anorexia, oral administration of SJDBT prevented the cisplatin-induced reduction of food intake, inhibiting weight loss. The results of multiplex assays showed that SJDBT only altered the levels of interleukin (IL)-6 and leptin in the serum and fat tissue. In addition, SJDBT maintained the serum leptin level and increased the serum IL-6 level, whereas cisplatin reduced the levels of both serum leptin and IL‑6. Furthermore, SJDBT was revealed to increase the levels of leptin and IL-6 in the fat tissue by activating the JAK1/STAT3 signaling pathway. In conclusion, the present results revealed that SJDBT ameliorated cisplatin-induced anorexia, suggesting its usefulness in the prevention of anorexia during chemotherapy.
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April-2016
Volume 13 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Woo SM, Choi YK, Kim AJ, Yun YJ, Shin YC, Cho SG and Ko SG: Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice. Mol Med Rep 13: 2967-2972, 2016
APA
Woo, S., Choi, Y.K., Kim, A., Yun, Y.J., Shin, Y.C., Cho, S., & Ko, S.G. (2016). Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice. Molecular Medicine Reports, 13, 2967-2972. https://doi.org/10.3892/mmr.2016.4889
MLA
Woo, S., Choi, Y. K., Kim, A., Yun, Y. J., Shin, Y. C., Cho, S., Ko, S. G."Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice". Molecular Medicine Reports 13.4 (2016): 2967-2972.
Chicago
Woo, S., Choi, Y. K., Kim, A., Yun, Y. J., Shin, Y. C., Cho, S., Ko, S. G."Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice". Molecular Medicine Reports 13, no. 4 (2016): 2967-2972. https://doi.org/10.3892/mmr.2016.4889