Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2016 Volume 13 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2016 Volume 13 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice

  • Authors:
    • Sang‑Mi Woo
    • Youn Kyung Choi
    • Ah‑Jeong Kim
    • Yee Jin Yun
    • Yong Cheol Shin
    • Sung‑Gook Cho
    • Seong Gyu Ko
  • View Affiliations / Copyright

    Affiliations: Department of Preventive Medicine, College of Republic of Korean Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea
    Copyright: © Woo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2967-2972
    |
    Published online on: February 15, 2016
       https://doi.org/10.3892/mmr.2016.4889
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Despite its therapeutic advantages, chemotherapy can also cause adverse effects, including anorexia and loss of appetite. Although numerous patients with cancer have been reported to suffer from anorexia during or following chemotherapy, treatment options for anorexia remain to be determined. In Asian countries, traditional medicines are widely used to treat problems with appetite; sip-jeon-dea-bo-tang (SJDBT) is one of those medicines used for the treatment of anorexia. The present study demonstrated that SJDBT ameliorated cisplatin-induced anorexia. In a mouse model of chemotherapy-induced anorexia, oral administration of SJDBT prevented the cisplatin-induced reduction of food intake, inhibiting weight loss. The results of multiplex assays showed that SJDBT only altered the levels of interleukin (IL)-6 and leptin in the serum and fat tissue. In addition, SJDBT maintained the serum leptin level and increased the serum IL-6 level, whereas cisplatin reduced the levels of both serum leptin and IL‑6. Furthermore, SJDBT was revealed to increase the levels of leptin and IL-6 in the fat tissue by activating the JAK1/STAT3 signaling pathway. In conclusion, the present results revealed that SJDBT ameliorated cisplatin-induced anorexia, suggesting its usefulness in the prevention of anorexia during chemotherapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Inui A: Cancer anorexia-cachexia syndrome: Current issues in research and management. CA Cancer J Clin. 52:72–91. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Sinno MH, Coquerel Q, Boukhettala N, Coëffier M, Gallas S, Terashi M, Ibrahim A, Breuillé D, Déchelotte P and Fetissov SO: Chemotherapy-induced anorexia is accompanied by activation of brain pathways signaling dehydration. Physiol Behav. 101:639–648. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Jahn P, Renz P, Stukenkemper J, Book K, Kuss O, Jordan K, Horn I, Thoke-Colberg A, Schmoll HJ and Landenberger M: Reduction of chemotherapy-induced anorexia, nausea and emesis through a structured nursing intervention: A cluster-randomized multicenter trial. Support Care Cancer. 17:1543–1552. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Abell TL, Malagelada JR, Lucas AR, Brown ML, Camilleri M, Go VL, Azpiroz F, Callaway CW, Kao PC, Zinsmeister AR, et al: Gastric electromechanical and neurohormonal function in anorexia nervosa. Gastroenterology. 93:958–965. 1987.PubMed/NCBI

5 

Bernstein IL and Bernstein ID: Learned food aversions and cancer anorexia. Cancer Treat Rep. 65(Suppl 5): S43–S47. 1981.

6 

Mantovani G, Macció A, Massa E and Madeddu C: Managing cancer-related anorexia/cachexia. Drugs. 61:499–514. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Langhans W: Anorexia of infection: Current prospects. Nutrition. 16:996–1005. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Exton MS: Infection-induced anorexia: Active host defence strategy. Appetite. 29:369–383. 1997. View Article : Google Scholar

9 

Tohgo A, Kumazawa E, Akahane K, Asakawa A and Inui A: Anticancer drugs that induce cancer-associated cachectic syndromes. Expert Rev Anticancer Ther. 2:121–129. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Suárez-Pinilla P, Peña-Pérez C, Arbaizar-Barrenechea B, Crespo-Facorro B, Del Barrio JA, Treasure J and Llorca-Díaz J: Inpatient treatment for anorexia nervosa: A systematic review of randomized controlled trials. J Psychiatr Pract. 21:49–59. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Mondello P, Mian M, Aloisi C, Famá F, Mondello S and Pitini V: Cancer cachexia syndrome: Pathogenesis, diagnosis and new therapeutic options. Nutr Cancer. 67:12–26. 2015. View Article : Google Scholar

12 

Brennan AM and Mantzoros CS: Drug Insight: The role of leptin in human physiology and pathophysiology-emerging clinical applications. Nat Clin Pract Endocrinol Metab. 2:318–327. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Hebebrand J, Muller TD, Holtkamp K and Herpertz-Dahlmann B: The role of leptin in anorexia nervosa: Clinical implications. Mol Psychiatry. 12:23–35. 2007. View Article : Google Scholar

14 

Eckert ED, Pomeroy C, Raymond N, Kohler PF, Thuras P and Bowers CY: Leptin in anorexia nervosa. J Clin Endocrinol Metab. 83:791–795. 1998.PubMed/NCBI

15 

Smiechowska J, Utech A, Taffet G, Hayes T, Marcelli M and Garcia JM: Adipokines in patients with cancer anorexia and cachexia. J Investig Med. 58:554–559. 2010.PubMed/NCBI

16 

Tang CH, Lu DY, Yang RS, Tsai HY, Kao MC, Fu WM and Chen YF: Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB and p300 pathway in microglia. J Immunol. 179:1292–1302. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Trujillo ME, Sullivan S, Harten I, Schneider SH, Greenberg AS and Fried SK: Interleukin-6 regulates human adipose tissue lipid metabolism and leptin production in vitro. J Clin Endocrinol Metab. 89:5577–5582. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Engineer DR and Garcia JM: Leptin in anorexia and cachexia syndrome. Int J Pept. 2012:2874572012. View Article : Google Scholar : PubMed/NCBI

19 

Faggioni R, Feingold KR and Grunfeld C: Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J. 15:2565–2571. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Shirazi R, Palsdottir V, Collander J, Anesten F, Vogel H, Langlet F, Jaschke A, Schürmann A, Prévot V, Shao R, et al: Glucagon-like peptide 1 receptor induced suppression of food intake and body weight is mediated by central IL-1 and IL-6. Proc Natl Acad Sci USA. 110:16199–16204. 2013. View Article : Google Scholar

21 

Hübschle T, Thom E, Watson A, Roth J, Klaus S and Meyerhof W: Leptin-induced nuclear translocation of STAT3 immuno-reactivity in hypothalamic nuclei involved in body weight regulation. J Neurosci. 21:2413–2424. 2001.

22 

Priceman SJ, Kujawski M, Shen S, Cherryholmes GA, Lee H, Zhang C, Kruper L, Mortimer J, Jove R, Riggs AD and Yu H: Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance. Proc Natl Acad Sci USA. 110:13079–13084. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Borman NH: The history of ancient Korean medicine. Yonsei Med J. 7:103–118. 1966. View Article : Google Scholar : PubMed/NCBI

24 

Zee-Cheng RK: Shi-quan-da-bu-tang (ten significant tonic decoction), SQT. A potent Chinese biological response modifier in cancer immunotherapy, potentiation and detoxification of anticancer drugs. Methods Find Exp Clin Pharmacol. 14:725–736. 1992.PubMed/NCBI

25 

Saiki I: A Kampo medicine 'Juzen-taiho-to' prevention of malignant progression and metastasis of tumor cells and the mechanism of action. Biol Pharm Bull. 23:677–688. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Kishida Y, Nishii T, Inoue T, Nishida S, Arimitsu J, Yoshikawa H and Sugano N: Juzentaihoto (TJ-48), a traditional Japanese herbal medicine, influences hemoglobin recovery during preoperative autologous blood donation and after hip surgery. Int J Clin Pharmacol Ther. 47:716–721. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Wang CY, Bai XY and Wang CH: Traditional Chinese medicine: A treasured natural resource of anticancer drug research and development. Am J Chin Med. 42:543–559. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Kin R, Kato S, Kaneto N, Sakurai H, Hayakawa Y, Li F, Tanaka K, Saiki I and Yokoyama S: Procyanidin C1 from cinnamomi cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in the A549 lung cancer cell line. Int J Oncol. 43:1901–1906. 2013.PubMed/NCBI

29 

Matsuda T, Maekawa K, Asano K and Hisamitsu T: Suppressive effect of juzen-taiho-to on lung metastasis of b16 melanoma cells in vivo. Evid Based Complement Alternat Med. 2011:7431532011. View Article : Google Scholar :

30 

Choi YK, Jung KY, Woo SM, Yun YJ, Jun CY, Park JH, Shin YC, Cho SG and Ko SG: Effect of Sipjeondaebo-tang on cancer-induced anorexia and cachexia in CT-26 tumor-bearing mice. Mediators Inflamm. 2014:7365632014. View Article : Google Scholar : PubMed/NCBI

31 

Huang SM, Chien LY and Tai CJ, Chiou JF, Chen CS and Tai CJ: Effectiveness of 3-week intervention of Shi Quan Da Bu Tang for alleviating hematotoxicity among patients with breast carcinoma receiving chemotherapy. Integr Cancer Ther. 12:136–144. 2013. View Article : Google Scholar

32 

Ogawa K, Omatsu T, Matsumoto C, Tsuchiya N, Yamamoto M, Naito Y and Yoshikawa T: Protective effect of the Japanese traditional medicine juzentaihoto on myelosuppression induced by the anticancer drug TS-1 and identification of a potential biomarker of this effect. BMC Complement Altern Med. 12:1182012. View Article : Google Scholar : PubMed/NCBI

33 

Sugiyama K, Ueda H and Ichio Y: Protective effect of juzen-taiho-to against carboplatin-induced toxic side effects in mice. Biol Pharm Bull. 18:544–548. 1995. View Article : Google Scholar : PubMed/NCBI

34 

Talley RW, O'Bryan RM, Gutterman JU, Brownlee RW and McCredie KB: Clinical evaluation of toxic effects of cis-diamminedichloroplatinum (NSC-119875)-phase I clinical study. Cancer Chemother Rep. 57:465–471. 1973.PubMed/NCBI

35 

Safety MOFAD: Guidance on good manufacturing practices (GMP) for active pharmaceutical ingredients. 2nd Edition. Korea: 2015

36 

World Health Organization: Annex 3 supplementary guidelines on good manufacturing practices for the manufacture of herbal medicines. (WHO Technical Report Series). pp. 85–106. 2006

37 

Center for Drug Evaluation and Research PQMSC: Pharmaceutical components at risk for melamine contamination services. Dohah US: 1992

38 

Higby DJ, Wallace HJ Jr and Holland JF: Cis-diamminedichloroplatinum (NSC-119875): A phase I study. Cancer Chemother Rep. 57:459–463. 1973.PubMed/NCBI

39 

Poth KJ, Guminski AD, Thomas GP, Leo PJ, Jabbar IA and Saunders NA: Cisplatin treatment induces a transient increase in tumorigenic potential associated with high interleukin-6 expression in head and neck squamous cell carcinoma. Mol Cancer Ther. 9:2430–2439. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Fantuzzi G and Faggioni R: Leptin in the regulation of immunity, inflammation and hematopoiesis. J Leukoc Biol. 68:437–446. 2000.PubMed/NCBI

41 

Sugiyama K, Ueda H, Ichio Y and Yokota M: Improvement of cisplatin toxicity and lethality by juzen-taiho-to in mice. Biol Pharm Bull. 18:53–58. 1995. View Article : Google Scholar : PubMed/NCBI

42 

Suh SY, Choi YS, Yeom CH, Kwak SM, Yoon HM, Kim DG, Koh SJ, Park J, Lee MA, Lee YJ, et al: Interleukin-6 but not tumour necrosis factor-alpha predicts survival in patients with advanced cancer. Supportive Care Cancer. 21:3071–3077. 2013. View Article : Google Scholar

43 

Wang SW and Sun YM: The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review). Int J Oncol. 44:1032–1040. 2014.PubMed/NCBI

44 

Huang WL, Yeh HH, Lin CC, Lai WW, Chang JY, Chang WT and Su WC: Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: A biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells. Mol Cancer. 9:3092010. View Article : Google Scholar : PubMed/NCBI

45 

Saiki I, Yamaura T, Ohnishi Y, Hayakawa Y, Komatsu Y and Nunome S: HPLC analysis of juzen-taiho-to and its variant formulations and their antimetastatic efficacies. Chem Pharm Bull (Tokyo). 47:1170–1174. 1999. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Woo SM, Choi YK, Kim AJ, Yun YJ, Shin YC, Cho SG and Ko SG: Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice. Mol Med Rep 13: 2967-2972, 2016.
APA
Woo, S., Choi, Y.K., Kim, A., Yun, Y.J., Shin, Y.C., Cho, S., & Ko, S.G. (2016). Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice. Molecular Medicine Reports, 13, 2967-2972. https://doi.org/10.3892/mmr.2016.4889
MLA
Woo, S., Choi, Y. K., Kim, A., Yun, Y. J., Shin, Y. C., Cho, S., Ko, S. G."Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice". Molecular Medicine Reports 13.4 (2016): 2967-2972.
Chicago
Woo, S., Choi, Y. K., Kim, A., Yun, Y. J., Shin, Y. C., Cho, S., Ko, S. G."Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice". Molecular Medicine Reports 13, no. 4 (2016): 2967-2972. https://doi.org/10.3892/mmr.2016.4889
Copy and paste a formatted citation
x
Spandidos Publications style
Woo SM, Choi YK, Kim AJ, Yun YJ, Shin YC, Cho SG and Ko SG: Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice. Mol Med Rep 13: 2967-2972, 2016.
APA
Woo, S., Choi, Y.K., Kim, A., Yun, Y.J., Shin, Y.C., Cho, S., & Ko, S.G. (2016). Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice. Molecular Medicine Reports, 13, 2967-2972. https://doi.org/10.3892/mmr.2016.4889
MLA
Woo, S., Choi, Y. K., Kim, A., Yun, Y. J., Shin, Y. C., Cho, S., Ko, S. G."Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice". Molecular Medicine Reports 13.4 (2016): 2967-2972.
Chicago
Woo, S., Choi, Y. K., Kim, A., Yun, Y. J., Shin, Y. C., Cho, S., Ko, S. G."Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice". Molecular Medicine Reports 13, no. 4 (2016): 2967-2972. https://doi.org/10.3892/mmr.2016.4889
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team