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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April-2016 Volume 13 Issue 4

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

DNA methylation in endometriosis (Review)

Ourania Koukoura, Stavros Sifakis, Demetrios A. Spandidos
Pages: 2939-2948
Published online on: 22 February 2016

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Article Open Access

Vanillin and 4-hydroxybenzyl alcohol promotes cell proliferation and neuroblast differentiation in the dentate gyrus of mice via the increase of brain-derived neurotrophic factor and tropomyosin-related kinase B

Jeong‑Hwi Cho, Joon Ha Park, Ji Hyeon Ahn, Jae‑Chul Lee, In Koo Hwang, Seung Min Park, Ji Yun Ahn, Dong Won Kim, Jun Hwi Cho, Jong‑Dai Kim, Young-Myeong Kim, Moo‑Ho Won, Il-Jun Kang
Pages: 2949-2956
Published online on: 19 February 2016

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Article Open Access

Neuroprotective effects of Ilexonin A following transient focal cerebral ischemia in rats

Ai‑Ling Xu, Guan‑Yi Zheng, Zhi‑Jian Wang, Xiao‑Dong Chen, Qiong Jiang
Pages: 2957-2966
Published online on: 22 February 2016

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Article Open Access

Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice

Sang‑Mi Woo, Youn Kyung Choi, Ah‑Jeong Kim, Yee Jin Yun, Yong Cheol Shin, Sung‑Gook Cho, Seong Gyu Ko
Pages: 2967-2972
Published online on: 15 February 2016

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Article Open Access

Nuclear distribution of eIF3g and its interacting nuclear proteins in breast cancer cells

Qiaoli Zheng, Hao Liu, Jingjia Ye, Hui Zhang, Zhenyu Jia, Jiang Cao
Pages: 2973-2980
Published online on: 23 February 2016

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Article Open Access

Effect of exercise-induced neurogenesis on cognitive function deficit in a rat model of vascular dementia

Dong‑Hee Choi, Kyoung‑Hee Lee, Jongmin Lee
Pages: 2981-2990
Published online on: 15 February 2016

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Article Open Access

Forkhead box O1 promotes INS‑1 cell apoptosis by reducing the expression of CD24

Yuhang Ma, Xuejiao Wang, Yongde Peng, Xiaoying Ding
Pages: 2991-2998
Published online on: 16 February 2016

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Article Open Access

Collagen metabolic disorder induced by oxidative stress in human uterosacral ligament‑derived fibroblasts: A possible pathophysiological mechanism in pelvic organ prolapse

Cheng Liu, Qing Yang, Gui Fang, Bing‑Shu Li, De‑Bin Wu, Wen‑Jun Guo, Sha‑Sha Hong, Li Hong
Pages: 2999-3008
Published online on: 22 February 2016

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Article Open Access

Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways

Huiling Jing, Wenyan Sun, Jinghua Fan, Yanmin Zhang, Jiao Yang, Jinjing Jia, Jichang Li, Jiaqi Guo, Suju Luo, Yan Zheng
Pages: 3009-3016
Published online on: 19 February 2016

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Article Open Access

Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats

Zein Shaban Ibrahim, Mohamed Elsayed Alkafafy, Mohamed Mohamed Ahmed, Mohamed Mohamed Soliman
Pages: 3017-3026
Published online on: 22 February 2016

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Article Open Access

Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer

Jiangman Duan, Li Sun, Hongxiang Huang, Zhenzhen Wu, Lin Wang, Wangjun Liao
Pages: 3027-3035
Published online on: 17 February 2016

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Article Open Access

Effects of tanshinone IIA on fibrosis in a rat model of cirrhosis through heme oxygenase-1, inflammation, oxidative stress and apoptosis

Ming Shu, Xiao‑Rong Hu, Zuo‑An Hung, Dam‑Dan Huang, Shun Zhang
Pages: 3036-3042
Published online on: 10 February 2016

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Article Open Access

Therapeutic effects of various methods of MSC transplantation on cerebral resuscitation following cardiac arrest in rats

Ka‑Hong Leong, Li‑Li Zhou, Qing‑Ming Lin, Peng Wang, Lan Yao, Zi‑Tong Huang
Pages: 3043-3051
Published online on: 22 February 2016

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Article Open Access

Scutellaria baicalensis Georgi extract protects against alcohol‑induced acute liver injury in mice and affects the mechanism of ER stress

Qingqing Dong, Fei Chu, Chengzhu Wu, Qiang Huo, Huaiyong Gan, Xiaoming Li, Hao Liu
Pages: 3052-3062
Published online on: 23 February 2016

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Article Open Access

Integrated microRNA‑gene analysis of coronary artery disease based on miRNA and gene expression profiles

Xiangdong Xu, Hongsong Li
Pages: 3063-3073
Published online on: 23 February 2016

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Article Open Access

Long non-coding RNA-Low Expression in Tumor inhibits the invasion and metastasis of esophageal squamous cell carcinoma by regulating p53 expression

Peng‑Li Wang, Bin Liu, Yang Xia, Chun‑Feng Pan, Teng Ma, Yi‑Jiang Chen
Pages: 3074-3082
Published online on: 19 February 2016

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Article Open Access

Neuroprotective effects of ginsenosides on neural progenitor cells against oxidative injury

Jun Ye, Jian‑Ping Yao, Xu Wang, Minying Zheng, Peng Li, Chengwei He, Jian‑Bo Wan, Xiaoli Yao, Huanxing Su
Pages: 3083-3091
Published online on: 19 February 2016

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Article Open Access

Omacetaxine mepesuccinate induces apoptosis and cell cycle arrest, promotes cell differentiation, and reduces telomerase activity in diffuse large B‑cell lymphoma cells

Lina Zhang, Zhenzhu Chen, Wenli Zuo, Xinghu Zhu, Yufu Li, Xinjian Liu, Xudong Wei
Pages: 3092-3100
Published online on: 16 February 2016

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Article Open Access

Protective effect of grape seed extract against cadmium-induced testicular dysfunction

Adel Alkhedaide, Zafer Saad Alshehri, Ayman Sabry, Tulip Abdel‑Ghaffar, Mohamed Mohamed Soliman, Hossam Attia
Pages: 3101-3109
Published online on: 23 February 2016

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Article

Pyropia yezoensis glycoprotein regulates antioxidant status and prevents hepatotoxicity in a rat model of D-galactosamine/lipopolysaccharide-induced acute liver failure

Jeong‑Wook Choi, In‑Hye Kim, Young‑Min Kim, Min‑Kyeong Lee, Taek‑Jeong Nam
Pages: 3110-3114
Published online on: 23 February 2016

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Article

Release mechanism of high mobility group nucleosome binding domain 1 from lipopolysaccharide-stimulated macrophages

Taisuke Murakami, Zhongshuang Hu, Hiroshi Tamura, Isao Nagaoka
Pages: 3115-3120
Published online on: 16 February 2016

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Article

Apr3 accelerates the senescence of human retinal pigment epithelial cells

Song Han, Qingjun Lu, Ningli Wang
Pages: 3121-3126
Published online on: 22 February 2016

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Article

Novel mutations in the CYP11B2 gene causing aldosterone synthase deficiency

Niu Li, Juan Li, Yu Ding, Tingting Yu, Yongnian Shen, Qihua Fu, Yiping Shen, Xiaodong Huang, Jian Wang
Pages: 3127-3132
Published online on: 18 February 2016

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Article

Shaking improves the whole bone marrow adherent method of purification

Guoying Deng, Weiheng Wang, Chengwei Yang, Rui Gao, Xiangqun Yang, Xiaojian Ye
Pages: 3133-3138
Published online on: 22 February 2016

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Article

MicroRNA-200b inhibits epithelial-mesenchymal transition and migration of cervical cancer cells by directly targeting RhoE

Yan‑Xiang Cheng, Gan‑Tao Chen, Chuang Chen, Qi‑Fan Zhang, Feng Pan, Min Hu, Bing‑Shu Li
Pages: 3139-3146
Published online on: 23 February 2016

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Article

Carbonated soft drinks induce oxidative stress and alter the expression of certain genes in the brains of Wistar rats

Adel El‑Terras, Mohamed Mohamed Soliman, Adel Alkhedaide, Hossam Fouad Attia, Abdullah Alharthy, Abdel Elah Banaja
Pages: 3147-3154
Published online on: 18 February 2016

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Article

MicroRNA-200b suppresses cell invasion and metastasis by inhibiting the epithelial-mesenchymal transition in cervical carcinoma

Yan‑Xiang Cheng, Qi‑Fan Zhang, Li Hong, Feng Pan, Jin‑Ling Huang, Bing‑Shu Li, Min Hu
Pages: 3155-3160
Published online on: 19 February 2016

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Article

Nitidine chloride inhibits ovarian cancer cell migration and invasion by suppressing MMP-2/9 production via the ERK signaling pathway

Xiangxiu Sun, Lin Lin, Ying Chen, Tianfeng Liu, Ronghua Liu, Zhongde Wang, Kai Mou, Jia Xu, Bo Li, Haibo Song
Pages: 3161-3168
Published online on: 23 February 2016

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Article

Point mutation in mitochondrial tRNA gene is associated with polycystic ovary syndrome and insulin resistance

Yu Ding, Guangchao Zhuo, Caijuan Zhang, Jianhang Leng
Pages: 3169-3172
Published online on: 19 February 2016

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Article

Functional analysis of the TMPRSS2:ERG fusion gene in cisplatin‑induced cell death

Junqi Wu, Linfeng Chi, Zhanghui Chen, Xianghong Lu, Suping Xiao, Guanglin Zhang, Jindan Luo, Ge‑Ming Chen, Jun Yang
Pages: 3173-3180
Published online on: 16 February 2016

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Article

Putative modifier genes in mevalonate kinase deficiency

Annalisa Marcuzzi, Diego Vozzi, Martina Girardelli, Paola Maura Tricarico, Alessandra Knowles, Sergio Crovella, Josef Vuch, Alberto Tommasini, Elisa Piscianz, Anna Monica Bianco
Pages: 3181-3189
Published online on: 22 February 2016

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Article

Knockdown of ephrin receptor A7 suppresses the proliferation and metastasis of A549 human lung cancer cells

Ronghui Li, Yingyan Sun, Aiying Jiang, Yan Wu, Chengwei Li, Mingchun Jin, Hairun Yan, Hong Jin
Pages: 3190-3196
Published online on: 18 February 2016

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Article

Improvement of the cytotoxic T lymphocyte response against hepatocellular carcinoma by transduction of cancer cells with an adeno-associated virus carrying the interferon-γ gene

Jun Zhou, Ping Ma, Jun Li, Xiaonan Cui, Wei Song
Pages: 3197-3205
Published online on: 10 February 2016

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Article

Downregulation of long non-coding RNA TRIM52-AS1 functions as a tumor suppressor in renal cell carcinoma

Zan Liu, Hai‑Yan Yan, Shun‑Yao Xia, Cheng Zhang, You‑Cheng Xiu
Pages: 3206-3212
Published online on: 18 February 2016

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Article

Connexin32‑mediated antitumor effects of suicide gene therapy against hepatocellular carcinoma: In vitro and in vivo anticancer activity

Lun Wu, Wen‑Bo Zhou, Feng Shen, Wei Liu, Hong‑Wei Wu, Shi‑Ji Zhou, Sheng‑Wei Li
Pages: 3213-3219
Published online on: 16 February 2016

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Article

MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9

Jianhong Wang, Jingcheng Li, Fuqiang Guo, Yong Yan
Pages: 3220-3226
Published online on: 18 February 2016

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Article

mTOR signaling pathway is inhibited downstream of the cyclophilin D-mediated mitochondrial permeability transition in honokiol-triggered regulated necrosis

Wei Tian, Jieni Xiong, Saisa Zhu, Dong Xu, Hong Shen, Yongchuan Deng
Pages: 3227-3235
Published online on: 10 February 2016

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Article

Downregulation of miR‑429 and inhibition of cell migration and invasion in nasopharyngeal carcinoma

Fangzheng Wang, Chuner Jiang, Quanquan Sun, Fenqin Yan, Lei Wang, Zhenfu Fu, Tongxin Liu, Fujun Hu
Pages: 3236-3242
Published online on: 23 February 2016

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Article

Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway

Nan Feng, Jianmin Luo, Ximin Guo
Pages: 3243-3248
Published online on: 10 February 2016

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Article

TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration

Li Chen, Yujing Bai, Min Zhao, Yanrong Jiang
Pages: 3249-3256
Published online on: 15 February 2016

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Article

Triptolide sensitizes human breast cancer cells to tumor necrosis factor‑α‑induced apoptosis by inhibiting activation of the nuclear factor‑κB pathway

Xiaoli Cheng, Wenli Shi, Canguo Zhao, Dan Zhang, Piao Liang, Guohui Wang, Li Lu
Pages: 3257-3264
Published online on: 23 February 2016

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Article

Downregulation of VEGF and upregulation of TL1A expression induce HUVEC apoptosis in response to high glucose stimuli

Miao Yu, Guihua Lu, Xun Zhu, Zhibin Huang, Chong Feng, Rong Fang, Yesong Wang, Xiuren Gao
Pages: 3265-3272
Published online on: 22 February 2016

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Article

Decreased miR-143 and increased miR-21 placental expression levels are associated with macrosomia

Ji‑Tai Zhang, Qian‑Ying Cai, Si‑Si Ji, Heng‑Xin Zhang, Yu‑Huan Wang, Hong‑Tao Yan, Xin‑Jun Yang
Pages: 3273-3280
Published online on: 15 February 2016

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Article

Hypoxia increases the heterogeneity of melanoma cell populations and affects the response to vemurafenib

Daniela Pucciarelli, Nina Lengger, Martina Takáčová, Lucia Csaderova, Maria Bartosova, Heimo Breiteneder, Silvia Pastorekova, Christine Hafner
Pages: 3281-3288
Published online on: 10 February 2016

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Article

Astragaloside IV suppresses inflammatory mediator production in synoviocytes and collagen‑induced arthritic rats

Hao Xu, Chang‑Yao Wang, Hai‑Ning Zhang, Cheng‑Yu Lv, Ying‑Zhen Wang
Pages: 3289-3296
Published online on: 22 February 2016

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Article

Polydatin-induced cell apoptosis and cell cycle arrest are potentiated by Janus kinase 2 inhibition in leukemia cells

Wei‑Jie Cao, Ke Wu, Chong Wang, Ding‑Ming Wan
Pages: 3297-3302
Published online on: 18 February 2016

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Article

Characterization of the malaria parasite protein PfTip, a novel invasion-related protein

Xuewu Liu, Yuxiao Huang, Jiao Liang, Jun Wang, Yan Shen, Yinghui Li, Ya Zhao
Pages: 3303-3310
Published online on: 18 February 2016

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Article

Antiproliferative activity of a series of 5‑(1H‑1,2,3‑triazolyl) methyl‑ and 5‑acetamidomethyl‑oxazolidinone derivatives

Omar M. Hedaya, Princy M. Mathew, Fatima H. Mohamed, Oludotun A. Phillips, Yunus A. Luqmani
Pages: 3311-3318
Published online on: 23 February 2016

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Article

Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF

Lin Quan, Hua He
Pages: 3319-3325
Published online on: 23 February 2016

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Article

Identification of long-non coding RNA UCA1 as an oncogene in renal cell carcinoma

Yifan Li, Tiantian Wang, Yuchi Li, Duqun Chen, Zuhu Yu, Lu Jin, Liangchao Ni, Shangqi Yang, Xiangming Mao, Yaoting Gui, Yongqing Lai
Pages: 3326-3334
Published online on: 16 February 2016

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Article

Anti-inflammatory effects of essential oils extracted from Chamaecyparis obtusa on murine models of inflammation and RAW 264.7 cells

Yujin Park, Seung‑Ah Yoo, Wan‑Uk Kim, Chul‑Soo Cho, Jong‑Min Woo, Chong‑Hyeon Yoon
Pages: 3335-3341
Published online on: 18 February 2016

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Article

Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression

Shihong Ma, Wenhua Tan, Botao Du, Wei Liu, Weijia Li, Dehong Che, Guangmei Zhang
Pages: 3342-3348
Published online on: 16 February 2016

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Article

MicroRNA-200c inhibits the metastasis of non-small cell lung cancer cells by targeting ZEB2, an epithelial-mesenchymal transition regulator Retraction in /10.3892/mmr.2021.12212

Aihong Jiao, Minghua Sui, Liangming Zhang, Ping Sun, Dongmei Geng, Weiwei Zhang, Xiuwen Wang, Junxia Li
Pages: 3349-3355
Published online on: 17 February 2016

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Article

Elevated caspase‑1 activity and IL‑1β expression are associated with the IPAF inflammasome in an experimental model of allergy

Hamid Reza Nouri, Ahmad Karkhah, Iraj Mohammadzadeh, Mojtaba Sankian
Pages: 3356-3362
Published online on: 23 February 2016

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Article

Regulation by AMP-activated protein kinase of PGE2-induced osteoprotegerin synthesis in osteoblasts

Shingo Kainuma, Takanobu Otsuka, Gen Kuroyanagi, Naohiro Yamamoto, Rie Matsushima‑Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Pages: 3363-3369
Published online on: 17 February 2016

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Article

In human alloreactive CD4+ T-cells, dichloroacetate inhibits aerobic glycolysis, induces apoptosis and favors differentiation towards the regulatory T-cell subset instead of effector T-cell subsets

Theodoros Eleftheriadis, Maria Sounidaki, Georgios Pissas, Georgia Antoniadi, Vassilios Liakopoulos, Ioannis Stefanidis
Pages: 3370-3376
Published online on: 19 February 2016

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Article

Radioresistance of granulation tissue-derived cells from skin wounds combined with total body irradiation

Tingyu Dai, Zelin Chen, Li Tan, Chunmeng Shi
Pages: 3377-3383
Published online on: 23 February 2016

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Correction Open Access

[Corrigendum] Knockdown of eukaryotic translation initiation factor 4E suppresses cell growth and invasion, and induces apoptosis and cell cycle arrest in a human lung adenocarcinoma cell line

Baofu Chen, Bo Zhang, Lilong Xia, Jian Zhang, Yu Chen, Quanteng Hu, Chengchu Zhu
Pages: 3384-3384
Published online on: 23 February 2016

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Review Open Access

Role of neuroinflammation in neurodegenerative diseases (Review)

Wei‑Wei Chen, Xia Zhang, Wen‑Juan Huang
Pages: 3391-3396
Published online on: 29 February 2016

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Review Open Access

Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review)

Ruiqi Feng, Lijuan Li, Haiyan Yu, Min Liu, Wei Zhao
Pages: 3397-3400
Published online on: 02 March 2016

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Review

Benzene exposure is associated with epigenetic changes (Review)

Concettina Fenga, Silvia Gangemi, Chiara Costa
Pages: 3401-3405
Published online on: 01 March 2016

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Article Open Access

Pretreatment of BMSCs with TZD solution decreases the proliferation rate of MCF‑7 cells by reducing FGF4 protein expression

Boon‑Yin Khoo, Kalpanah Nadarajan, Siang‑Yian Shim, Noorizan Miswan, Chuan‑Bing Zang, Kurt Possinger, Elena Elstner
Pages: 3406-3414
Published online on: 02 March 2016

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Article Open Access

Targeted inhibition of survivin with YM155 promotes apoptosis of hypoxic human pulmonary arterial smooth muscle cells via the upregulation of voltage-dependent K+ channels

Shuai Zhang, Bo Liu, Zaiwen Fan, Dong Wang, Ying Liu, Jian Li, Ning Wang, Yi Liu, Bo Zhang
Pages: 3415-3422
Published online on: 04 March 2016

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Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells Retraction in /10.3892/mmr.2026.13875

Wei Shi, Jiagang Deng, Rongsheng Tong, Yong Yang, Xia He, Jianzhen Lv, Hailian Wang, Shaoping Deng, Ping Qi, Dingding Zhang, Yi Wang
Pages: 3423-3432
Published online on: 29 February 2016

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Enhanced autophagy in cytarabine arabinoside-resistant U937 leukemia cells and its potential as a target for overcoming resistance

June‑Won Cheong, Yundeok Kim, Ju In Eom, Hoi‑Kyung Jeung, Yoo Hong Min
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Published online on: 29 February 2016

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Cannabinoid CB2 receptors are involved in the regulation of fibrogenesis during skin wound repair in mice

Shan‑Shan Li, Lin‑Lin Wang, Min Liu, Shu‑Kun Jiang, Miao Zhang, Zhi‑Ling Tian, Meng Wang, Jiao‑Yong Li, Rui Zhao, Da‑Wei Guan
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In vivo treatment of rat arterial adventitia with interleukin‑1β induces intimal proliferation via the JAK2/STAT3 signaling pathway

Xiao Wang, Lihua Chen, Jie Liu, Tao Yan, Gangyong Wu, Yang Xia, Gangjun Zong, Fengsheng Li
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Published online on: 07 March 2016

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Impaired function of the intestinal barrier in a novel sub-health rat model

Sisi Feng, Weidong Liu, Shengnan Zuo, Tingyan Xie, Hui Deng, Qiuhuan Zhang, Baiyun Zhong
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Constitutive expression of Wnt/β‑catenin target genes promotes proliferation and invasion of liver cancer stem cells

Wei Chen, Yu‑Wei Zhang, Yang Li, Jian‑Wen Zhang, Tong Zhang, Bin‑Sheng Fu, Qi Zhang, Nan Jiang
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Intervertebral disc regeneration using platelet‑rich plasma‑containing bone marrow‑derived mesenchymal stem cells: A preliminary investigation

Shan‑Zheng Wang, Ji‑Yang Jin, Yu‑Dong Guo, Liang‑Yu Ma, Qing Chang, Xin‑Gui Peng, Fang‑Fang Guo, Hai‑Xiang Zhang, Xin‑Feng Hu, Chen Wang
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SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α

Fang Zhou, Aiguo Dai, Yongliang Jiang, Xiaowu Tan, Xiufeng Zhang
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Integrated analysis of DNA methylation profiles and gene expression profiles to identify genes associated with pilocytic astrocytomas

Ruigang Zhou, Yigang Man
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Published online on: 29 February 2016

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Characterization of bone marrow-derived mesenchymal stem cells from dimethyloxallyl glycine-preconditioned mice: Evaluation of the feasibility of dimethyloxallyl glycine as a mobilization agent

Tingting Ge, Qin Yu, Wei Liu, Li Cong, Lizhen Liu, Yan Wang, Liping Zhou, Deju Lin
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Long‑term follow‑up of buserelin‑induced enteric neuropathy in rats

Anette Jönsson, Elin Sand, Eva Ekblad, Bodil Ohlsson
Pages: 3507-3513
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Downregulation of epidermal growth factor receptor family receptors and ligands in a mutant K-ras group of patients with colorectal cancer

Tomoko Nagaoka, Kazutaka Kitaura, Yukinaga Miyata, Kenichi Kumagai, Goro Kaneda, Hideki Kanazawa, Satsuki Suzuki, Yoshiki Hamada, Ryuji Suzuki
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Low levels of inflammation and the absence of subclinical atherosclerosis in rheumatoid arthritis

Salvatore Santo Signorelli, Saverio Candido, Rossella Salemi, Valerio Fiore, Marco Mangiafico, Massimo Libra
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Growth inhibition effects of ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid on colorectal carcinoma cells and colon carcinoma-bearing mice

Hua Ye, Qiong Wu, Meng Guo, Kefeng Wu, Yingnian Lv, Fengyan Yu, Yi Liu, Xiaosheng Gao, Yuzhen Zhu, Liao Cui, Nianci Liang, Tu Yun, Li Li, Xuebao Zheng
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Expression of lactate dehydrogenase C in MDA‑MB‑231 cells and its role in tumor invasion and migration

Lingying Kong, Wei Du, Zhaolei Cui, Li Wang, Zhi Yang, Hongsheng Zhang, Donghong Lin
Pages: 3533-3538
Published online on: 02 March 2016

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Effect and mechanism of fuzhisan and donepezil on the sirtuin 1 pathway and amyloid precursor protein metabolism in PC12 cells

Peng Guo, Desheng Wang, Xiaomin Wang, Honglin Feng, Ying Tang, Ruihong Sun, Yan Zheng, Lin Dong, Jiaying Zhao, Xin Zhang, Shuyu Wang, Hongxu Sun
Pages: 3539-3546
Published online on: 01 March 2016

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Comparative proteomic analysis of heat stress proteins associated with rat sperm maturation

Xiaomei Wang, Fujun Liu, Xin Gao, Xin Liu, Xiaojun Kong, Haiyan Wang, Jianyuan Li
Pages: 3547-3552
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Paeoniflorin attenuates ultraviolet B-induced apoptosis in human keratinocytes by inhibiting the ROS-p38-p53 pathway

Lingwen Kong, Shangshang Wang, Xiao Wu, Fuguo Zuo, Haihong Qin, Jinfeng Wu
Pages: 3553-3558
Published online on: 01 March 2016

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Article

Endothelin‑1 induces oncostatin M expression in osteoarthritis osteoblasts by trans‑activating the oncostatin M gene promoter via Ets‑1

Ren Wu, Wanchun Wang, Guoliang Huang, Xinzhan Mao, You Chen, Qi Tang, Lele Liao
Pages: 3559-3566
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Effect of transforming growth factor-β3 on the expression of Smad3 and Smad7 in tenocytes

Ke Jiang, Guo Chun, Ziming Wang, Quanyin Du, Aimin Wang, Yan Xiong
Pages: 3567-3573
Published online on: 29 February 2016

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Atorvastatin attenuates atherosclerotic plaque destabilization by inhibiting endoplasmic reticulum stress in hyperhomocysteinemic mice

Fang Jia, Chunfang Wu, Zhenyue Chen, Guoping Lu, Jianhui Sun
Pages: 3574-3580
Published online on: 03 March 2016

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Article

Hepatitis B virus replication is upregulated in proliferated peripheral blood lymphocytes

Qin Yan, Ying‑Hua Lan, Yan‑Xin Huang, Rong‑Shan Fan, Lan Liu, Shu‑Peng Song, Yong‑Guo Li
Pages: 3581-3587
Published online on: 03 March 2016

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Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice

Qu Liu, Bao‑Shan Li, Yu‑Jiao Song, Ming‑Gen Hu, Jian‑Yue Lu, Ang Gao, Xue‑Jun Sun, Xi‑Ming Guo, Rong Liu
Pages: 3588-3596
Published online on: 01 March 2016

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Sasanquasaponin promotes cellular chloride efflux and elicits cardioprotection via the PKCε pathway

Ling‑Yu Qiu, He‑Ping Chen, Yu‑Feng Yan, Yuan‑Yuan Li, Huan Wang, Zhang‑Ping Liao, Qi‑Ren Huang
Pages: 3597-3603
Published online on: 07 March 2016

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CXCR4 antagonist AMD3100 ameliorates thyroid damage in autoimmune thyroiditis in NOD.H‑2h4 mice

Xin Liu, Jinyuan Mao, Cheng Han, Shiqiao Peng, Chenyan Li, Ting Jin, Chenling Fan, Zhongyan Shan, Weiping Teng
Pages: 3604-3612
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SASH1 inhibits cervical cancer cell proliferation and invasion by suppressing the FAK pathway

Hui Chen, Dongliang Wang, Yuling Liu
Pages: 3613-3618
Published online on: 29 February 2016

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Expression and purification of FGF21 in Pichia pastoris and its effect on fibroblast-cell migration

Yonghuan Song, Jian Ding, Rilong Jin, Jinhee Jung, Shi Li, Jingquan Yang, Anyuan Wang, Zhijie Li
Pages: 3619-3626
Published online on: 26 February 2016

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Protectin D1 reduces concanavalin A-induced liver injury by inhibiting NF-κB-mediated CX3CL1/CX3CR1 axis and NLR family, pyrin domain containing 3 inflammasome activation

Jun Ren, Shanshan Meng, Bingdi Yan, Jinyan Yu, Jing Liu
Pages: 3627-3638
Published online on: 04 March 2016

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Glycyrrhizic acid prevents enteritis through reduction of NF‑κB p65 and p38MAPK expression in rat

Yi‑Ming Wang, Guo‑Qiang Du
Pages: 3639-3646
Published online on: 07 March 2016

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Interleukin‑12B is upregulated by decoy receptor 3 in rheumatoid synovial fibroblasts

Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Masahiro Kurosaka
Pages: 3647-3652
Published online on: 07 March 2016

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Ameliorative effects of pomegranate on carbon tetrachloride hepatotoxicity in rats: A molecular and histopathological study

Zein Shaban Ibrahim, Mohamed Abdo Nassan, Mohamed Mohamed Soliman
Pages: 3653-3660
Published online on: 01 March 2016

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Sensitization of hepatocellular carcinoma cells to irradiation by miR‑34a through targeting lactate dehydrogenase‑A

Xiaogang Li, Ping Lu, Bo Li, Rong Yang, Yan Chu, Zhiping Zhang, Hongwei Wan, Chao Niu, Chunxiao Wang, Kaiyuan Luo
Pages: 3661-3667
Published online on: 03 March 2016

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Apoptosis is induced by shikonin through the mitochondrial signaling pathway

Xuxia Tang, Chen Zhang, Jiongzhou Wei, Yuting Fang, Rongxiang Zhao, Jianxin Yu
Pages: 3668-3674
Published online on: 02 March 2016

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Mucin 1 and poly I:C activates dendritic cells and effectively eradicates pituitary tumors as a prophylactic vaccine

Dehua Sui, Lixin Ma, Meng Li, Wei Shao, Hongpeng Du, Ke Li, Zhenzhu Li, Zefu Li
Pages: 3675-3683
Published online on: 02 March 2016

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Article

Leptin induces the apoptosis of chondrocytes in an in vitro model of osteoarthritis via the JAK2‑STAT3 signaling pathway

Zi Ming Zhang, Chao Shen, Hai Li, Qing Fan, Jing Ding, Fang Chun Jin, Lin Sha
Pages: 3684-3690
Published online on: 03 March 2016

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TMEM16A contributes to angiotensin II-induced cerebral vasoconstriction via the RhoA/ROCK signaling pathway

Rong‑Shan Li, Yong Wang, Hui‑Shen Chen, Fang‑Yong Jiang, Qiang Tu, Wen‑Jun Li, Rui‑Xing Yin
Pages: 3691-3699
Published online on: 04 March 2016

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The effects of perfluorocarbon on ICAM-1 expression in LPS-induced A549 cells and the potential mechanism

Lu Cao, Chun‑Sun Li, Yan Chang, Zhi‑Xin Liang, Liang‑An Chen
Pages: 3700-3708
Published online on: 01 March 2016

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Correction Open Access

[Corrigendum] Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC-α/ERK1/2 pathway: An in vitro investigation

Xu‑Dong Cheng, Jun‑Fei Gu, Jia‑Rui Yuan, Liang Feng, Xiao‑Bin Jia
Pages: 3709-3710
Published online on: 04 March 2016

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[Corrigendum] Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway

Wei Zhao, Mingshu Lu, Qiwen Zhang
Pages: 3711-3711
Published online on: 03 March 2016

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August-2026 Volume 34 Issue 2

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CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells

Lenka Slavickova, Michaela Nemcova, Dominika Svehlova, Veronika Frybortova, Jirina Manakova, Eva Kriegova, Jiri Minarik, Katerina Smesny Trtkova
Article Number: 237
Published online on: 25 June 2026

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Mulberroside A attenuates H2O2‑induced oxidative stress and barrier dysfunction in Caco‑2 cells through Nrf2/HO‑1‑associated antioxidant signaling

Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin
Article Number: 236
Published online on: 25 June 2026

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[Retracted] Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen
Article Number: 235
Published online on: 23 June 2026

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Sulforaphane attenuates cisplatin‑induced acute kidney injury by inhibiting oxidative stress, inflammation and apoptosis via regulation of NRF2

Zeyu Wu, Mengting Lu, Lei Xu, Ming Luo, Limei Shan, Hongxia Xing, Wenwen Li, Junling Qian
Article Number: 234
Published online on: 19 June 2026

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Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein

Weiguang Luo, Mei He, Huiling Wang
Article Number: 233
Published online on: 19 June 2026

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Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)

Xiaokang Wang, Qiwen Tan, Jingcheng Xu, Yunlin Yang, Haoyue Huang, Xiaomei Teng, Weihua Wu
Article Number: 232
Published online on: 18 June 2026

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Degraded sulfated galactan derived from Gracilaria fisheri induces immunogenic cell death in MDA‑MB‑231 cells

Tawut Rudtanatip, Yada Polsan, Waraporn Sakaew, Somsuda Somintara, Jenjiralai Phanphak, Jamal El‑Abid, Kanokpan Wongprasert, Choowadee Pariwatthanakun
Article Number: 231
Published online on: 17 June 2026

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Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells

Qing Deng, Xiujuan Liu, Dan Wen, Yuhua Cheng, Qing Zhao, Yu Wang, Yu Xiang, Qinkai Chen, Jinlei Lv
Article Number: 230
Published online on: 17 June 2026

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A β‑1,3‑1,6‑glucan from Aureobasidium pullulans enhances apoptotic and autophagic pathways in colorectal cancer cells

Ji-Won Park, Gyeong Mim Mun, Tae Min Jo, Ji A Shin, Takao Kuge, Hisashi Kimoto, Jin-Kyung Kim
Article Number: 229
Published online on: 16 June 2026

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Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions

Stefan Linsler, Anna-Lena Moroldo, Walter Schulz‑Schaeffer, Ralf Ketter, Joachim Oertel, Steffi Urbschat
Article Number: 228
Published online on: 12 June 2026

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Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions

Congcong Xie, Zehao Liu, Tong Chen, Hui Lu, Xiujia Zhang, Wenbo Yu, Jiaxin Zhang, Dandan Shang, Xueying Wang
Article Number: 227
Published online on: 11 June 2026

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Strontium‑based metal‑organic framework/alendronate‑silk fibroin hydrogels promote tendon‑bone interface healing

Tao Yang, Hanji Zhang, Mingjun Li, Yiming Ren, Yunbo Sun, Weiyu Hou, Mengqiang Tian
Article Number: 226
Published online on: 11 June 2026

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[Retracted] Tripterygium glycoside suppresses epithelial‑to‑­­ mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He
Article Number: 225
Published online on: 08 June 2026

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Gut microbiota‑derived metabolites in cardiovascular disease: Focus on trimethylamine N‑oxide, short‑chain fatty acids and bile acids (Review)

Meizhu Gao, Zhenming Hao, Yiling Li, Weixue Liu, Fubao Zhang
Article Number: 224
Published online on: 08 June 2026

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Fucoxanthin alleviates chondrocyte inflammation and osteoarthritis by modulating the JAK2/STAT3 signaling pathway

Miradj Siddick Adam, Huangming Zhuang, Xunshan Ren, Yuelong Zhang, Panghu Zhou
Article Number: 223
Published online on: 08 June 2026

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Prediction of molecular targets for zedoary turmeric oil in inhibiting proliferation and inducing apoptosis in non‑small cell lung cancer

Huaiyong Li, Lili Liu, Qingzhu Yang, Yao Li, Yongli Song, Jing Jiang, Zhenzhong Wu, Weiwei Zhang, Baisong Lou
Article Number: 222
Published online on: 08 June 2026

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Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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September-2026 Volume 34 Issue 3

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Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis

Shaocong Lu, Fangla Luo, Niqi Chen, Gongde Shi, Yeru Chen
Article Number: 257
Published online on: 16 July 2026

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[Expression of Concern] Chrysophanol inhibits proliferation and induces apoptosis through NF‑κB/cyclin D1 and NF‑κB/Bcl‑2 signaling cascade in breast cancer cell lines

Li Ren, Zhouping Li, Chunmei Dai, Danyu Zhao, Yanjie Wang, Chunyu Ma, Chun Liu
Article Number: 256
Published online on: 15 July 2026

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PCSK9 alleviates doxorubicin‑induced pyroptosis of cardiomyocytes

Chaochu Cui, Jinyu Zhao, Xiaoqian Li, Shengming Huang, Gang Liu, Xinhui Xu, Can Guo, Tiesuo Zhao, Jiang Du, Shipeng Li, Xianwei Wang, Jianbo Yang
Article Number: 255
Published online on: 14 July 2026

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From cell to disease: Regulatory networks and mechanisms of super‑enhancers in aging (Review)

Xiaodan Wang, Weiqian Deng, Shuangxi Tu, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 254
Published online on: 14 July 2026

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[Retracted] Matrine‑induced apoptosis in Hep3B cells via the inhibition of MDM2

Ning Zhou, Jiequn Li, Ting Li, Guangshun Chen, Zhongqiang Zhang, Zhongzhou Si
Article Number: 253
Published online on: 13 July 2026

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Role of PANoptosis in the development of gastric immunity and related gastric mucosal disease (Review)

Lan Wang, Zhiyuan Ma, Bei Ji, Shuhui Liu, Shuji Terai, Biguang Tuo, Taolang Li, Xuemei Liu
Article Number: 252
Published online on: 09 July 2026

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Article

Leonurine inhibits the proliferation and metastasis of liver cancer cells by regulating the PI3K/AKT signaling pathway via epithelial‑mesenchymal transition

Bowen Hu, Maher Al Hussan, Jiakai Zhang, Peihao Wen, Changjun Huang, Yang Chen, Huanfei Ding
Article Number: 251
Published online on: 08 July 2026

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[Corrigendum] Resistin aggravates the expression of proinflammatory cytokines in cerulein‑stimulated AR42J pancreatic acinar cells

Chong-Yi Jiang, Wei Wang
Article Number: 250
Published online on: 08 July 2026

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A‑Raf: A serine/threonine protein kinase with important biological functions (Review)

Muhan Yang, Mengying Chen, Jinmei Wei, Yanling Li, Chen Long, Yan Lei, Yanhong Zhou
Article Number: 249
Published online on: 07 July 2026

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Gut dysbiosis‑derived butyrate loss predicts feeding intolerance: Multiomics evidence guiding nurse‑driven microbiota‑supportive interventions (Review)

Ling Wei, Xiaohua Kong, Yuying Li, Huixia Wu, Yirong Gan, Fang Sun
Article Number: 248
Published online on: 07 July 2026

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[Retracted] Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis

Jun Chen, Ting Zhang, Qingqing Luo, Ruyi Wang, Yuting Dai, Zhenyuan Chen, Chutian Zhang, Xuzheng Chen, Guangwen Wu
Article Number: 247
Published online on: 06 July 2026

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Laggera alata attenuates LPS‑induced systemic inflammation and hepatic‑pulmonary injury by regulating PINK1/Parkin-associated mitophagy and macrophage polarization

Jiangcun Wei, Wen Zhong, Guangyun Zhou, Mingtao Huang, Xiaodong Huang, Jing Liang
Article Number: 246
Published online on: 02 July 2026

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Proteolysis‑targeting chimeras in oral squamous cell carcinoma: Current evidence, translational challenges and future directions (Review)

Yun Bai, Danhua Ma, Xi Yang, Min Wang
Article Number: 245
Published online on: 02 July 2026

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Evolving role of biomarkers beyond prostate‑specific antigen in refining prostate cancer screening: From blood‑based tests to urinary and genetic markers (Review)

Luxi Li, Linyue Zhang, Zehong Li, Keqiang Chai, Weidong Ren
Article Number: 244
Published online on: 02 July 2026

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Nanocurcumin attenuates brain injury in rats with desert dry‑heat‑induced exertional heat stroke by suppressing TLR4/MyD88/NF‑κB signaling

Lisong Su, Jinquan Qu, Jiajia Li, Wenhui Shi, Laiyang Song, Feixing Liang, Jiangwei Liu
Article Number: 243
Published online on: 02 July 2026

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TREM2 in glioma: Reprogramming the immune microenvironment from mechanistic understanding to clinical translation (Review)

Junqi Fan, Hongyan Shen, Dan Liu, Songbai Luo, Qingqing Huang, Yi Wen, Libang Yuan
Article Number: 242
Published online on: 02 July 2026

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Human parvovirus B19 VP1u‑induced osteoclastogenesis is enhanced by RANKL in RAW264.7 macrophage cells

Chun-Yu Lin, Bor-Show Tzang, Yi-Hsuan Lin, Chih-Chen Tzang, Tsai-Ching Hsu
Article Number: 241
Published online on: 30 June 2026

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[Retracted] Anti‑tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC‑803 proliferation via phospho­extracellular signal‑regulated kinase‑, Src‑, c‑Jun N‑terminal kinase‑ and phosphoinositide 3­-kinase‑associated pathways  

Jialiang Hu, Tao Cheng, Lijun Zhang, Beicheng Sun, Lei Deng, Hanmei Xu
Article Number: 240
Published online on: 29 June 2026

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Aspirin prevents postoperative peritoneal adhesions by inhibiting the TGF‑β1/Smad signaling pathway in rats

Siqi Yan, Yuan Ren, Bingyan Liu, Pai Xiong, Yimin Sun
Article Number: 239
Published online on: 29 June 2026

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Morinda officinalis oligosaccharides ameliorate corticosterone‑induced depression‑like behaviour in mice by modulating the BDNF signalling pathway and gut microbiota

Mengjie He, Zixuan Liu, Yuxin Chen, Xiaoru Wu, Xueling Dai, Qian Liu, Shuo Wang, Zeping Zuo, Yaxuan Sun
Article Number: 238
Published online on: 29 June 2026

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