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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April-2016 Volume 13 Issue 4

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

DNA methylation in endometriosis (Review)

Ourania Koukoura, Stavros Sifakis, Demetrios A. Spandidos
Pages: 2939-2948
Published online on: 22 February 2016

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Article Open Access

Vanillin and 4-hydroxybenzyl alcohol promotes cell proliferation and neuroblast differentiation in the dentate gyrus of mice via the increase of brain-derived neurotrophic factor and tropomyosin-related kinase B

Jeong‑Hwi Cho, Joon Ha Park, Ji Hyeon Ahn, Jae‑Chul Lee, In Koo Hwang, Seung Min Park, Ji Yun Ahn, Dong Won Kim, Jun Hwi Cho, Jong‑Dai Kim, Young-Myeong Kim, Moo‑Ho Won, Il-Jun Kang
Pages: 2949-2956
Published online on: 19 February 2016

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Article Open Access

Neuroprotective effects of Ilexonin A following transient focal cerebral ischemia in rats

Ai‑Ling Xu, Guan‑Yi Zheng, Zhi‑Jian Wang, Xiao‑Dong Chen, Qiong Jiang
Pages: 2957-2966
Published online on: 22 February 2016

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Article Open Access

Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice

Sang‑Mi Woo, Youn Kyung Choi, Ah‑Jeong Kim, Yee Jin Yun, Yong Cheol Shin, Sung‑Gook Cho, Seong Gyu Ko
Pages: 2967-2972
Published online on: 15 February 2016

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Article Open Access

Nuclear distribution of eIF3g and its interacting nuclear proteins in breast cancer cells

Qiaoli Zheng, Hao Liu, Jingjia Ye, Hui Zhang, Zhenyu Jia, Jiang Cao
Pages: 2973-2980
Published online on: 23 February 2016

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Article Open Access

Effect of exercise-induced neurogenesis on cognitive function deficit in a rat model of vascular dementia

Dong‑Hee Choi, Kyoung‑Hee Lee, Jongmin Lee
Pages: 2981-2990
Published online on: 15 February 2016

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Article Open Access

Forkhead box O1 promotes INS‑1 cell apoptosis by reducing the expression of CD24

Yuhang Ma, Xuejiao Wang, Yongde Peng, Xiaoying Ding
Pages: 2991-2998
Published online on: 16 February 2016

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Article Open Access

Collagen metabolic disorder induced by oxidative stress in human uterosacral ligament‑derived fibroblasts: A possible pathophysiological mechanism in pelvic organ prolapse

Cheng Liu, Qing Yang, Gui Fang, Bing‑Shu Li, De‑Bin Wu, Wen‑Jun Guo, Sha‑Sha Hong, Li Hong
Pages: 2999-3008
Published online on: 22 February 2016

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Article Open Access

Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways

Huiling Jing, Wenyan Sun, Jinghua Fan, Yanmin Zhang, Jiao Yang, Jinjing Jia, Jichang Li, Jiaqi Guo, Suju Luo, Yan Zheng
Pages: 3009-3016
Published online on: 19 February 2016

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Article Open Access

Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats

Zein Shaban Ibrahim, Mohamed Elsayed Alkafafy, Mohamed Mohamed Ahmed, Mohamed Mohamed Soliman
Pages: 3017-3026
Published online on: 22 February 2016

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Article Open Access

Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer

Jiangman Duan, Li Sun, Hongxiang Huang, Zhenzhen Wu, Lin Wang, Wangjun Liao
Pages: 3027-3035
Published online on: 17 February 2016

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Article Open Access

Effects of tanshinone IIA on fibrosis in a rat model of cirrhosis through heme oxygenase-1, inflammation, oxidative stress and apoptosis

Ming Shu, Xiao‑Rong Hu, Zuo‑An Hung, Dam‑Dan Huang, Shun Zhang
Pages: 3036-3042
Published online on: 10 February 2016

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Article Open Access

Therapeutic effects of various methods of MSC transplantation on cerebral resuscitation following cardiac arrest in rats

Ka‑Hong Leong, Li‑Li Zhou, Qing‑Ming Lin, Peng Wang, Lan Yao, Zi‑Tong Huang
Pages: 3043-3051
Published online on: 22 February 2016

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Article Open Access

Scutellaria baicalensis Georgi extract protects against alcohol‑induced acute liver injury in mice and affects the mechanism of ER stress

Qingqing Dong, Fei Chu, Chengzhu Wu, Qiang Huo, Huaiyong Gan, Xiaoming Li, Hao Liu
Pages: 3052-3062
Published online on: 23 February 2016

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Article Open Access

Integrated microRNA‑gene analysis of coronary artery disease based on miRNA and gene expression profiles

Xiangdong Xu, Hongsong Li
Pages: 3063-3073
Published online on: 23 February 2016

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Article Open Access

Long non-coding RNA-Low Expression in Tumor inhibits the invasion and metastasis of esophageal squamous cell carcinoma by regulating p53 expression

Peng‑Li Wang, Bin Liu, Yang Xia, Chun‑Feng Pan, Teng Ma, Yi‑Jiang Chen
Pages: 3074-3082
Published online on: 19 February 2016

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Article Open Access

Neuroprotective effects of ginsenosides on neural progenitor cells against oxidative injury

Jun Ye, Jian‑Ping Yao, Xu Wang, Minying Zheng, Peng Li, Chengwei He, Jian‑Bo Wan, Xiaoli Yao, Huanxing Su
Pages: 3083-3091
Published online on: 19 February 2016

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Article Open Access

Omacetaxine mepesuccinate induces apoptosis and cell cycle arrest, promotes cell differentiation, and reduces telomerase activity in diffuse large B‑cell lymphoma cells

Lina Zhang, Zhenzhu Chen, Wenli Zuo, Xinghu Zhu, Yufu Li, Xinjian Liu, Xudong Wei
Pages: 3092-3100
Published online on: 16 February 2016

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Article Open Access

Protective effect of grape seed extract against cadmium-induced testicular dysfunction

Adel Alkhedaide, Zafer Saad Alshehri, Ayman Sabry, Tulip Abdel‑Ghaffar, Mohamed Mohamed Soliman, Hossam Attia
Pages: 3101-3109
Published online on: 23 February 2016

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Article

Pyropia yezoensis glycoprotein regulates antioxidant status and prevents hepatotoxicity in a rat model of D-galactosamine/lipopolysaccharide-induced acute liver failure

Jeong‑Wook Choi, In‑Hye Kim, Young‑Min Kim, Min‑Kyeong Lee, Taek‑Jeong Nam
Pages: 3110-3114
Published online on: 23 February 2016

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Article

Release mechanism of high mobility group nucleosome binding domain 1 from lipopolysaccharide-stimulated macrophages

Taisuke Murakami, Zhongshuang Hu, Hiroshi Tamura, Isao Nagaoka
Pages: 3115-3120
Published online on: 16 February 2016

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Article

Apr3 accelerates the senescence of human retinal pigment epithelial cells

Song Han, Qingjun Lu, Ningli Wang
Pages: 3121-3126
Published online on: 22 February 2016

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Article

Novel mutations in the CYP11B2 gene causing aldosterone synthase deficiency

Niu Li, Juan Li, Yu Ding, Tingting Yu, Yongnian Shen, Qihua Fu, Yiping Shen, Xiaodong Huang, Jian Wang
Pages: 3127-3132
Published online on: 18 February 2016

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Article

Shaking improves the whole bone marrow adherent method of purification

Guoying Deng, Weiheng Wang, Chengwei Yang, Rui Gao, Xiangqun Yang, Xiaojian Ye
Pages: 3133-3138
Published online on: 22 February 2016

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Article

MicroRNA-200b inhibits epithelial-mesenchymal transition and migration of cervical cancer cells by directly targeting RhoE

Yan‑Xiang Cheng, Gan‑Tao Chen, Chuang Chen, Qi‑Fan Zhang, Feng Pan, Min Hu, Bing‑Shu Li
Pages: 3139-3146
Published online on: 23 February 2016

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Article

Carbonated soft drinks induce oxidative stress and alter the expression of certain genes in the brains of Wistar rats

Adel El‑Terras, Mohamed Mohamed Soliman, Adel Alkhedaide, Hossam Fouad Attia, Abdullah Alharthy, Abdel Elah Banaja
Pages: 3147-3154
Published online on: 18 February 2016

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Article

MicroRNA-200b suppresses cell invasion and metastasis by inhibiting the epithelial-mesenchymal transition in cervical carcinoma

Yan‑Xiang Cheng, Qi‑Fan Zhang, Li Hong, Feng Pan, Jin‑Ling Huang, Bing‑Shu Li, Min Hu
Pages: 3155-3160
Published online on: 19 February 2016

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Article

Nitidine chloride inhibits ovarian cancer cell migration and invasion by suppressing MMP-2/9 production via the ERK signaling pathway

Xiangxiu Sun, Lin Lin, Ying Chen, Tianfeng Liu, Ronghua Liu, Zhongde Wang, Kai Mou, Jia Xu, Bo Li, Haibo Song
Pages: 3161-3168
Published online on: 23 February 2016

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Article

Point mutation in mitochondrial tRNA gene is associated with polycystic ovary syndrome and insulin resistance

Yu Ding, Guangchao Zhuo, Caijuan Zhang, Jianhang Leng
Pages: 3169-3172
Published online on: 19 February 2016

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Article

Functional analysis of the TMPRSS2:ERG fusion gene in cisplatin‑induced cell death

Junqi Wu, Linfeng Chi, Zhanghui Chen, Xianghong Lu, Suping Xiao, Guanglin Zhang, Jindan Luo, Ge‑Ming Chen, Jun Yang
Pages: 3173-3180
Published online on: 16 February 2016

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Article

Putative modifier genes in mevalonate kinase deficiency

Annalisa Marcuzzi, Diego Vozzi, Martina Girardelli, Paola Maura Tricarico, Alessandra Knowles, Sergio Crovella, Josef Vuch, Alberto Tommasini, Elisa Piscianz, Anna Monica Bianco
Pages: 3181-3189
Published online on: 22 February 2016

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Article

Knockdown of ephrin receptor A7 suppresses the proliferation and metastasis of A549 human lung cancer cells

Ronghui Li, Yingyan Sun, Aiying Jiang, Yan Wu, Chengwei Li, Mingchun Jin, Hairun Yan, Hong Jin
Pages: 3190-3196
Published online on: 18 February 2016

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Article

Improvement of the cytotoxic T lymphocyte response against hepatocellular carcinoma by transduction of cancer cells with an adeno-associated virus carrying the interferon-γ gene

Jun Zhou, Ping Ma, Jun Li, Xiaonan Cui, Wei Song
Pages: 3197-3205
Published online on: 10 February 2016

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Article

Downregulation of long non-coding RNA TRIM52-AS1 functions as a tumor suppressor in renal cell carcinoma

Zan Liu, Hai‑Yan Yan, Shun‑Yao Xia, Cheng Zhang, You‑Cheng Xiu
Pages: 3206-3212
Published online on: 18 February 2016

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Article

Connexin32‑mediated antitumor effects of suicide gene therapy against hepatocellular carcinoma: In vitro and in vivo anticancer activity

Lun Wu, Wen‑Bo Zhou, Feng Shen, Wei Liu, Hong‑Wei Wu, Shi‑Ji Zhou, Sheng‑Wei Li
Pages: 3213-3219
Published online on: 16 February 2016

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Article

MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9

Jianhong Wang, Jingcheng Li, Fuqiang Guo, Yong Yan
Pages: 3220-3226
Published online on: 18 February 2016

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Article

mTOR signaling pathway is inhibited downstream of the cyclophilin D-mediated mitochondrial permeability transition in honokiol-triggered regulated necrosis

Wei Tian, Jieni Xiong, Saisa Zhu, Dong Xu, Hong Shen, Yongchuan Deng
Pages: 3227-3235
Published online on: 10 February 2016

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Article

Downregulation of miR‑429 and inhibition of cell migration and invasion in nasopharyngeal carcinoma

Fangzheng Wang, Chuner Jiang, Quanquan Sun, Fenqin Yan, Lei Wang, Zhenfu Fu, Tongxin Liu, Fujun Hu
Pages: 3236-3242
Published online on: 23 February 2016

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Article

Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway

Nan Feng, Jianmin Luo, Ximin Guo
Pages: 3243-3248
Published online on: 10 February 2016

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Article

TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration

Li Chen, Yujing Bai, Min Zhao, Yanrong Jiang
Pages: 3249-3256
Published online on: 15 February 2016

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Article

Triptolide sensitizes human breast cancer cells to tumor necrosis factor‑α‑induced apoptosis by inhibiting activation of the nuclear factor‑κB pathway

Xiaoli Cheng, Wenli Shi, Canguo Zhao, Dan Zhang, Piao Liang, Guohui Wang, Li Lu
Pages: 3257-3264
Published online on: 23 February 2016

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Article

Downregulation of VEGF and upregulation of TL1A expression induce HUVEC apoptosis in response to high glucose stimuli

Miao Yu, Guihua Lu, Xun Zhu, Zhibin Huang, Chong Feng, Rong Fang, Yesong Wang, Xiuren Gao
Pages: 3265-3272
Published online on: 22 February 2016

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Article

Decreased miR-143 and increased miR-21 placental expression levels are associated with macrosomia

Ji‑Tai Zhang, Qian‑Ying Cai, Si‑Si Ji, Heng‑Xin Zhang, Yu‑Huan Wang, Hong‑Tao Yan, Xin‑Jun Yang
Pages: 3273-3280
Published online on: 15 February 2016

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Article

Hypoxia increases the heterogeneity of melanoma cell populations and affects the response to vemurafenib

Daniela Pucciarelli, Nina Lengger, Martina Takáčová, Lucia Csaderova, Maria Bartosova, Heimo Breiteneder, Silvia Pastorekova, Christine Hafner
Pages: 3281-3288
Published online on: 10 February 2016

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Article

Astragaloside IV suppresses inflammatory mediator production in synoviocytes and collagen‑induced arthritic rats

Hao Xu, Chang‑Yao Wang, Hai‑Ning Zhang, Cheng‑Yu Lv, Ying‑Zhen Wang
Pages: 3289-3296
Published online on: 22 February 2016

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Article

Polydatin-induced cell apoptosis and cell cycle arrest are potentiated by Janus kinase 2 inhibition in leukemia cells

Wei‑Jie Cao, Ke Wu, Chong Wang, Ding‑Ming Wan
Pages: 3297-3302
Published online on: 18 February 2016

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Article

Characterization of the malaria parasite protein PfTip, a novel invasion-related protein

Xuewu Liu, Yuxiao Huang, Jiao Liang, Jun Wang, Yan Shen, Yinghui Li, Ya Zhao
Pages: 3303-3310
Published online on: 18 February 2016

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Article

Antiproliferative activity of a series of 5‑(1H‑1,2,3‑triazolyl) methyl‑ and 5‑acetamidomethyl‑oxazolidinone derivatives

Omar M. Hedaya, Princy M. Mathew, Fatima H. Mohamed, Oludotun A. Phillips, Yunus A. Luqmani
Pages: 3311-3318
Published online on: 23 February 2016

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Article

Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF

Lin Quan, Hua He
Pages: 3319-3325
Published online on: 23 February 2016

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Article

Identification of long-non coding RNA UCA1 as an oncogene in renal cell carcinoma

Yifan Li, Tiantian Wang, Yuchi Li, Duqun Chen, Zuhu Yu, Lu Jin, Liangchao Ni, Shangqi Yang, Xiangming Mao, Yaoting Gui, Yongqing Lai
Pages: 3326-3334
Published online on: 16 February 2016

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Article

Anti-inflammatory effects of essential oils extracted from Chamaecyparis obtusa on murine models of inflammation and RAW 264.7 cells

Yujin Park, Seung‑Ah Yoo, Wan‑Uk Kim, Chul‑Soo Cho, Jong‑Min Woo, Chong‑Hyeon Yoon
Pages: 3335-3341
Published online on: 18 February 2016

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Article

Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression

Shihong Ma, Wenhua Tan, Botao Du, Wei Liu, Weijia Li, Dehong Che, Guangmei Zhang
Pages: 3342-3348
Published online on: 16 February 2016

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Article

MicroRNA-200c inhibits the metastasis of non-small cell lung cancer cells by targeting ZEB2, an epithelial-mesenchymal transition regulator Retraction in /10.3892/mmr.2021.12212

Aihong Jiao, Minghua Sui, Liangming Zhang, Ping Sun, Dongmei Geng, Weiwei Zhang, Xiuwen Wang, Junxia Li
Pages: 3349-3355
Published online on: 17 February 2016

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Article

Elevated caspase‑1 activity and IL‑1β expression are associated with the IPAF inflammasome in an experimental model of allergy

Hamid Reza Nouri, Ahmad Karkhah, Iraj Mohammadzadeh, Mojtaba Sankian
Pages: 3356-3362
Published online on: 23 February 2016

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Article

Regulation by AMP-activated protein kinase of PGE2-induced osteoprotegerin synthesis in osteoblasts

Shingo Kainuma, Takanobu Otsuka, Gen Kuroyanagi, Naohiro Yamamoto, Rie Matsushima‑Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Pages: 3363-3369
Published online on: 17 February 2016

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Article

In human alloreactive CD4+ T-cells, dichloroacetate inhibits aerobic glycolysis, induces apoptosis and favors differentiation towards the regulatory T-cell subset instead of effector T-cell subsets

Theodoros Eleftheriadis, Maria Sounidaki, Georgios Pissas, Georgia Antoniadi, Vassilios Liakopoulos, Ioannis Stefanidis
Pages: 3370-3376
Published online on: 19 February 2016

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Article

Radioresistance of granulation tissue-derived cells from skin wounds combined with total body irradiation

Tingyu Dai, Zelin Chen, Li Tan, Chunmeng Shi
Pages: 3377-3383
Published online on: 23 February 2016

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Correction Open Access

[Corrigendum] Knockdown of eukaryotic translation initiation factor 4E suppresses cell growth and invasion, and induces apoptosis and cell cycle arrest in a human lung adenocarcinoma cell line

Baofu Chen, Bo Zhang, Lilong Xia, Jian Zhang, Yu Chen, Quanteng Hu, Chengchu Zhu
Pages: 3384-3384
Published online on: 23 February 2016

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Review Open Access

Role of neuroinflammation in neurodegenerative diseases (Review)

Wei‑Wei Chen, Xia Zhang, Wen‑Juan Huang
Pages: 3391-3396
Published online on: 29 February 2016

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Review Open Access

Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review)

Ruiqi Feng, Lijuan Li, Haiyan Yu, Min Liu, Wei Zhao
Pages: 3397-3400
Published online on: 02 March 2016

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Review

Benzene exposure is associated with epigenetic changes (Review)

Concettina Fenga, Silvia Gangemi, Chiara Costa
Pages: 3401-3405
Published online on: 01 March 2016

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Article Open Access

Pretreatment of BMSCs with TZD solution decreases the proliferation rate of MCF‑7 cells by reducing FGF4 protein expression

Boon‑Yin Khoo, Kalpanah Nadarajan, Siang‑Yian Shim, Noorizan Miswan, Chuan‑Bing Zang, Kurt Possinger, Elena Elstner
Pages: 3406-3414
Published online on: 02 March 2016

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Targeted inhibition of survivin with YM155 promotes apoptosis of hypoxic human pulmonary arterial smooth muscle cells via the upregulation of voltage-dependent K+ channels

Shuai Zhang, Bo Liu, Zaiwen Fan, Dong Wang, Ying Liu, Jian Li, Ning Wang, Yi Liu, Bo Zhang
Pages: 3415-3422
Published online on: 04 March 2016

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Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells Retraction in /10.3892/mmr.2026.13875

Wei Shi, Jiagang Deng, Rongsheng Tong, Yong Yang, Xia He, Jianzhen Lv, Hailian Wang, Shaoping Deng, Ping Qi, Dingding Zhang, Yi Wang
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Published online on: 29 February 2016

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Enhanced autophagy in cytarabine arabinoside-resistant U937 leukemia cells and its potential as a target for overcoming resistance

June‑Won Cheong, Yundeok Kim, Ju In Eom, Hoi‑Kyung Jeung, Yoo Hong Min
Pages: 3433-3440
Published online on: 29 February 2016

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Cannabinoid CB2 receptors are involved in the regulation of fibrogenesis during skin wound repair in mice

Shan‑Shan Li, Lin‑Lin Wang, Min Liu, Shu‑Kun Jiang, Miao Zhang, Zhi‑Ling Tian, Meng Wang, Jiao‑Yong Li, Rui Zhao, Da‑Wei Guan
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Published online on: 02 March 2016

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In vivo treatment of rat arterial adventitia with interleukin‑1β induces intimal proliferation via the JAK2/STAT3 signaling pathway

Xiao Wang, Lihua Chen, Jie Liu, Tao Yan, Gangyong Wu, Yang Xia, Gangjun Zong, Fengsheng Li
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Published online on: 07 March 2016

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Impaired function of the intestinal barrier in a novel sub-health rat model

Sisi Feng, Weidong Liu, Shengnan Zuo, Tingyan Xie, Hui Deng, Qiuhuan Zhang, Baiyun Zhong
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Constitutive expression of Wnt/β‑catenin target genes promotes proliferation and invasion of liver cancer stem cells

Wei Chen, Yu‑Wei Zhang, Yang Li, Jian‑Wen Zhang, Tong Zhang, Bin‑Sheng Fu, Qi Zhang, Nan Jiang
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Intervertebral disc regeneration using platelet‑rich plasma‑containing bone marrow‑derived mesenchymal stem cells: A preliminary investigation

Shan‑Zheng Wang, Ji‑Yang Jin, Yu‑Dong Guo, Liang‑Yu Ma, Qing Chang, Xin‑Gui Peng, Fang‑Fang Guo, Hai‑Xiang Zhang, Xin‑Feng Hu, Chen Wang
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SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α

Fang Zhou, Aiguo Dai, Yongliang Jiang, Xiaowu Tan, Xiufeng Zhang
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Integrated analysis of DNA methylation profiles and gene expression profiles to identify genes associated with pilocytic astrocytomas

Ruigang Zhou, Yigang Man
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Published online on: 29 February 2016

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Characterization of bone marrow-derived mesenchymal stem cells from dimethyloxallyl glycine-preconditioned mice: Evaluation of the feasibility of dimethyloxallyl glycine as a mobilization agent

Tingting Ge, Qin Yu, Wei Liu, Li Cong, Lizhen Liu, Yan Wang, Liping Zhou, Deju Lin
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Long‑term follow‑up of buserelin‑induced enteric neuropathy in rats

Anette Jönsson, Elin Sand, Eva Ekblad, Bodil Ohlsson
Pages: 3507-3513
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Downregulation of epidermal growth factor receptor family receptors and ligands in a mutant K-ras group of patients with colorectal cancer

Tomoko Nagaoka, Kazutaka Kitaura, Yukinaga Miyata, Kenichi Kumagai, Goro Kaneda, Hideki Kanazawa, Satsuki Suzuki, Yoshiki Hamada, Ryuji Suzuki
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Low levels of inflammation and the absence of subclinical atherosclerosis in rheumatoid arthritis

Salvatore Santo Signorelli, Saverio Candido, Rossella Salemi, Valerio Fiore, Marco Mangiafico, Massimo Libra
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Growth inhibition effects of ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid on colorectal carcinoma cells and colon carcinoma-bearing mice

Hua Ye, Qiong Wu, Meng Guo, Kefeng Wu, Yingnian Lv, Fengyan Yu, Yi Liu, Xiaosheng Gao, Yuzhen Zhu, Liao Cui, Nianci Liang, Tu Yun, Li Li, Xuebao Zheng
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Expression of lactate dehydrogenase C in MDA‑MB‑231 cells and its role in tumor invasion and migration

Lingying Kong, Wei Du, Zhaolei Cui, Li Wang, Zhi Yang, Hongsheng Zhang, Donghong Lin
Pages: 3533-3538
Published online on: 02 March 2016

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Effect and mechanism of fuzhisan and donepezil on the sirtuin 1 pathway and amyloid precursor protein metabolism in PC12 cells

Peng Guo, Desheng Wang, Xiaomin Wang, Honglin Feng, Ying Tang, Ruihong Sun, Yan Zheng, Lin Dong, Jiaying Zhao, Xin Zhang, Shuyu Wang, Hongxu Sun
Pages: 3539-3546
Published online on: 01 March 2016

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Comparative proteomic analysis of heat stress proteins associated with rat sperm maturation

Xiaomei Wang, Fujun Liu, Xin Gao, Xin Liu, Xiaojun Kong, Haiyan Wang, Jianyuan Li
Pages: 3547-3552
Published online on: 02 March 2016

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Paeoniflorin attenuates ultraviolet B-induced apoptosis in human keratinocytes by inhibiting the ROS-p38-p53 pathway

Lingwen Kong, Shangshang Wang, Xiao Wu, Fuguo Zuo, Haihong Qin, Jinfeng Wu
Pages: 3553-3558
Published online on: 01 March 2016

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Endothelin‑1 induces oncostatin M expression in osteoarthritis osteoblasts by trans‑activating the oncostatin M gene promoter via Ets‑1

Ren Wu, Wanchun Wang, Guoliang Huang, Xinzhan Mao, You Chen, Qi Tang, Lele Liao
Pages: 3559-3566
Published online on: 02 March 2016

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Effect of transforming growth factor-β3 on the expression of Smad3 and Smad7 in tenocytes

Ke Jiang, Guo Chun, Ziming Wang, Quanyin Du, Aimin Wang, Yan Xiong
Pages: 3567-3573
Published online on: 29 February 2016

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Atorvastatin attenuates atherosclerotic plaque destabilization by inhibiting endoplasmic reticulum stress in hyperhomocysteinemic mice

Fang Jia, Chunfang Wu, Zhenyue Chen, Guoping Lu, Jianhui Sun
Pages: 3574-3580
Published online on: 03 March 2016

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Hepatitis B virus replication is upregulated in proliferated peripheral blood lymphocytes

Qin Yan, Ying‑Hua Lan, Yan‑Xin Huang, Rong‑Shan Fan, Lan Liu, Shu‑Peng Song, Yong‑Guo Li
Pages: 3581-3587
Published online on: 03 March 2016

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Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice

Qu Liu, Bao‑Shan Li, Yu‑Jiao Song, Ming‑Gen Hu, Jian‑Yue Lu, Ang Gao, Xue‑Jun Sun, Xi‑Ming Guo, Rong Liu
Pages: 3588-3596
Published online on: 01 March 2016

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Sasanquasaponin promotes cellular chloride efflux and elicits cardioprotection via the PKCε pathway

Ling‑Yu Qiu, He‑Ping Chen, Yu‑Feng Yan, Yuan‑Yuan Li, Huan Wang, Zhang‑Ping Liao, Qi‑Ren Huang
Pages: 3597-3603
Published online on: 07 March 2016

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CXCR4 antagonist AMD3100 ameliorates thyroid damage in autoimmune thyroiditis in NOD.H‑2h4 mice

Xin Liu, Jinyuan Mao, Cheng Han, Shiqiao Peng, Chenyan Li, Ting Jin, Chenling Fan, Zhongyan Shan, Weiping Teng
Pages: 3604-3612
Published online on: 02 March 2016

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SASH1 inhibits cervical cancer cell proliferation and invasion by suppressing the FAK pathway

Hui Chen, Dongliang Wang, Yuling Liu
Pages: 3613-3618
Published online on: 29 February 2016

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Expression and purification of FGF21 in Pichia pastoris and its effect on fibroblast-cell migration

Yonghuan Song, Jian Ding, Rilong Jin, Jinhee Jung, Shi Li, Jingquan Yang, Anyuan Wang, Zhijie Li
Pages: 3619-3626
Published online on: 26 February 2016

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Protectin D1 reduces concanavalin A-induced liver injury by inhibiting NF-κB-mediated CX3CL1/CX3CR1 axis and NLR family, pyrin domain containing 3 inflammasome activation

Jun Ren, Shanshan Meng, Bingdi Yan, Jinyan Yu, Jing Liu
Pages: 3627-3638
Published online on: 04 March 2016

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Glycyrrhizic acid prevents enteritis through reduction of NF‑κB p65 and p38MAPK expression in rat

Yi‑Ming Wang, Guo‑Qiang Du
Pages: 3639-3646
Published online on: 07 March 2016

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Interleukin‑12B is upregulated by decoy receptor 3 in rheumatoid synovial fibroblasts

Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Masahiro Kurosaka
Pages: 3647-3652
Published online on: 07 March 2016

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Ameliorative effects of pomegranate on carbon tetrachloride hepatotoxicity in rats: A molecular and histopathological study

Zein Shaban Ibrahim, Mohamed Abdo Nassan, Mohamed Mohamed Soliman
Pages: 3653-3660
Published online on: 01 March 2016

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Sensitization of hepatocellular carcinoma cells to irradiation by miR‑34a through targeting lactate dehydrogenase‑A

Xiaogang Li, Ping Lu, Bo Li, Rong Yang, Yan Chu, Zhiping Zhang, Hongwei Wan, Chao Niu, Chunxiao Wang, Kaiyuan Luo
Pages: 3661-3667
Published online on: 03 March 2016

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Apoptosis is induced by shikonin through the mitochondrial signaling pathway

Xuxia Tang, Chen Zhang, Jiongzhou Wei, Yuting Fang, Rongxiang Zhao, Jianxin Yu
Pages: 3668-3674
Published online on: 02 March 2016

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Mucin 1 and poly I:C activates dendritic cells and effectively eradicates pituitary tumors as a prophylactic vaccine

Dehua Sui, Lixin Ma, Meng Li, Wei Shao, Hongpeng Du, Ke Li, Zhenzhu Li, Zefu Li
Pages: 3675-3683
Published online on: 02 March 2016

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Leptin induces the apoptosis of chondrocytes in an in vitro model of osteoarthritis via the JAK2‑STAT3 signaling pathway

Zi Ming Zhang, Chao Shen, Hai Li, Qing Fan, Jing Ding, Fang Chun Jin, Lin Sha
Pages: 3684-3690
Published online on: 03 March 2016

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TMEM16A contributes to angiotensin II-induced cerebral vasoconstriction via the RhoA/ROCK signaling pathway

Rong‑Shan Li, Yong Wang, Hui‑Shen Chen, Fang‑Yong Jiang, Qiang Tu, Wen‑Jun Li, Rui‑Xing Yin
Pages: 3691-3699
Published online on: 04 March 2016

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The effects of perfluorocarbon on ICAM-1 expression in LPS-induced A549 cells and the potential mechanism

Lu Cao, Chun‑Sun Li, Yan Chang, Zhi‑Xin Liang, Liang‑An Chen
Pages: 3700-3708
Published online on: 01 March 2016

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Correction Open Access

[Corrigendum] Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC-α/ERK1/2 pathway: An in vitro investigation

Xu‑Dong Cheng, Jun‑Fei Gu, Jia‑Rui Yuan, Liang Feng, Xiao‑Bin Jia
Pages: 3709-3710
Published online on: 04 March 2016

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[Corrigendum] Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway

Wei Zhao, Mingshu Lu, Qiwen Zhang
Pages: 3711-3711
Published online on: 03 March 2016

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May-2026 Volume 33 Issue 5

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CiteScore: 8.5

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Identification of STMN1 as a lactylation‑related driver of lung cancer progression using Mendelian randomization

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Article Number: 156
Published online on: 30 March 2026

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Advances in the mechanisms of extracellular vesicles and circulating tumor cells in hepatocellular carcinoma metastasis (Review)

Sitong Yi, Wenxin Liu, Zhaohui Wang
Article Number: 155
Published online on: 30 March 2026

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Diagnostic importance of serum markers in lung cancer

Qichen Liang, Jianmei Song, Haixiang Wei, Lu Ning, Baoyu He, Ziteng Zhang
Article Number: 154
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VSNL1 attenuates hypoxia‑induced myocardial apoptosis by regulating the CNP/NPRB pathway

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Article Number: 153
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Article Number: 152
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Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review)

Hong Wang, Hongyuan Lv, Xiaolin Zhang, Meifang Liu, Liyuan Wang
Article Number: 151
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Tonsil‑derived mesenchymal stem cell‑derived extracellular vesicles suppress MAPK‑NF‑κB signaling and restore osteogenic differentiation in LPS‑stimulated periodontal ligament fibroblasts

Won-Jung Bae, Su Kang Kim, Han-Soo Kim, Sang Wook Kang, Ju Yeon Ban
Article Number: 150
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Succinylation modification in diabetes and diabetic complications: Mechanisms and functions (Review)

Yeteng Xiong, Fei Luo, Bingnan Li, Qinfeng Yang
Article Number: 149
Published online on: 26 March 2026

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Polyphyllin II regulates ROS levels and promotes ferroptosis in bladder cancer cells

Quanlai Qiao, Ruifang Guo, Zhonghua Sun, Yaxin Shi, Yuning Xie, Zhiyong Liu
Article Number: 148
Published online on: 26 March 2026

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Veronicastrum sibiricum (L.) Pennell extract alleviates inflammation‑induced muscle atrophy through NLRP3 inflammasome regulation and mitochondrial function restoration

Eunhye Lee, Minjeong Kwon, Ju-Ock Nam
Article Number: 147
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Role and clinical importance of lactylation in tumors (Review)

Chaowei Zhang, Xinyu Tang, Yuxuan Han, Weiyi Yao, Qing Hong, Yanan Zhu, Na Chen
Article Number: 146
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Photodynamic therapy: A paradigm shift in overcoming drug‑resistant tuberculosis (Review)

Shuhao Cheng, Yuqing Wang, Jie Yao, Guodong Cheng, Gengzhi Ye, Fapeng Shi, Xiaolei Ma
Article Number: 145
Published online on: 26 March 2026

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Heterogeneous nuclear ribonucleoprotein K in cancer biology and its therapeutic applications (Review)

Yiyu Qin, Yang Zhou
Article Number: 144
Published online on: 26 March 2026

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[Retracted] Na+/K+‑ATPase DR region‑specific antibody protects U251 cells against hypoxia reperfusion‑induced injury via the PI3K/AKT and ERK pathways

Huilin Gong, Pengbiao Lü, Jiangwei Zhang, Dandong Li, Jin Zheng, Jinning Song
Article Number: 143
Published online on: 23 March 2026

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Multi‑omics and their integration in psoriasis research (Review)

Hengyan Zhang, Danping Li, Lijuan Zhu, Heguo Yan, Licong Yang, Xuesong Yang, Ye Zhou
Article Number: 142
Published online on: 23 March 2026

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LDHA protects vascular endothelial cells from oxidative stress‑induced mitochondrial damage via HIF‑1α activation and glycolytic reprogramming

Beibei Dai, Lili Yang, Yu Zhang, Aiyong Yu
Article Number: 141
Published online on: 23 March 2026

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Mechanism of BRCC36 affecting cardiac rupture after acute infarction through the Wnt‑JNK signaling pathway

Yongzhe Guo, Linyan Chen, Shumei Li, Xintao Zhang, Huizhong Lin
Article Number: 140
Published online on: 20 March 2026

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[Corrigendum] Puerarin alleviates the ototoxicity of gentamicin by inhibiting the mitochondria‑dependent apoptosis pathway

Ping Niu, Yuxuan Sun, Shiyi Wang, Guang Li, Xiaomin Tang, Jiaqiang Sun, Chunchen Pan, Jingwu Sun
Article Number: 139
Published online on: 19 March 2026

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Role of liver X receptors in the pathogenesis and treatment of chronic liver disease (Review)

Honghui You, Xiangjun Tang, Xiaoyan Fu, Jiaqi Zhou, Liyuan Wang, Hongxia Zhang, Xianhong Du, Shujuan Liang, Meifang Liu
Article Number: 138
Published online on: 19 March 2026

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Mechanistic insights and therapeutic potential of sphingosine‑1‑phosphate in the development of pulmonary fibrosis (Review)

Yanling Qin, Chenqi Tang, Sen Tan, Guangnan Liu
Article Number: 137
Published online on: 18 March 2026

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Advances in the biological functions of miR‑205 in various diseases (Review)

Dandan Chai, Hua Du, Yingxu Shi
Article Number: 136
Published online on: 18 March 2026

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[Retracted] MicroRNA‑25‑3p regulates human nucleus pulposus cell proliferation and apoptosis in intervertebral disc degeneration by targeting Bim

Zhifang Zhao, Jie Zheng, Youchen Ye, Kefeng Zhao, Ruozhang Wang, Ran Wang
Article Number: 135
Published online on: 16 March 2026

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Precision medicine approach to coronary artery disease: Haptoglobin phenotype‑guided risk assessment

Zhengxin He, Hong Liu, Keran Jia, Daxin Lei, Liyun An, Jia Wang, Fukun Wang
Article Number: 134
Published online on: 12 March 2026

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[Expression of Concern] Dexmedetomidine protects against sepsis‑associated encephalopathy through Hsp90/AKT signaling

Lijun Yin, Xuejun Chen, Hongbo Ji, Shunli Gao
Article Number: 133
Published online on: 11 March 2026

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Glucose‑driven TRIB3 enhances the tumorigenic potential of colon cancer via the PI3K/AKT pathway

Yunting Bai, Xuying Huang, Guangyu An, Yang Ge, Rui Yan, Dan Yu
Article Number: 132
Published online on: 10 March 2026

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[Retracted] miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8

Yan-Yan Bai, Jun-Zhi Niu
Article Number: 131
Published online on: 09 March 2026

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Dexmedetomidine protects against myocardial ischemia reperfusion injury by inhibiting the TLR2‑NF‑κB pathway in diabetic mice

Zhengjie Chen, Liangyu Zheng, Gang Chen
Article Number: 130
Published online on: 06 March 2026

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Long non‑coding RNA NKILA regulates the JAK2/STAT3 pathway to exacerbate TGF‑β1‑mediated renal fibrosis

Yu Han, Siqi Yang, Jing Zhang, Yaoguang Wang, Xi Zhao, Huan Liu
Article Number: 129
Published online on: 05 March 2026

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[Retracted] Combination of HSP90 and autophagy inhibitors promotes hepatocellular carcinoma apoptosis following incomplete thermal ablation

Fen Chen, Haiyang Xie, Haiwei Bao, Laurencia Violetta, Shusen Zheng
Article Number: 128
Published online on: 05 March 2026

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Advances regarding physiological functions and mechanisms of theaflavin‑3,3'‑digallate (Review)

Teng Ma, Siwei Zhang, Miaomiao Xiao, Zhijian Ma, Junhong Guan
Article Number: 127
Published online on: 04 March 2026

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Mechanisms and therapeutic potential of glycyrrhizic acid: Insights into key signaling pathways and disease modulation (Review)

Jinjin Yu, Huiheng Qu, Weicheng Xu, Yiming Fang, Nan Wang, Wei Shi
Article Number: 126
Published online on: 04 March 2026

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Pyroptosis in cerebral ischemia‑reperfusion injury: Molecular mechanisms and therapeutic implications (Review)

Ze Li, Qiuli Ming, Tianyu Yang, Mengna Liu, Linpeng Fu, Jingshuang Yang, Zhaofeng Lu
Article Number: 125
Published online on: 04 March 2026

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Characteristics of chromosomal instability‑related lncRNAs associated with progression and prognosis in breast cancer

Qi Chen, Hui Chen, Hui Yang, Yin Tao, Xiaolan Zhu
Article Number: 124
Published online on: 04 March 2026

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[Corrigendum] Associations between Huwe1 and autophagy in rat cerebral neuron oxygen‑glucose deprivation and reperfusion injury 

Guo-Qian He, Yan Chen, Hui-Juan Liao, Wen-Ming Xu, Wei Zhang, Guo-Lin He
Article Number: 123
Published online on: 26 February 2026

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June-2026 Volume 33 Issue 6

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CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Potential for anti‑angiogenic therapy targeting the receptor for advanced glycation end products/VEGF axis in ulcerative colitis (Review)

Chen Xu, Yuting Li, Yahua Hong, Dayong Zhou, Kun He, Lianghui Wang, Feng Hong
Article Number: 166
Published online on: 09 April 2026

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[Retracted] Molecular mechanisms underlying mangiferin‑induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells

Wei Shi, Jiagang Deng, Rongsheng Tong, Yong Yang, Xia He, Jianzhen Lv, Hailian Wang, Shaoping Deng, Ping Qi, Dingding Zhang, Yi Wang
Article Number: 165
Published online on: 07 April 2026

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Mechanism of and research progress on alterations in the RET gene in thyroid cancer (Review)

Meng Wei, Rui Wang, Jincan Qian, Qiang Fang, Jun Tao
Article Number: 164
Published online on: 02 April 2026

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Current research progress on extracellular vesicles derived from mesenchymal stem cells in tuberculosis treatment (Review)

Dejun Fan, Yan Yang, Li Yang
Article Number: 163
Published online on: 01 April 2026

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Uremic toxin p‑cresyl sulfate enhances the calcification of aortic valvular interstitial cells via klotho/sirtuin‑1 signaling

Shao-Jung Li, Tzu-Yu Cheng, Yu-Hsun Kao, Wei-Yu Chen, Cheng-Chih Chung, Nguyen Ngoc Trang, Pao-Huan Chen, Yi-Jen Chen
Article Number: 162
Published online on: 01 April 2026

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Exercise‑induced extracellular vesicle microRNA regulates physiological function (Review)

Zhonglei Wang, Wenjue Guo, Haojia He, Yi Zhang, Na Li
Article Number: 161
Published online on: 01 April 2026

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[Expression of Concern] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 160
Published online on: 01 April 2026

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Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review)

Beomwoo Lee, Changgyu Son, Sunho Eom, Yuwen Li, Seon-Hwan Kim, Jongsun Park
Article Number: 159
Published online on: 30 March 2026

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Combining bioinformatics prediction with experimental validation to explore the ameliorative effect of Psoralea corylifolia on vitiligo

Chen Zhang, Zhanhong Cao, Mengyang Wei, Xuanxuan Zhu, Yan Yan, Zhenhua Wang, Meng Zhang
Article Number: 158
Published online on: 30 March 2026

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[Retracted] All‑trans‑retinoic acid inhibits chondrogenesis of rat embryo hindlimb bud mesenchymal cells by down­regulating p53 expression

Tao-Gen Zhang, Xue-Dong Li, Guo-Yong Yu, Peng Xie, Yun-Guo Wang, Zhao-Yong Liu, Quan Hong, De-Zhong Liu, Shi-Xin Du
Article Number: 157
Published online on: 30 March 2026

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