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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April-2016 Volume 13 Issue 4

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

DNA methylation in endometriosis (Review)

Ourania Koukoura, Stavros Sifakis, Demetrios A. Spandidos
Pages: 2939-2948
Published online on: 22 February 2016

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Article Open Access

Vanillin and 4-hydroxybenzyl alcohol promotes cell proliferation and neuroblast differentiation in the dentate gyrus of mice via the increase of brain-derived neurotrophic factor and tropomyosin-related kinase B

Jeong‑Hwi Cho, Joon Ha Park, Ji Hyeon Ahn, Jae‑Chul Lee, In Koo Hwang, Seung Min Park, Ji Yun Ahn, Dong Won Kim, Jun Hwi Cho, Jong‑Dai Kim, Young-Myeong Kim, Moo‑Ho Won, Il-Jun Kang
Pages: 2949-2956
Published online on: 19 February 2016

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Article Open Access

Neuroprotective effects of Ilexonin A following transient focal cerebral ischemia in rats

Ai‑Ling Xu, Guan‑Yi Zheng, Zhi‑Jian Wang, Xiao‑Dong Chen, Qiong Jiang
Pages: 2957-2966
Published online on: 22 February 2016

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Article Open Access

Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice

Sang‑Mi Woo, Youn Kyung Choi, Ah‑Jeong Kim, Yee Jin Yun, Yong Cheol Shin, Sung‑Gook Cho, Seong Gyu Ko
Pages: 2967-2972
Published online on: 15 February 2016

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Article Open Access

Nuclear distribution of eIF3g and its interacting nuclear proteins in breast cancer cells

Qiaoli Zheng, Hao Liu, Jingjia Ye, Hui Zhang, Zhenyu Jia, Jiang Cao
Pages: 2973-2980
Published online on: 23 February 2016

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Article Open Access

Effect of exercise-induced neurogenesis on cognitive function deficit in a rat model of vascular dementia

Dong‑Hee Choi, Kyoung‑Hee Lee, Jongmin Lee
Pages: 2981-2990
Published online on: 15 February 2016

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Article Open Access

Forkhead box O1 promotes INS‑1 cell apoptosis by reducing the expression of CD24

Yuhang Ma, Xuejiao Wang, Yongde Peng, Xiaoying Ding
Pages: 2991-2998
Published online on: 16 February 2016

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Article Open Access

Collagen metabolic disorder induced by oxidative stress in human uterosacral ligament‑derived fibroblasts: A possible pathophysiological mechanism in pelvic organ prolapse

Cheng Liu, Qing Yang, Gui Fang, Bing‑Shu Li, De‑Bin Wu, Wen‑Jun Guo, Sha‑Sha Hong, Li Hong
Pages: 2999-3008
Published online on: 22 February 2016

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Article Open Access

Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways

Huiling Jing, Wenyan Sun, Jinghua Fan, Yanmin Zhang, Jiao Yang, Jinjing Jia, Jichang Li, Jiaqi Guo, Suju Luo, Yan Zheng
Pages: 3009-3016
Published online on: 19 February 2016

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Article Open Access

Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats

Zein Shaban Ibrahim, Mohamed Elsayed Alkafafy, Mohamed Mohamed Ahmed, Mohamed Mohamed Soliman
Pages: 3017-3026
Published online on: 22 February 2016

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Article Open Access

Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer

Jiangman Duan, Li Sun, Hongxiang Huang, Zhenzhen Wu, Lin Wang, Wangjun Liao
Pages: 3027-3035
Published online on: 17 February 2016

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Article Open Access

Effects of tanshinone IIA on fibrosis in a rat model of cirrhosis through heme oxygenase-1, inflammation, oxidative stress and apoptosis

Ming Shu, Xiao‑Rong Hu, Zuo‑An Hung, Dam‑Dan Huang, Shun Zhang
Pages: 3036-3042
Published online on: 10 February 2016

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Article Open Access

Therapeutic effects of various methods of MSC transplantation on cerebral resuscitation following cardiac arrest in rats

Ka‑Hong Leong, Li‑Li Zhou, Qing‑Ming Lin, Peng Wang, Lan Yao, Zi‑Tong Huang
Pages: 3043-3051
Published online on: 22 February 2016

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Article Open Access

Scutellaria baicalensis Georgi extract protects against alcohol‑induced acute liver injury in mice and affects the mechanism of ER stress

Qingqing Dong, Fei Chu, Chengzhu Wu, Qiang Huo, Huaiyong Gan, Xiaoming Li, Hao Liu
Pages: 3052-3062
Published online on: 23 February 2016

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Article Open Access

Integrated microRNA‑gene analysis of coronary artery disease based on miRNA and gene expression profiles

Xiangdong Xu, Hongsong Li
Pages: 3063-3073
Published online on: 23 February 2016

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Article Open Access

Long non-coding RNA-Low Expression in Tumor inhibits the invasion and metastasis of esophageal squamous cell carcinoma by regulating p53 expression

Peng‑Li Wang, Bin Liu, Yang Xia, Chun‑Feng Pan, Teng Ma, Yi‑Jiang Chen
Pages: 3074-3082
Published online on: 19 February 2016

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Article Open Access

Neuroprotective effects of ginsenosides on neural progenitor cells against oxidative injury

Jun Ye, Jian‑Ping Yao, Xu Wang, Minying Zheng, Peng Li, Chengwei He, Jian‑Bo Wan, Xiaoli Yao, Huanxing Su
Pages: 3083-3091
Published online on: 19 February 2016

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Article Open Access

Omacetaxine mepesuccinate induces apoptosis and cell cycle arrest, promotes cell differentiation, and reduces telomerase activity in diffuse large B‑cell lymphoma cells

Lina Zhang, Zhenzhu Chen, Wenli Zuo, Xinghu Zhu, Yufu Li, Xinjian Liu, Xudong Wei
Pages: 3092-3100
Published online on: 16 February 2016

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Article Open Access

Protective effect of grape seed extract against cadmium-induced testicular dysfunction

Adel Alkhedaide, Zafer Saad Alshehri, Ayman Sabry, Tulip Abdel‑Ghaffar, Mohamed Mohamed Soliman, Hossam Attia
Pages: 3101-3109
Published online on: 23 February 2016

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Article

Pyropia yezoensis glycoprotein regulates antioxidant status and prevents hepatotoxicity in a rat model of D-galactosamine/lipopolysaccharide-induced acute liver failure

Jeong‑Wook Choi, In‑Hye Kim, Young‑Min Kim, Min‑Kyeong Lee, Taek‑Jeong Nam
Pages: 3110-3114
Published online on: 23 February 2016

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Article

Release mechanism of high mobility group nucleosome binding domain 1 from lipopolysaccharide-stimulated macrophages

Taisuke Murakami, Zhongshuang Hu, Hiroshi Tamura, Isao Nagaoka
Pages: 3115-3120
Published online on: 16 February 2016

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Article

Apr3 accelerates the senescence of human retinal pigment epithelial cells

Song Han, Qingjun Lu, Ningli Wang
Pages: 3121-3126
Published online on: 22 February 2016

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Article

Novel mutations in the CYP11B2 gene causing aldosterone synthase deficiency

Niu Li, Juan Li, Yu Ding, Tingting Yu, Yongnian Shen, Qihua Fu, Yiping Shen, Xiaodong Huang, Jian Wang
Pages: 3127-3132
Published online on: 18 February 2016

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Article

Shaking improves the whole bone marrow adherent method of purification

Guoying Deng, Weiheng Wang, Chengwei Yang, Rui Gao, Xiangqun Yang, Xiaojian Ye
Pages: 3133-3138
Published online on: 22 February 2016

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Article

MicroRNA-200b inhibits epithelial-mesenchymal transition and migration of cervical cancer cells by directly targeting RhoE

Yan‑Xiang Cheng, Gan‑Tao Chen, Chuang Chen, Qi‑Fan Zhang, Feng Pan, Min Hu, Bing‑Shu Li
Pages: 3139-3146
Published online on: 23 February 2016

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Article

Carbonated soft drinks induce oxidative stress and alter the expression of certain genes in the brains of Wistar rats

Adel El‑Terras, Mohamed Mohamed Soliman, Adel Alkhedaide, Hossam Fouad Attia, Abdullah Alharthy, Abdel Elah Banaja
Pages: 3147-3154
Published online on: 18 February 2016

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Article

MicroRNA-200b suppresses cell invasion and metastasis by inhibiting the epithelial-mesenchymal transition in cervical carcinoma

Yan‑Xiang Cheng, Qi‑Fan Zhang, Li Hong, Feng Pan, Jin‑Ling Huang, Bing‑Shu Li, Min Hu
Pages: 3155-3160
Published online on: 19 February 2016

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Article

Nitidine chloride inhibits ovarian cancer cell migration and invasion by suppressing MMP-2/9 production via the ERK signaling pathway

Xiangxiu Sun, Lin Lin, Ying Chen, Tianfeng Liu, Ronghua Liu, Zhongde Wang, Kai Mou, Jia Xu, Bo Li, Haibo Song
Pages: 3161-3168
Published online on: 23 February 2016

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Article

Point mutation in mitochondrial tRNA gene is associated with polycystic ovary syndrome and insulin resistance

Yu Ding, Guangchao Zhuo, Caijuan Zhang, Jianhang Leng
Pages: 3169-3172
Published online on: 19 February 2016

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Article

Functional analysis of the TMPRSS2:ERG fusion gene in cisplatin‑induced cell death

Junqi Wu, Linfeng Chi, Zhanghui Chen, Xianghong Lu, Suping Xiao, Guanglin Zhang, Jindan Luo, Ge‑Ming Chen, Jun Yang
Pages: 3173-3180
Published online on: 16 February 2016

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Article

Putative modifier genes in mevalonate kinase deficiency

Annalisa Marcuzzi, Diego Vozzi, Martina Girardelli, Paola Maura Tricarico, Alessandra Knowles, Sergio Crovella, Josef Vuch, Alberto Tommasini, Elisa Piscianz, Anna Monica Bianco
Pages: 3181-3189
Published online on: 22 February 2016

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Article

Knockdown of ephrin receptor A7 suppresses the proliferation and metastasis of A549 human lung cancer cells

Ronghui Li, Yingyan Sun, Aiying Jiang, Yan Wu, Chengwei Li, Mingchun Jin, Hairun Yan, Hong Jin
Pages: 3190-3196
Published online on: 18 February 2016

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Article

Improvement of the cytotoxic T lymphocyte response against hepatocellular carcinoma by transduction of cancer cells with an adeno-associated virus carrying the interferon-γ gene

Jun Zhou, Ping Ma, Jun Li, Xiaonan Cui, Wei Song
Pages: 3197-3205
Published online on: 10 February 2016

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Article

Downregulation of long non-coding RNA TRIM52-AS1 functions as a tumor suppressor in renal cell carcinoma

Zan Liu, Hai‑Yan Yan, Shun‑Yao Xia, Cheng Zhang, You‑Cheng Xiu
Pages: 3206-3212
Published online on: 18 February 2016

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Article

Connexin32‑mediated antitumor effects of suicide gene therapy against hepatocellular carcinoma: In vitro and in vivo anticancer activity

Lun Wu, Wen‑Bo Zhou, Feng Shen, Wei Liu, Hong‑Wei Wu, Shi‑Ji Zhou, Sheng‑Wei Li
Pages: 3213-3219
Published online on: 16 February 2016

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Article

MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9

Jianhong Wang, Jingcheng Li, Fuqiang Guo, Yong Yan
Pages: 3220-3226
Published online on: 18 February 2016

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Article

mTOR signaling pathway is inhibited downstream of the cyclophilin D-mediated mitochondrial permeability transition in honokiol-triggered regulated necrosis

Wei Tian, Jieni Xiong, Saisa Zhu, Dong Xu, Hong Shen, Yongchuan Deng
Pages: 3227-3235
Published online on: 10 February 2016

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Article

Downregulation of miR‑429 and inhibition of cell migration and invasion in nasopharyngeal carcinoma

Fangzheng Wang, Chuner Jiang, Quanquan Sun, Fenqin Yan, Lei Wang, Zhenfu Fu, Tongxin Liu, Fujun Hu
Pages: 3236-3242
Published online on: 23 February 2016

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Article

Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway

Nan Feng, Jianmin Luo, Ximin Guo
Pages: 3243-3248
Published online on: 10 February 2016

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Article

TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration

Li Chen, Yujing Bai, Min Zhao, Yanrong Jiang
Pages: 3249-3256
Published online on: 15 February 2016

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Article

Triptolide sensitizes human breast cancer cells to tumor necrosis factor‑α‑induced apoptosis by inhibiting activation of the nuclear factor‑κB pathway

Xiaoli Cheng, Wenli Shi, Canguo Zhao, Dan Zhang, Piao Liang, Guohui Wang, Li Lu
Pages: 3257-3264
Published online on: 23 February 2016

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Article

Downregulation of VEGF and upregulation of TL1A expression induce HUVEC apoptosis in response to high glucose stimuli

Miao Yu, Guihua Lu, Xun Zhu, Zhibin Huang, Chong Feng, Rong Fang, Yesong Wang, Xiuren Gao
Pages: 3265-3272
Published online on: 22 February 2016

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Article

Decreased miR-143 and increased miR-21 placental expression levels are associated with macrosomia

Ji‑Tai Zhang, Qian‑Ying Cai, Si‑Si Ji, Heng‑Xin Zhang, Yu‑Huan Wang, Hong‑Tao Yan, Xin‑Jun Yang
Pages: 3273-3280
Published online on: 15 February 2016

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Article

Hypoxia increases the heterogeneity of melanoma cell populations and affects the response to vemurafenib

Daniela Pucciarelli, Nina Lengger, Martina Takáčová, Lucia Csaderova, Maria Bartosova, Heimo Breiteneder, Silvia Pastorekova, Christine Hafner
Pages: 3281-3288
Published online on: 10 February 2016

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Article

Astragaloside IV suppresses inflammatory mediator production in synoviocytes and collagen‑induced arthritic rats

Hao Xu, Chang‑Yao Wang, Hai‑Ning Zhang, Cheng‑Yu Lv, Ying‑Zhen Wang
Pages: 3289-3296
Published online on: 22 February 2016

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Article

Polydatin-induced cell apoptosis and cell cycle arrest are potentiated by Janus kinase 2 inhibition in leukemia cells

Wei‑Jie Cao, Ke Wu, Chong Wang, Ding‑Ming Wan
Pages: 3297-3302
Published online on: 18 February 2016

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Article

Characterization of the malaria parasite protein PfTip, a novel invasion-related protein

Xuewu Liu, Yuxiao Huang, Jiao Liang, Jun Wang, Yan Shen, Yinghui Li, Ya Zhao
Pages: 3303-3310
Published online on: 18 February 2016

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Article

Antiproliferative activity of a series of 5‑(1H‑1,2,3‑triazolyl) methyl‑ and 5‑acetamidomethyl‑oxazolidinone derivatives

Omar M. Hedaya, Princy M. Mathew, Fatima H. Mohamed, Oludotun A. Phillips, Yunus A. Luqmani
Pages: 3311-3318
Published online on: 23 February 2016

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Article

Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF

Lin Quan, Hua He
Pages: 3319-3325
Published online on: 23 February 2016

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Article

Identification of long-non coding RNA UCA1 as an oncogene in renal cell carcinoma

Yifan Li, Tiantian Wang, Yuchi Li, Duqun Chen, Zuhu Yu, Lu Jin, Liangchao Ni, Shangqi Yang, Xiangming Mao, Yaoting Gui, Yongqing Lai
Pages: 3326-3334
Published online on: 16 February 2016

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Article

Anti-inflammatory effects of essential oils extracted from Chamaecyparis obtusa on murine models of inflammation and RAW 264.7 cells

Yujin Park, Seung‑Ah Yoo, Wan‑Uk Kim, Chul‑Soo Cho, Jong‑Min Woo, Chong‑Hyeon Yoon
Pages: 3335-3341
Published online on: 18 February 2016

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Article

Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression

Shihong Ma, Wenhua Tan, Botao Du, Wei Liu, Weijia Li, Dehong Che, Guangmei Zhang
Pages: 3342-3348
Published online on: 16 February 2016

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Article

MicroRNA-200c inhibits the metastasis of non-small cell lung cancer cells by targeting ZEB2, an epithelial-mesenchymal transition regulator Retraction in /10.3892/mmr.2021.12212

Aihong Jiao, Minghua Sui, Liangming Zhang, Ping Sun, Dongmei Geng, Weiwei Zhang, Xiuwen Wang, Junxia Li
Pages: 3349-3355
Published online on: 17 February 2016

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Article

Elevated caspase‑1 activity and IL‑1β expression are associated with the IPAF inflammasome in an experimental model of allergy

Hamid Reza Nouri, Ahmad Karkhah, Iraj Mohammadzadeh, Mojtaba Sankian
Pages: 3356-3362
Published online on: 23 February 2016

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Article

Regulation by AMP-activated protein kinase of PGE2-induced osteoprotegerin synthesis in osteoblasts

Shingo Kainuma, Takanobu Otsuka, Gen Kuroyanagi, Naohiro Yamamoto, Rie Matsushima‑Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Pages: 3363-3369
Published online on: 17 February 2016

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Article

In human alloreactive CD4+ T-cells, dichloroacetate inhibits aerobic glycolysis, induces apoptosis and favors differentiation towards the regulatory T-cell subset instead of effector T-cell subsets

Theodoros Eleftheriadis, Maria Sounidaki, Georgios Pissas, Georgia Antoniadi, Vassilios Liakopoulos, Ioannis Stefanidis
Pages: 3370-3376
Published online on: 19 February 2016

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Article

Radioresistance of granulation tissue-derived cells from skin wounds combined with total body irradiation

Tingyu Dai, Zelin Chen, Li Tan, Chunmeng Shi
Pages: 3377-3383
Published online on: 23 February 2016

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Correction Open Access

[Corrigendum] Knockdown of eukaryotic translation initiation factor 4E suppresses cell growth and invasion, and induces apoptosis and cell cycle arrest in a human lung adenocarcinoma cell line

Baofu Chen, Bo Zhang, Lilong Xia, Jian Zhang, Yu Chen, Quanteng Hu, Chengchu Zhu
Pages: 3384-3384
Published online on: 23 February 2016

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Review Open Access

Role of neuroinflammation in neurodegenerative diseases (Review)

Wei‑Wei Chen, Xia Zhang, Wen‑Juan Huang
Pages: 3391-3396
Published online on: 29 February 2016

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Review Open Access

Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review)

Ruiqi Feng, Lijuan Li, Haiyan Yu, Min Liu, Wei Zhao
Pages: 3397-3400
Published online on: 02 March 2016

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Review

Benzene exposure is associated with epigenetic changes (Review)

Concettina Fenga, Silvia Gangemi, Chiara Costa
Pages: 3401-3405
Published online on: 01 March 2016

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Article Open Access

Pretreatment of BMSCs with TZD solution decreases the proliferation rate of MCF‑7 cells by reducing FGF4 protein expression

Boon‑Yin Khoo, Kalpanah Nadarajan, Siang‑Yian Shim, Noorizan Miswan, Chuan‑Bing Zang, Kurt Possinger, Elena Elstner
Pages: 3406-3414
Published online on: 02 March 2016

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Article Open Access

Targeted inhibition of survivin with YM155 promotes apoptosis of hypoxic human pulmonary arterial smooth muscle cells via the upregulation of voltage-dependent K+ channels

Shuai Zhang, Bo Liu, Zaiwen Fan, Dong Wang, Ying Liu, Jian Li, Ning Wang, Yi Liu, Bo Zhang
Pages: 3415-3422
Published online on: 04 March 2016

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Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells

Wei Shi, Jiagang Deng, Rongsheng Tong, Yong Yang, Xia He, Jianzhen Lv, Hailian Wang, Shaoping Deng, Ping Qi, Dingding Zhang, Yi Wang
Pages: 3423-3432
Published online on: 29 February 2016

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Enhanced autophagy in cytarabine arabinoside-resistant U937 leukemia cells and its potential as a target for overcoming resistance

June‑Won Cheong, Yundeok Kim, Ju In Eom, Hoi‑Kyung Jeung, Yoo Hong Min
Pages: 3433-3440
Published online on: 29 February 2016

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Cannabinoid CB2 receptors are involved in the regulation of fibrogenesis during skin wound repair in mice

Shan‑Shan Li, Lin‑Lin Wang, Min Liu, Shu‑Kun Jiang, Miao Zhang, Zhi‑Ling Tian, Meng Wang, Jiao‑Yong Li, Rui Zhao, Da‑Wei Guan
Pages: 3441-3450
Published online on: 02 March 2016

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In vivo treatment of rat arterial adventitia with interleukin‑1β induces intimal proliferation via the JAK2/STAT3 signaling pathway

Xiao Wang, Lihua Chen, Jie Liu, Tao Yan, Gangyong Wu, Yang Xia, Gangjun Zong, Fengsheng Li
Pages: 3451-3458
Published online on: 07 March 2016

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Impaired function of the intestinal barrier in a novel sub-health rat model

Sisi Feng, Weidong Liu, Shengnan Zuo, Tingyan Xie, Hui Deng, Qiuhuan Zhang, Baiyun Zhong
Pages: 3459-3465
Published online on: 04 March 2016

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Constitutive expression of Wnt/β‑catenin target genes promotes proliferation and invasion of liver cancer stem cells

Wei Chen, Yu‑Wei Zhang, Yang Li, Jian‑Wen Zhang, Tong Zhang, Bin‑Sheng Fu, Qi Zhang, Nan Jiang
Pages: 3466-3474
Published online on: 07 March 2016

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Intervertebral disc regeneration using platelet‑rich plasma‑containing bone marrow‑derived mesenchymal stem cells: A preliminary investigation

Shan‑Zheng Wang, Ji‑Yang Jin, Yu‑Dong Guo, Liang‑Yu Ma, Qing Chang, Xin‑Gui Peng, Fang‑Fang Guo, Hai‑Xiang Zhang, Xin‑Feng Hu, Chen Wang
Pages: 3475-3481
Published online on: 07 March 2016

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SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α

Fang Zhou, Aiguo Dai, Yongliang Jiang, Xiaowu Tan, Xiufeng Zhang
Pages: 3482-3490
Published online on: 03 March 2016

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Integrated analysis of DNA methylation profiles and gene expression profiles to identify genes associated with pilocytic astrocytomas

Ruigang Zhou, Yigang Man
Pages: 3491-3497
Published online on: 29 February 2016

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Characterization of bone marrow-derived mesenchymal stem cells from dimethyloxallyl glycine-preconditioned mice: Evaluation of the feasibility of dimethyloxallyl glycine as a mobilization agent

Tingting Ge, Qin Yu, Wei Liu, Li Cong, Lizhen Liu, Yan Wang, Liping Zhou, Deju Lin
Pages: 3498-3506
Published online on: 29 February 2016

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Long‑term follow‑up of buserelin‑induced enteric neuropathy in rats

Anette Jönsson, Elin Sand, Eva Ekblad, Bodil Ohlsson
Pages: 3507-3513
Published online on: 03 March 2016

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Article

Downregulation of epidermal growth factor receptor family receptors and ligands in a mutant K-ras group of patients with colorectal cancer

Tomoko Nagaoka, Kazutaka Kitaura, Yukinaga Miyata, Kenichi Kumagai, Goro Kaneda, Hideki Kanazawa, Satsuki Suzuki, Yoshiki Hamada, Ryuji Suzuki
Pages: 3514-3520
Published online on: 01 March 2016

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Article

Low levels of inflammation and the absence of subclinical atherosclerosis in rheumatoid arthritis

Salvatore Santo Signorelli, Saverio Candido, Rossella Salemi, Valerio Fiore, Marco Mangiafico, Massimo Libra
Pages: 3521-3524
Published online on: 02 March 2016

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Article

Growth inhibition effects of ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid on colorectal carcinoma cells and colon carcinoma-bearing mice

Hua Ye, Qiong Wu, Meng Guo, Kefeng Wu, Yingnian Lv, Fengyan Yu, Yi Liu, Xiaosheng Gao, Yuzhen Zhu, Liao Cui, Nianci Liang, Tu Yun, Li Li, Xuebao Zheng
Pages: 3525-3532
Published online on: 29 February 2016

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Article

Expression of lactate dehydrogenase C in MDA‑MB‑231 cells and its role in tumor invasion and migration

Lingying Kong, Wei Du, Zhaolei Cui, Li Wang, Zhi Yang, Hongsheng Zhang, Donghong Lin
Pages: 3533-3538
Published online on: 02 March 2016

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Article

Effect and mechanism of fuzhisan and donepezil on the sirtuin 1 pathway and amyloid precursor protein metabolism in PC12 cells

Peng Guo, Desheng Wang, Xiaomin Wang, Honglin Feng, Ying Tang, Ruihong Sun, Yan Zheng, Lin Dong, Jiaying Zhao, Xin Zhang, Shuyu Wang, Hongxu Sun
Pages: 3539-3546
Published online on: 01 March 2016

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Comparative proteomic analysis of heat stress proteins associated with rat sperm maturation

Xiaomei Wang, Fujun Liu, Xin Gao, Xin Liu, Xiaojun Kong, Haiyan Wang, Jianyuan Li
Pages: 3547-3552
Published online on: 02 March 2016

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Article

Paeoniflorin attenuates ultraviolet B-induced apoptosis in human keratinocytes by inhibiting the ROS-p38-p53 pathway

Lingwen Kong, Shangshang Wang, Xiao Wu, Fuguo Zuo, Haihong Qin, Jinfeng Wu
Pages: 3553-3558
Published online on: 01 March 2016

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Article

Endothelin‑1 induces oncostatin M expression in osteoarthritis osteoblasts by trans‑activating the oncostatin M gene promoter via Ets‑1

Ren Wu, Wanchun Wang, Guoliang Huang, Xinzhan Mao, You Chen, Qi Tang, Lele Liao
Pages: 3559-3566
Published online on: 02 March 2016

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Effect of transforming growth factor-β3 on the expression of Smad3 and Smad7 in tenocytes

Ke Jiang, Guo Chun, Ziming Wang, Quanyin Du, Aimin Wang, Yan Xiong
Pages: 3567-3573
Published online on: 29 February 2016

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Article

Atorvastatin attenuates atherosclerotic plaque destabilization by inhibiting endoplasmic reticulum stress in hyperhomocysteinemic mice

Fang Jia, Chunfang Wu, Zhenyue Chen, Guoping Lu, Jianhui Sun
Pages: 3574-3580
Published online on: 03 March 2016

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Article

Hepatitis B virus replication is upregulated in proliferated peripheral blood lymphocytes

Qin Yan, Ying‑Hua Lan, Yan‑Xin Huang, Rong‑Shan Fan, Lan Liu, Shu‑Peng Song, Yong‑Guo Li
Pages: 3581-3587
Published online on: 03 March 2016

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Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice

Qu Liu, Bao‑Shan Li, Yu‑Jiao Song, Ming‑Gen Hu, Jian‑Yue Lu, Ang Gao, Xue‑Jun Sun, Xi‑Ming Guo, Rong Liu
Pages: 3588-3596
Published online on: 01 March 2016

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Article

Sasanquasaponin promotes cellular chloride efflux and elicits cardioprotection via the PKCε pathway

Ling‑Yu Qiu, He‑Ping Chen, Yu‑Feng Yan, Yuan‑Yuan Li, Huan Wang, Zhang‑Ping Liao, Qi‑Ren Huang
Pages: 3597-3603
Published online on: 07 March 2016

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Article

CXCR4 antagonist AMD3100 ameliorates thyroid damage in autoimmune thyroiditis in NOD.H‑2h4 mice

Xin Liu, Jinyuan Mao, Cheng Han, Shiqiao Peng, Chenyan Li, Ting Jin, Chenling Fan, Zhongyan Shan, Weiping Teng
Pages: 3604-3612
Published online on: 02 March 2016

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SASH1 inhibits cervical cancer cell proliferation and invasion by suppressing the FAK pathway

Hui Chen, Dongliang Wang, Yuling Liu
Pages: 3613-3618
Published online on: 29 February 2016

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Article

Expression and purification of FGF21 in Pichia pastoris and its effect on fibroblast-cell migration

Yonghuan Song, Jian Ding, Rilong Jin, Jinhee Jung, Shi Li, Jingquan Yang, Anyuan Wang, Zhijie Li
Pages: 3619-3626
Published online on: 26 February 2016

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Protectin D1 reduces concanavalin A-induced liver injury by inhibiting NF-κB-mediated CX3CL1/CX3CR1 axis and NLR family, pyrin domain containing 3 inflammasome activation

Jun Ren, Shanshan Meng, Bingdi Yan, Jinyan Yu, Jing Liu
Pages: 3627-3638
Published online on: 04 March 2016

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Glycyrrhizic acid prevents enteritis through reduction of NF‑κB p65 and p38MAPK expression in rat

Yi‑Ming Wang, Guo‑Qiang Du
Pages: 3639-3646
Published online on: 07 March 2016

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Article

Interleukin‑12B is upregulated by decoy receptor 3 in rheumatoid synovial fibroblasts

Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Masahiro Kurosaka
Pages: 3647-3652
Published online on: 07 March 2016

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Ameliorative effects of pomegranate on carbon tetrachloride hepatotoxicity in rats: A molecular and histopathological study

Zein Shaban Ibrahim, Mohamed Abdo Nassan, Mohamed Mohamed Soliman
Pages: 3653-3660
Published online on: 01 March 2016

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Article

Sensitization of hepatocellular carcinoma cells to irradiation by miR‑34a through targeting lactate dehydrogenase‑A

Xiaogang Li, Ping Lu, Bo Li, Rong Yang, Yan Chu, Zhiping Zhang, Hongwei Wan, Chao Niu, Chunxiao Wang, Kaiyuan Luo
Pages: 3661-3667
Published online on: 03 March 2016

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Article

Apoptosis is induced by shikonin through the mitochondrial signaling pathway

Xuxia Tang, Chen Zhang, Jiongzhou Wei, Yuting Fang, Rongxiang Zhao, Jianxin Yu
Pages: 3668-3674
Published online on: 02 March 2016

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Article

Mucin 1 and poly I:C activates dendritic cells and effectively eradicates pituitary tumors as a prophylactic vaccine

Dehua Sui, Lixin Ma, Meng Li, Wei Shao, Hongpeng Du, Ke Li, Zhenzhu Li, Zefu Li
Pages: 3675-3683
Published online on: 02 March 2016

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Article

Leptin induces the apoptosis of chondrocytes in an in vitro model of osteoarthritis via the JAK2‑STAT3 signaling pathway

Zi Ming Zhang, Chao Shen, Hai Li, Qing Fan, Jing Ding, Fang Chun Jin, Lin Sha
Pages: 3684-3690
Published online on: 03 March 2016

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Article

TMEM16A contributes to angiotensin II-induced cerebral vasoconstriction via the RhoA/ROCK signaling pathway

Rong‑Shan Li, Yong Wang, Hui‑Shen Chen, Fang‑Yong Jiang, Qiang Tu, Wen‑Jun Li, Rui‑Xing Yin
Pages: 3691-3699
Published online on: 04 March 2016

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Article

The effects of perfluorocarbon on ICAM-1 expression in LPS-induced A549 cells and the potential mechanism

Lu Cao, Chun‑Sun Li, Yan Chang, Zhi‑Xin Liang, Liang‑An Chen
Pages: 3700-3708
Published online on: 01 March 2016

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Correction Open Access

[Corrigendum] Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC-α/ERK1/2 pathway: An in vitro investigation

Xu‑Dong Cheng, Jun‑Fei Gu, Jia‑Rui Yuan, Liang Feng, Xiao‑Bin Jia
Pages: 3709-3710
Published online on: 04 March 2016

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Correction Open Access

[Corrigendum] Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway

Wei Zhao, Mingshu Lu, Qiwen Zhang
Pages: 3711-3711
Published online on: 03 March 2016

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March-2026 Volume 33 Issue 3

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article

CTRP4 ameliorates dexamethasone‑induced insulin resistance through the IRS‑1/PI3K/AKT pathway in 3T3‑L1 adipocytes

Maireyanmu Rouzi, Xi Sun, Luguang Sheng, Bilin Xu, Tao Lei, Jun Lu, Jie Gao
Article Number: 101
Published online on: 27 January 2026

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PTUPB, a soluble epoxide hydrolase/cyclooxygenase‑2 dual inhibitor, reduces endothelial‑to‑mesenchymal transition and improves doxorubicin‑induced vascular and cardiac toxicity

Hevna Dhulkifle, Lubna Therachiyil, Maram H. Hasan, Shahd M. Younis, Nizar A. Al‑Shar'i, Huseyin C. Yalcin, Zaid H. Maayah
Article Number: 100
Published online on: 27 January 2026

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[Retracted] miR‑367 enhances the proliferation and invasion of cutaneous malignant melanoma by regulating phosphatase and tensin homolog expression

Jianwen Long, Jing Luo, Xuwen Yin
Article Number: 99
Published online on: 26 January 2026

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Advances in the mechanisms of the NLRP3 inflammasome in sepsis‑induced cardiomyopathy and targeted therapeutic studies 
(Review)

Yifei Chen, Zhaohui Zhang, Gaosheng Zhou
Article Number: 98
Published online on: 22 January 2026

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HMGN2 induces pyroptosis in tumour cells by modulating the STT3B/PD‑L1/caspase‑1/GSDMD axis

Wenwen Han, Hongli Chen, Bomiao Cui, Jiao Chen, Ping Zhang, Yun Feng
Article Number: 97
Published online on: 22 January 2026

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Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway

Miaomiao Wu, Yating An, Yongmin Li, Wei He, Ying Wang, Yaqi Wang, Caixia Wu
Article Number: 96
Published online on: 22 January 2026

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PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)

Chen Zhou, Yifei Wang, Jie Zhao, Yantao Yang, Yuhang Yuan, Xiaochen Hou, Yu Tang, Lianhua Ye
Article Number: 95
Published online on: 22 January 2026

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[Retracted] Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species

Uddin Md Nazim, Honghua Yin, Sang-Youel Park
Article Number: 94
Published online on: 19 January 2026

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Converting ‘cold’ to ‘hot’ hepatocellular carcinoma for improved immunotherapy (Review)

Ching-Hua Hsieh, Pei-Chin Chuang
Article Number: 93
Published online on: 15 January 2026

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Pathological mechanism of ferroptosis in a rat model of α‑naphthyl isothiocyanate‑induced chronic cholestasis

Zhen Guo, Jiaxuan Wang, Yiwen Wang, Xinzhu Liu, Yubing Xia, Ping Liu, Li Qi, Jia Liu, Xiaoning Wang
Article Number: 92
Published online on: 14 January 2026

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[Corrigendum] Role of hypoxia‑inducible factor‑1α and CD146 in epidermal growth factor receptor‑mediated angiogenesis in salivary gland adenoid cystic carcinom

Wei-Ming Wang, Zhi-Li Zhao, Wen-Feng Zhang, Yi-Fang Zhao, Lu Zhang, Zhi-Jun Sun
Article Number: 91
Published online on: 13 January 2026

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Klebsiella pneumoniae and pyogenic liver abscess: Emerging clinical threats, virulence mechanisms and therapeutic strategies (Review)

Gulam Mustafa Hasan, Taj Mohammad, Sobia Zaidi, Anas Shamsi, Sukhwinder Singh Sohal, Md. Imtaiyaz Hassan
Article Number: 90
Published online on: 13 January 2026

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Collagen III regulates the termination of liver regeneration by suppressing hepatocyte proliferation and promoting functional recovery

Haiyang Peng, Zhiyong Chen, Qiwei Zhang, Yuezhou Zhang, Peng Yang, Jianping Gong, Andong Zhao
Article Number: 89
Published online on: 13 January 2026

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Application of extracellular vesicles in the diagnosis and treatment of chronic obstructive pulmonary disease (Review)

Yixin Zhang, Tong Ren, Jianbo Xue, Yan Yu, Xianqiang Zhou, Xiaoyi Hu, Wenyi Yu, Zhancheng Gao, Cuiling Feng
Article Number: 88
Published online on: 13 January 2026

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Cigarette smoke combined with Klebsiella pneumoniae induce damage to the air‑blood barrier in chronic obstructive pulmonary disease rats via the MAPK/NF‑κB/IκBα pathway

Yange Tian, Kexin Xu, Ruilong Lu, Kangchen Li, Xuejie Shao, Yixi Liao, Yakun Zhao, Zhiguang Qiu, Haoran Dong, Xuefang Liu
Article Number: 87
Published online on: 12 January 2026

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[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells

Qing Ding, Yi Chen, Qing Zhang, Yanling Guo, Zhi Huang, Liqing Dai, Sudan Cao
Article Number: 86
Published online on: 12 January 2026

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Anxiety‑induced overactive bladder: The role of oxidative stress and NF‑κB signaling pathway with Hsp90 as a potential biomarker

Zhipeng Zhou, Lina Xu, Han Wu, Huaishan Hong
Article Number: 85
Published online on: 12 January 2026

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Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene

Zi-Run Jin, Yong-Wei Huo, Bo-Heng Liu, Hong Tian, Shuo Yuan, Yue Tian, Ke Xi, Jie Cai, Hui Jiang, Yong Jiang, Guo-Gang Xing
Article Number: 84
Published online on: 12 January 2026

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Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway

Pei Li, Xinyu Wan, Wenjie Li, Ding Cheng, Ying Yang, Yuhan Wang, Ruyuan Zhu, Yanjing Chen, Haixia Liu, Zhiguo Zhang
Article Number: 83
Published online on: 12 January 2026

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Prolyl hydroxylase domain proteins: Localization, regulation, function and their role in erythropoiesis (Review)

Yan Hou, Zhao-Hua Zhang, Wen-Qian Li, Guo-Xiong Han, Kuo Shen, You-Bang Xie
Article Number: 82
Published online on: 12 January 2026

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Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review)

Bing-Yu Liang, Zi-Yue Fu, Fen-Fen Li, Ping-Ting Zhou, Zi-Hui Xie, Ke Han, Yan-Xun Han, Shan-Wen Chen, Yi Zhao, Hai-Feng Pan, Ye-Hai Liu, Yu-Chen Liu
Article Number: 81
Published online on: 07 January 2026

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Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)

Xinyue Wang, Xiaohang Zhang, Jianing Lin, Ping Lin
Article Number: 80
Published online on: 05 January 2026

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Preliminary exploration of the putative function of SF3A2 in clear cell renal cell carcinoma

Ru Chen, Jie Xu
Article Number: 79
Published online on: 05 January 2026

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Retraction Open Access

[Retracted] TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway

Lin Wang, Chen Chen, Shuzhi Feng, Jianli Tian
Article Number: 78
Published online on: 05 January 2026

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Journal Cover
April-2026 Volume 33 Issue 4

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Integrative bioinformatics and experimental analysis reveals FRA1 as a key mediator of tubulointerstitial inflammation in lupus nephritis

Wenpeng Ni, Jialin He, Zhouyu Zeng, Jialong Ke, Runpei Lin, Jianming Peng, Kunyi Deng, Lijuan Wen, Yanhui Chen, Chilun Zhang, Yanfen Li, Guanghong Gu
Article Number: 103
Published online on: 28 January 2026

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[Corrigendum] Resveratrol improves neurological outcome and neuroinflammation following spinal cord injury through enhancing autophagy involving the AMPK/mTOR pathway

Hong-Yu Meng, De-Cheng Shao, Han Li, Xiao-Dan Huang, Guang Yang, Bing Xu, Hai-Yun Niu
Article Number: 102
Published online on: 28 January 2026

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