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Article

TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration

  • Authors:
    • Li Chen
    • Yujing Bai
    • Min Zhao
    • Yanrong Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, People's Hospital, Peking University and Key Laboratory of Vision Loss and Restoration, Ministry of Education and Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing 100044, P.R. China
  • Pages: 3249-3256
    |
    Published online on: February 15, 2016
       https://doi.org/10.3892/mmr.2016.4890
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Abstract

Subretinally-deposited amyloid-β (Aβ) is an important factor in age‑related macular degradation (AMD) often leading to irreversible blindness in the elderly population. The molecular mechanism underlying Aβ deposition during AMD remains unclear. The expression of inflammatory and angiogenic factors was examined by treatment of retinal pigment epithelial (RPE) cells with the oligomeric form of Aβ (OAβ1-42). Changes in the mRNA expression levels of various cytokines was detected by the QuantiGenePlex 6.0 Reagent system, and the protein expression level was determined by western blotting. Culture supernatants were detected using a multiplex cytokine assay and enzyme-linked immunosorbent assays. The in vitro tube formation was evaluated by a Matrigel assay. The present study highlights that OAβ1‑42 activates the toll-like receptor 4 (TLR4), myeloid differentiation factor 88 and phosphorylation nuclear factor-κB signaling pathway in RPE cells. Additionally, it increased the mRNA and protein expression of interleukin (IL)-6, IL-8, IL-33, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and angiopoietin 2. Furthermore, the TLR4 inhibitor (COBRA) attenuated the expression of inflammatory and angiogenesis factors, particularly IL-6, IL-8, IL-33, bFGF and VEGF. When human umbilical vein endothelial cells (HUVECs) were co-cultured with the COBRA-treated RPE cell culture supernatant the length of the endothelial cell network (measured by calculating tip cell lengths of endothelial cells) was impaired when compared with the HUVECs that were co‑cultured with the cell supernatant exposed to OAβ1‑42. These results suggest that the TLR4-associated pathway may be a potential target for the treatment of AMD.
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1 

Coleman HR, Chan CC, Ferris FL III and Chew EY: Age-related macular degeneration. Lancet. 372:1835–1845. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Jager RD, Mieler WF and Miller JW: Age-related macular degeneration. N Engl J Med. 358:2606–2617. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Bird AC, Bressler NM, Bressler SB, Chisholm IH, Coscas G, Davis MD, de Jong PT, Klaver CC, Klein BE, Klein R, et al The International ARM Epidemiological Study Group: An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv Ophthalmol. 39:367–374. 1995. View Article : Google Scholar : PubMed/NCBI

4 

Bressler NM, Silva JC, Bressler SB, Fine SL and Green WR: Clinicopathologic correlation of drusen and retinal pigment epithelial abnormalities in age-related macular degeneration. Retina. 14:130–142. 1994. View Article : Google Scholar : PubMed/NCBI

5 

Ferreira ST, Vieira MN and De Felice FG: Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases. IUBMB Life. 59:332–345. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Johnson LV, Leitner WP, Rivest AJ, Staples MK, Radeke MJ and Anderson DH: The Alzheimer's A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad Sci USA. 99:11830–11835. 2002. View Article : Google Scholar

7 

Yoshida T, Ohno-Matsui K, Ichinose S, Sato T, Iwata N, Saido TC, Hisatomi T, Mochizuki M and Morita I: The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. J Clin Invest. 115:2793–2800. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Teplow DB, Lazo ND, Bitan G, Bernstein S, Wyttenbach T, Bowers MT, Baumketner A, Shea JE, Urbanc B, Cruz L, et al: Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach. Acc Chem Res. 39:635–645. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Hoyer W, Grönwall C, Jonsson A, Ståhl S and Härd T: Stabilization of a beta-hairpin in monomeric Alzheimer's amyloid-beta peptide inhibits amyloid formation. Proc Natl Acad Sci USA. 105:5099–5104. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Gouras GK, Olsson TT and Hansson O: β-Amyloid peptides and amyloid plaques in Alzheimer's disease. Neurotherapeutics. 12:3–11. 2015. View Article : Google Scholar :

11 

Liu RT, Gao J, Cao S, Sandhu N, Cui JZ, Chou CL, Fang E and Matsubara JA: Inflammatory mediators induced by amyloid-beta in the retina and RPE in vivo: Implications for inflammasome activation in age-related macular degeneration. Invest Ophthalmol Vis Sci. 54:2225–2237. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Bruban J, Glotin AL, Dinet V, Chalour N, Sennlaub F, Jonet L, An N, Faussat AM and Mascarelli F: Amyloid-beta(1–42) alters structure and function of retinal pigmented epithelial cells. Aging Cell. 8:162–177. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Liu RT, Wang A, To E, Gao J, Cao S, Cui JZ and Matsubara JA: Vinpocetine inhibits amyloid-beta induced activation of NF-κB, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells. Exp Eye Res. 127:49–58. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Cao L, Liu C, Wang F and Wang H: SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway. Braz J Med Biol Res. 46:659–669. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Liu XC, Liu XF, Jian CX, Li CJ and He SZ: IL-33 is induced by amyloid-β stimulation and regulates inflammatory cytokine production in retinal pigment epithelium cells. Inflammation. 35:776–784. 2012. View Article : Google Scholar

16 

Jantaratnotai N, Ling A, Cheng J, Schwab C, McGeer PL and McLarnon JG: Upregulation and expression patterns of the angiogenic transcription factor ets-1 in Alzheimer's disease brain. J Alzheimers Dis. 37:367–377. 2013.PubMed/NCBI

17 

Fioravanzo L, Venturini M, Di Liddo R, Marchi F, Grandi C, Parnigotto PP and Folin M: Involvement of rat hippocampal astrocytes in β-amyloid-induced angiogenesis and neuroinflammation. Curr Alzheimer Res. 7:591–601. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Kijlstra A, La Heij E and Hendrikse F: Immunological factors in the pathogenesis and treatment of age-related macular degeneration. Ocul Immunol Inflamm. 13:3–11. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Bryant CE, Spring DR, Gangloff M and Gay NJ: The molecular basis of the host response to lipopolysaccharide. Nat Rev Microbiol. 8:8–14. 2010.

20 

Seddon JM, Santangelo SL, Book K, Chong S and Cote J: A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions. Am J Hum Genet. 73:780–790. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Abecasis GR, Yashar BM, Zhao Y, Ghiasvand NM, Zareparsi S, Branham KE, Reddick AC, Trager EH, Yoshida S, Bahling J, et al: Age-related macular degeneration: A high-resolution genome scan for susceptibility loci in a population enriched for late-stage disease. Am J Hum Genet. 74:482–494. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Kindzelskii AL, Elner VM, Elner SG, Yang D, Hughes BA and Petty HR: Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments. J Gen Physiol. 124:139–149. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Zhou X, Yuan L, Zhao X, Hou C, Ma W, Yu H and Xiao R: Genistein antagonizes inflammatory damage induced by β-amyloid peptide in microglia through TLR4 and NF-κB. Nutrition. 30:90–95. 2014. View Article : Google Scholar

24 

Mohr T and Desser L: Plant proteolytic enzyme papain abrogates angiogenic activation of human umbilical vein endothelial cells (HUVEC) in vitro. BMC Complement Altern Med. 13:2312013. View Article : Google Scholar : PubMed/NCBI

25 

Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, Rickman DW, Toth CA, Sullivan PM and Bowes Rickman C: Apolipoprotein E allele-dependent pathogenesis: A model for age-related retinal degeneration. Proc Natl Acad Sci USA. 102:11900–11905. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Buschini E, Piras A, Nuzzi R and Vercelli A: Age related macular degeneration and drusen: Neuroinflammation in the retina. Prog Neurobiol. 95:14–25. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Qi Y, Zhao M, Bai Y, Huang L, Yu W, Bian Z, Zhao M and Li X: Retinal ischemia/reperfusion injury is mediated by Toll-like receptor 4 activation of NLRP3 inflammasomes. Invest Ophthalmol Vis Sci. 55:5466–5475. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Smith PD, Shimamura M, Musgrove LC, Dennis EA, Bimczok D, Novak L, Ballestas M, Fenton A, Dandekar S, Britt WJ and Smythies LE: Cytomegalovirus enhances macrophage TLR expression and MyD88-mediated signal transduction to potentiate inducible inflammatory responses. J Immunol. 193:5604–5612. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Park MY and Mun ST: Carnosic acid inhibits TLR4-MyD88 signaling pathway in LPS-stimulated 3T3-L1 adipocytes. Nutr Res Pract. 8:516–520. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Novack GD: Pharmacotherapy for the treatment of choroidal neovascularization due to age-related macular degeneration. Annu Rev Pharmacol Toxicol. 48:61–78. 2008. View Article : Google Scholar

31 

Stahl A, Paschek L, Martin G, Feltgen N, Hansen LL and Agostini HT: Combinatory inhibition of VEGF and FGF2 is superior to solitary VEGF inhibition in an in vitro model of RPE-induced angiogenesis. Graefes Arch Clin Exp Ophthalmol. 247:767–773. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Nagineni CN, Samuel W, Nagineni S, Pardhasaradhi K, Wiggert B, Detrick B and Hooks JJ: Transforming growth factor-beta induces expression of vascular endothelial growth factor in human retinal pigment epithelial cells: Involvement of mitogen-activated protein kinases. J Cell Physiol. 197:453–462. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Asahara T, Chen D, Takahashi T, Fujikawa K, Kearney M, Magner M, Yancopoulos GD and Isner JM: Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ Res. 83:233–240. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Seddon JM, George S, Rosner B and Rifai N: Progression of age-related macular degeneration: Prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers. Arch Ophthalmol. 123:774–782. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Jonas JB, Tao Y, Neumaier M and Findeisen P: Cytokine concentration in aqueous humour of eyes with exudative age-related macular degeneration. Acta Ophthalmol. 90:e381–e388. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Kurji KH, Cui JZ, Lin T, Harriman D, Prasad SS, Kojic L and Matsubara JA: Microarray analysis identifies changes in inflammatory gene expression in response to amyloid-beta stimulation of cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 51:1151–1163. 2010. View Article : Google Scholar

37 

Préfontaine D, Nadigel J, Chouiali F, Audusseau S, Semlali A, Chakir J, Martin JG and Hamid Q: Increased IL-33 expression by epithelial cells in bronchial asthma. J Allergy Clin Immunol. 125:752–754. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen L, Bai Y, Zhao M and Jiang Y: TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration. Mol Med Rep 13: 3249-3256, 2016.
APA
Chen, L., Bai, Y., Zhao, M., & Jiang, Y. (2016). TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration. Molecular Medicine Reports, 13, 3249-3256. https://doi.org/10.3892/mmr.2016.4890
MLA
Chen, L., Bai, Y., Zhao, M., Jiang, Y."TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration". Molecular Medicine Reports 13.4 (2016): 3249-3256.
Chicago
Chen, L., Bai, Y., Zhao, M., Jiang, Y."TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration". Molecular Medicine Reports 13, no. 4 (2016): 3249-3256. https://doi.org/10.3892/mmr.2016.4890
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Bai Y, Zhao M and Jiang Y: TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration. Mol Med Rep 13: 3249-3256, 2016.
APA
Chen, L., Bai, Y., Zhao, M., & Jiang, Y. (2016). TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration. Molecular Medicine Reports, 13, 3249-3256. https://doi.org/10.3892/mmr.2016.4890
MLA
Chen, L., Bai, Y., Zhao, M., Jiang, Y."TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration". Molecular Medicine Reports 13.4 (2016): 3249-3256.
Chicago
Chen, L., Bai, Y., Zhao, M., Jiang, Y."TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration". Molecular Medicine Reports 13, no. 4 (2016): 3249-3256. https://doi.org/10.3892/mmr.2016.4890
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