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Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer

  • Authors:
    • Jiangman Duan
    • Li Sun
    • Hongxiang Huang
    • Zhenzhen Wu
    • Lin Wang
    • Wangjun Liao
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
    Copyright: © Duan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3027-3035
    |
    Published online on: February 17, 2016
       https://doi.org/10.3892/mmr.2016.4902
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Abstract

Fatty acid synthase (FASN), a lipogenic multi-enzyme complex, is reported to be overexpressed in various types of of tumor tissues and serves an important role in tumor development and progression. However, the expression of FASN and its possible role in gastric cancer (GC) remains to be defined. In the present study, FASN expression in a group sample of 167 GC tissues was detected by immunohistochemistry and its correlation with clinicopathological features was analyzed. By clinical analysis, it was identified that FASN overexpression was positively correlated with the overall survival [P=0.008; hazard ratio (HR), 4.412; 95% confidence interval (CI), 1.463‑13.305] and recurrence rate (P=0.014; HR, 1.705; 95% CI, 1.116‑2.606) in patients with GC. In addition, expression of the FASN protein in GC tissues was correlated with age (P=0.032), clinical stage (P<0.001), gastric wall invasion (P=0.014), lymph node metastasis (P<0.001) and distant metastasis (P<0.001), however not with gender (P>0.05). In addition, FASN was observed to be overexpressed in GC tissues at an mRNA and protein level, compared with the adjacent non-cancerous tissues (P<0.05). Taken together, it was suggested that FASN was closely associated with GC metastasis and survival, which further provided evidence that FASN may be a promising prognostic biomarker for patients with GC.
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Copy and paste a formatted citation
Spandidos Publications style
Duan J, Sun L, Huang H, Wu Z, Wang L and Liao W: Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer. Mol Med Rep 13: 3027-3035, 2016.
APA
Duan, J., Sun, L., Huang, H., Wu, Z., Wang, L., & Liao, W. (2016). Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer. Molecular Medicine Reports, 13, 3027-3035. https://doi.org/10.3892/mmr.2016.4902
MLA
Duan, J., Sun, L., Huang, H., Wu, Z., Wang, L., Liao, W."Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer". Molecular Medicine Reports 13.4 (2016): 3027-3035.
Chicago
Duan, J., Sun, L., Huang, H., Wu, Z., Wang, L., Liao, W."Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer". Molecular Medicine Reports 13, no. 4 (2016): 3027-3035. https://doi.org/10.3892/mmr.2016.4902
Copy and paste a formatted citation
x
Spandidos Publications style
Duan J, Sun L, Huang H, Wu Z, Wang L and Liao W: Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer. Mol Med Rep 13: 3027-3035, 2016.
APA
Duan, J., Sun, L., Huang, H., Wu, Z., Wang, L., & Liao, W. (2016). Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer. Molecular Medicine Reports, 13, 3027-3035. https://doi.org/10.3892/mmr.2016.4902
MLA
Duan, J., Sun, L., Huang, H., Wu, Z., Wang, L., Liao, W."Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer". Molecular Medicine Reports 13.4 (2016): 3027-3035.
Chicago
Duan, J., Sun, L., Huang, H., Wu, Z., Wang, L., Liao, W."Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer". Molecular Medicine Reports 13, no. 4 (2016): 3027-3035. https://doi.org/10.3892/mmr.2016.4902
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