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Article

MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9

  • Authors:
    • Jianhong Wang
    • Jingcheng Li
    • Fuqiang Guo
    • Yong Yan
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing 400042, P.R. China, Department of Neurology, The Affiliated Hospital of University of Electronic Science and Technology, Sichuan Provincial People's Hospital, Chengdu, Sichuan 610054, P.R. China, Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
  • Pages: 3220-3226
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    Published online on: February 18, 2016
       https://doi.org/10.3892/mmr.2016.4907
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Abstract

MicroRNA (miR)-133a expression has been reported to be downregulated in numerous human malignancies. However, the expression levels and function of miR-133a have not yet been investigated in human glioma. In the present study, the expression of miR‑133a was analyzed by reverse transcription‑quantitative polymerase chain reaction. Following transfection of miR‑133a, cell proliferation, cell migration, cell invasion and luciferase assays, and western blot analysis were conducted in glioma cell lines. The present study demonstrated that miR‑133a was downregulated in human glioma tissues compared with in normal adjacent tissues. In addition, the results indicated that miR‑133a was likely to directly target matrix metallopeptidase 9 in glioma. These results suggest that miR-133a may be considered as a target for the treatment of human glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Li J, Guo F and Yan Y: MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9. Mol Med Rep 13: 3220-3226, 2016.
APA
Wang, J., Li, J., Guo, F., & Yan, Y. (2016). MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9. Molecular Medicine Reports, 13, 3220-3226. https://doi.org/10.3892/mmr.2016.4907
MLA
Wang, J., Li, J., Guo, F., Yan, Y."MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9". Molecular Medicine Reports 13.4 (2016): 3220-3226.
Chicago
Wang, J., Li, J., Guo, F., Yan, Y."MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9". Molecular Medicine Reports 13, no. 4 (2016): 3220-3226. https://doi.org/10.3892/mmr.2016.4907
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Li J, Guo F and Yan Y: MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9. Mol Med Rep 13: 3220-3226, 2016.
APA
Wang, J., Li, J., Guo, F., & Yan, Y. (2016). MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9. Molecular Medicine Reports, 13, 3220-3226. https://doi.org/10.3892/mmr.2016.4907
MLA
Wang, J., Li, J., Guo, F., Yan, Y."MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9". Molecular Medicine Reports 13.4 (2016): 3220-3226.
Chicago
Wang, J., Li, J., Guo, F., Yan, Y."MicroRNA-133a inhibits the malignant behavior of glioma via downregulation of matrix metallopeptidase 9". Molecular Medicine Reports 13, no. 4 (2016): 3220-3226. https://doi.org/10.3892/mmr.2016.4907
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