Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2016 Volume 13 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2016 Volume 13 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review)

  • Authors:
    • Ruiqi Feng
    • Lijuan Li
    • Haiyan Yu
    • Min Liu
    • Wei Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, Yunnan Provincial Mental Hospital, Kunming, Yunnan 650223, P.R. China, Administrative Office, School of Public Health, Dali University, Dali, Yunnan 671000, P.R. China, Department of Pharmacy, Yunnan Provincial Mental Hospital, Kunming, Yunnan 650223, P.R. China, Department of Ophthalmology, School of Clinical Medicine, Dali University, Dali, Yunnan 671000, P.R. China
    Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3397-3400
    |
    Published online on: March 2, 2016
       https://doi.org/10.3892/mmr.2016.4966
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Alzheimer's disease affects 27 million individuals and is the most common cause of dementia worldwide. The pathology of Alzheimer's disease is primarily due to the β‑amyloid deposits and neurofibrillary tangles. These deposits exist largely in the cerebral blood vessels, but have also been shown to exist in retinal vessels. A new class of cells that were recently identified, known as melanopsin‑expressing retinal ganglion cells (mRGCs), are involved in the non‑image forming functions of the eye. These functions include circadian activities such as temperature rhythms, melatonin release and rest‑activity cycles. Circadian dysfunction has been investigated in many cases of Alzheimer's disease. In this review, we outline the current accepted Alzheimer's disease pathology, the role of mRCGs in optic neuropathies and the role of mRCGs, leading to circadian dysfunction, in Alzheimer's disease.
View Figures

Figure 1

View References

1 

Arriagada PV, Growdon JH, Hedley-Whyte ET and Hyman BT: Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology. 42:6311992. View Article : Google Scholar : PubMed/NCBI

2 

Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, et al: Dominantly Inherited Alzheimer Network: Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med. 367:795–804. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Weiner MW, Veitch DP, Aisen PS, et al: Alzheimer's Disease Neuroimaging Initiative: The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception. Alzheimers Dement. 8(Suppl 1): S1–S68. 2012. View Article : Google Scholar :

4 

Mishima K, Okawa M, Hozumi S and Hishikawa Y: Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons. Chronobiol Int. 17:419–432. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Hatfield CF, Herbert J, van Someren EJW, Hodges JR and Hastings MH: Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia. Brain. 127:1061–1074. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Tranah GJ, Blackwell T, Stone KL, et al: SOF Research Group: Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women. Ann Neurol. 70:722–732. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Sherman SM, Mumford JA and Schnyer DM: Hippocampal activity mediates the relationship between circadian activity rhythms and memory in older adults. Neuropsychologia. 75:617–625. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Yoneda S, Hara H, Hirata A, Fukushima M, Inomata Y and Tanihara H: Vitreous fluid levels of β-amyloid (1–42) and tau in patients with retinal diseases. Jap J Ophthalmol. 106–108. 2005. View Article : Google Scholar

9 

Ning A, Cui J, To E, Ashe KH and Matsubara J: Amyloid-β deposits lead to retinal degeneration in a mouse model of Alzheimer disease. Invest Ophthalmol Vis Sci. 49:5136–5143. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Cotman SL, Halfter W and Cole GJ: Agrin binds to β-amyloid (Aβ), accelerates Aβ fibril formation, and is localized to Aβ deposits in Alzheimer's disease brain. Mol Cell Neurosci. 15:183–198. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Koronyo-Hamaoui M, Koronyo Y, Ljubimov AV, Miller CA, Ko MK, Black KL, Schwartz M and Farkas DL: Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model. Neuroimage. 54(Suppl 1): S204–S217. 2011. View Article : Google Scholar

12 

LeGates TA, Altimus CM, Yang S, Kirkwood A, Weber ET and Hattar S: Melanopsin-expressing retinal ganglion cells mediate light modulation of cognitive functions and mood related behaviors. Invest Ophthalmol Vis Sci. 52:34652011.

13 

Sosa-Ortiz AL, Acosta-Castillo I and Prince MJ: Epidemiology of dementias and Alzheimer's disease. Arch Med Res. 43:600–608. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Lopez AD, Mathers CD, Ezzati M, Jamison DT and Murray CJ: Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet. 367:1747–1757. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Karran E, Mercken M and De Strooper B: The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics. Nat Rev Drug Discov. 10:698–712. 2011. View Article : Google Scholar : PubMed/NCBI

16 

De Strooper B, Vassar R and Golde T: The secretases:enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol. 6:99–107. 2010. View Article : Google Scholar : PubMed/NCBI

17 

de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, et al: Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. 73:685–697. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Bancher C, Brunner C, Lassmann H, Budka H, Jellinger K, Wiche G, Seitelberger F, Grundke-Iqbal I, Iqbal K and Wisniewski HM: Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease. Brain Res. 477:90–99. 1989. View Article : Google Scholar : PubMed/NCBI

19 

LeGates TA, Altimus CM, Wang H, Lee HK, Yang S, Zhao H, Kirkwood A, Weber ET and Hattar S: Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature. 491:594–598. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Cui Q, Ren C, Sollars PJ, Pickard GE and So KF: The injury resistant ability of melanopsin-expressing intrinsically photosensitive retinal ganglion cells. Neuroscience. 284:845–853. 2015. View Article : Google Scholar :

21 

González Fleitas MF, Bordone M, Rosenstein RE and Dorfman D: Effect of retinal ischemia on the non-image forming visual system. Chronobiol Int. 32:152–163. 2015. View Article : Google Scholar

22 

Czeisler CA, Shanahan TL, Klerman EB, Martens H, Brotman DJ, Emens JS, Klein T and Rizzo JF: Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med. 332:6–11. 1995. View Article : Google Scholar : PubMed/NCBI

23 

Moura AL, Nagy BV, La Morgia C, Barboni P, Oliveira AG, Salomão SR, Berezovsky A, de Moraes-Filho MN, Chicani CF, Belfort R Jr, et al: The pupil light reflex in Leber's hereditary optic neuropathy: Evidence for preservation of melanopsin-expressing retinal ganglion cells. Invest Ophthalmol Vis Sci. 54:4471–4477. 2013. View Article : Google Scholar : PubMed/NCBI

24 

de Zavalía N, Plano SA, Fernandez DC, Lanzani MF, Salido E, Belforte N, Sarmiento MI, Golombek DA and Rosenstein RE: Effect of experimental glaucoma on the non-image forming visual system. J Neurochem. 117:904–914. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Noseda R, Kainz V, Jakubowski M, Gooley JJ, Saper CB, Digre K and Burstein R: A neural mechanism for exacerbation of headache by light. Nat Neurosci. 13:239–245. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Ross-Cisneros F, La Morgia C, Pan B, Hannibal J, Carelli V and Sadun A: A Histopathologic and morphometric analysis of degenerating melanopsin retinal ganglion cells in Alzheimer's disease. Invest Ophthalmol Vis Sci. 54:2992013.

27 

van Someren EJ, Hagebeuk EE, Lijzenga C, Scheltens P, de Rooij SE, Jonker C, Pot AM, Mirmiran M and Swaab DF: Circadian rest-activity rhythm disturbances in Alzheimer's disease. Biol Psychiatry. 40:259–270. 1996. View Article : Google Scholar : PubMed/NCBI

28 

Hofman MA and Swaab DF: Living by the clock: the circadian pacemaker in older people. Ageing Res Rev. 5:33–51. 2006. View Article : Google Scholar

29 

La Morgia C, Gallassi R, Sambati L, Provini F, Ross-Cisneros FN, Pan B, Barboni P, et al: Melanopsin retinal ganglion cells and circadian dysfunction in Alzheimer's disease. Acta Ophthalmologica. 91:02013. View Article : Google Scholar

30 

La Morgia C, Ross-Cisneros FN, Koronyo Y, Hannibal J, Gallassi R, Cantalupo G, Sambati L, Pan BX, Tozer KR, Barboni P, et al: Melanopsin retinal ganglion cell loss in Alzheimer's disease. Ann Neurol. Oct 27–2015.Epub ahead of print.

31 

Dai J, Swaab DF, Van der Vliet J and Buijs RM: Postmortem tracing reveals the organization of hypothalamic projections of the suprachiasmatic nucleus in the human brain. J Comp Neurol. 400:87–102. 1998. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Feng R, Li L, Yu H, Liu M and Zhao W: Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review). Mol Med Rep 13: 3397-3400, 2016.
APA
Feng, R., Li, L., Yu, H., Liu, M., & Zhao, W. (2016). Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review). Molecular Medicine Reports, 13, 3397-3400. https://doi.org/10.3892/mmr.2016.4966
MLA
Feng, R., Li, L., Yu, H., Liu, M., Zhao, W."Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review)". Molecular Medicine Reports 13.4 (2016): 3397-3400.
Chicago
Feng, R., Li, L., Yu, H., Liu, M., Zhao, W."Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review)". Molecular Medicine Reports 13, no. 4 (2016): 3397-3400. https://doi.org/10.3892/mmr.2016.4966
Copy and paste a formatted citation
x
Spandidos Publications style
Feng R, Li L, Yu H, Liu M and Zhao W: Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review). Mol Med Rep 13: 3397-3400, 2016.
APA
Feng, R., Li, L., Yu, H., Liu, M., & Zhao, W. (2016). Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review). Molecular Medicine Reports, 13, 3397-3400. https://doi.org/10.3892/mmr.2016.4966
MLA
Feng, R., Li, L., Yu, H., Liu, M., Zhao, W."Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review)". Molecular Medicine Reports 13.4 (2016): 3397-3400.
Chicago
Feng, R., Li, L., Yu, H., Liu, M., Zhao, W."Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review)". Molecular Medicine Reports 13, no. 4 (2016): 3397-3400. https://doi.org/10.3892/mmr.2016.4966
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team