Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo

  • Authors:
    • Xin Li
    • Jinmei Xu
    • Xi Tang
    • Yilun Liu
    • Xiaoping Yu
    • Zhi Wang
    • Weihua Liu
  • View Affiliations

  • Published online on: March 16, 2016     https://doi.org/10.3892/mmr.2016.4990
  • Pages: 4007-4013
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Abstract

Trastuzumab (Herceptin®) is a recombinant humanized monoclonal antibody that is targeted against the human epidermal growth factor receptor 2 (HER2) tyrosine kinase receptor. Trastuzumab has been successfully used to treat patients with HER2-positive breast cancer, which accounts for ~25% of invasive breast cancer. However, the majority of patients who initially respond to trastuzumab demonstrate disease progression within 1 year of treatment. Therefore, identifying alternative drugs that overcome trastuzumab resistance and target HER2 may increase the magnitude and duration of response. Through a high‑throughput screening approach, we previously identified numerous anthocyanins that exert activity in HER2‑positive human breast cancer cell lines. The present study aimed to evaluate the anti‑tumor properties of anthocyanins against parental HER2‑positive cells and derivative trastuzumab‑resistant cells in vitro and in vivo. Cell proliferation, western blotting, Annexin V staining, migration and invasion assays were used to determine the effects of anthocyanins in vitro. Cyanidin-3-glucoside and peonidin-3-glucoside were able to inhibit phosphorylation of HER2, induce apoptosis, suppress migration and invasion, and inhibit tumor cell growth. Coupled with the fact that anthocyanins have been used for decades as supplements for the treatment of various types of cancer in Asia, the present study may have established a framework for the development and testing of anthocyanins as a novel treatment paradigm used to overcome classical trastuzumab-resistance and to improve the outcome of this disease.
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May-2016
Volume 13 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Li X, Xu J, Tang X, Liu Y, Yu X, Wang Z and Liu W: Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo. Mol Med Rep 13: 4007-4013, 2016
APA
Li, X., Xu, J., Tang, X., Liu, Y., Yu, X., Wang, Z., & Liu, W. (2016). Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo. Molecular Medicine Reports, 13, 4007-4013. https://doi.org/10.3892/mmr.2016.4990
MLA
Li, X., Xu, J., Tang, X., Liu, Y., Yu, X., Wang, Z., Liu, W."Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo". Molecular Medicine Reports 13.5 (2016): 4007-4013.
Chicago
Li, X., Xu, J., Tang, X., Liu, Y., Yu, X., Wang, Z., Liu, W."Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo". Molecular Medicine Reports 13, no. 5 (2016): 4007-4013. https://doi.org/10.3892/mmr.2016.4990