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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-2016 Volume 13 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo

  • Authors:
    • Xin Li
    • Jinmei Xu
    • Xi Tang
    • Yilun Liu
    • Xiaoping Yu
    • Zhi Wang
    • Weihua Liu
  • View Affiliations / Copyright

    Affiliations: Administrative Office, Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China, Department of Scientific Research, First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China, Department of Public Health, Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China
  • Pages: 4007-4013
    |
    Published online on: March 16, 2016
       https://doi.org/10.3892/mmr.2016.4990
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Abstract

Trastuzumab (Herceptin®) is a recombinant humanized monoclonal antibody that is targeted against the human epidermal growth factor receptor 2 (HER2) tyrosine kinase receptor. Trastuzumab has been successfully used to treat patients with HER2-positive breast cancer, which accounts for ~25% of invasive breast cancer. However, the majority of patients who initially respond to trastuzumab demonstrate disease progression within 1 year of treatment. Therefore, identifying alternative drugs that overcome trastuzumab resistance and target HER2 may increase the magnitude and duration of response. Through a high‑throughput screening approach, we previously identified numerous anthocyanins that exert activity in HER2‑positive human breast cancer cell lines. The present study aimed to evaluate the anti‑tumor properties of anthocyanins against parental HER2‑positive cells and derivative trastuzumab‑resistant cells in vitro and in vivo. Cell proliferation, western blotting, Annexin V staining, migration and invasion assays were used to determine the effects of anthocyanins in vitro. Cyanidin-3-glucoside and peonidin-3-glucoside were able to inhibit phosphorylation of HER2, induce apoptosis, suppress migration and invasion, and inhibit tumor cell growth. Coupled with the fact that anthocyanins have been used for decades as supplements for the treatment of various types of cancer in Asia, the present study may have established a framework for the development and testing of anthocyanins as a novel treatment paradigm used to overcome classical trastuzumab-resistance and to improve the outcome of this disease.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, Xu J, Tang X, Liu Y, Yu X, Wang Z and Liu W: Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo. Mol Med Rep 13: 4007-4013, 2016.
APA
Li, X., Xu, J., Tang, X., Liu, Y., Yu, X., Wang, Z., & Liu, W. (2016). Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo. Molecular Medicine Reports, 13, 4007-4013. https://doi.org/10.3892/mmr.2016.4990
MLA
Li, X., Xu, J., Tang, X., Liu, Y., Yu, X., Wang, Z., Liu, W."Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo". Molecular Medicine Reports 13.5 (2016): 4007-4013.
Chicago
Li, X., Xu, J., Tang, X., Liu, Y., Yu, X., Wang, Z., Liu, W."Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo". Molecular Medicine Reports 13, no. 5 (2016): 4007-4013. https://doi.org/10.3892/mmr.2016.4990
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Xu J, Tang X, Liu Y, Yu X, Wang Z and Liu W: Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo. Mol Med Rep 13: 4007-4013, 2016.
APA
Li, X., Xu, J., Tang, X., Liu, Y., Yu, X., Wang, Z., & Liu, W. (2016). Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo. Molecular Medicine Reports, 13, 4007-4013. https://doi.org/10.3892/mmr.2016.4990
MLA
Li, X., Xu, J., Tang, X., Liu, Y., Yu, X., Wang, Z., Liu, W."Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo". Molecular Medicine Reports 13.5 (2016): 4007-4013.
Chicago
Li, X., Xu, J., Tang, X., Liu, Y., Yu, X., Wang, Z., Liu, W."Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo". Molecular Medicine Reports 13, no. 5 (2016): 4007-4013. https://doi.org/10.3892/mmr.2016.4990
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