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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
May-2016 Volume 13 Issue 5

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review)

Kuo Yan, Li‑Na Gao, Yuan‑Lu Cui, Yi Zhang, Xin Zhou
Pages: 3715-3723
Published online on: 18 March 2016

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Article Open Access

Temporal profiles of blood pressure, circulating nitric oxide, and adrenomedullin as predictors of clinical outcome in acute ischemic stroke patients

Marta Serrano‑Ponz, Carmen Rodrigo‑Gasqué, Eva Siles, Esther Martínez‑Lara, Laura Ochoa‑Callejero, Alfredo Martínez
Pages: 3724-3734
Published online on: 18 March 2016

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Article Open Access

Whole-genome re-sequencing for the identification of high contribution susceptibility gene variants in patients with type 2 diabetes

Xiaojuan Sun, Weiguo Sui, Xiaobing Wang, Xianliang Hou, Minglin Ou, Yong Dai, Yueying Xiang
Pages: 3735-3746
Published online on: 18 March 2016

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Article Open Access

Osteo-/odontogenic differentiation of BMP2 and VEGF gene-co-transfected human stem cells from apical papilla

Wen Zhang, Xiaolei Zhang, Junqi Ling, Xi Wei, Yutao Jian
Pages: 3747-3754
Published online on: 16 March 2016

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Article Open Access

Mesenchymal stem cells ameliorate inflammatory cytokine-induced impairment of AT-II cells through a keratinocyte growth factor-dependent PI3K/Akt/mTOR signaling pathway

Jiwei Li, Sha Huang, Junhua Zhang, Changjiang Feng, Dongyun Gao, Bin Yao, Xu Wu, Xiaobing Fu
Pages: 3755-3762
Published online on: 18 March 2016

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Article Open Access

Curcumin induces G2/M arrest and triggers apoptosis via FoxO1 signaling in U87 human glioma cells

Chao Cheng, Jian‑Tong Jiao, Yu Qian, Xiao‑Yi Guo, Jin Huang, Min‑Chao Dai, Lei Zhang, Xiao‑Peng Ding, Da Zong, Jun‑Fei Shao
Pages: 3763-3770
Published online on: 21 March 2016

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Article Open Access

Inhibition of mTOR signaling protects photoreceptor cells against serum deprivation by reducing oxidative stress and inducing G2/M cell cycle arrest

Bin Fan, Fu‑Qaing Li, Jing‑Yao Song, Xu Chen, Guang‑Yu Li
Pages: 3771-3778
Published online on: 18 March 2016

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Article Open Access

Screening for genes and subnetworks associated with pancreatic cancer based on the gene expression profile

Jin Long, Zhe Liu, Xingda Wu, Yuanhong Xu, Chunlin Ge
Pages: 3779-3786
Published online on: 18 March 2016

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Article Open Access

Farnesyl pyrophosphate synthase inhibitor, ibandronate, improves endothelial function in spontaneously hypertensive rats

Jie Han, Dong‑Mei Jiang, Yang Ye, Chang‑Qing Du, Jian Yang, Shen‑Jiang Hu
Pages: 3787-3796
Published online on: 21 March 2016

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Profiling lethal factor interacting proteins from human stomach using T7 phage display screening

Albin Cardona‑Correa, Carlos Rios‑Velazquez
Pages: 3797-3804
Published online on: 21 March 2016

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Article Open Access

Fibulin-3 may improve vascular health through inhibition of MMP-2/9 and oxidative stress in spontaneously hypertensive rats

Zhongwei Lin, Zhuo Wang, Guobiao Li, Bowei Li, Wenlin Xie, Dingcheng Xiang
Pages: 3805-3812
Published online on: 21 March 2016

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Article Open Access

GGsTOP increases migration of human periodontal ligament cells in vitro via reactive oxygen species pathway

Ying Jiang, Xiang Wang, Ying Li, Sen Mu, Shuang Zhou, Yi Liu, Bin Zhang
Pages: 3813-3820
Published online on: 21 March 2016

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Article Open Access

Hypoxia is important in F‑18 FDG accumulation in thecoma‑fibroma tumors on F‑18 FDG PET/CT scans

Hiroko Seino, Shuichi Ono, Hiroyuki Miura, Satoko Morohashi, Yunyan Wu, Fumiyasu Tsushima, Yoshihiro Takai, Hiroshi Kijima
Pages: 3821-3827
Published online on: 21 March 2016

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Article Open Access

Expression of MIF and c-erbB-2 in endometrial cancer

Wei Xiao, Xiujuan Dong, Honghui Zhao, Shiyu Han, Ruixue Nie, Xiahua Zhang, Ruifang An
Pages: 3828-3834
Published online on: 16 March 2016

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Article Open Access

Inhibition of the translocation and extracellular release of high-mobility group box 1 alleviates liver damage in fibrotic mice in response to D-galactosamine/lipopolysaccharide challenge

Li Bai, Ming Kong, Qingfen Zheng, Xiaohui Zhang, Xin Liu, Kejia Zu, Yu Chen, Sujun Zheng, Junfeng Li, Feng Ren, Jinli Lou, Shuang Liu, Zhongping Duan
Pages: 3835-3841
Published online on: 18 March 2016

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Article Open Access

The ‘selfish brain’ is regulated by aquaporins and autophagy under nutrient deprivation

Qiao Ye, Yonghong Wu, Yan Gao, Zhihui Li, Weiguang Li, Chenggang Zhang
Pages: 3842-3848
Published online on: 11 March 2016

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Article Open Access

Co-culture with podoplanin+ cells protects leukemic blast cells with leukemia-associated antigens in the tumor microenvironment

Ji Yoon Lee, A‑Reum Han, Sung‑Eun Lee, Woo‑Sung Min, Hee‑Je Kim
Pages: 3849-3857
Published online on: 18 March 2016

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Article Open Access

Knockdown of ANXA1 suppresses the biological behavior of human NSCLC cells in vitro

Ying Fang, Xiaoying Guan, Tonghui Cai, Jie Long, Hongyan Wang, Xiaobin Xie, Yajie Zhang
Pages: 3858-3866
Published online on: 21 March 2016

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Article Open Access

S-Adenosylmethionine suppresses the expression of Smad3/4 in activated human hepatic stellate cells via Rac1 promoter methylation

Kangqi Bian, Feng Zhang, Tingting Wang, Xiaoping Zou, Xuhong Duan, Guangxia Chen, Yuzheng Zhuge
Pages: 3867-3873
Published online on: 17 March 2016

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Article Open Access

Altered function of monocytes/macrophages in patients with autoimmune hepatitis

Rui Lin, Jie Zhang, Lu Zhou, Bangmao Wang
Pages: 3874-3880
Published online on: 17 March 2016

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Article Open Access

Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice

Yuan‑Yuan Deng, Muhammad Shamoon, Yue He, Madhav Bhatia, Jia Sun
Pages: 3881-3885
Published online on: 18 March 2016

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Article Open Access

IL‑6 and IL‑8 enhance factor H binding to the cell membranes

Sylwia Popek, Lucyna Kapka‑Skrzypczak, Krzysztof Sawicki, Ewa Wolińska, Maciej Skrzypczak, Magdalena Czajka
Pages: 3886-3894
Published online on: 18 March 2016

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Article Open Access

Antiadipogenic effects of subthermal electric stimulation at 448 kHz on differentiating human mesenchymal stem cells

María Luisa Hernández‑Bule, Javier Martínez‑Botas, María Ángeles Trillo, Carlos L Paíno, Alejandro Úbeda
Pages: 3895-3903
Published online on: 21 March 2016

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Article Open Access

Translational informatics approach for identifying the functional molecular communicators linking coronary artery disease, infection and inflammation

Ankit Sharma, Madankumar Ghatge, Lakshmi Mundkur, Rajani Kanth Vangala
Pages: 3904-3912
Published online on: 18 March 2016

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Article Open Access

Gene expression profile analysis of pancreatic cancer based on microarray data

Jin Long, Zhe Liu, Xingda Wu, Yuanhong Xu, Chunlin Ge
Pages: 3913-3919
Published online on: 21 March 2016

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Article Open Access

Transcription factor‑microRNA synergistic regulatory network revealing the mechanism of polycystic ovary syndrome

Hai‑Ying Liu, Yu‑Ling Huang, Jian‑Qiao Liu, Qing Huang
Pages: 3920-3928
Published online on: 21 March 2016

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Article

MicroRNA-200b inhibits the proliferation of hepatocellular carcinoma by targeting DNA methyltransferase 3a

Xing‑Yu Li, Xing‑Zi Feng, Jian‑Zhong Tang, Kun Dong, Jun‑Feng Wang, Chun‑Cheng Meng, Jun Wang, Yi‑Wo Mo, Zhi‑Wei Sun
Pages: 3929-3935
Published online on: 16 March 2016

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Article

Melatonin attenuates hLRRK2-induced sleep disturbances and synaptic dysfunction in a Drosophila model of Parkinson's disease

Xicui Sun, Dongzhi Ran, Xiaofeng Zhao, Yi Huang, Simei Long, Fengyin Liang, Wenyuan Guo, Frederick C. Nucifora, Huaiyu Gu, Xilin Lu, Ling Chen, Jinsheng Zeng, Christopher A. Ross, Zhong Pei
Pages: 3936-3944
Published online on: 16 March 2016

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Article

Effect of recombinant human erythropoietin and doxorubicin in combination on the proliferation of MCF-7 and MDA-MB231 breast cancer cells

Esam M. Radwan, Rasedee Abdullah, Mothanna Sadiq Al‑Qubaisi, Mohamed E. El Zowalaty, Seïf‑Eddine Naadja, Noorjahan B. Alitheen, Abdul‑Rahman Omar
Pages: 3945-3952
Published online on: 16 March 2016

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Article

Protective effect of berberine on doxorubicin‑induced acute hepatorenal toxicity in rats

Xueyan Chen, Yu Zhang, Zhongning Zhu, Huanlong Liu, Huicai Guo, Chen Xiong, Kerang Xie, Xiaofei Zhang, Suwen Su
Pages: 3953-3960
Published online on: 21 March 2016

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Article

Expression of trophinin and dipeptidyl peptidase IV in endometrial co-culture in the presence of an embryo: A comparative immunocytochemical study

Elif Gelenli Dolanbay, Melda Yardimoglu, Ender Yalcinkaya, Yusufhan Yazir, Ayca Aksoy, Erdal Karaoz, Eray Caliskan
Pages: 3961-3968
Published online on: 21 March 2016

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Article

PageRank analysis reveals topologically expressed genes correspond to psoriasis and their functions are associated with apoptosis resistance

Xue Zeng, Jingjing Zhao, Xiaohong Wu, Hongbo Shi, Wali Liu, Bingnan Cui, Li Yang, Xu Ding, Ping Song
Pages: 3969-3976
Published online on: 18 March 2016

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Article

CGRP may regulate bone metabolism through stimulating osteoblast differentiation and inhibiting osteoclast formation

Haitao He, Jianshen Chai, Shengfu Zhang, Linlin Ding, Peng Yan, Wenjun Du, Zhenzhou Yang
Pages: 3977-3984
Published online on: 21 March 2016

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Article

Studies on the purification of polysaccharides separated from Tremella fuciformis and their neuroprotective effect

Yaxiang Jin, Xinyu Hu, Yan Zhang, Tianji Liu
Pages: 3985-3992
Published online on: 21 March 2016

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Article

Lazaroid U83836E protects the heart against ischemia reperfusion injury via inhibition of oxidative stress and activation of PKC

Li‑Na Lai, Xiao‑Jing Zhang, Xiao‑Yi Zhang, Li‑Hua Song, Chun‑Hua Guo, Jing‑Wen Lei, Xiao‑Liang Song
Pages: 3993-4000
Published online on: 21 March 2016

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Article

p38 mitogen-activated protein kinase inhibition modulates nucleus pulposus cell apoptosis in spontaneous resorption of herniated intervertebral discs: An experimental study in rats

Yu Zhu, Jin‑Tao Liu, Li‑Yan Yang, Wen‑Pei Du, Xiao‑Chun Li, Xiang Qian, Peng‑Fei Yu, Jian‑Wen Liu, Hong Jiang
Pages: 4001-4006
Published online on: 22 March 2016

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Article

Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo

Xin Li, Jinmei Xu, Xi Tang, Yilun Liu, Xiaoping Yu, Zhi Wang, Weihua Liu
Pages: 4007-4013
Published online on: 16 March 2016

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Article

Inhibition of RANKL-induced osteoclast differentiation through the downregulation of c-Fos and NFATc1 by Eremochloa ophiuroides (centipedegrass) extract

Bo‑Yun Choi, Chul‑Hong Park, Yun Hee Na, Hyoung‑Woo Bai, Jae‑Young Cho, Byung Yeoup Chung
Pages: 4014-4022
Published online on: 18 March 2016

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Article

Sulforaphane promotes immune responses in a WEHI‑3‑induced leukemia mouse model through enhanced phagocytosis of macrophages and natural killer cell activities in vivo

Yung‑Luen Shih, Lung‑Yuan Wu, Ching‑Hsiao Lee, Yung‑Liang Chen, Shu‑Ching Hsueh, Hsu‑Feng Lu, Nien‑Chieh Liao, Jing‑Gung Chung
Pages: 4023-4029
Published online on: 21 March 2016

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Article

miR‑19a‑3p targets PMEPA1 and induces prostate cancer cell proliferation, migration and invasion

Sujuan Feng, Xuhui Zhu, Bohan Fan, Dawei Xie, Tao Li, Xiaodong Zhang
Pages: 4030-4038
Published online on: 21 March 2016

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Article

X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism: Identification and in vitro study of a novel small indel in the NR0B1 gene

Tingting Yu, Jian Wang, Yongguo Yu, Xiaodong Huang, Qihua Fu, Yiping Shen, Fuxiang Chen
Pages: 4039-4045
Published online on: 18 March 2016

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Article

Role of estrogen receptor in breast cancer cell gene expression

Yabing Zheng, Xiying Shao, Yuan Huang, Lei Shi, Bo Chen, Xiaojia Wang, Hongjian Yang, Zhanhong Chen, Xiping Zhang
Pages: 4046-4050
Published online on: 21 March 2016

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Article

Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords

Lin‑Lin Wang, Dong‑Ling Shi, Hui‑Yao Gu, Ming‑Zhi Zheng, Jue Hu, Xing‑Hui Song, Yue‑Liang Shen, Ying‑Ying Chen
Pages: 4051-4057
Published online on: 21 March 2016

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Article

NAMPT protects against 6-hydroxydopamine-induced neurotoxicity in PC12 cells through modulating SIRT1 activity

Xiao‑Dong Zou, Shao‑Qing Guo, Zhi‑Wei Hu, Wei‑Lang Li
Pages: 4058-4064
Published online on: 21 March 2016

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Article

Rubus coreanus Miquel extract causes apoptosis of doxorubicin-resistant NCI/ADR-RES ovarian cancer cells via JNK phosphorylation

Min Kyoung Kim, Hyeong Sim Choi, Sung‑Gook Cho, Yong Cheol Shin, Seong‑Gyu Ko
Pages: 4065-4072
Published online on: 17 March 2016

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Article

Astaxanthin reduces isoflurane-induced neuroapoptosis via the PI3K/Akt pathway

Chun‑Mei  Wang, Xiao‑Lan  Cai, Qing‑Ping  Wen
Pages: 4073-4078
Published online on: 21 March 2016

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Article

Anticancer effect of docetaxel induces apoptosis of prostate cancer via the cofilin-1 and paxillin signaling pathway

Pan Xiao, Tianjia Ma, Chunwen Zhou, Yang Xu, Yuqiang Liu, Huaiqiang Zhang
Pages: 4079-4084
Published online on: 18 March 2016

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Article

miR‑30a‑5p in the tumorigenesis of renal cell carcinoma: A tumor suppressive microRNA

Yifan Li, Yuchi Li, Duqun Chen, Lu Jin, Zhengming Su, Jiaju Liu, Hongfang Duan, Xiaoqing Li, Zhengyu Qi, Min Shi, Liangchao Ni, Shangqi Yang, Yaoting Gui, Xiangming Mao, Yun Chen, Yongqing Lai
Pages: 4085-4094
Published online on: 21 March 2016

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Article

rs621554 single nucleotide polymorphism of DLC1 is associated with breast cancer susceptibility and prognosis

Xia Ding, Sumei Gao, Qifeng Yang
Pages: 4095-4100
Published online on: 08 March 2016

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Article

MicroRNA-21 modulates radiation resistance through upregulation of hypoxia-inducible factor-1α-promoted glycolysis in non-small cell lung cancer cells

Shumei Jiang, Renben Wang, Hongjiang Yan, Linzhi Jin, Xue Dou, Dong Chen
Pages: 4101-4107
Published online on: 18 March 2016

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Article

MicroRNA-335-5p inhibits osteoblast apoptosis induced by high glucose

Jiling Li, Zhengping Feng, Lixue Chen, Xiaoju Wang, Huacong Deng
Pages: 4108-4112
Published online on: 16 March 2016

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Article

Characteristics of B cell‑associated gene expression in patients with coronary artery disease

Wenwen Yan, Haoming Song, Jinfa Jiang, Wenjun Xu, Zhu Gong, Qianglin Duan, Chuangrong Li, Yuan Xie, Lemin Wang
Pages: 4113-4121
Published online on: 21 March 2016

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Article

Vagus nerve electrical stimulation inhibits serum levels of S100A8 protein in septic shock rats

Ming Lei, Xin‑Xin Liu
Pages: 4122-4128
Published online on: 18 March 2016

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Article Open Access

Effects of NOX1 on fibroblastic changes of endothelial cells in radiation‑induced pulmonary fibrosis

Seo‑Hyun Choi, Miseon Kim, Hae‑June Lee, Eun‑Ho Kim, Chun‑Ho Kim, Yoon‑Jin Lee
Pages: 4135-4142
Published online on: 05 April 2016

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Article Open Access

Correlation between insulin‑like growth factor binding protein 3 and metastasis‑associated gene 1 protein in esophageal squamous cell carcinoma

Haiping Yang, Lijuan Xu, Haili Qian, Xinqiang Niu, Dan Zhao, Zhilong Zhao, Jun Wu, Junfeng Liu, Yanyu Wang
Pages: 4143-4150
Published online on: 28 March 2016

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Article Open Access

Differential expression of EBV proteins LMP1 and BHFR1 in EBV‑associated gastric and nasopharyngeal cancer tissues

Ailiang Wang, Wei Zhang, Meng Jin, Jianbo Zhang, Sheng Li, Feng Tong, Yanbing Zhou
Pages: 4151-4158
Published online on: 05 April 2016

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Article Open Access

Inhibition of histone deacetylases by trans-cinnamic acid and its antitumor effect against colon cancer xenografts in athymic mice

Bingyan Zhu, Boyang Shang, Yi Li, Yongsu Zhen
Pages: 4159-4166
Published online on: 23 March 2016

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Article Open Access

Extracts of Bauhinia championii (Benth.) Benth. attenuate the inflammatory response in a rat model of collagen-induced arthritis

Wei Xu, Mingqing Huang, Yuqin Zhang, Huang Li, Haiyin Zheng, Lishuang Yu, Kedan Chu, Yu Lin, Lidian Chen
Pages: 4167-4174
Published online on: 30 March 2016

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Article Open Access

Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling

Rong Yang, Liang Zhong, Xiao‑Qun Yang, Kai‑Ling Jiang, Liu Li, Hao Song, Bei‑Zhong Liu
Pages: 4175-4182
Published online on: 28 March 2016

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Article Open Access

Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model

Yingying Yue, Peng Li, Nannan Song, Bingqing Li, Zhihui Li, Yuqi Guo, Weidong Zhang, Ming Q. Wei, Zhongtao Gai, Hong Meng, Jiwen Wang, Lizeng Qin
Pages: 4183-4190
Published online on: 31 March 2016

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Metabolic profiling of Shu-Yu capsule in rat serum based on metabolic fingerprinting analysis using HPLC-ESI-MSn

Fang Li, You‑Bo Zhang, Xia Wei, Chun‑Hong Song, Ming‑Qi Qiao, Hui‑Yun Zhang
Pages: 4191-4204
Published online on: 04 April 2016

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Lycopene protects human SH‑SY5Y neuroblastoma cells against hydrogen peroxide‑induced death via inhibition of oxidative stress and mitochondria‑associated apoptotic pathways

Chunsheng Feng, Tianfei Luo, Shuyan Zhang, Kai Liu, Yanhong Zhang, Yinan Luo, Pengfei Ge
Pages: 4205-4214
Published online on: 28 March 2016

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Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model

Huimin Wang, Huiling Wang, Huixin Cheng, Zhenyong Che
Pages: 4215-4220
Published online on: 28 March 2016

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Effect of ATRA on the expression of HOXA5 gene in K562 cells and its relationship with cell cycle and apoptosis

Wen‑Jun Liu, Teng Zhang, Qu‑Lian Guo, Chun‑Yan Liu, Yong‑Qi Bai
Pages: 4221-4228
Published online on: 04 April 2016

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MicroRNA-29b inhibits TGF-β1-induced fibrosis via regulation of the TGF-β1/Smad pathway in primary human endometrial stromal cells

Jingxiong Li, Bohong Cen, Siping Chen, Yuanli He
Pages: 4229-4237
Published online on: 30 March 2016

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Galangin inhibits cell invasion by suppressing the epithelial-mesenchymal transition and inducing apoptosis in renal cell carcinoma

Jingyi Cao, Hainan Wang, Feifei Chen, Jianzheng Fang, Aiming Xu, Wei Xi, Shengli Zhang, Gang Wu, Zengjun Wang
Pages: 4238-4244
Published online on: 24 March 2016

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Expression patterns of Wnt signaling component, secreted frizzled‑related protein 3 in astrocytoma and glioblastoma

Nives Pećina‑Šlaus, Anja Kafka, Ana Maria Varošanec, Leon Marković, Željka Krsnik, Niko Njirić, Goran Mrak
Pages: 4245-4251
Published online on: 28 March 2016

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Expression of SOFAT by T- and B-lineage cells may contribute to bone loss

Christian R. Jarry, Elizabeth F. Martinez, Daiane C. Peruzzo, Vanessa Carregaro, Laís A. Sacramento, Vera C. Araújo, M. Neale Weitzmann, Marcelo H. Napimoga
Pages: 4252-4258
Published online on: 24 March 2016

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Expression profile analysis of head and neck squamous cell carcinomas using data from The Cancer Genome Atlas

Li Yan, Cheng Zhan, Jihong Wu, Shengzi Wang
Pages: 4259-4265
Published online on: 28 March 2016

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Effects of resveratrol and genistein on nuclear factor‑κB, tumor necrosis factor‑α and matrix metalloproteinase‑9 in patients with chronic obstructive pulmonary disease

Xiao‑Ju Liu, Hai‑Rong Bao, Xiao‑Li Zeng, Jun‑Ming Wei
Pages: 4266-4272
Published online on: 28 March 2016

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Article

Clinical, pathological and genetic characteristics of autosomal dominant inherited dynamin 2 centronuclear myopathy Retraction in /10.3892/mmr.2016.5267

Xinhong Liu, Huamin Wu, Jian Gong, Tao Wang, Chuanzhu Yan
Pages: 4273-4278
Published online on: 28 March 2016

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Article

MicroRNA-197 inhibits cell proliferation by targeting GAB2 in glioblastoma

Li‑Qiang Tian, En‑Qin Liu, Xi‑De Zhu, Xin‑Gong Wang, Jian Li, Guang‑Ming Xu
Pages: 4279-4288
Published online on: 31 March 2016

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Article

Inhibitory effect of Zanthoxylum bungeanum seed oil on ovalbumin‑induced lung inflammation in a murine model of asthma

Jun‑Qin Wang, Xiao‑Wei Li, Mingyi Liu, Sheng‑Chun Wang, Zeng‑Fa Cao
Pages: 4289-4302
Published online on: 28 March 2016

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Article

Transfection of chondromodulin I into human breast cancer cells and its effect on the inhibition of cancer cell growth

Jie Shao, Linghong Gan, Jie Wang
Pages: 4303-4308
Published online on: 31 March 2016

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Article

Role of N-acetylgalactosaminyltransferase 6 in early tumorigenesis and formation of metastasis

Friederike Liesche, Alexandra C. Kölbl, Matthias Ilmer, Stefan Hutter, Udo Jeschke, Ulrich Andergassen
Pages: 4309-4314
Published online on: 24 March 2016

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Article

Co‑inhibition of miRNA‑21 and miRNA‑221 induces apoptosis by enhancing the p53‑mediated expression of pro‑apoptotic miRNAs in laryngeal squamous cell carcinoma

Xuan Kan, Yanan Sun, Jianguang Lu, Minghua Li, Yu Wang, Qiuying Li, Ying Liu, Ming Liu, Linli Tian
Pages: 4315-4320
Published online on: 28 March 2016

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Article

Digital gene expression profiling analysis of childhood acute lymphoblastic leukemia

Ming‑Yi Zhao, Yan Yu, Min Xie, Ming‑Hua Yang, Shan Zhu, Liang‑Chun Yang, Rui Kang, Dao‑Lin Tang, Ling‑Ling Zhao, Li‑Zhi Cao
Pages: 4321-4328
Published online on: 05 April 2016

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Article

Construction of SET overexpression vector and its effects on the proliferation and apoptosis of 293T cells

Yuan Wang, Peng‑Cheng He, Yan‑Feng Liu, Jun Qi, Mei Zhang
Pages: 4329-4334
Published online on: 28 March 2016

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Article

Attenuation of liver fibrosis by herbal compound 861 via upregulation of BMP-7/Smad signaling in the bile duct ligation model rat

Fei Hou, Ruixia Liu, Xiaoya Liu, Lijian Cui, Yan Wen, Songbiao Yan, Chenghong Yin
Pages: 4335-4342
Published online on: 30 March 2016

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Article

Nox4 has a crucial role in uric acid‑induced oxidative stress and apoptosis in renal tubular cells

Zhuohang Li, Yiyu Sheng, Cheng Liu, Kuiqing Li, Xin Huang, Jian Huang, Kewei Xu
Pages: 4343-4348
Published online on: 04 April 2016

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Article

TBX5 loss-of-function mutation contributes to atrial fibrillation and atypical Holt-Oram syndrome

Dong‑Feng Guo, Ruo‑Gu Li, Fang Yuan, Hong‑Yu Shi, Xu‑Min Hou, Xin‑Kai Qu, Ying‑Jia Xu, Min Zhang, Xu Liu, Jin‑Qi Jiang, Yi‑Qing Yang, Xing‑Biao Qiu
Pages: 4349-4356
Published online on: 24 March 2016

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Article

CXCL12/CXCR4 signaling pathway regulates cochlear development in neonatal mice

Wen Zhang, Ji‑Zhou Sun, Yu Han, Jun Chen, Hui Liu, Ye Wang, Bo Yue, Yang Chen
Pages: 4357-4364
Published online on: 04 April 2016

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Article

Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages

Soo‑Jin Jeong, Ohn‑Soon Kim, Sae‑Rom Yoo, Chang‑Seob Seo, Yeji Kim, Hyeun‑Kyoo Shin
Pages: 4365-4371
Published online on: 04 April 2016

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Article

Nuclear respiratory factor 1 overexpression attenuates anti-benzopyrene‑7,8-diol-9,10-epoxide-induced S-phase arrest of bronchial epithelial cells

Jing Wu, Yaning Wang, Da Wo, Lijuan Zhang, Jue Li
Pages: 4372-4378
Published online on: 30 March 2016

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Article

MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1 Corrigendum in /10.3892/mmr.2022.12799

Deyao Wu, Xiaobing Niu, Huixing Pan, Yunfeng Zhou, Ping Qu, Jian Zhou
Pages: 4379-4385
Published online on: 28 March 2016

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Article

Chemical chaperone 4-phenylbutyric acid protects H9c2 cardiomyocytes from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis

Lian Jian, Yuan Lu, Shan Lu, Chengzhi Lu
Pages: 4386-4392
Published online on: 30 March 2016

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Article

Resistance of mitochondrial DNA-depleted cells against oxidized low-density lipoprotein-induced macrophage pyroptosis

Hai Yan, Yunyun Li, Xue Peng, Dake Huang, Li Gui, Baojun Huang
Pages: 4393-4399
Published online on: 31 March 2016

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Article

shRNA-mediated RPS15A silencing inhibits U937 acute myeloid leukemia cell proliferation and enhances apoptosis

Guangyao Li, Li Zhang, Jizhu Liu, Taiwu Xiao, Guozhen Liu, Jingxia Wang, Ming Hou
Pages: 4400-4406
Published online on: 30 March 2016

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Article

Disrupted intestinal structure in a rat model of intermittent hypoxia

Junping Wu, Xin Sun, Qi Wu, Hongwei Li, Li Li, Jing Feng, Subei Zhang, Long Xu, Kuan Li, Xue Li, Xing Wang, Huaiyong Chen
Pages: 4407-4413
Published online on: 30 March 2016

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Article

Inhibition of the Rac1-WAVE2-Arp2/3 signaling pathway promotes radiosensitivity via downregulation of cofilin-1 in U251 human glioma cells

Tao Zhou, Chen‑Han Wang, Hua Yan, Rui Zhang, Jin‑Bing Zhao, Chun‑Fa Qian, Hong Xiao, Hong‑Yi Liu
Pages: 4414-4420
Published online on: 05 April 2016

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Article

Functionally conserved effects of rapamycin exposure on zebrafish

Ceren Sucularli, Huma Shehwana, Cem Kuscu, Dilay Ciglidag Dungul, Hilal Ozdag, Ozlen Konu
Pages: 4421-4430
Published online on: 28 March 2016

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Article

Knockdown of Nogo gene by short hairpin RNA interference promotes functional recovery of spinal cord injury in a rat model

Guo‑Min Liu, Yun‑Gang Luo, Juan Li, Kun Xu
Pages: 4431-4436
Published online on: 30 March 2016

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Article

Effect of growth differentiation factor‑9 C447T and G546A polymorphisms on the outcomes of in vitro fertilization

Monika Serdyńska‑Szuster, Piotr Jędrzejczak, Katarzyna Ewa Ożegowska, Hanna Hołysz, Leszek Pawelczyk, Paweł Piotr Jagodziński
Pages: 4437-4442
Published online on: 28 March 2016

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Article

Time-dependent activity of Na+/H+ exchanger isoform 1 and homeostasis of intracellular pH in astrocytes exposed to CoCl2 treatment

Peng Wang, Ling Li, Zhenxiang Zhang, Quancheng Kan, Feng Gao, Suyan Chen
Pages: 4443-4450
Published online on: 30 March 2016

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Article

Role of extracellular signal‑regulated kinase 1/2 signal transduction pathway in insulin secretion by β‑TC6 cells

Ben Niu, Lijuan Liu, Heng Su, Xueshan Xia, Qiu He, Yue Feng, Yuanming Xue, Xinming Yan
Pages: 4451-4454
Published online on: 28 March 2016

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Article

Knockdown of SCARA5 inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration through suppression of the PDGF signaling pathway

Jiangtao Zhao, Liguo Jian, Lihua Zhang, Tongbin Ding, Xiaowei Li, Dong Cheng, Shaohui Niu, Liqiang Sun, En Li, Shichao Liu, Youxu Jiang, Lu Liu
Pages: 4455-4460
Published online on: 30 March 2016

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Article

Artemisinin inhibits gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis

Jianguang Jia, Yiyu Qin, Ligong Zhang, Chenxu Guo, Yaguo Wang, Xicheng Yue, Jun Qian
Pages: 4461-4468
Published online on: 30 March 2016

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Article

Knockdown of LI-cadherin alters expression of matrix metalloproteinase-2 and -9 and galectin-3

Qiongfang Yu, Wei Shen, Huangyan Zhou, Weiguo Dong, Dian Gao
Pages: 4469-4474
Published online on: 30 March 2016

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Article

Piperlongumine inhibits gastric cancer cells via suppression of the JAK1,2/STAT3 signaling pathway

Baoji Song, Hongjie Zhan, Quan Bian, Junping Gu
Pages: 4475-4480
Published online on: 05 April 2016

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Article

Upregulation of long non coding RNA PCAT-1 contributes to cell proliferation, migration and apoptosis in hepatocellular carcinoma

Jifeng Wen, Jun Xu, Qifeng Sun, Chengliang Xing, Wenzhe Yin
Pages: 4481-4486
Published online on: 30 March 2016

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Article

Maternal undernutrition leads to elevated hepatic triglycerides in male rat offspring due to increased expression of lipoprotein lipase

Wei‑Fen Zhu, Jian‑Fang Zhu, Li Liang, Zheng Shen, Ying‑Min Wang
Pages: 4487-4493
Published online on: 23 March 2016

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Article

Tumor-promoting function of single nucleotide polymorphism rs1836724 (C3388T) alters multiple potential legitimate microRNA binding sites at the 3'-untranslated region of ErbB4 in breast cancer

Fatemeh Bagheri, Hamzeh Mesrian Tanha, Marjan Mojtabavi Naeini, Kamran Ghaedi, Mansoureh Azadeh
Pages: 4494-4498
Published online on: 31 March 2016

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Article

miR‑140‑5p regulates angiogenesis following ischemic stroke by targeting VEGFA

Jijun Sun, Shuxin Tao, Lifeng Liu, Dong Guo, Zhangyong Xia, Min Huang
Pages: 4499-4505
Published online on: 30 March 2016

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Article

3-Deoxyglucosone induces insulin resistance by impairing insulin signaling in HepG2 cells

Guoqiang Liang, Fei Wang, Xiudao Song, Lurong Zhang, Zhen Qian, Guorong Jiang
Pages: 4506-4512
Published online on: 04 April 2016

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Article

A comparative study of the timecourse of the expression of the thermo‑inducible HSP70 gene in clinical and environmental isolates of Aspergillus fumigatus

Golnaz Sharafi, Ali Reza Khosravi, Ghasem Vahedi, Ramak Yahyaraeyat, Teimur Abbasi
Pages: 4513-4521
Published online on: 28 March 2016

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Journal Cover
July-2026 Volume 34 Issue 1

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Editorial Open Access

Regulatory mechanisms and therapeutic potential of N6-methyladenosine modification in retinal diseases (Review)

Wenyao Zhang, Jinying Chen, Jingxiang Zhong
Article Number: 213
Published online on: 29 May 2026

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Review Open Access

Epigenetic orchestration of scar formation: Therapeutic potential of targeting DNA methylation and non‑coding RNAs in cutaneous fibrosis (Review)

Jinshun Li, Weiyun Liu, Jin Yang, Yanan Li
Article Number: 212
Published online on: 29 May 2026

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Elucidating the multitarget neuroprotective mechanisms of protocatechuic acid in neurological disorders (Review)

Xiaoyan Xue, Yongchang Lai, Shasha Song, Liping Wu, Lifang Wang
Article Number: 211
Published online on: 29 May 2026

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[Retracted] Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP‑9 signaling pathway in DU145 cells

Yuan Zeng, Ying Yang
Article Number: 210
Published online on: 27 May 2026

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FOSL2 drives transcriptional activation of super‑enhancer-regulated DYNC1H1 to promote hypoxia‑induced oral squamous cell carcinoma progression

Linyu Jin, Jing Zhang, Wenjing Wang, Nan Zhang, Yang Liu, Alin Tian, Weiwei Yin, Yongle Qiu
Article Number: 209
Published online on: 25 May 2026

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Targeting lipophagy in atherosclerosis: Molecular mechanisms, pathogenesis and therapeutic interventions (Review)

Songhua Nan, Chaojie Peng, Xue Meng, Jingnan Jia, Fangfang Zhao, Yinglin Cui
Article Number: 208
Published online on: 22 May 2026

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Mechanisms of pruritus and advances in traditional Chinese medicine therapy (Review)

Hailing Zhang, Yongji Li, Yuan Liu, Danyi Feng, Letao Zhao, Ran Chen, Xiwu Zhang, Jinjin Dou
Article Number: 207
Published online on: 22 May 2026

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Reprogramming of the hepatic ubiquitin‑immune axis: A unifying mechanism in liver disease progression (Review)

Yadi Ju, Xiaodan Chong, Weichen Ning, Yan Shi, Yangyang Li, Yihai Shi
Article Number: 206
Published online on: 22 May 2026

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Role of the PI3K/AKT signaling pathway in regulating gene expression in rheumatoid arthritis (Review)

Chengzhi Cong, Yuan Wang, Jian Liu, Chao Jin
Article Number: 205
Published online on: 21 May 2026

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Biomarkers of radioresistance in lung cancer: Current insights and future directions (Review)

Fatima Zohra Attouahri, Imane Chaoui, Abdelilah Laraqui, Mohamed Rida Tagajdid, Mohammed Oukabli, Mohammed El Marjany, Meriem Khyatti, Mohammed Attaleb, Mouna Ababou, Khalid Ennibi, Khaoula Errafii, Mohammed El Mzibri
Article Number: 204
Published online on: 21 May 2026

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Epigenetic research methods and animal models for intervertebral disc degeneration (Review)

Xinliang Cui, Li Zeng, Wei Zhang, Leimin Xi, Rui Wang, Diff Jia, Safa, Haoyu Feng, Huidong Jia
Article Number: 203
Published online on: 21 May 2026

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Article Open Access

ZBTB16 upregulation maintains copper homeostasis to support esophageal tumor progression

Jingyi Wang, Bin Yang, Shengzu Peng, Bin Yang
Article Number: 202
Published online on: 21 May 2026

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Correction Open Access

[Corrigendum] MicroRNA‑1 promotes cartilage matrix synthesis and regulates chondrocyte differentiation via post‑​transcriptional suppression of Ihh expression  

Taoyu Chen, Xianda Che, Pengfei Han, Jiangong Lu, Chunfang Wang, Bin Liang, Ziqi Hou, Xiaochun Wei, Lei Wei, Pengcui Li
Article Number: 201
Published online on: 20 May 2026

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Estrogen deficiency as a common driver and integrative mechanism in osteoporosis‑osteoarthritis comorbidity (Review)

Jian Cheng, Xiaodong Wu, Lu Zhao, Shuai Jiang, Wenjie Zhao, Weishuai Zhang
Article Number: 200
Published online on: 20 May 2026

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Role of RNA 5‑methylcytosine modification in cancer: Insights from coding and non‑coding RNAs (Review)

Qin Jiang, Yi Gong, Mimi Zhai, Tenglong Tang, Sushun Liu
Article Number: 199
Published online on: 20 May 2026

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m6A modification in skeletal system diseases (Review)

Xi Xie, Chen Li, Haotian Zheng, Guang Gan, Xi Gao
Article Number: 198
Published online on: 19 May 2026

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Dynamic regulation of the ‘mitochondria‑immune axis’ in myocardial infarction: Molecular mechanisms driving macrophage polarization through energy metabolism disorders (Review)

Yu Zhang, Hao Feng, Qin Wu, Shuxian Yang, Yundong Jiang, Houping Xu, Li Dong, Xiaolin Li, Hui Chen, Gang Luo
Article Number: 197
Published online on: 19 May 2026

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Retraction Open Access

[Retracted] Homeobox B9 facilitates hypertrophic scar formation via activating the mitogen‑activated protein kinase signaling pathway

Qun Xie, Dandan Liu, Mosheng Yu, Xiaowei Wu, Yueqiang Zhao, Qiang Hu, Qi Wang
Article Number: 196
Published online on: 18 May 2026

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Polysaccharides: Natural candidates for targeting immunometabolic regulation in hepatocellular carcinoma (Review)

Changmei Wu, Jinjin Dou, Xiwu Zhang
Article Number: 195
Published online on: 18 May 2026

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Article Open Access

NF‑κB signaling drives Th17‑mediated lacrimal gland injury and tear dysfunction in a murine model of primary Sjögren's syndrome

Jiajun Xie, Huina Zhang, Wenyue Shen, Juan Ye
Article Number: 194
Published online on: 18 May 2026

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POSTN(+) fibroblasts and SPP1(+) macrophages in scar formation: A review of mechanisms and therapeutic targets (Review)

Haotian Wu, Xianglin Dong
Article Number: 193
Published online on: 15 May 2026

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Emerging role of DYRK1A as a target in cardiovascular diseases (Review)

Liqing Yu, Qionghong Cheng, Jun Wu
Article Number: 192
Published online on: 15 May 2026

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Retraction Open Access

[Retracted] Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1

Peng Zou, Xiaoxiao Liu, Gang Li, Yangang Wang
Article Number: 191
Published online on: 05 May 2026

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Gut microbiota and its metabolites: Key factors of drug resistance in the treatment of advanced prostate cancer (Review)

Jingheng Song, Hongguo Cui, Peisen Yang, Yankai Xu, Yuanyuan Liu, Gang Zhang, Yangyang Liu, Aimin Tian, Jizhong Che, Hui Sun, Zhengchao Zhang
Article Number: 190
Published online on: 04 May 2026

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Cepharanthine inhibits lysosomes and induces apoptosis in triple‑negative breast cancer cells

Juan Li, Siqin Zhou, Yu Wang, Guanghan Ou, Danli Yang, Liwen Shen
Article Number: 189
Published online on: 04 May 2026

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Review Open Access

Applications of humanized mice in Mycobacterium tuberculosis infections (Review)

Binghua Han, Fang Liu, Jinzhao Long, Jiongjiong Wang, Yange Cui, Haiyan Yang
Article Number: 188
Published online on: 04 May 2026

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Research progress on neutrophil extracellular traps in sepsis‑induced coagulopathy (Review)

Jiandong Hu, Mengli Jin, Zhihua Cao, Binbin Zheng, Yuan Zheng, Hao Shen
Article Number: 187
Published online on: 04 May 2026

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Multifaceted regulatory role of proline‑ and glutamine-rich splicing factor in tumors (Review)

Shilin Zhang, Zhenhua Li, Li Fu
Article Number: 186
Published online on: 04 May 2026

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Article Open Access

Effects of ALDH2 gene expression on the oxidative stress‑mediated NF‑κB/mTOR pathway in ketamine‑induced cystitis

Xiao Jian Xi, Yong Yao, Peng Gu, Min Hao Zhang
Article Number: 185
Published online on: 04 May 2026

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Retraction Open Access

[Retracted] Rosiglitazone exerts neuroprotective effects via the suppression of neuronal autophagy and apoptosis in the cortex following traumatic brain injury

Junchao Yao, Kebin Zheng, Xiang Zhang
Article Number: 184
Published online on: 29 April 2026

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Journal Cover
August-2026 Volume 34 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Molecular mechanisms of iron metabolism and ferroptosis in cardiovascular diseases and intervention strategies targeting natural products (Review)

Liangqing Ge, Tianqing Zhang, Jiangbiao Yu, Sijie Xiao, Yu Zhou, Li Luo
Article Number: 221
Published online on: 05 June 2026

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Correction Open Access

[Corrigendum] Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis

Ruiqiao Guan, Zhihao Li, Xiaohong Dai, Wei Zou, Xueping Yu, Hao Liu, Qiuxin Chen, Wei Teng, Peng Liu, Xiaoying Liu, Shanshan Dong
Article Number: 220
Published online on: 03 June 2026

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LINC01117 promotes the malignant proliferation of lung adenocarcinoma by increasing HOXD8 mRNA stability

Lizhong Zeng, Jie Shi, Cai Zhang, Yujiao Dong, Yang Chen, Qiuhong Zhang, Long Zhang, Shuanying Yang
Article Number: 219
Published online on: 03 June 2026

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Targeting regulatory T cells in the prostate cancer microenvironment: From mechanisms to therapeutics (Review)

Hua Luo
Article Number: 218
Published online on: 03 June 2026

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Dapagliflozin alleviates heart failure with preserved ejection fraction potentially by regulating the AIM2/caspase‑1/GSDMD pathway and attenuating pyroptosis

Sailiang Ding, Hao Yang, Ting Lu, Yibin Luo, Liang Xu, Xianghui Zeng
Article Number: 217
Published online on: 03 June 2026

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[Retracted] Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models

Yong Liu, Yan Zhang, Ming Hu, Yu-Hu Li, Xing-Hua Cao
Article Number: 216
Published online on: 02 June 2026

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Review Open Access

SIRT1/AMPK/PGC1α pathway in ischemic stroke: Elucidating neuroprotective strategies (Review)

Irum Naz Abbasi, Nashwa Amin, Qiaolu Xu, Azhar Badry Hussain, Fei Wu, Xia Yuan, Yang Yang, Suhong Ye, Marong Fang, Yihua Jiang
Article Number: 215
Published online on: 02 June 2026

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Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review)

Yinhuan Wang, Jiefang Guan
Article Number: 214
Published online on: 29 May 2026

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