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Altered function of monocytes/macrophages in patients with autoimmune hepatitis

  • Authors:
    • Rui Lin
    • Jie Zhang
    • Lu Zhou
    • Bangmao Wang
  • View Affiliations / Copyright

    Affiliations: Department of Digestive Diseases, General Hospital, Tianjin Medical University, Tianjin 300052, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3874-3880
    |
    Published online on: March 17, 2016
       https://doi.org/10.3892/mmr.2016.4998
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Abstract

The pathogenesis of autoimmune hepatitis (AIH) involves the intervention of the innate and adaptive immune responses. In the current study, the alterations in monocytes/Kupffer cells (KCs) were investigated in patients with AIH. A total of 21 patients with AIH at different stages of the disease, and 7 controls with non‑alcoholic fatty liver disease were selected. The abundance of VAV1 and p21‑activated kinase 1 (PAK1) in the liver and KCs was analyzed. In addition, the expression levels of HLA‑DR and CD80 in the peripheral blood monocytes (PBMs) were measured, and phagocytosis of PBMs was assessed. KCs of AIH patients exhibited higher expression levels of VAV1 and PAK1. This upregulated expression was associated with disease progression. A reduced expression of HLA‑DR and CD80, and reduced capacity of E. coli phagocytosis in PBMs was observed for patients with AIH. This downregulated expression was associated with disease progression. The results of the current study indicated that defective function of KCs and PBMs may be involved in the pathogenesis of AIH.
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1 

Ma Y, Bogdanos DP, Hussain MJ, Underhill J, Bansal S, Longhi MS, Cheeseman P, Mieli-Vergani G and Vergani D: Polyclonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2. Gastroenterology. 130:868–882. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Seki E and Schnabl B: Role of innate immunity and the microbiota in liver fibrosis: Crosstalk between the liver and gut. J Physiol. 590:447–458. 2012. View Article : Google Scholar :

3 

Lleo A, Bowlus CL, Yang GX, Invernizzi P, Podda M, Van de Water J, Ansari AA, Coppel RL, Worman HJ, Gores GJ and Gershwin ME: Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis. Hepatology. 52:987–998. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Bouwens L, Baekeland M, De Zanger R and Wisse E: Quantitation, tissue distribution and proliferation kinetics of Kupffer cells in normal rat liver. Hepatology. 6:718–722. 1986. View Article : Google Scholar : PubMed/NCBI

5 

Baffy G: Kupffer cells in non-alcoholic fatty liver disease: The emerging view. J Hepatol. 51:212–223. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Burdo TH, Lackner A and Williams KC: Monocyte/macrophages and their role in HIV neuropathogenesis. Immunol Rev. 254:102–113. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Pul R, Morbiducci F, Škuljec J, Skripuletz T, Singh V, Diederichs U, Garde N, Voss EV, Trebst C and Stangel M: Glatiramer acetate increases phagocytic activity of human monocytes in vitro and in multiple sclerosis patients. PLoS One. 7:e518672012. View Article : Google Scholar

8 

Booth S, Florida-James GD, McFarlin BK, Spielmann G, O'Connor DP and Simpson RJ: The impact of acute strenuous exercise on TLR2, TLR4 and HLA.DR expression on human blood monocytes induced by autologous serum. Eur J Appl Physiol. 110:1259–1268. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Wang D, Yuan F, Wang L and Wei W: Paeoniflorin inhibits function and down-regulates HLA-DR and CD80 expression of human peripheral blood monocytes stimulated by rhIL-1β. Int Immunopharmacol. 14:172–178. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Jennings RT and Knaus UG: Rho family and Rap GTPase activation assays. Methods Mol Biol. 1124:79–88. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Katzav S: Vav1:A hematopoietic signal transduction molecule involved in human malignancies. Int J Biochem Cell Biol. 41:1245–1248. 2009. View Article : Google Scholar

12 

Jhaveri KA, Debnath P, Chernoff J, Sanders J and Schwartz MA: The role of p21-activated kinase in the initiation of atherosclerosis. BMC Cardiovasc Disord. 12(55)2012.PubMed/NCBI

13 

Hennes EM, Zeniya M, Czaja AJ, Parés A, Dalekos GN, Krawitt EL, Bittencourt PL, Porta G, Boberg KM, Hofer H, et al: Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology. 48:169–176. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M and Sanyal AJ; American Gastroenterological Association; American Association for the Study of Liver Diseases; American College of Gastroenterologyh: The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American gastroenterological association, American association for the study of liver diseases and American college of gastroenterology. Gastroenterology. 142:1592–1609. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Gille C, Leiber A, Mundle I, Spring B, Abele H, Spellerberg B, Hartmann H, Poets ChF and Orlikowsky TW: Phagocytosis and postphagocytic reaction of cord blood and adult blood monocyte after infection with green fluorescent protein-labeled Escherichia coli and group B Streptococci. Cytometry B Clin Cytom. 76:271–284. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Liberal R, Longhi MS, Mieli-Vergani G and Vergani D: Pathogenesis of autoimmune hepatitis. Best Pract Res Clin Gastroenterol. 25:653–664. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Heymann F, Hammerich L, Storch D, Bartneck M, Huss S, Rüsseler V, Gassler N, Lira SA, Luedde T, Trautwein C and Tacke F: Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. Hepatology. 55:898–909. 2012. View Article : Google Scholar

18 

Yu Z, Otsuka H, Yamaguchi K, Kuroishi T, Sasano T, Sugawara S, Nakamura M and Endo Y: Roles of platelets and macrophages in the protective effects of lipopolysaccharide against concanavalin A-induced murine hepatitis. Biochim Biophys Acta. 1812.1069–1079. 2011.

19 

Naito M, Hasegawa G and Takahashi K: Development, differentiation and maturation of Kupffer cells. Microsc Res Tech. 39:350–364. 1997. View Article : Google Scholar

20 

Etienne-Manneville S and Hall A: Rho GTPases in cell biology. Nature. 420:629–635. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Swetman CA, Leverrier Y, Garg R, Gan CH, Ridley AJ, Katz DR and Chain BM: Extension, retraction and contraction in the formation of a dendritic cell dendrite: Distinct roles for Rho GTPases. Eur J Immunol. 32:2074–2083. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Ridley AJ: Rho proteins, PI 3-kinases and monocyte/macrophage motility. FEBS Lett. 498:168–171. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Tse SM, Furuya W, Gold E, Schreiber AD, Sandvig K, Inman RD and Grinstein S: Differential role of actin, clathrin and dynamin in Fc gamma receptor-mediated endocytosis and phagocytosis. J Biol Chem. 278:3331–3338. 2003. View Article : Google Scholar

24 

Chrencik JE, Brooun A, Zhang H, Mathews II, Hura GL, Foster SA, Perry JJ, Streiff M, Ramage P, Widmer H, et al: Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. J Mol Biol. 380:828–843. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Wells CM, Bhavsar PJ, Evans IR, Vigorito E, Turner M, Tybulewicz V and Ridley AJ: Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization. Exp Cell Res. 310:303–310. 2005. View Article : Google Scholar : PubMed/NCBI

26 

de la Fuente H, Mittelbrunn M, Sánchez-Martín L, Vicente-Manzanares M, Lamana A, Pardi R, Cabañas C and Sánchez-Madrid F: Synaptic clusters of MHC class II molecules induced on DCs by adhesion molecule-mediated initial T-cell scanning. Mol Biol Cell. 16:3314–3322. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Arias-Romero LE and Chernoff J: A tale of two Paks. Biol Cell. 100:97–108. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Delorme V, Machacek M, DerMardirossian C, Anderson KL, Wittmann T, Hanein D, Waterman-Storer C, Danuser G and Bokoch GM: Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks. Dev Cell. 13:646–662. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Hsu HY and Twu YC: Tumor necrosis factor-alpha-mediated protein kinases in regulation of scavenger receptor and foam cell. J Biol Chem. 275:41035–41048. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lin R, Zhang J, Zhou L and Wang B: Altered function of monocytes/macrophages in patients with autoimmune hepatitis. Mol Med Rep 13: 3874-3880, 2016.
APA
Lin, R., Zhang, J., Zhou, L., & Wang, B. (2016). Altered function of monocytes/macrophages in patients with autoimmune hepatitis. Molecular Medicine Reports, 13, 3874-3880. https://doi.org/10.3892/mmr.2016.4998
MLA
Lin, R., Zhang, J., Zhou, L., Wang, B."Altered function of monocytes/macrophages in patients with autoimmune hepatitis". Molecular Medicine Reports 13.5 (2016): 3874-3880.
Chicago
Lin, R., Zhang, J., Zhou, L., Wang, B."Altered function of monocytes/macrophages in patients with autoimmune hepatitis". Molecular Medicine Reports 13, no. 5 (2016): 3874-3880. https://doi.org/10.3892/mmr.2016.4998
Copy and paste a formatted citation
x
Spandidos Publications style
Lin R, Zhang J, Zhou L and Wang B: Altered function of monocytes/macrophages in patients with autoimmune hepatitis. Mol Med Rep 13: 3874-3880, 2016.
APA
Lin, R., Zhang, J., Zhou, L., & Wang, B. (2016). Altered function of monocytes/macrophages in patients with autoimmune hepatitis. Molecular Medicine Reports, 13, 3874-3880. https://doi.org/10.3892/mmr.2016.4998
MLA
Lin, R., Zhang, J., Zhou, L., Wang, B."Altered function of monocytes/macrophages in patients with autoimmune hepatitis". Molecular Medicine Reports 13.5 (2016): 3874-3880.
Chicago
Lin, R., Zhang, J., Zhou, L., Wang, B."Altered function of monocytes/macrophages in patients with autoimmune hepatitis". Molecular Medicine Reports 13, no. 5 (2016): 3874-3880. https://doi.org/10.3892/mmr.2016.4998
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